| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuai Wang, Quan Lin, Zhengjie Wang, Xiaolei Pa. Ropivacaine induces neurotoxicity by activating MAPK/p38 signal to upregulate Fas expression in neurogliocyte. Neuroscience letters. vol 706. 2019-12-27. PMID:31028842. |
ropivacaine-induced upregulation of fas activated mitochondria-dependent intrinsic apoptosis, including the decrease of the mitochondria membrane potential, opening the mitochondrial permeability transition pore, releasing cytochrome c, and translocating bcl-2 family members. |
2019-12-27 |
2023-08-13 |
Not clear |
| Shuai Wang, Quan Lin, Zhengjie Wang, Xiaolei Pa. Ropivacaine induces neurotoxicity by activating MAPK/p38 signal to upregulate Fas expression in neurogliocyte. Neuroscience letters. vol 706. 2019-12-27. PMID:31028842. |
knockdown of fas significantly suppressed the ropivacaine-induced apoptosis. |
2019-12-27 |
2023-08-13 |
Not clear |
| Shuai Wang, Quan Lin, Zhengjie Wang, Xiaolei Pa. Ropivacaine induces neurotoxicity by activating MAPK/p38 signal to upregulate Fas expression in neurogliocyte. Neuroscience letters. vol 706. 2019-12-27. PMID:31028842. |
furthermore, knockdown of p38 or p38 inhibitor remarkably decreased the expression of fas and attenuated ropivacaine-induced cell apoptosis, indicating that activation of the mapk/p38/fas signal contributed to the ropivacaine-caused neurotoxicity. |
2019-12-27 |
2023-08-13 |
Not clear |
| b' Jan \\xc5\\xa0r\\xc3\\xa1mek, Vlasta N\\xc4\\x9bmcov\\xc3\\xa1-F\\xc3\\xbcrstov\\xc3\\xa1, Jan Pol\\xc3\\xa1k, Jan Kov\\xc3\\xa1\\xc5\\x9. Hypoxia Modulates Effects of Fatty Acids on NES2Y Human Pancreatic \\xce\\xb2-cells. International journal of molecular sciences. vol 20. issue 14. 2019-12-27. PMID:31336948.' |
saturated fatty acids (fas) induce apoptosis in the human pancreatic nes2y β-cell line while unsaturated fas have nearly no detrimental effect. |
2019-12-27 |
2023-08-13 |
human |
| Amira Saleh, Hassan M ElFayoumi, Mahmoud Youns, Waleed Baraka. Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 2. 2019-12-24. PMID:30465055. |
cancer is associated with mutations in genes controlling proliferation and apoptosis, oxidative stress, fatty acid synthase (fas) expression, and other mechanisms. |
2019-12-24 |
2023-08-13 |
Not clear |
| Jianxin Huo, Shengli Xu, Kong-Peng La. FAIM: An Antagonist of Fas-Killing and Beyond. Cells. vol 8. issue 6. 2019-12-23. PMID:31167518. |
fas apoptosis inhibitory molecule (faim) is an anti-apoptotic protein that is up-regulated in b cell receptor (bcr)-activated b cells and confers upon them resistance to fas-mediated cell death. |
2019-12-23 |
2023-08-13 |
Not clear |
| Donglai Zhou, Tingting Ding, Bin Ni, Yunyan Jing, Shanxin Li. Hydroxysafflor Yellow A mitigated myocardial ischemia/reperfusion injury by inhibiting the activation of the JAK2/STAT1 pathway. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173173. |
in addition, ag490 and s1491 were also identified to alleviate the h/r‑induced apoptosis by inhibiting caspase 3 activity and modulating the expression levels of cleaved caspase‑3, tumor necrosis factor receptor superfamily member 6 (fas), fas ligand, b‑cell lymphoma 2 (bcl‑2) and bcl‑2‑associated x protein. |
2019-12-23 |
2023-08-13 |
Not clear |
| Feng Liu, Fuhai Wang, Xiaofeng Dong, Peng Xiu, Pengfei Sun, Zhongchao Li, Xuetao Shi, Jingtao Zhon. T7 peptide cytotoxicity in human hepatocellular carcinoma cells is mediated by suppression of autophagy. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173192. |
the t7 peptide induced apoptosis in hcc cells through upregulation of bax, fas, and fas ligand, and through upregulation of the anti‑apoptotic protein bcl‑2. |
2019-12-23 |
2023-08-13 |
human |
| Shruti Sharma, Antonio Carmona, Agnieszka Skowronek, Fangyan Yu, Mark O Collins, Sindhu Naik, Claire M Murzeau, Pei-Li Tseng, Kai S Erdman. Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95. Nature communications. vol 10. issue 1. 2019-12-18. PMID:31308371. |
fas plays a major role in regulating ligand-induced apoptosis in many cell types. |
2019-12-18 |
2023-08-13 |
Not clear |
| Shruti Sharma, Antonio Carmona, Agnieszka Skowronek, Fangyan Yu, Mark O Collins, Sindhu Naik, Claire M Murzeau, Pei-Li Tseng, Kai S Erdman. Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95. Nature communications. vol 10. issue 1. 2019-12-18. PMID:31308371. |
it is well known that several cancers demonstrate reduced cell surface levels of fas and thus escape a potential control system via ligand-induced apoptosis, although underlying mechanisms are unclear. |
2019-12-18 |
2023-08-13 |
Not clear |
| Hongjing Zhao, Yu Wang, Menghao Guo, Dongxue Fei, Mengyao Mu, Hongxian Yu, Mingwei Xin. Hepatoprotective effects of zinc (II) via cytochrome P-450/reactive oxygen species and canonical apoptosis pathways after arsenite waterborne exposure in common carp. Chemosphere. vol 236. 2019-12-16. PMID:31549675. |
this hypothesis was further suggested by caspase-3-executed apoptosis by death receptor pathway (fas, tnf-α and caspase-8) and mitochondrial pathway (bax, bcl-2 and caspase-9). |
2019-12-16 |
2023-08-13 |
Not clear |
| Laura Ioana Gavrilas, Daniel Cruceriu, Corina Ionescu, Doina Miere, Ovidiu Balacesc. Pro-apoptotic genes as new targets for single and combinatorial treatments with resveratrol and curcumin in colorectal cancer. Food & function. vol 10. issue 6. 2019-12-06. PMID:31169275. |
our data pointed out, for the first time, that several genes involved in the modulation of apoptosis, including pmaip1, bid, zmat3, casp3, casp7, and fas, represent new targets of both singular and combinatorial treatments with resveratrol and curcumin, and also the combinatorial approach of curcumin and resveratrol exhibits a more powerful gene regulating effect compared to single treatment. |
2019-12-06 |
2023-08-13 |
Not clear |
| Qiwei Chen, Sudha Priya Soundara Pandi, Lauren Kerrigan, Noel G McElvaney, Catherine M Greene, J Stuart Elborn, Clifford C Taggart, Sinéad Weldo. Cystic fibrosis epithelial cells are primed for apoptosis as a result of increased Fas (CD95). Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. vol 17. issue 5. 2019-12-02. PMID:29486923. |
cystic fibrosis epithelial cells are primed for apoptosis as a result of increased fas (cd95). |
2019-12-02 |
2023-08-13 |
Not clear |
| Sonia Meynier, Frédéric Rieux-Lauca. FAS and RAS related Apoptosis defects: From autoimmunity to leukemia. Immunological reviews. vol 287. issue 1. 2019-12-02. PMID:30565243. |
fas and ras related apoptosis defects: from autoimmunity to leukemia. |
2019-12-02 |
2023-08-13 |
human |
| Rui Huang, Jun Zhang, Changjun Ren, Xuhui Zhang, Licai Gu, Yan Dong, Juan Zhang, Jing Zhan. Effect of erythropoietin on Fas/FasL expression in brain tissues of neonatal rats with hypoxic-ischemic brain damage. Neuroreport. vol 30. issue 4. 2019-11-29. PMID:30672890. |
our findings suggest that epo may reduce cell apoptosis after hypoxic-ischemic damage through reduction of the expression of fas and fasl, and that optimal therapeutic time window is 6-24 h after hibd. |
2019-11-29 |
2023-08-13 |
rat |
| Dina M Aresvik, Torstein Øverland, Kari Lima, Rolf D Pettersen, Tore G Abrahamse. Lymphocyte Apoptosis and FAS Expression in Patients with 22q11.2 Deletion Syndrome. Journal of clinical immunology. vol 39. issue 1. 2019-11-26. PMID:30569262. |
lymphocyte apoptosis and fas expression in patients with 22q11.2 deletion syndrome. |
2019-11-26 |
2023-08-13 |
Not clear |
| Buttyan, Shabsigh, Perlman, Colombe. Regulation of Apoptosis in the Prostate Gland by Androgenic Steroids. Trends in endocrinology and metabolism: TEM. vol 10. issue 2. 2019-11-20. PMID:10322394. |
there is now evidence for a critical cell signaling pathway, regulated by c-fos expression, necessary for castration-induced apoptosis, as well as evidence that this signaling initiates an abrupt and transient alteration in the synthesis of fas antigen, p53, bax and bcl-2 proteins in the androgen receptor-expressing prostate epithelial cells, the cellular compartment that appears to be the most affected by castration. |
2019-11-20 |
2023-08-12 |
Not clear |
| Kataoka, Tsuru. Physician Education: Apoptosis. The oncologist. vol 1. issue 6. 2019-11-20. PMID:10388021. |
cell injuries that induce apoptosis include those that cause dna damage such as radiation and anticancer drugs, those that are mediated by the tnf receptor and fas receptor (the so-called "death signal receptors"), and the deprivation of cytokines that supply survival signals such as il-3 and erythropoietin. |
2019-11-20 |
2023-08-12 |
mouse |
| Kornblau, Konopleva, Andreef. Apoptosis regulating proteins as targets of therapy for haematological malignancies. Expert opinion on investigational drugs. vol 8. issue 12. 2019-11-20. PMID:11139839. |
agents that trigger signalling of fas or tumour necrosis factor- (tnf-) related apoptosis inducing ligand (trail) receptor seek to induce the extrinsic pathway at the cell surface. |
2019-11-20 |
2023-08-12 |
Not clear |
| H. S. Ryu, K. H. Chang, S. J. Chang, M. S. Kim, H. J. Joo, K. S. O. Expression of TRAIL (TNF-related apoptosis-inducing ligand) receptors in cervical cancer. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 10. issue 5. 2019-11-20. PMID:11240708. |
some of the well known regulators of apoptosis are cytokines of the tumor necrosis factor (tnf) ligand family, such as fas ligand (fas l) and tnf, which induce apoptosis by activation of their corresponding receptors, fas and tnfr-1. |
2019-11-20 |
2023-08-12 |
human |