| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroaki Kaku, Alexander V Ludlow, Michael F Gutknecht, Thomas L Rothstei. FAIM Opposes Aggregation of Mutant SOD1 That Typifies Some Forms of Familial Amyotrophic Lateral Sclerosis. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32153351. |
here we identify fas apoptosis inhibitory molecule (faim), a highly evolutionarily conserved 20 kda protein, as an agent with this activity. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hiroaki Kaku, Thomas L Rothstei. FAIM Is a Non-redundant Defender of Cellular Viability in the Face of Heat and Oxidative Stress and Interferes With Accumulation of Stress-Induced Protein Aggregates. Frontiers in molecular biosciences. vol 7. 2020-09-28. PMID:32175331. |
here we report a novel molecule that plays a non-redundant role in maintaining homeostasis, fas apoptosis inhibitory molecule (faim). |
2020-09-28 |
2023-08-13 |
mouse |
| Shuying Miao, Caihong Lv, Ying Liu, Jie Zhao, Ting Li, Chunjiang Wang, Yunfei Xu, Xiaoli Wang, Xianzhong Xiao, Huali Zhan. Pharmacologic Blockade of 15-PGDH Protects Against Acute Renal Injury Induced by LPS in Mice. Frontiers in physiology. vol 11. 2020-09-28. PMID:32231583. |
additionally, inhibition of 15-pgdh also reversed lps-induced apoptosis of renal cells, increased expression of anti-apoptotic protein bcl-2, and downregulated expression of fas, caspase-3, and caspase-8. |
2020-09-28 |
2023-08-13 |
mouse |
| Guofu Yi, He Li, You Li, Fen Zhao, Zhiwei Ying, Menglan Liu, Jian Zhang, Xinqi Li. The protective effect of soybean protein-derived peptides on apoptosis via the activation of PI3K-AKT and inhibition on apoptosis pathway. Food science & nutrition. vol 8. issue 8. 2020-09-28. PMID:32884739. |
to further study its molecular mechanisms, western blot analysis demonstrated that sbp could activate the pi3k-akt pathway by increasing the phosphorylation of pi3k and akt and inhibiting apoptosis pathway by downregulating the expressions of pro-apoptotic proteins of bim, bax, fas, and fasl and promoting the expressions of anti-apoptotic proteins of bcl-xl and bcl-2. |
2020-09-28 |
2023-08-13 |
human |
| Lindsay J Bailey-Steinitz, Ying-Hsuan Shih, Monte J Radeke, Pete J Coffe. An in vitro model of chronic wounding and its implication for age-related macular degeneration. PloS one. vol 15. issue 7. 2020-09-22. PMID:32701996. |
genes associated with the major rpe cell functions (lrat, mitf, rdh11) significantly downregulate after wounding, in addition to differential expression of genes associated with the cell cycle (cdk1, cdc6, cdc20), inflammation (il-18, ccl2), and apoptosis (fas). |
2020-09-22 |
2023-08-13 |
human |
| Roman C Brands, Mario J J Scheurer, Stefan Hartmann, Axel Seher, Christian Freudlsperger, Julius Moratin, Christian Linz, Alexander C Kübler, Urs D A Müller-Richte. Sensitization of head and neck squamous cell carcinoma to apoptosis by combinational SMAC mimetic and Fas ligand-Fc treatment in vitro. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. vol 48. issue 7. 2020-09-17. PMID:32507671. |
sensitization of head and neck squamous cell carcinoma to apoptosis by combinational smac mimetic and fas ligand-fc treatment in vitro. |
2020-09-17 |
2023-08-13 |
Not clear |
| Pei-Pei Wang, Yong-Hui Wang, Li-Sen Wang, Tao W. [Anti-tumor effect and its related mechanisms of cinobufotalin combined with cisplatin on H22 liver cancer mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 16. 2020-09-17. PMID:32893593. |
the general condition of mice during the intervention was observed, and the inhibition rate, tumor mass, thymus index, histopathological changes of the tumors, apoptotic rate of the tumors, the expressions of phosphatidylinositol 3-kinase(pi3 k), protein kinase b(akt), apoptosis related gene(fas), fas ligand(fasl) mrna and protein phosphorylated akt(pakt) protein in the tumors of each group were compared. |
2020-09-17 |
2023-08-13 |
mouse |
| Seokhwi Kim, Jongpil Shin, Hyunsik Oh, Sangphil Ahn, Nury Kim, Won Do He. An inducible system for in vitro and in vivo Fas activation using FKBP-FRB-rapamycin complex. Biochemical and biophysical research communications. vol 523. issue 2. 2020-09-15. PMID:31882118. |
a chemically inducible activation system for fas (cd95/apo-1), which works efficiently to induce apoptosis and leads non-apoptotic pathways, has not yet been developed. |
2020-09-15 |
2023-08-13 |
Not clear |
| Yuting Jiang, Yanmei Yang, Chengzhi Zhang, Wei Huang, Liaowei Wu, Jian Wang, Mengyao Su, Dianjun Sun, Yanhui Ga. Upregulation of miR-200c-3p induced by NaF promotes endothelial apoptosis by activating Fas pathway. Environmental pollution (Barking, Essex : 1987). vol 266. issue Pt 1. 2020-09-15. PMID:32629210. |
upregulation of mir-200c-3p induced by naf promotes endothelial apoptosis by activating fas pathway. |
2020-09-15 |
2023-08-13 |
human |
| Yuting Jiang, Yanmei Yang, Chengzhi Zhang, Wei Huang, Liaowei Wu, Jian Wang, Mengyao Su, Dianjun Sun, Yanhui Ga. Upregulation of miR-200c-3p induced by NaF promotes endothelial apoptosis by activating Fas pathway. Environmental pollution (Barking, Essex : 1987). vol 266. issue Pt 1. 2020-09-15. PMID:32629210. |
fluoride stimulation increased caspase-dependent apoptosis through mir-200c-3p upregulation, with repressing expression of its target gene fas-associated phosphatase 1 (fap-1), which functioned as fas inhibitor. |
2020-09-15 |
2023-08-13 |
human |
| Yuting Jiang, Yanmei Yang, Chengzhi Zhang, Wei Huang, Liaowei Wu, Jian Wang, Mengyao Su, Dianjun Sun, Yanhui Ga. Upregulation of miR-200c-3p induced by NaF promotes endothelial apoptosis by activating Fas pathway. Environmental pollution (Barking, Essex : 1987). vol 266. issue Pt 1. 2020-09-15. PMID:32629210. |
this resulted in activation of fas-associated extrinsic apoptosis via interaction with increased fas, fadd, cleaved caspase-8 and cleaved caspase-3. |
2020-09-15 |
2023-08-13 |
human |
| Ágatha Nagli de Mello Gomes, Maria Aparecida Nagai, Silvia Vanessa Lourenço, Cláudia Malheiros Coutinho-Camill. Apoptosis and proliferation during human salivary gland development. Journal of anatomy. vol 234. issue 6. 2020-09-11. PMID:30861119. |
questions remain as to whether the latter mechanism participates in the maintenance of the ductal lumen; therefore, the present study investigated the expression of proteins prostate apoptosis response-4 (par-4), fas cell surface death receptor (fas), fas ligand (fasl), pleckstrin homology-like domain family a member 1 (phlda1), caspase-3, b-cell cll/lymphoma 2 (bcl-2), survivin, ki-67, mucin 1 (muc1), and secreted protein acidic and cysteine-rich (sparc) during distinct phases of human sg development (50 specimens). |
2020-09-11 |
2023-08-13 |
human |
| Young Jae Moon, Zhongkai Zhang, In Hyuk Bang, Oh Kwang Kwon, Sun-Jung Yoon, Jung Ryul Kim, Sangkyu Lee, Eun Ju Bae, Byung-Hyun Par. Sirtuin 6 in preosteoclasts suppresses age- and estrogen deficiency-related bone loss by stabilizing estrogen receptor α. Cell death and differentiation. vol 26. issue 11. 2020-09-08. PMID:30787391. |
sirt6-mediated erα stabilization promoted transcription of fas ligand in preosteoclasts, resulting in apoptosis of osteoclasts. |
2020-09-08 |
2023-08-13 |
mouse |
| Bin Xiao, Xiao Li, Xiu-Yun Feng, Shuai Gong, Zhi-Bin Li, Jie Zhang, Hong-Jie Yuan, Jing-He Ta. Restraint stress of male mice induces apoptosis in spermatozoa and spermatogenic cells: role of the FasL/Fas system†. Biology of reproduction. vol 101. issue 1. 2020-09-07. PMID:31066896. |
the results showed that the male restraint reduced motility, fertilization rates, and mitochondrial membrane potential while increasing apoptosis and fas expression in spermatozoa. |
2020-09-07 |
2023-08-13 |
mouse |
| Xing Xiao, Pei Qiu, Hui-Zhen Gong, Xue-Ming Chen, Yan Sun, An Hong, Yi M. PACAP ameliorates hepatic metabolism and inflammation through up-regulating FAIM in obesity. Journal of cellular and molecular medicine. vol 23. issue 9. 2020-08-28. PMID:31270932. |
our previous study showed that fas apoptosis inhibitory molecule (faim) is a new mediator of akt2 signalling, increases the insulin signalling pathway and lipid metabolism. |
2020-08-28 |
2023-08-13 |
mouse |
| Siwei Tan, Minyi Xu, Bilun Ke, Yu Lu, Huiling Liu, Jie Jiang, Bin W. IL-6-driven FasL promotes NF-κBp65/PUMA-mediated apoptosis in portal hypertensive gastropathy. Cell death & disease. vol 10. issue 10. 2020-08-20. PMID:31582729. |
il-6-driven fasl from myeloid cells combines with epithelial fas receptor to encourage nf-κbp65/puma-mediated epithelial apoptosis in phg, and inhibition of nf-κbp65 or knockout of puma alleviates fas/fasl-mediated epithelial apoptosis in phg. |
2020-08-20 |
2023-08-13 |
mouse |
| E D Bazhanova, V N Anisimo. [FAS- and TNF-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.] Advances in gerontology = Uspekhi gerontologii. vol 33. issue 1. 2020-08-18. PMID:32362081. |
the apoptosis level of neurons in hypothalamic sections (supraoptic and paraventricular nuclei) (tunel) and expression of caspase-8, cd178 (fasl), fas, fadd, tradd (western blotting) was determined. |
2020-08-18 |
2023-08-13 |
mouse |
| E D Bazhanova, V N Anisimo. [FAS- and TNF-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.] Advances in gerontology = Uspekhi gerontologii. vol 33. issue 1. 2020-08-18. PMID:32362081. |
fas, adapter proteins associated with the death domain (fadd and tradd), caspase-8 expression is activated in hypothalamus in fvb/n mice (wild type) during aging, and it correlates with an increase in the apoptosis level. |
2020-08-18 |
2023-08-13 |
mouse |
| b' \\xc5\\x9eerife \\xc3\\x96zlem Gen\\xc3\\xa7, Sava\\xc5\\x9f Karaku\\xc5\\x9f, Ali \\xc3\\x87etin, Meral \\xc3\\x87etin, Halef Okan Do\\xc4\\x9fan, Elif \\xc3\\x9cnver Korgal\\xc4\\xb. Serum Bcl-2, caspase-9 and soluble FasL levels as perinatal markers in late preterm pregnancies with intrauterine growth restriction. The Turkish journal of pediatrics. vol 61. issue 5. 2020-07-21. PMID:32105000.' |
the aim of the study was to test the measurability of the severity of apoptosis using bcl-2, caspase-9, soluble fas ligand (sfasl) markers and the maternal blood sample in addition to the diagnostic methods commonly used to diagnose iugr; and to decrease the rates of adverse perinatal outcomes due to iugr and to evaluate the fetal well-being status without feeling a need for invasive procedures. |
2020-07-21 |
2023-08-13 |
Not clear |
| Cao Yirong, Wang Shengchen, Sun Jiaxin, Wang Shuting, Zhang Ziwe. DEHP induces neutrophil extracellular traps formation and apoptosis in carp isolated from carp blood via promotion of ROS burst and autophagy. Environmental pollution (Barking, Essex : 1987). vol 262. 2020-07-10. PMID:32179220. |
moreover, our results proved that dehp could increase reactive oxygen species (ros) levels, decrease the expression of the anti-autophagy factor (mtor) and the anti-apoptosis gene bcl-2, and increase the expression of pro-autophagy genes (dynein, beclin-1 and lc3b) and the pro-apoptosis factors (bax, fas, fasl, caspase3, caspase8, and caspase9), thus promoting autophagy and apoptosis. |
2020-07-10 |
2023-08-13 |
Not clear |