| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S H Lee, M S Shin, J Y Lee, W S Park, S Y Kim, J J Jang, S M Dong, E Y Na, C S Kim, S H Kim, N J Yo. In vivo expression of soluble Fas and FAP-1: possible mechanisms of Fas resistance in human hepatoblastomas. The Journal of pathology. vol 188. issue 2. 2000-02-29. PMID:10398166. |
taken together, these findings demonstrated that fas, a death receptor, and its ligand are co-expressed in hepatoblastomas in vivo, but some inhibitors of fas-mediated apoptosis are also expressed in these tumours. |
2000-02-29 |
2023-08-12 |
human |
| S H Lee, M S Shin, J Y Lee, W S Park, S Y Kim, J J Jang, S M Dong, E Y Na, C S Kim, S H Kim, N J Yo. In vivo expression of soluble Fas and FAP-1: possible mechanisms of Fas resistance in human hepatoblastomas. The Journal of pathology. vol 188. issue 2. 2000-02-29. PMID:10398166. |
these results suggest that it is probably due to the action of inhibitory molecules of the fas pathway that the tumour cells of hepatoblastomas do not kill themselves in an autocrine-driven cycle and that in this manner hepatoblastomas avoid apoptosis. |
2000-02-29 |
2023-08-12 |
human |
| H Kong, A H Kim, J R Orlinick, M V Cha. A comparison of the cytoplasmic domains of the Fas receptor and the p75 neurotrophin receptor. Cell death and differentiation. vol 6. issue 11. 2000-02-29. PMID:10578183. |
these chimeric receptors, one containing the p75 transmembrane domain and the other containing the fasr transmembrane portion, as well as wild-type p75 and fas receptors, were transiently transfected into human u373 glioma cells and human embryonic kidney 293 cells (293 cells), which are both responsive to fas-mediated apoptosis. |
2000-02-29 |
2023-08-12 |
human |
| C G Ferreira, C Tolis, S W Span, G J Peters, T van Lopik, A J Kummer, H M Pinedo, G Giaccon. Drug-induced apoptosis in lung cnacer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 1. 2000-02-28. PMID:10656451. |
all lung cancer cell lines expressed fas and fasl at rna and protein levels, and apoptosis could be induced in four of six cell lines upon exposure to the fas agonistic monoclonal antibody (mab) clb-cd95/15. |
2000-02-28 |
2023-08-12 |
Not clear |
| C G Ferreira, C Tolis, S W Span, G J Peters, T van Lopik, A J Kummer, H M Pinedo, G Giaccon. Drug-induced apoptosis in lung cnacer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 1. 2000-02-28. PMID:10656451. |
moreover, no correlation was observed in lung cancer cell lines between sensitivity to drugs and to a fas agonistic mab, and preincubation of cells with either the fas-antagonistic mab clb-cd95/2 or a fasl-neutralizing mab did not protect from drug-induced apoptosis. |
2000-02-28 |
2023-08-12 |
Not clear |
| E S Pizer, J Thupari, W F Han, M L Pinn, F J Chrest, G L Frehywot, C A Townsend, F P Kuhajd. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer research. vol 60. issue 2. 2000-02-28. PMID:10667561. |
simultaneous exposure of breast cancer cells to tofa and an fas inhibitor resulted in significantly reduced cytotoxicity and apoptosis. |
2000-02-28 |
2023-08-12 |
mouse |
| S Hashimoto, A Kobayashi, K Kooguchi, Y Kitamura, H Onodera, H Nakajim. Upregulation of two death pathways of perforin/granzyme and FasL/Fas in septic acute respiratory distress syndrome. American journal of respiratory and critical care medicine. vol 161. issue 1. 2000-02-25. PMID:10619826. |
quantitative polymerase chain reaction (pcr) analysis revealed that the messenger ribonucleic acids (mrnas) for several apoptosis molecules, such as perforin, granzyme a, granzyme b, fasl, and fas were highly upregulated in the acute phase of ards following sepsis. |
2000-02-25 |
2023-08-12 |
human |
| S T Ju, K Matsui, M Ozdemirl. Molecular and cellular mechanisms regulating T and B cell apoptosis through Fas/FasL interaction. International reviews of immunology. vol 18. issue 5-6. 2000-02-25. PMID:10672498. |
binding of fas by fasl induces apoptosis of the fas-expressing cells. |
2000-02-25 |
2023-08-12 |
Not clear |
| M Delgado, D Gane. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit antigen-induced apoptosis of mature T lymphocytes by inhibiting Fas ligand expression. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 3. 2000-02-24. PMID:10640731. |
vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit antigen-induced apoptosis of mature t lymphocytes by inhibiting fas ligand expression. |
2000-02-24 |
2023-08-12 |
Not clear |
| C Perkins, C N Kim, G Fang, K N Bhall. Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L). Blood. vol 95. issue 3. 2000-02-24. PMID:10648417. |
significantly, as(2)o(3)-induced apoptosis of hl-60/bcr-abl and k562 cells was associated with a decline in bcr-abl protein levels, without any significant alterations in the levels of bcl-x(l), bax, apaf-1, fas, and fasl. |
2000-02-24 |
2023-08-12 |
human |
| K J Micoli, G Pan, Y Wu, J P Williams, W J Cook, J M McDonal. Requirement of calmodulin binding by HIV-1 gp160 for enhanced FAS-mediated apoptosis. The Journal of biological chemistry. vol 275. issue 2. 2000-02-18. PMID:10625668. |
this enhanced apoptosis in response to fas antibody or c(2)-ceramide is associated with activation of caspase 3, a critical mediator of apoptosis. |
2000-02-18 |
2023-08-12 |
human |
| B Ségui, C Bezombes, E Uro-Coste, J A Medin, N Andrieu-Abadie, N Augé, A Brouchet, G Laurent, R Salvayre, J P Jaffrézou, T Levad. Stress-induced apoptosis is not mediated by endolysosomal ceramide. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 1. 2000-02-17. PMID:10627278. |
also, induction of apoptosis using anti-cd95 (fas) or anti-cd40 antibodies, tnf-alpha, daunorubicin, and ionizing radiation was similar in control and farber disease lymphoid cells. |
2000-02-17 |
2023-08-12 |
Not clear |
| W C Powell, B Fingleton, C L Wilson, M Boothby, L M Matrisia. The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Current biology : CB. vol 9. issue 24. 2000-02-16. PMID:10607586. |
the metalloproteinase matrilysin proteolytically generates active soluble fas ligand and potentiates epithelial cell apoptosis. |
2000-02-16 |
2023-08-12 |
Not clear |
| W C Powell, B Fingleton, C L Wilson, M Boothby, L M Matrisia. The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Current biology : CB. vol 9. issue 24. 2000-02-16. PMID:10607586. |
the fas ligand/fas receptor (fasl/fas) system is an important mediator of apoptosis in the immune system where the juxtaposition of cells expressing the cell-surface ligand induces the apoptotic pathway in fas-expressing lymphocytes. |
2000-02-16 |
2023-08-12 |
Not clear |
| T Iida, H Ichimura, T Shimada, K Ibuki, M Ui, K Tamaru, T Kuwata, S Yonehara, J Imanishi, M Hayam. Role of apoptosis induction in both peripheral lymph nodes and thymus in progressive loss of CD4+ cells in SHIV-infected macaques. AIDS research and human retroviruses. vol 16. issue 1. 2000-02-15. PMID:10628812. |
in the 89.6p-infected macaques, fas antigen expression and the extent of apoptosis in pbmcs and peripheral lymph nodes increased at 1-2 weeks postinfection. |
2000-02-15 |
2023-08-12 |
Not clear |
| C A Rubio, B Jacobsson, E Castaños-Vele. Cytotoxic intraepithelial lymphocytes in colorectal polyps and carcinomas. Anticancer research. vol 19. issue 4B. 2000-02-15. PMID:10652615. |
the upregulation of cd3-t, mhc class ii molecules, and tia 1 in iels of neoplastic colorectal lesions suggests that they are activated and cytotoxic; however, they undergo apoptosis due to the downregulation of the fas molecules. |
2000-02-15 |
2023-08-12 |
Not clear |
| M Karas, T Z Zaks, J L Liu, D LeRoit. T cell receptor-induced activation and apoptosis in cycling human T cells occur throughout the cell cycle. Molecular biology of the cell. vol 10. issue 12. 2000-02-14. PMID:10588669. |
susceptibility to apoptosis induced by recombinant fas ligand and activation-induced cell death were also studied. |
2000-02-14 |
2023-08-12 |
human |
| S H Lee, M S Shin, W S Park, S Y Kim, H S Kim, J H Lee, S Y Han, H K Lee, J Y Park, R R Oh, J J Jang, J Y Lee, N J Yo. Immunohistochemical localization of FAP-1, an inhibitor of Fas-mediated apoptosis, in normal and neoplastic human tissues. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 107. issue 12. 2000-02-14. PMID:10660140. |
fas, a death receptor, is widely expressed in human tissue, but its expression, although a prerequisite for the induction of apoptosis, does not predict its biological function. |
2000-02-14 |
2023-08-12 |
human |
| S H Lee, M S Shin, W S Park, S Y Kim, H S Kim, J H Lee, S Y Han, H K Lee, J Y Park, R R Oh, J J Jang, J Y Lee, N J Yo. Immunohistochemical localization of FAP-1, an inhibitor of Fas-mediated apoptosis, in normal and neoplastic human tissues. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 107. issue 12. 2000-02-14. PMID:10660140. |
to understand the mechanisms of fas resistance in human tissues in vivo, we performed immunohistochemistry using an antibody against fas-associated phosphatase-1 (fap-1), which interacts with the cytosolic domain of fas and inhibits fas-mediated apoptosis. |
2000-02-14 |
2023-08-12 |
human |
| S H Lee, M S Shin, W S Park, S Y Kim, H S Kim, J H Lee, S Y Han, H K Lee, J Y Park, R R Oh, J J Jang, J Y Lee, N J Yo. Immunohistochemical localization of FAP-1, an inhibitor of Fas-mediated apoptosis, in normal and neoplastic human tissues. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 107. issue 12. 2000-02-14. PMID:10660140. |
taken together, these findings demonstrated that fap-1 is widely expressed in normal human tissues and partly overlapped with fas expression described in earlier reports, suggesting that fap-1 may have an important role in the regulation of apoptosis in vivo. |
2000-02-14 |
2023-08-12 |
human |