| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruxue Huang, Lulu Ding, Ying Ye, Ke Wang, Wenjing Yu, Bingzhao Yan, Zongping Liu, Jicang Wan. Protective effect of quercetin on cadmium-induced renal apoptosis through cyt-c/caspase-9/caspase-3 signaling pathway. Frontiers in pharmacology. vol 13. 2022-09-02. PMID:36052148. |
cadmium (cd), a heavy metal, has harmful effects on animal and human health, and it can also obviously induce cell apoptosis. |
2022-09-02 |
2023-08-14 |
human |
| Abdulmohsen I Algefar. Renoprotective and Oxidative Stress-Modulating Effects of Taxifolin against Cadmium-Induced Nephrotoxicity in Mice. Life (Basel, Switzerland). vol 12. issue 8. 2022-08-26. PMID:36013329. |
cadmium (cd) is an inessential trace metal that accumulates in the kidney and may lead to renal toxicity by mediating oxidative stress (os), inflammatory reactions, and apoptosis. |
2022-08-26 |
2023-08-14 |
mouse |
| David T Asuzu, Reinier Alvarez, Patrick A Fletcher, Debjani Mandal, Kory Johnson, Weiwei Wu, Abdel Elkahloun, Paul Clavijo, Clint Allen, Dragan Maric, Abhik Ray-Chaudhury, Sharika Rajan, Zied Abdullaev, Diana Nwokoye, Kenneth Aldape, Lynnette K Nieman, Constantine Stratakis, Stanko S Stojilkovic, Prashant Chittiboin. Pituitary adenomas evade apoptosis via noxa deregulation in Cushing's disease. Cell reports. vol 40. issue 8. 2022-08-24. PMID:36001971. |
using primary cd adenoma cell cultures and a corticotroph-enriched mouse cell line, we find that selective proteasomal inhibition with bortezomib stabilizes noxa and induces apoptosis, indicating its utility as an anti-tumor agent. |
2022-08-24 |
2023-08-14 |
mouse |
| Zhe-Zhi Li, Xuan-Wei Zhou, Li-Jun Che. Transcriptomic analysis of cadmium toxicity and molecular response in the spiderling of Pirata subpiraticus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022-08-18. PMID:35981662. |
further enrichment analysis showed that cd exposure could activate the apoptosis pathway in the spider via the up-regulation of several key factors, including caspase-10, α-tubulin, actin, etc. |
2022-08-18 |
2023-08-14 |
spider |
| Fan Yu, Lianqi Yan, Jian Sun, Yumeng Zhao, Yan Yuan, Jianhong Gu, Jianchun Bian, Hui Zou, Zongping Li. Gap junction intercellular communication mediates cadmium-induced apoptosis in hepatocytes via the Fas/FasL pathway. Environmental toxicology. 2022-08-03. PMID:35920667. |
we established a cd poisoning model in vitro by co-culturing cd-exposed and unexposed hepatocytes and found that 18β-glycyrrhetinic acid (ga), a gjic inhibitor, can effectively reduce the apoptosis rate of healthy cells co-cultured with apoptotic cells treated with cd. |
2022-08-03 |
2023-08-14 |
Not clear |
| Yanhua Wang, You Weng, Lu Lv, Dou Wang, Guiling Yang, Yuanxiang Jin, Qiang Wan. Transgenerational effects of co-exposure to cadmium and carbofuran on zebrafish based on biochemical and transcriptomic analyses. Journal of hazardous materials. vol 439. 2022-07-26. PMID:35882171. |
through maternal transmission, co-exposure of cd and car caused toxicity to 4-day-old larvae of the f1 generation, evidenced by the significant changes in t4 and vtg levels, cyp450 activity, and the relative transcriptional levels of genes related to the hormone, oxidative stress, and apoptosis. |
2022-07-26 |
2023-08-14 |
zebrafish |
| Dan Chen, Yujie Yao, Xu Shi, Xiaohang Li, Wei Cui, Shiwen X. Cadmium exposure causes mitochondrial fission and fusion disorder in the pig hypothalamus via the PI3K/AKT pathway. Ecotoxicology and environmental safety. vol 242. 2022-07-25. PMID:35872487. |
high doses of cd cause cytotoxicity, including programmed necrosis and apoptosis, which has aroused widespread concern. |
2022-07-25 |
2023-08-14 |
Not clear |
| Na Pan, Liping Lu, Dongtang Zhang, Xiayan Wan. Evaluation of the effect of nitrate and chloride on Cd(II)-induced cell oxidative stress by scanning electrochemical microscopy. Analytical methods : advancing methods and applications. 2022-06-28. PMID:35762516. |
literature studies have documented that cd could stimulate cellular oxidative stress, and the increased intracellular reactive oxygen species (ros) might destroy certain proteins and dna and subsequently lead to cell apoptosis. |
2022-06-28 |
2023-08-14 |
human |
| Emmanuel Joseph Ikokide, Ademola Adetokunbo Oyagbemi, Matthew Olugbenga Oyeyem. Impacts of cadmium on male fertility: Lessons learnt so far. Andrologia. 2022-06-28. PMID:35765120. |
cd exerts its deleterious impacts on the testes (male reproductive system) by inducing oxidative stress, spermatogenic cells apoptosis, testicular inflammation, decreasing androgenic and sperm cell functions, disrupting ionic homeostasis, pathways and epigenetic gene regulation, damaging vascular endothelium and blood testes barrier. |
2022-06-28 |
2023-08-14 |
Not clear |
| Arba Karcini, Iulia M Laza. The SKBR3 cell-membrane proteome reveals telltales of aberrant cancer cell proliferation and targets for precision medicine applications. Scientific reports. vol 12. issue 1. 2022-06-27. PMID:35760832. |
classification into proteins with receptor/enzymatic activity, cd antigens, transporters, and cell adhesion/junction proteins uncovered overlapping roles in processes that drive cell growth, apoptosis, differentiation, immune response, adhesion and migration, as well as alternate pathways for proliferation. |
2022-06-27 |
2023-08-14 |
Not clear |
| Esam O Kamel, Wail M Gad-Elrab, Mohammed A Ahmed, Zuhair M Mohammedsaleh, Emad H M Hassanein, Fares E M Al. Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1-7 Signals. Biological trace element research. 2022-05-19. PMID:35590119. |
moreover, candesartan attenuated cd hepatorenal apoptosis by upregulating bcl-2 and downregulating bax and cyt-c proteins. |
2022-05-19 |
2023-08-13 |
Not clear |
| Jiaming Zheng, Guobin Qiu, Yewen Zhou, Kezhe Ma, Sheng Cu. Hepatoprotective Effects of Taurine Against Cadmium-Induced Liver Injury in Female Mice. Biological trace element research. 2022-05-17. PMID:35581430. |
taken together, these observations demonstrate that tau has an important hepatic protective function against the inflammation and apoptosis induced by cd. |
2022-05-17 |
2023-08-13 |
mouse |
| Haoran Zhang, Fuqing Zhao, Xiaoxue Gai, Jingzeng Cai, Xintong Zhang, Xiaoming Chen, Yue Zhu, Ziwei Zhan. Astilbin attenuates apoptosis induced by cadmium through oxidative stress in carp (Cyprinus carpio L.) head kidney lymphocyte. Fish & shellfish immunology. 2022-05-16. PMID:35577320. |
after exposure to cd, the level of oxidative stress in head kidney lymphocytes increased, and the mrna and protein expression of apoptosis-related markers fas, fadd, caspase8 and caspase3 increased significantly (p < 0.05), which led to lymphocytes apoptosis. |
2022-05-16 |
2023-08-13 |
Not clear |
| Haoran Zhang, Fuqing Zhao, Xiaoxue Gai, Jingzeng Cai, Xintong Zhang, Xiaoming Chen, Yue Zhu, Ziwei Zhan. Astilbin attenuates apoptosis induced by cadmium through oxidative stress in carp (Cyprinus carpio L.) head kidney lymphocyte. Fish & shellfish immunology. 2022-05-16. PMID:35577320. |
hoechst staining and ao/eb staining also showed that the level of apoptosis increased after exposure to cd. |
2022-05-16 |
2023-08-13 |
Not clear |
| Haoran Zhang, Fuqing Zhao, Xiaoxue Gai, Jingzeng Cai, Xintong Zhang, Xiaoming Chen, Yue Zhu, Ziwei Zhan. Astilbin attenuates apoptosis induced by cadmium through oxidative stress in carp (Cyprinus carpio L.) head kidney lymphocyte. Fish & shellfish immunology. 2022-05-16. PMID:35577320. |
ast treatment reduced oxidative stress and apoptosis induced by cd. |
2022-05-16 |
2023-08-13 |
Not clear |
| Haoran Zhang, Fuqing Zhao, Xiaoxue Gai, Jingzeng Cai, Xintong Zhang, Xiaoming Chen, Yue Zhu, Ziwei Zhan. Astilbin attenuates apoptosis induced by cadmium through oxidative stress in carp (Cyprinus carpio L.) head kidney lymphocyte. Fish & shellfish immunology. 2022-05-16. PMID:35577320. |
in addition, oxidative stress inhibitor nac could also reduce head kidney lymphocytes apoptosis induced by cd, indicating that oxidative stress was involved in this process. |
2022-05-16 |
2023-08-13 |
Not clear |
| Haoran Zhang, Fuqing Zhao, Xiaoxue Gai, Jingzeng Cai, Xintong Zhang, Xiaoming Chen, Yue Zhu, Ziwei Zhan. Astilbin attenuates apoptosis induced by cadmium through oxidative stress in carp (Cyprinus carpio L.) head kidney lymphocyte. Fish & shellfish immunology. 2022-05-16. PMID:35577320. |
our results suggested that ast can alleviate the apoptosis of carp head kidney lymphocytes induced by cd through oxidative stress. |
2022-05-16 |
2023-08-13 |
Not clear |
| He Ding, Zhiqiang Li, Xin Li, Xiaorui Yang, Jing Zhao, Jing Guo, Wenfa Lu, Hongyu Liu, Jun Wan. FTO Alleviates CdCl International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563339. |
the flow cytometry results showed that cd increased the degree of apoptosis and level of superoxide anion (o |
2022-05-14 |
2023-08-13 |
Not clear |
| Estefani Yaquelin Hernández-Cruz, Isabel Amador-Martínez, Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, José Pedraza Chaverr. Renal damage induced by cadmium and its possible therapy by mitochondrial transplantation. Chemico-biological interactions. 2022-05-02. PMID:35500868. |
the mitochondria play a fundamental role in the nephrotoxicity of cd; cd enters the mitochondria and affects the electron transport system (ets), increases the production of reactive oxygen species (ros), decreases the mitochondrial membrane potential (Δψm), alters mitochondrial dynamics, induces mutations in mitochondrial deoxyribonucleic acid (mtdna) and decreased biogenesis leading to increased mitophagy, autophagy, and inevitably apoptosis. |
2022-05-02 |
2023-08-13 |
Not clear |
| Matthew P Shaughnessy, Christine J Park, Pooja S Salvi, Robert A Cowle. Jejunoileal mucosal growth in mice with a limited microbiome. PloS one. vol 17. issue 3. 2022-03-29. PMID:35349599. |
after treatment, small intestinal villus height (vh), crypt depth (cd), mucosal surface area (msa), crypt proliferation index (cpi), apoptosis, and villus and crypt cell types were assessed. |
2022-03-29 |
2023-08-13 |
mouse |