| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Ortiz, C Lorz, J Egid. The Fas ligand/Fas system in renal injury. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 14. issue 8. 1999-10-08. PMID:10462254. |
evidence that fasl and fas participate in renal injury may be summarized along modified koch's postulates (table 1): (i) fasl is expressed by renal cells and during renal injury, (ii) activation of the fas receptor promotes apoptosis of cultured renal cells, (iii) fas agonists induce glomerular injury but they may also decrease renal injury by limiting injurious immunological responses, (iv) mice with disrupted fasl/fas systems are protected from tubular cell injury during ischaemia reperfusion, although they develop autoimmune glomerulonephritis if other genetic predisposing factors are present. |
1999-10-08 |
2023-08-12 |
mouse |
| A Ortiz, C Lorz, J Egid. The Fas ligand/Fas system in renal injury. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 14. issue 8. 1999-10-08. PMID:10462254. |
possible therapeutic interventions include fas agonists, soluble fas receptors, or other antagonists, and targetting of fas to undesired cells, such as fibroblasts, in order to decrease their numbers in a physiological manner through apoptosis. |
1999-10-08 |
2023-08-12 |
mouse |
| J D Bretz, P L Arscott, A Myc, J R Bake. Inflammatory cytokine regulation of Fas-mediated apoptosis in thyroid follicular cells. The Journal of biological chemistry. vol 274. issue 36. 1999-10-07. PMID:10464273. |
the occurrence of apoptosis in thyroid follicular cells induced by fas activation has been a subject of much debate. |
1999-10-07 |
2023-08-12 |
human |
| J D Bretz, P L Arscott, A Myc, J R Bake. Inflammatory cytokine regulation of Fas-mediated apoptosis in thyroid follicular cells. The Journal of biological chemistry. vol 274. issue 36. 1999-10-07. PMID:10464273. |
this is due, in part, to the fact that no physiologically relevant treatment conditions have been reported to cause rapid and extensive fas-mediated apoptosis in thyroid cells, whereas treatment with the protein synthesis inhibitor cycloheximide prior to fas activation allows for massive cell death. |
1999-10-07 |
2023-08-12 |
human |
| J D Bretz, P L Arscott, A Myc, J R Bake. Inflammatory cytokine regulation of Fas-mediated apoptosis in thyroid follicular cells. The Journal of biological chemistry. vol 274. issue 36. 1999-10-07. PMID:10464273. |
to reconcile the conflicting reports, we set out to identify physiologically relevant conditions in which rapid, massive thyroid cell apoptosis in response to fas activation could be demonstrated. |
1999-10-07 |
2023-08-12 |
human |
| J O'Connell, M W Bennett, G C O'Sullivan, J K Collins, F Shanaha. Resistance to Fas (APO-1/CD95)-mediated apoptosis and expression of Fas ligand in esophageal cancer: the Fas counterattack. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. vol 12. issue 2. 1999-10-07. PMID:10466039. |
resistance to fas (apo-1/cd95)-mediated apoptosis and expression of fas ligand in esophageal cancer: the fas counterattack. |
1999-10-07 |
2023-08-12 |
Not clear |
| J O'Connell, M W Bennett, G C O'Sullivan, J K Collins, F Shanaha. Resistance to Fas (APO-1/CD95)-mediated apoptosis and expression of Fas ligand in esophageal cancer: the Fas counterattack. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. vol 12. issue 2. 1999-10-07. PMID:10466039. |
as the triggering agonist for fas receptor (fas or apo-1/cd95)-mediated apoptosis of lymphocytes, fasl normally plays immune down-regulatory roles, including activation-induced cell death of t and b cells, as well as maintaining immune privilege in certain organs. |
1999-10-07 |
2023-08-12 |
Not clear |
| J O'Connell, M W Bennett, G C O'Sullivan, J K Collins, F Shanaha. Resistance to Fas (APO-1/CD95)-mediated apoptosis and expression of Fas ligand in esophageal cancer: the Fas counterattack. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. vol 12. issue 2. 1999-10-07. PMID:10466039. |
fas ligand expressed by esophageal cell lines has been shown to induce apoptosis of cocultured fas-sensitive lymphoid cells in vitro. |
1999-10-07 |
2023-08-12 |
Not clear |
| J O'Connell, M W Bennett, G C O'Sullivan, J K Collins, F Shanaha. Resistance to Fas (APO-1/CD95)-mediated apoptosis and expression of Fas ligand in esophageal cancer: the Fas counterattack. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. vol 12. issue 2. 1999-10-07. PMID:10466039. |
by expressing functional fas ligand, esophageal cancer cells can deplete antitumor lymphocytes by inducing apoptosis. |
1999-10-07 |
2023-08-12 |
Not clear |
| G Feldman. [Apoptosis]. Annales pharmaceutiques francaises. vol 57. issue 4. 1999-10-07. PMID:10472702. |
cell integration of these new findings with regard to apoptosis is illustrated by the description of the apoptotic fas pathway, the mode of action of the proapoptotic cytokine tnf alpha and the analysis of the apoptosis mechanism when dna is damaged and when the p53 gene is overexpressed. |
1999-10-07 |
2023-08-12 |
human |
| J Mathieu, S Richard, B Ballester, Y Chancerelle, E Multo. [Apoptosis and gamma rays]. Annales pharmaceutiques francaises. vol 57. issue 4. 1999-10-07. PMID:10472704. |
three main proteins are involved in the regulation of radiation-induced apoptosis: p53, fas and bcl-2. |
1999-10-07 |
2023-08-12 |
Not clear |
| J Zhang, B Ma, A Marshak-Rothstein, A Fin. Characterization of a novel cis-element that regulates Fas ligand expression in corneal endothelial cells. The Journal of biological chemistry. vol 274. issue 37. 1999-10-07. PMID:10473616. |
constitutively expressed fas ligand in the cornea, sertoli cell of the testes, paneth cell of the intestines, and clara cell of the airway protect surrounding parenchymal tissue by inducing apoptosis of fas(+) immune cells during inflammatory reactions. |
1999-10-07 |
2023-08-12 |
mouse |
| D S Tew. Cell death and oxidative stress in gliomas. Neuropathology and applied neurobiology. vol 25. issue 4. 1999-10-07. PMID:10476044. |
therefore, in 46 gliomas (including astrocytomas, oligodendrogliomas, oligo-astrocytomas, and glioblastomas), the relationship of apoptosis and necrosis and the expression of apoptosis-promoting (p53, bax, fas, fas-l) and inhibiting (bcl-2) factors as well as of different isoforms of nos (nosb, nose, nosi) and manganese superoxide dismutase (mnsod) were studied. |
1999-10-07 |
2023-08-12 |
Not clear |
| S Khan, R P Cleveland, C J Koch, J R Schellin. Hypoxia induces renal tubular epithelial cell apoptosis in chronic renal disease. Laboratory investigation; a journal of technical methods and pathology. vol 79. issue 9. 1999-10-07. PMID:10496527. |
we have previously demonstrated enhanced, diffuse expression of the fas apoptosis receptor in os/+ tubules, providing a potential intermediary between hypoxia and apoptosis. |
1999-10-07 |
2023-08-12 |
mouse |
| S Khan, R P Cleveland, C J Koch, J R Schellin. Hypoxia induces renal tubular epithelial cell apoptosis in chronic renal disease. Laboratory investigation; a journal of technical methods and pathology. vol 79. issue 9. 1999-10-07. PMID:10496527. |
both in vitro hypoxic conditions stimulated rtc plasma membrane fas expression, and caused rtc apoptosis upon ligation with agonistic fas antibodies. |
1999-10-07 |
2023-08-12 |
mouse |
| M Chiravuri, T Schmitz, K Yardley, R Underwood, Y Dayal, B T Hube. A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. Journal of immunology (Baltimore, Md. : 1950). vol 163. issue 6. 1999-10-04. PMID:10477574. |
however, it differs from apoptosis induced by gamma irradiation in the same cells or by fas ligation in transformed lymphocytes in terms of caspase involvement. |
1999-10-04 |
2023-08-12 |
Not clear |
| D Zella, O Barabitskaja, L Casareto, F Romerio, P Secchiero, M S Reitz, R C Gallo, F F Weichol. Recombinant IFN-alpha (2b) increases the expression of apoptosis receptor CD95 and chemokine receptors CCR1 and CCR3 in monocytoid cells. Journal of immunology (Baltimore, Md. : 1950). vol 163. issue 6. 1999-10-04. PMID:10477584. |
we also provide evidence that, under these conditions, ifn-alpha treatment increased the expression of cd95 (fas, apo1), resulting in enhanced susceptibility to apoptosis. |
1999-10-04 |
2023-08-12 |
Not clear |
| P M Roger, G Bernard-Pomier, E Counillon, J P Breittmayer, A Bernard, P Dellamonic. Overexpression of Fas/CD95 and Fas-induced apoptosis in a patient with idiopathic CD4+ T lymphocytopenia. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. vol 28. issue 5. 1999-09-30. PMID:10452627. |
cd4+ t lymphopenia observed in our patient correlated with an overexpression of fas together with spontaneous and fas-induced apoptosis. |
1999-09-30 |
2023-08-12 |
human |
| N Giannoukakis, W A Rudert, S C Ghivizzani, A Gambotto, C Ricordi, M Trucco, P D Robbin. Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro. Diabetes. vol 48. issue 9. 1999-09-30. PMID:10480601. |
in particular, il-1beta can impair glucose-stimulated insulin production in beta-cells in vitro and can sensitize them to fas (cd95)/fasl-triggered apoptosis. |
1999-09-30 |
2023-08-12 |
human |
| N Niitsu, K Sasaki, M Umed. A high serum soluble Fas/APO-1 level is associated with a poor outcome of aggressive non-Hodgkin's lymphoma. Leukemia. vol 13. issue 9. 1999-09-30. PMID:10482996. |
soluble fas (sfas) in the serum is believed to be able to inhibit apoptosis of lymphocytes. |
1999-09-30 |
2023-08-12 |
Not clear |