| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y J Park, S Lee, T J Kieffer, G L Warnock, N Safikhan, M Speck, Z Hao, M Woo, L Marzba. Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide. Diabetologia. 2021-10-21. PMID:22301943. |
conclusions/interpretation: the aggregation of biosynthetic hiapp produced in islets induces beta cell apoptosis, at least partially, via fas upregulation and the fas-mediated apoptotic pathway. |
2021-10-21 |
2023-08-12 |
mouse |
| b' Barbara Bessette, Karine Durand, St\\xc3\\xa9phanie Giraud, Ga\\xc3\\xablle B\\xc3\\xa9gaud, Muriel Mathonnet, Fabrice Lallou\\xc3\\xa. Decrease in Fas-induced apoptosis by the \\xce\\xb3-secretase inhibitor is dependent on p75(NTR) in a glioblastoma cell line. Experimental and therapeutic medicine. vol 3. issue 5. 2021-10-21. PMID:22969985.' |
fas receptor activation was found to promote cell death apoptosis in several cell lines. |
2021-10-21 |
2023-08-12 |
Not clear |
| b' Barbara Bessette, Karine Durand, St\\xc3\\xa9phanie Giraud, Ga\\xc3\\xablle B\\xc3\\xa9gaud, Muriel Mathonnet, Fabrice Lallou\\xc3\\xa. Decrease in Fas-induced apoptosis by the \\xce\\xb3-secretase inhibitor is dependent on p75(NTR) in a glioblastoma cell line. Experimental and therapeutic medicine. vol 3. issue 5. 2021-10-21. PMID:22969985.' |
whereas the u-87 mg cells expressed the fas receptor at the cell membrane, apoptosis induced by fas activation was decreased by the γ-secretase inhibitor. |
2021-10-21 |
2023-08-12 |
Not clear |
| Bertrand C Lian. Increased expression but not sensitivity to Fas/CD95 in glioblastoma cells depleted of mitochondrial DNA. Experimental and therapeutic medicine. vol 1. issue 6. 2021-10-21. PMID:22993639. |
mitochondria and fas (cd95) play a role in tumorigenicity and apoptosis. |
2021-10-21 |
2023-08-12 |
Not clear |
| Bertrand C Lian. Increased expression but not sensitivity to Fas/CD95 in glioblastoma cells depleted of mitochondrial DNA. Experimental and therapeutic medicine. vol 1. issue 6. 2021-10-21. PMID:22993639. |
in the present study, the functional relationship of mitochondria to fas in mediating apoptosis was investigated. |
2021-10-21 |
2023-08-12 |
Not clear |
| Xiaoni Liu, Xiaoxin Zh. Stellera chamaejasme L. extract induces apoptosis of human lung cancer cells via activation of the death receptor-dependent pathway. Experimental and therapeutic medicine. vol 4. issue 4. 2021-10-21. PMID:23170112. |
furthermore, we observed that esc-2 resulted in apoptosis, activation of caspase-8 and caspase-3, and an increase in fas expression, indicating that the nci-h157 cell growth inhibitory activity of esc-2 was due to death receptor-dependent pathway-mediated apoptosis, which may partly explain the anti-cancer activity of esc-2. |
2021-10-21 |
2023-08-12 |
human |
| Man-Man Lu, Qian-Ling Ye, Chen-Chen Feng, Jie Yang, Tao Zhang, Jing Li, Rui-Xue Leng, Hai-Feng Pan, Hui Yuan, Dong-Qing Y. Association of FAS gene polymorphisms with systemic lupus erythematosus: A case-control study and meta-analysis. Experimental and therapeutic medicine. vol 4. issue 3. 2021-10-21. PMID:23181125. |
the association of functional polymorphisms in the promoter of the apoptosis gene fas with systemic lupus erythematosus (sle) susceptibility has been a controversial subject. |
2021-10-21 |
2023-08-12 |
human |
| E M Saleh, R A El-Awady, N Ani. Predictive markers for the response to 5-fluorouracil therapy in cancer cells: Constant-field gel electrophoresis as a tool for prediction of response to 5-fluorouracil-based chemotherapy. Oncology letters. vol 5. issue 1. 2021-10-21. PMID:23255942. |
determination of fas ligand (fas-l) and caspase 9 as representative markers for the extrinsic and intrinsic pathways of apoptosis, respectively, revealed that 5fu-induced apoptosis in hct116 and hepg2 results from the expression of fas-l (extrinsic pathway). |
2021-10-21 |
2023-08-12 |
Not clear |
| Xiao Xiao, Lijun Chen, Ying Ouyang, Wenbo Zhu, Pengxin Qiu, Xinwen Su, Yunling Dou, Lipeng Tang, Min Yan, Haipeng Zhang, Xiaoxiao Yang, Dong Xu, Guangmei Ya. Pregnenolone, a cholesterol metabolite, induces glioma cell apoptosis via activating extrinsic and intrinsic apoptotic pathways. Oncology letters. vol 8. issue 2. 2021-10-21. PMID:25013479. |
in the c6 cells, upregulation of fas and fas ligand triggered the activation of the extrinsic pathway, whereas knockdown of fas significantly abrogated the cell apoptosis that was induced by pregnenolone. |
2021-10-21 |
2023-08-13 |
Not clear |
| Kathleen Ponzetti, Melissa King, Anna Gates, M Sawkat Anwer, Cynthia Rl Webste. Cyclic AMP-guanine exchange factor activation inhibits JNK-dependent lipopolysaccharide-induced apoptosis in rat hepatocytes. Hepatic medicine : evidence and research. vol 2010. issue 2. 2021-10-20. PMID:21743791. |
lps-induced apoptosis was additive to that induced by glycochenodeoxycholate or fas ligand, was associated with activation of c-jun n-terminal kinase b (jnk) and p38 mitogen-activated protein kinases (mapk), and inhibition of protein kinase (akt). |
2021-10-20 |
2023-08-12 |
rat |
| Kathleen Ponzetti, Melissa King, Anna Gates, M Sawkat Anwer, Cynthia Rl Webste. Cyclic AMP-guanine exchange factor activation inhibits JNK-dependent lipopolysaccharide-induced apoptosis in rat hepatocytes. Hepatic medicine : evidence and research. vol 2010. issue 2. 2021-10-20. PMID:21743791. |
cpt-2-me-camp, an activator of camp-gef, decreased apoptosis due to lps alone or in combination with glycochenodeoxycholate or fas ligand. |
2021-10-20 |
2023-08-12 |
rat |
| Aude Magerus, Clara Bercher-Brayer, Frédéric Rieux-Lauca. The genetic landscape of the FAS pathway deficiencies. Biomedical journal. vol 44. issue 4. 2021-10-20. PMID:34171534. |
moreover, the uncomplete clinical penetrance associated with mutations affecting the intracellular domain of fas, in patient lacking additional fas somatic event, suggested a potential digenic inheritance with a fas mutation accompanied by a genetic modifier possibly impacting another player of the lymphocytes homeostasis (affecting the survival, activation or apoptosis of the peripheral leukocytes). |
2021-10-20 |
2023-08-13 |
Not clear |
| Jun Wu, Xi Chen, Jiaxi Zhang, Jianming Chen, Yajun Wang, Ting Wei, Jinyao Ma, Yuanqi Li, Ting Mo, Zhan He, Haitao Zhan. Tachyplesin induces apoptosis in non-small cell lung cancer cells and enhances the chemosensitivity of A549/DDP cells to cisplatin by activating Fas and necroptosis pathway. Chemical biology & drug design. vol 97. issue 4. 2021-10-12. PMID:33245189. |
tachyplesin induces apoptosis in non-small cell lung cancer cells and enhances the chemosensitivity of a549/ddp cells to cisplatin by activating fas and necroptosis pathway. |
2021-10-12 |
2023-08-13 |
human |
| Jun Wu, Xi Chen, Jiaxi Zhang, Jianming Chen, Yajun Wang, Ting Wei, Jinyao Ma, Yuanqi Li, Ting Mo, Zhan He, Haitao Zhan. Tachyplesin induces apoptosis in non-small cell lung cancer cells and enhances the chemosensitivity of A549/DDP cells to cisplatin by activating Fas and necroptosis pathway. Chemical biology & drug design. vol 97. issue 4. 2021-10-12. PMID:33245189. |
further mechanistic examination revealed that tachyplesin induced apoptosis in a549/ddp cells by increasing fas, fasl and p-ripk1 levels. |
2021-10-12 |
2023-08-13 |
human |
| Ming-Guang Mao, Jia Xu, Rui-Ting Liu, Lin Ye, Rui Wang, Jie-Lan Jian. Fas/FasL of pacific cod mediated apoptosis. Developmental and comparative immunology. vol 119. 2021-10-11. PMID:33482239. |
fas and fas ligand (fasl) pathway plays important roles in virus defense and cell apoptosis. |
2021-10-11 |
2023-08-13 |
Not clear |
| Juan Wang, Zeyuan Cao, Panpan Wang, Xiao Zhang, Jianxia Tang, Yifan He, Zhiqing Huang, Xueli Mao, Songtao Shi, Xiaoxing Ko. Apoptotic Extracellular Vesicles Ameliorate Multiple Myeloma by Restoring Fas-Mediated Apoptosis. ACS nano. vol 15. issue 9. 2021-10-08. PMID:34506129. |
several types of cancer cells display reduced expression of fas on the cell surface and are thus capable of escaping fas ligand-induced apoptosis. |
2021-10-08 |
2023-08-13 |
mouse |
| Carmen Mikacenic, Pavan Bhatraju, Cassianne Robinson-Cohen, Susanna Kosamo, Alison E Fohner, Victoria Dmyterko, S Alice Long, Karen Cerosaletti, Carolyn S Calfee, Michael A Matthay, Keith R Walley, James A Russell, Jason D Christie, Nuala J Meyer, David C Christiani, Mark M Wurfe. Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness. Critical care medicine. 2021-10-05. PMID:34593707. |
previous studies support a role for fas cell surface death receptor (fas)-mediated apoptosis in organ dysfunction. |
2021-10-05 |
2023-08-13 |
Not clear |
| Yang Yu, Meng Chen, Shiyao Yang, Bingyi Shao, Liang Chen, Lei Dou, Jing Gao, Deqin Yan. Osthole enhances the immunosuppressive effects of bone marrow-derived mesenchymal stem cells by promoting the Fas/FasL system. Journal of cellular and molecular medicine. vol 25. issue 10. 2021-10-04. PMID:33749126. |
in vivo and in vitro tests showed that because of the down-regulation of fas and fasl expression, the ability of osteoporotic bmscs to induce t-cell apoptosis decreased. |
2021-10-04 |
2023-08-13 |
Not clear |
| Leonardo Lorente, María M Martín, Antonia Pérez-Cejas, Agustín F González-Rivero, Luis Ramos-Gómez, Jordi Solé-Violán, Juan J Cáceres, Judith Cabrera, Andrea Alvarez-Castillo, Carmen Ferrer-Moure, Alejandro Jiméne. High Serum Soluble Fas Ligand Levels in Non-survivor Traumatic Brain Injury Patients. Neurocritical care. vol 35. issue 1. 2021-09-29. PMID:33403586. |
soluble fas ligand (sfasl) is one of the main ligands that activates the apoptosis extrinsic pathway. |
2021-09-29 |
2023-08-13 |
Not clear |
| Jian-Chang Lin, Zhao-Hong Chen, Xiao-Dong Chen, Shun-Bin Wan. Circulating sFasL Levels Predict the Severity and Outcome of Burn Injury: A Prospective Observational Study. The Journal of surgical research. vol 265. 2021-09-27. PMID:33862353. |
soluble fas ligand (sfasl) participates in apoptosis and inflammatory response. |
2021-09-27 |
2023-08-13 |
Not clear |