| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huan Liu, Xiuhui Tian, Lisheng Jiang, Dianfeng Han, Shunxin Hu, Yanmei Cui, Fang Jiang, Yongchun Liu, Yingjiang Xu, Huanjun L. Sources, bioaccumulation, and toxicity mechanisms of cadmium in Chlamys farreri. Journal of hazardous materials. vol 453. 2023-04-14. PMID:37058935. |
additionally, we combined a multi-omics approach to reveal a network of oxidative stress-induced toxicity mechanisms of cd in scallops, identifying differentially expressed genes and proteins involved in metal ion binding, oxidative stress, energy metabolism, and apoptosis. |
2023-04-14 |
2023-08-14 |
Not clear |
| Xishuai Tong, Xiaohui Fu, Gengsheng Yu, Huayi Qu, Hui Zou, Ruilong Song, Yonggang Ma, Yan Yuan, Jianchun Bian, Jianhong Gu, Zongping Li. Polystyrene exacerbates cadmium-induced mitochondrial damage to lung by blocking autophagy in mice. Environmental toxicology. 2023-04-06. PMID:37022104. |
the cytotoxicity of cd includes oxidative stress, apoptosis, and mitochondrial histopathological changes. |
2023-04-06 |
2023-08-14 |
mouse |
| Dantong Jia, Xiuqi You, Moran Tang, Yitao Lyu, Jingrun Hu, Weiling Su. Single and combined genotoxicity of metals and fluoroquinolones to zebrafish embryos at environmentally relevant concentrations. Aquatic toxicology (Amsterdam, Netherlands). vol 258. 2023-04-05. PMID:37019017. |
the upregulation of nucleic acid metabolites and the dysregulation of proteins confirmed the occurrence of dna damage and apoptosis, and further revealed the inhibition of dna repair by cd and binding of dna or dna topoisomerase by fqs. |
2023-04-05 |
2023-08-14 |
zebrafish |
| Shing-Hsien Chou, Hung-Chen Lin, Shao-Wei Chen, Yu-Ting Tai, Shih-Ming Jung, Fu-Hsiang Ko, Jong-Hwei Su Pang, Pao-Hsien Ch. Cadmium exposure induces histological damage and cytotoxicity in the cardiovascular system of mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-03-23. PMID:36958389. |
cd also induced the apoptosis of cardiomyocytes and increased the expression levels of matrix metalloproteinase (mmp)-2 and mmp-14 in cardiac tissues. |
2023-03-23 |
2023-08-14 |
mouse |
| Hao Liu, Rong Wang, Huijuan OuYang, Yi Wang, Jie Wu, Mengyuan Li, Yuan Hu, Yuyou Yao, Yehao Liu, Yanli J. Cadmium Induced Mouse Spermatogonia Apoptosis via Mitochondrial Calcium Overload Mediated by IP Toxicology. 2023-02-02. PMID:36731763. |
cadmium induced mouse spermatogonia apoptosis via mitochondrial calcium overload mediated by ip cadmium (cd) is a toxic metal and also a well-known reproductive toxicant. |
2023-02-02 |
2023-08-14 |
mouse |
| Hao Liu, Rong Wang, Huijuan OuYang, Yi Wang, Jie Wu, Mengyuan Li, Yuan Hu, Yuyou Yao, Yehao Liu, Yanli J. Cadmium Induced Mouse Spermatogonia Apoptosis via Mitochondrial Calcium Overload Mediated by IP Toxicology. 2023-02-02. PMID:36731763. |
cd could induce germ cells apoptosis in mouse testes, however, the mechanism remains unclear. |
2023-02-02 |
2023-08-14 |
mouse |
| Yongjie Xu, Tao Peng, Qin Zhou, Jiawei Zhu, Gengze Liao, Fei Zou, Xiaojing Men. Evaluation of the oxidative toxicity induced by lead, manganese, and cadmium using genetically modified nrf2a-mutant zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-01-30. PMID:36717045. |
of concern, cd exposure caused significant toxic damage, including increased mortality and malformation rates, apoptosis of brain neurons, and severe locomotor behavior aberration in mutant zebrafish. |
2023-01-30 |
2023-08-14 |
zebrafish |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in our study, cd is believed to induce mitochondrial dysfunction and endoplasmic reticulum stress (ers) in a dose-dependent manner, thereby leading to apoptosis, as evident by elevated drp1, fis1, grp78, chop, atf4, p-eif2α, p-perk, bax, cleaved caspase 3 proteins expression and ros levels, and decreased the levels of mfn2, opa1, bcl2, and intracellular collagen i, b-alp, runx2, and bgp genes. |
2023-01-20 |
2023-08-14 |
Not clear |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in conclusion, we found that cd was involved in mitochondrial dysfunction, ers, and apoptosis in mc3t3-e1 cells, while nac and 4-pba relieved ers and attenuated cell apoptosis. |
2023-01-20 |
2023-08-14 |
Not clear |
| Davide Di Paola, Enrico Gugliandolo, Fabiano Capparucci, Marika Cordaro, Carmelo Iaria, Rosalba Siracusa, Ramona D'Amico, Roberta Fusco, Daniela Impellizzeri, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalia Crupi, Alessio Filippo Peritor. Early Exposure to Environmental Pollutants: Imidacloprid Potentiates Cadmium Toxicity on Zebrafish Retinal Cells Death. Animals : an open access journal from MDPI. vol 12. issue 24. 2022-12-23. PMID:36552404. |
in addition, co-exposure to 50 and 195 μm, respectively, for cd and imi, also showed increased apoptosis in eye cells, accompanied by up regulation of genes associated with antioxidant markers (cat, sod1, nrf2 and ho-1). |
2022-12-23 |
2023-08-14 |
cat |
| Hui Zou, Yan Chen, Huayi Qu, Jian Sun, Tao Wang, Yonggang Ma, Yan Yuan, Jianchun Bian, Zongping Li. Microplastics Exacerbate Cadmium-Induced Kidney Injury by Enhancing Oxidative Stress, Autophagy, Apoptosis, and Fibrosis. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430889. |
in addition, the involvement of oxidative stress, autophagy, apoptosis, and fibrosis in the damaging effects of mps and cd on mouse kidneys were investigated. |
2022-11-26 |
2023-08-14 |
mouse |
| Mohamed Kh ElMahdy, Mennatallah O Zaki, Ahmed A Al-Karmalawy, Walied Abdo, Sulaiman Mohammed Alnasser, Samar A Anta. Glimepiride ameliorates renal toxicity induced by cadmium in mice: Modulation of Jun N terminal kinase (JNK)/nuclear factor kappa B (NF-κB) and phosphatidylinositol 3-kinases (PI3K)/protein kinase (AKT) pathways. Life sciences. 2022-11-14. PMID:36375572. |
cd was associated with nephrotoxicity through different mechanisms including apoptosis, inflammation, and oxidative stress. |
2022-11-14 |
2023-08-14 |
mouse |
| Fei Luan, Ziqin Lei, Xi Peng, Li Chen, Lixia Peng, Yao Liu, Zhili Rao, Ruocong Yang, Nan Zen. Cardioprotective effect of cinnamaldehyde pretreatment on ischemia/ reperfusion injury via inhibiting NLRP3 inflammasome activation and gasdermin D mediated cardiomyocyte pyroptosis. Chemico-biological interactions. vol 368. 2022-11-07. PMID:36341777. |
the results found that cd significantly improved cardiac diastolic function, decreased cardiac infarct size and myocardial injury enzymes, inhibited cardiomyocyte apoptosis, attenuated cardiac structure abnormality, and mitigated oxidative stress and inflammatory response. |
2022-11-07 |
2023-08-14 |
rat |
| Adel G Bakr, Emad H M Hassanein, Fares E M Ali, Ehab A M El-Shour. Combined apocynin and carvedilol protect against cadmium-induced testicular damage via modulation of inflammatory response and redox-sensitive pathways. Life sciences. 2022-11-06. PMID:36336125. |
testicular damage is considered a severe complication of cadmium (cd) exposure which is associated with tissue oxidative stress damage, inflammation, and apoptosis. |
2022-11-06 |
2023-08-14 |
rat |
| Lilik Duwi Wahyudi, Seon Hui Yu, Min Kyung Ch. The effect of curcumin on the cadmium-induced mitochondrial apoptosis pathway by metallothionein 2A regulation. Life sciences. 2022-10-15. PMID:36243116. |
cd resulted in apoptosis as shown by annexin v/7-aad double staining. |
2022-10-15 |
2023-08-14 |
human |
| Lilik Duwi Wahyudi, Seon Hui Yu, Min Kyung Ch. The effect of curcumin on the cadmium-induced mitochondrial apoptosis pathway by metallothionein 2A regulation. Life sciences. 2022-10-15. PMID:36243116. |
curcumin inhibited the early and late apoptosis caused by cd. |
2022-10-15 |
2023-08-14 |
human |
| Huanshan He, Xiaoying Chen, Xiang Li, Kangqi Yang, Jintao Li, Huaiping Sh. Lactoferrin alleviates spermatogenesis dysfunction caused by bisphenol A and cadmium via ameliorating disordered autophagy, apoptosis and oxidative stress. International journal of biological macromolecules. 2022-10-02. PMID:36183753. |
bpa (50 mg/kg) and cd (1.6 mg/kg) caused severe damage to testis, including globally decreased germ cell counts, poor sperm quality, disordered apoptosis, oxidative stress, and autophagy; however bioactive substances comprehensively ameliorated spermatogenetic dysfunction via mitigating the increased levels of bax/bcl2, lc3ii/lc3i, and p62. |
2022-10-02 |
2023-08-14 |
mouse |
| Shuzhen Liu, Dongmei Yu, Peng Wei, Jiansheng Cai, Min Xu, Haoyu He, Xu Tang, Chuntao Nong, Yi Wei, Xia Xu, Xiaoting Mo, Zhiyong Zhang, Jian Qi. JAK2/STAT3 Signaling Pathway and Klotho Gene in Cadmium-induced Neurotoxicity In Vitro and In Vivo. Biological trace element research. 2022-09-27. PMID:36166115. |
different concentrations of cd and jak2/stat3 signaling pathway inhibitors were used to treat pc12 cells and thus detect the apoptosis rate. |
2022-09-27 |
2023-08-14 |
rat |
| Shuzhen Liu, Dongmei Yu, Peng Wei, Jiansheng Cai, Min Xu, Haoyu He, Xu Tang, Chuntao Nong, Yi Wei, Xia Xu, Xiaoting Mo, Zhiyong Zhang, Jian Qi. JAK2/STAT3 Signaling Pathway and Klotho Gene in Cadmium-induced Neurotoxicity In Vitro and In Vivo. Biological trace element research. 2022-09-27. PMID:36166115. |
in comparison with the high-dose cd exposure group, after adding tyrphostin ag490 (ag490), the apoptosis rate of pc12 cells increased, whereas the phosphorylation levels of jak2 and stat3 in the cells decreased significantly (p < 0.05). |
2022-09-27 |
2023-08-14 |
rat |
| Shuangquan Wen, Li Wang, Chaofan Zhang, Ruilong Song, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yua. PINK1/Parkin-mediated mitophagy modulates cadmium-induced apoptosis in rat cerebral cortical neurons. Ecotoxicology and environmental safety. vol 244. 2022-09-09. PMID:36084502. |
furthermore, the results of the in vivo experiments showed that cd simultaneously activated both mitophagy and apoptosis and that the suppression of mitophagy by csa aggravated cd-induced apoptosis. |
2022-09-09 |
2023-08-14 |
rat |