All Relations between apoptosis and fak

Publication Sentence Publish Date Extraction Date Species
Piman Pocasap, Auemduan Prawan, Sarinya Kongpetch, Laddawan Senggunpra. Network pharmacology- and cell-based assessments identify the FAK/Src pathway as a molecular target for the antimetastatic effect of momordin Ic against cholangiocarcinoma. Heliyon. vol 10. issue 11. 2024-07-04. PMID:38961933. the results unveiled the potential involvement of mic in apoptosis and cell migration, pinpointing src and fak as key targets. 2024-07-04 2024-07-10 Not clear
Fei Ding, Peng Zheng, Hong-Ting Fang, Yuan-Yuan Luo, Xi-Yue Yan, Hui-Jian Chen, You-E Ya. Adipocyte-specific FAK deletion promotes pancreatic β-cell apoptosis via adipose inflammatory response to exacerbate diabetes mellitus. Clinical and translational medicine. vol 14. issue 7. 2024-06-26. PMID:38925910. adipocyte-specific fak deletion promotes pancreatic β-cell apoptosis via adipose inflammatory response to exacerbate diabetes mellitus. 2024-06-26 2024-06-29 Not clear
Juanjuan Xu, Manjun Lv, Xiaohong N. Marein Alleviates Doxorubicin-Induced Cardiotoxicity through FAK/AKT Pathway Modulation while Potentiating its Anticancer Activity. Cardiovascular toxicology. 2024-06-19. PMID:38896162. mechanistically, mar reduced inflammation, oxidative stress, and apoptosis in cardiomyocytes, potentially via activation of the focal adhesion kinase (fak)/akt pathway. 2024-06-19 2024-06-21 mouse
Xiaochen Wang, Yifan Zhang, Kun Chi, Yuwei Ji, Keying Zhang, Ping Li, Zhangning Fu, Xu Wang, Shaoyuan Cui, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Hanyu Zhu, Quan Hon. IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin α5/FAK in diabetic kidney disease. Apoptosis : an international journal on programmed cell death. 2024-05-25. PMID:38796567. furthermore, igfbp2 facilitated apoptosis, which was characterized by increase in inflammation and oxidative stress, by binding with integrin α5 (itga5) of podocytes, and then activating the phosphorylation of focal adhesion kinase (fak)-mediated mitochondrial injury, including membrane potential decreasing, ros production increasing. 2024-05-25 2024-05-31 mouse
Xiaochen Wang, Yifan Zhang, Kun Chi, Yuwei Ji, Keying Zhang, Ping Li, Zhangning Fu, Xu Wang, Shaoyuan Cui, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Hanyu Zhu, Quan Hon. IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin α5/FAK in diabetic kidney disease. Apoptosis : an international journal on programmed cell death. 2024-05-25. PMID:38796567. moreover, itga5 knockdown or fak inhibition attenuated the podocyte apoptosis caused by high glucose or igfbp2 overexpression. 2024-05-25 2024-05-31 mouse
Mingming Xue, Lingyu Xing, Yilin Yang, Mian Shao, Fengqing Liao, Feixiang Xu, Yumei Chen, Sheng Wang, Bin Chen, Chenling Yao, Guorong Gu, Chaoyang Ton. A decrease in integrin α5β1/FAK is associated with increased apoptosis of aortic smooth muscle cells in acute type a aortic dissection. BMC cardiovascular disorders. vol 24. issue 1. 2024-03-27. PMID:38532364. human aortic smooth muscle cells (hasmcs) exhibit decreased proliferation and increased apoptosis, and integrin α5β1 and fak are important proangiogenic factors involved in regulating angiogenesis. 2024-03-27 2024-03-29 human
Jiancong Wu, Xiaobi Huang, Xiaofang Li, Honglian Zhou, Xiaorao Chen, Yongyang Chen, Yudong Guo, Jian Huang, Hanqing Huang, Zhong Huang, Guoan Chen, Zhixiong Yang, Jian Zhang, Wenmei S. Suppression of the long non-coding RNA LINC01279 triggers autophagy and apoptosis in lung cancer by regulating FAK and SIN3A. Discover. Oncology. vol 15. issue 1. 2024-01-03. PMID:38168833. suppression of the long non-coding rna linc01279 triggers autophagy and apoptosis in lung cancer by regulating fak and sin3a. 2024-01-03 2024-01-06 human
Anqi Huo, Xiangyang Xion. PAICS as a potential target for cancer therapy linking purine biosynthesis to cancer progression. Life sciences. 2023-09-06. PMID:37673296. evidence suggests that paics and its catalytic product, n-succinylcarboxamide-5-aminoimidazole ribonucleotide (saicar), could inhibit tumor cell apoptosis and promote the growth, epithelial-mesenchymal transition (emt), invasion, and metastasis by regulating signaling pathways such as pyruvate kinase m2 (pkm2), extracellular signal-related kinases 1 and 2 (erk1/2), focal adhesion kinase (fak) and so on. 2023-09-06 2023-10-07 Not clear
Chao-Cheng Chen, Suyang Wang, Jr-Ming Yang, Chuan-Hsiang Huan. Targeting Ras signaling excitability in cancer cells through combined inhibition of FAK and PI3K. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398082. we found that the combination of fak and pi3k inhibitors synergistically suppressed the growth of select cervical and pancreatic cancer cell lines through increased apoptosis and decreased mitosis. 2023-07-03 2023-08-14 human
Malcy Tarin, Fariba Némati, Didier Decaudin, Christine Canbezdi, Benjamin Marande, Lisseth Silva, Héloïse Derrien, Aart G Jochemsen, Sophie Gardrat, Sophie Piperno-Neumann, Manuel Rodrigues, Pascale Mariani, Nathalie Cassoux, Marc-Henri Stern, Sergio Roman-Roman, Samar Alsafad. FAK Inhibitor-Based Combinations with MEK or PKC Inhibitors Trigger Synergistic Antitumor Effects in Uveal Melanoma. Cancers. vol 15. issue 8. 2023-05-16. PMID:37190207. the combined inhibition of fak and mek or pkc had highly synergistic effects by reducing cell viability and inducing apoptosis. 2023-05-16 2023-08-14 Not clear
Kainan Zhang, Xizhou An, Yao Zhu, Lan Huang, Xinyuan Yao, Xing Zeng, Shaoyan Liang, Jie Y. Netrin-1 inducing antiapoptotic effect of acute myeloid leukemia cells in a concentration-dependent manner through the Unc-5 netrin receptor B-focal adhesion kinase axis. Cancer biology & therapy. vol 24. issue 1. 2023-04-10. PMID:37038247. both fak and akt inhibitors abrogated the effects of netrin-1 on the proliferation and apoptosis of aml cells. 2023-04-10 2023-08-14 Not clear
Mikiko Takebayashi Kano, Toshio Kokuryo, Taisuke Baba, Kimitoshi Yamazaki, Junpei Yamaguchi, Masaki Sunagawa, Atsushi Ogura, Nobuyuki Watanabe, Shunsuke Onoe, Kazushi Miyata, Takashi Mizuno, Kay Uehara, Tsuyoshi Igami, Yukihiro Yokoyama, Tomoki Ebata, Masato Nagin. Cyclodextrin Conjugated α-Bisabolol Suppresses FAK Phosphorylation and Induces Apoptosis in Pancreatic Cancer. Anticancer research. vol 43. issue 3. 2023-02-28. PMID:36854520. cyclodextrin conjugated α-bisabolol suppresses fak phosphorylation and induces apoptosis in pancreatic cancer. 2023-02-28 2023-08-14 Not clear
Ya-Hui Chen, Jyun-Xue Wu, Shun-Fa Yang, Yi-Hsuan Hsia. Synergistic Combination of Luteolin and Asiatic Acid on Cervical Cancer In Vitro and In Vivo. Cancers. vol 15. issue 2. 2023-01-21. PMID:36672499. furthermore, lut combined with asa induced apoptosis and inhibited migration through downregulated pi3k/akt (pi3k, akt and p70s6k), jnk/p38 mapk and fak (integrin β1, paxillin and fak) signaling and upregulated erk signaling. 2023-01-21 2023-08-14 Not clear
Yuehong Zhao, Xiaoli Zhang, Xiaona Zhang, Guoqing Shen, Weiwei Li, Qun Wan. Integrinβ1/FAK/ERK signalling pathway is essential for Chinese mitten crab Eriocheir sinensis hemocyte survival. Fish & shellfish immunology. 2022-12-05. PMID:36470403. treatment with an integrinβ1 inhibitor rgd (a conserved tripeptide arg-gly-asp), decreased the levels of fak and erk expression and phosphorylation, followed by an intensification of apoptosis. 2022-12-05 2023-08-14 Not clear
Hamed Alizadeh Pahlavan. Exercise-induced signaling pathways to counteracting cardiac apoptotic processes. Frontiers in cell and developmental biology. vol 10. 2022-08-29. PMID:36036015. however, research on exercise and factors such as pim-1, notch, and fak in cardiac apoptosis is scarce, so further research is needed. 2022-08-29 2023-08-14 Not clear
Lu Ye, Ru Liu, Ping Lin, Wenjun Wan. Krüppel-like transcription factor 16 transcriptional up-regulation of cellular retinoic acid-binding proteins-2 promotes the invasion and migration and inhibits apoptosis of retinoblastoma cells by regulating integrin-β1/focal adhesion kinase /extracellular signal-regulated kinase pathway. Bioengineered. vol 13. issue 2. 2022-06-07. PMID:35671035. we conducted this study, aiming to explore the molecular mechanism of krüppel-like transcription factor 16 (klf16)/cellular retinoic acid-binding proteins-2 (crabp2) in regulating the invasion and migration and apoptosis of rb cells via integrin-β1/focal adhesion kinase (fak)/extracellular signal-regulated kinase (erk) pathway. 2022-06-07 2023-08-14 Not clear
Cuihong Fan, Zhaojia Wu, David M L Cooper, Adam Magnus, Kim Harrison, B Frank Eames, Rajni Chibbar, Gary Groot, Junqiong Huang, Harald Genth, Jun Zhang, Xing Tan, Yulin Deng, Jim Xian. Activation of Focal Adhesion Kinase Restores Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation via Wnt/Β-Catenin Pathway. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628403. we previously demonstrated that smg altered the focal adhesion kinase (fak)-regulated mtorc1, ampk and erk1/2 pathways, leading to the inhibition of tumor cell proliferation/metastasis and promoting cell apoptosis. 2022-05-28 2023-08-13 mouse
Fei Yang, Kangping Xu, Sha Zhang, Jinlin Zhang, Yaoren Qiu, Jin Luo, Guishan Tan, Zhenxing Zou, Wenxuan Wang, Fenghua Kan. Discovery of novel chloropyramine-cinnamic acid hybrids as potential FAK inhibitors for intervention of metastatic triple-negative breast cancer. Bioorganic & medicinal chemistry. vol 66. 2022-05-15. PMID:35569251. further mechanism studies indicated the ability of 7d in disrupting y925 autophosphorylation of fak, reducing formation of focal adhesions (fas) and stress fibers (sfs) as well as inducing apoptosis of tnbc cells. 2022-05-15 2023-08-13 Not clear
Aranka Brockmueller, Parviz Shayan, Mehdi Shakibae. Evidence That β1-Integrin Is Required for the Anti-Viability and Anti-Proliferative Effect of Resveratrol in CRC Cells. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563105. similarly, resveratrol-blocked tme-induced p65-nf-kb and its promoted gene markers linked to proliferation (cyclin d1), invasion (focal adhesion kinase, fak), or apoptosis (caspase-3), were largely abrogated by anti-β1-integrin or rgd peptide, suggesting that β1-integrin is a potential transmission pathway for resveratrol/integrin down-stream signaling in crc cells. 2022-05-14 2023-08-13 Not clear
Yuan Du, Shenglan Li, Tong Zhou, Jing Zhao, Jiguang Li. SIPA1 boosts migration and proliferation, and blocks apoptosis of glioma by activating the phosphorylation of the FAK signaling pathway. Journal of medical biochemistry. vol 41. issue 1. 2022-04-18. PMID:35431649. sipa1 boosts migration and proliferation, and blocks apoptosis of glioma by activating the phosphorylation of the fak signaling pathway. 2022-04-18 2023-08-13 Not clear