| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Yamamoto, Y Uemura, K Tanaka, K Nakai, C Yamamoto, H Takemoto, K Kamata, H Hirata, K Hiok. Cycloprodigiosin hydrochloride, H(+)/CL(-) symporter, induces apoptosis and differentiation in HL-60 cells. International journal of cancer. vol 88. issue 1. 2000-09-26. PMID:10962449. |
cprg * hcl lowered intracellular ph and induced apoptosis through up-regulation of fas ligand, activation of stress-activated protein kinase (sapk/jnk) and caspase. |
2000-09-26 |
2023-08-12 |
human |
| N Shinoura, Y Yoshida, A Asai, T Kirino, H Hamad. Adenovirus-mediated transfer of p53 and Fas ligand drastically enhances apoptosis in gliomas. Cancer gene therapy. vol 7. issue 5. 2000-09-21. PMID:10830720. |
adenovirus-mediated transfer of p53 and fas ligand drastically enhances apoptosis in gliomas. |
2000-09-21 |
2023-08-12 |
Not clear |
| A Chadderton, D J Villeneuve, S Gluck, A F Kirwan-Rhude, B R Gannon, D E Blais, A M Parissent. Role of specific apoptotic pathways in the restoration of paclitaxel-induced apoptosis by valspodar in doxorubicin-resistant MCF-7 breast cancer cells. Breast cancer research and treatment. vol 59. issue 3. 2000-09-21. PMID:10832593. |
however, mcf-7adr cells possess a deletion mutation in p53 and have considerably reduced levels of the fas receptor, fas ligand, caspase-2, caspase-6, and caspase-8, suggesting that paclitaxel resistance may also stem from a bona fide block in paclitaxel-induced apoptosis in these cells. |
2000-09-21 |
2023-08-12 |
human |
| A Chadderton, D J Villeneuve, S Gluck, A F Kirwan-Rhude, B R Gannon, D E Blais, A M Parissent. Role of specific apoptotic pathways in the restoration of paclitaxel-induced apoptosis by valspodar in doxorubicin-resistant MCF-7 breast cancer cells. Breast cancer research and treatment. vol 59. issue 3. 2000-09-21. PMID:10832593. |
morever, it appears that changes in the levels/activity of p53, the fas receptor, fas ligand, caspase-2, caspase-6, or caspase-8 activity have little effect on paclitaxel-induced cytotoxicity and apoptosis in human breast cancer cells. |
2000-09-21 |
2023-08-12 |
human |
| J Ehrmann, D Galuszková, J Ehrmann, I Krc, V Jezdinská, B Vojtések, P G Murray, Z Kolá. Apoptosis-related proteins, BCL-2, BAX, FAS, FAS-L and PCNA in liver biopsies of patients with chronic hepatitis B virus infection. Pathology oncology research : POR. vol 6. issue 2. 2000-09-21. PMID:10936789. |
however, the increased numbers of both bax and fas positive lymphocytes in chb suggest that these cells may be particularly sensitive to fas-l mediated apoptosis potentially resulting in lowered viability of these lymphocytes. |
2000-09-21 |
2023-08-12 |
Not clear |
| G J Inman, M J Allda. Apoptosis induced by TGF-beta 1 in Burkitt's lymphoma cells is caspase 8 dependent but is death receptor independent. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 5. 2000-09-19. PMID:10946276. |
furthermore, blocking experiments indicated that tgf-beta-mediated apoptosis is not dependent on fas ligand, tnf-alpha, tumor necrosis-like apoptosis-inducing ligand, or tnf-like weak inducer of apoptosis signaling. |
2000-09-19 |
2023-08-12 |
Not clear |
| C Odaka, T Mizuoch. Angiotensin-converting enzyme inhibitor captopril prevents activation-induced apoptosis by interfering with T cell activation signals. Clinical and experimental immunology. vol 121. issue 3. 2000-09-18. PMID:10971519. |
on the other hand, captopril did not interfere with fas signalling, since anti-fas antibody-induced apoptosis in fas+ jurkat cells was unaffected by the drug. |
2000-09-18 |
2023-08-12 |
human |
| C Odaka, T Mizuoch. Angiotensin-converting enzyme inhibitor captopril prevents activation-induced apoptosis by interfering with T cell activation signals. Clinical and experimental immunology. vol 121. issue 3. 2000-09-18. PMID:10971519. |
furthermore, we examined whether captopril blocks activation-induced apoptosis by interfering with expression of fas, fas ligand (fasl), or both on t cell hybridomas. |
2000-09-18 |
2023-08-12 |
human |
| L Qi, K H Si. CpG-specific common commitment in caspase-dependent and -independent cell deaths. Molecular cell biology research communications : MCBRC. vol 3. issue 1. 2000-09-15. PMID:10683315. |
however, we show cpg oligonucleotides (odn) blocking caspase-dependent fas(cd95) ligand-mediated apoptosis as well as caspase-independent etoposide-mediated apoptosis and etoposide-zvad-mediated necrosis. |
2000-09-15 |
2023-08-12 |
caenorhabditis_elegans |
| M Iwata, K Harada, K Hiramatsu, K Tsuneyama, S Kaneko, K Kobayashi, Y Nakanum. Fas ligand expressing mononuclear cells around intrahepatic bile ducts co-express CD68 in primary biliary cirrhosis. Liver. vol 20. issue 2. 2000-09-15. PMID:10847481. |
apoptosis, including the fas system, has been implicated in progressive bile duct loss in primary biliary cirrhosis (pbc). |
2000-09-15 |
2023-08-12 |
Not clear |
| S Simizu, F Shibasaki, H Osad. Bcl-2 inhibits calcineurin-mediated Fas ligand expression in antitumor drug-treated baby hamster kidney cells. Japanese journal of cancer research : Gann. vol 91. issue 7. 2000-09-14. PMID:10920278. |
we report here that an increase of fas and fas ligand (fasl) expression was required for antitumor drug-induced apoptosis in wi-38 and baby hamster kidney (bhk) cells, but not in hl-60 cells. |
2000-09-14 |
2023-08-12 |
human |
| S Simizu, F Shibasaki, H Osad. Bcl-2 inhibits calcineurin-mediated Fas ligand expression in antitumor drug-treated baby hamster kidney cells. Japanese journal of cancer research : Gann. vol 91. issue 7. 2000-09-14. PMID:10920278. |
although a caspase inhibitor, z-asp-ch2-dcb, suppressed the drug-induced apoptosis, it failed to inhibit the drug-induced expression of fas and fasl. |
2000-09-14 |
2023-08-12 |
human |
| S Simizu, F Shibasaki, H Osad. Bcl-2 inhibits calcineurin-mediated Fas ligand expression in antitumor drug-treated baby hamster kidney cells. Japanese journal of cancer research : Gann. vol 91. issue 7. 2000-09-14. PMID:10920278. |
these findings suggest that initially the fas / fasl system is activated by calcineurin-dependent transcription followed by activation of the downstream caspase cascade resulting in antitumor drug-induced apoptosis in bhk cells, but not in hl-60 cells. |
2000-09-14 |
2023-08-12 |
human |
| C M Mueller, D W Scot. Distinct molecular mechanisms of Fas resistance in murine B lymphoma cells. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 4. 2000-09-14. PMID:10925264. |
expression of the fas receptor on the b lymphoma cell lines did not correlate with their capacity to undergo fas-mediated apoptosis. |
2000-09-14 |
2023-08-12 |
Not clear |
| C M Mueller, D W Scot. Distinct molecular mechanisms of Fas resistance in murine B lymphoma cells. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 4. 2000-09-14. PMID:10925264. |
interestingly, ch33 demonstrated caspase 8 activity upon engagement of the fas receptor in the absence of pharmacological manipulation, suggesting that the block in apoptosis is downstream of the disc complex. |
2000-09-14 |
2023-08-12 |
Not clear |
| C Soubrane, R Mouawad, E C Antoine, O Verola, M Gil-Delgado, D Khaya. A comparative study of Fas and Fas-ligand expression during melanoma progression. The British journal of dermatology. vol 143. issue 2. 2000-09-14. PMID:10951137. |
fas receptor (apo-1/cd95) binding to its ligand, fas-ligand (fas-l), has been shown to trigger apoptosis in various cell types. |
2000-09-14 |
2023-08-12 |
Not clear |
| O Zoi-Toli, M H Vermeer, E De Vries, P Van Beek, C J Meijer, R Willemz. Expression of Fas and Fas-ligand in primary cutaneous T-cell lymphoma (CTCL): association between lack of Fas expression and aggressive types of CTCL. The British journal of dermatology. vol 143. issue 2. 2000-09-14. PMID:10951138. |
fas (cd95; apo-1) is a transmembrane protein that mediates apoptosis upon cross-linking with fas-ligand (fas-l). |
2000-09-14 |
2023-08-12 |
Not clear |
| L B Carter, J L Procter, J K Dale, S E Straus, C C Cantilen. Description of serologic features in autoimmune lymphoproliferative syndrome. Transfusion. vol 40. issue 8. 2000-09-14. PMID:10960521. |
autoimmune lymphoproliferative syndrome (alps) is a recently recognized and rare disorder associated with inherited defects in the fas: gene or other regulators of lymphocyte apoptosis. |
2000-09-14 |
2023-08-12 |
Not clear |
| Z Bacsó, R B Everson, J F Eliaso. The DNA of annexin V-binding apoptotic cells is highly fragmented. Cancer research. vol 60. issue 16. 2000-09-14. PMID:10969816. |
jurkat leukemia cells induced to undergo apoptosis by treatment with an antibody against the fas receptor have two annexin v (av)-binding subpopulations: (a) single-positive cells that bind av but not propidium iodide (pi); and (b) double-positive cells that bind av and pi. |
2000-09-14 |
2023-08-12 |
Not clear |
| N Taya, Y Torimoto, M Shindo, K Hirai, C Hasebe, Y Kohg. Fas-mediated apoptosis of peripheral blood mononuclear cells in patients with hepatitis C. British journal of haematology. vol 110. issue 1. 2000-09-13. PMID:10930983. |
fas-mediated apoptosis of peripheral blood mononuclear cells in patients with hepatitis c. in the present study, we demonstrated that a close relationship exists between hepatitis c virus (hcv) infection of peripheral blood mononuclear cells (pbmcs) and cell-surface fas expression in patients with hepatitis c, and showed the possibility of pbmcs apoptosis via a fas-mediated system. |
2000-09-13 |
2023-08-12 |
human |