| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lanfu Zhao, Yuan Wang, Quan Yan, Wenhai Lv, Yufu Zhang, Shiming H. Exogenous hydrogen sulfide exhibits anti-cancer effects though p38 MAPK signaling pathway in C6 glioma cells. Biological chemistry. vol 396. issue 11. 2016-08-17. PMID:26040007. |
these data suggest that nahs can effectively reduce cell number of c6 cells by triggering the apoptosis via caspase-dependent pathway. |
2016-08-17 |
2023-08-13 |
Not clear |
| Lanfu Zhao, Yuan Wang, Quan Yan, Wenhai Lv, Yufu Zhang, Shiming H. Exogenous hydrogen sulfide exhibits anti-cancer effects though p38 MAPK signaling pathway in C6 glioma cells. Biological chemistry. vol 396. issue 11. 2016-08-17. PMID:26040007. |
p38 mapk and p53 play an important role in nahs-induced apoptosis in c6 cells. |
2016-08-17 |
2023-08-13 |
Not clear |
| Yumei Zhang, Yu Pan, Zhixiang Bian, Peihua Chen, Shijian Zhu, Huiyi Gu, Liping Guo, Chun H. Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages. PloS one. vol 11. issue 1. 2016-07-01. PMID:26788916. |
on the other hand, the glucosylceramide synthase (gcs) inhibitor pdmp or the ceramide (c6) potentiated aldo-induced huvec apoptosis. |
2016-07-01 |
2023-08-13 |
human |
| Ana Zugic, Ivica Jeremic, Aleksandra Isakovic, Ivana Arsic, Snezana Savic, Vanja Tadi. Evaluation of Anticancer and Antioxidant Activity of a Commercially Available CO2 Supercritical Extract of Old Man's Beard (Usnea barbata). PloS one. vol 11. issue 1. 2016-06-29. PMID:26745885. |
further investigations suggested both sce and usnic acid to induce apoptosis and/or autophagy in b16 and c6, indicating higher cytotoxicity of sce to be related to the higher degree of ros production. |
2016-06-29 |
2023-08-13 |
mouse |
| A Ortega, E Rangel-López, A Hidalgo-Miranda, A Morales, E Ruiz-García, A Meneses-García, A Herrera-Gómez, J L Aguilar-Ponce, I G González-Herrera, P Guevara-Salazar, O Prospero-García, S A Del Ange. On the effects of CP 55-940 and other cannabinoid receptor agonists in C6 and U373 cell lines. Toxicology in vitro : an international journal published in association with BIBRA. vol 29. issue 7. 2016-06-22. PMID:26255146. |
herein we compared the effects of synthetic (cp 55-940 and win 55,212-2) and endogenous (anandamide or aea) cbs agonists (10-20 μm) on morphological changes, cell viability, and induction of apoptosis in primary astrocytes and in two glioblastoma cell lines (c6 and u373 cells) in order to characterize their possible differential actions on brain tumor cells. |
2016-06-22 |
2023-08-13 |
Not clear |
| A Ortega, E Rangel-López, A Hidalgo-Miranda, A Morales, E Ruiz-García, A Meneses-García, A Herrera-Gómez, J L Aguilar-Ponce, I G González-Herrera, P Guevara-Salazar, O Prospero-García, S A Del Ange. On the effects of CP 55-940 and other cannabinoid receptor agonists in C6 and U373 cell lines. Toxicology in vitro : an international journal published in association with BIBRA. vol 29. issue 7. 2016-06-22. PMID:26255146. |
cp 55-940 also induced apoptosis in both c6 and u373 cell lines. |
2016-06-22 |
2023-08-13 |
Not clear |
| Varadharajan Thiyagarajan, May-Jywan Tsai, Ching-Feng Wen. Antroquinonol Targets FAK-Signaling Pathway Suppressed Cell Migration, Invasion, and Tumor Growth of C6 Glioma. PloS one. vol 10. issue 10. 2016-06-16. PMID:26517117. |
antroquinonol significantly inhibits cell viability with an mtt assay in both n18 neuroblastoma and c6 glioma cell lines, which exhibits sub g1 phase cell cycle, and further induction of apoptosis is confirmed by a tunel assay. |
2016-06-16 |
2023-08-13 |
Not clear |
| J Jiang, Y-Q Lan, T Zhang, M Yu, X-Y Liu, L-H Li, X-P Che. The in vitro effects of caffeine on viability, cycle cycle profiles, proliferation, and apoptosis of glioblastomas. European review for medical and pharmacological sciences. vol 19. issue 17. 2016-05-18. PMID:26400523. |
we studied the effects of caffeine on cell viability, cell cycle profiles, proliferation, and apoptosis in rat c6 and human u87mg glioblastoma cell lines. |
2016-05-18 |
2023-08-13 |
human |
| J-D Liu, L-J Song, D-J Yan, Y-Y Feng, Y-G Zang, Y Yan. Caffeine inhibits the growth of glioblastomas through activating the caspase-3 signaling pathway in vitro. European review for medical and pharmacological sciences. vol 19. issue 16. 2016-05-02. PMID:26367732. |
to study the effects and associated mechanisms of caffeine on cell viability, cycle dynamics, proliferation and apoptosis both in glioblastoma c6 and u87mg cells. |
2016-05-02 |
2023-08-13 |
Not clear |
| K N Chidambara Murthy, Jinhee Kim, Amit Vikram, Bhimanagouda S Pati. Differential inhibition of human colon cancer cells by structurally similar flavonoids of citrus. Food chemistry. vol 132. issue 1. 2016-04-12. PMID:26434259. |
results of the currents study suggest that among the citrus flavonoids, double bond between c2 and c3 and hydroxyl group at c3, c6 are highly decisive for the proliferation inhibition and apoptosis induction ability. |
2016-04-12 |
2023-08-13 |
human |
| Ji-Ming Pan, Lu Zhou, Guang-Bin Wang, Guang-Wen Xia, Kun Xue, Xin-Guo Cui, Hong-Zhi Shi, Jian-Hui Liu, Jia H. Fatsioside A inhibits the growth of glioma cells via the induction of endoplasmic reticulum stress-mediated apoptosis. Molecular medicine reports. vol 11. issue 5. 2016-03-04. PMID:25608104. |
previous studies have shown that fatsioside a induces growth inhibition, cell cycle arrest and apoptosis in c6 rat glioma cells and u251 human glioma cells. |
2016-03-04 |
2023-08-13 |
human |
| Ping Yang, Lu Zhang, Qiao-Juan Shi, Yun-Bi Lu, Ming Wu, Er-Qing Wei, Wei-Ping Zhan. Nicotinamide phosphoribosyltransferase inhibitor APO866 induces C6 glioblastoma cell death via autophagy. Die Pharmazie. vol 70. issue 10. 2015-12-16. PMID:26601421. |
our previous study showed that apo866 inhibits the proliferation of c6 glioblastoma cells, but failed to induce apoptosis. |
2015-12-16 |
2023-08-13 |
Not clear |
| Min-Bin Chen, Qin Jiang, Yuan-yuan Liu, Yan Zhang, Bang-shun He, Mu-Xin Wei, Jian-Wei Lu, Yong Ji, Pei-Hua L. C6 ceramide dramatically increases vincristine sensitivity both in vivo and in vitro, involving AMP-activated protein kinase-p53 signaling. Carcinogenesis. vol 36. issue 9. 2015-12-15. PMID:26116623. |
in vitro, c6 and vincristine coadministration induced substantial necrosis and apoptosis in multiple human cancer cell lines, which were accompanied by a profound amp-activated protein kinase (ampk) activation, subsequent p53 activation, mtorc1 inactivation and bcl-2/hif-1α downregulation. |
2015-12-15 |
2023-08-13 |
human |
| Weiwei Ma, Bingjie Ding, Huanling Yu, Linhong Yuan, Yuandi Xi, Rong Xia. Genistein alleviates β-amyloid-induced inflammatory damage through regulating Toll-like receptor 4/nuclear factor κB. Journal of medicinal food. vol 18. issue 3. 2015-11-16. PMID:25384233. |
the current results showed that gen could alleviate aβ25-35-induced cell apoptosis and prevent aβ25-35-induced tnf-α and il-1β release from c6 cells. |
2015-11-16 |
2023-08-13 |
rat |
| Lelin Bing, Junfeng Wu, Jianfeng Zhang, Yinghui Chen, Zhen Hong, Hengbing Z. DHT inhibits the Aβ25-35-induced apoptosis by regulation of seladin-1, survivin, XIAP, bax, and bcl-xl expression through a rapid PI3-K/Akt signaling in C6 glial cell lines. Neurochemical research. vol 40. issue 1. 2015-11-10. PMID:25347962. |
dht inhibits the aβ25-35-induced apoptosis by regulation of seladin-1, survivin, xiap, bax, and bcl-xl expression through a rapid pi3-k/akt signaling in c6 glial cell lines. |
2015-11-10 |
2023-08-13 |
Not clear |
| Lelin Bing, Junfeng Wu, Jianfeng Zhang, Yinghui Chen, Zhen Hong, Hengbing Z. DHT inhibits the Aβ25-35-induced apoptosis by regulation of seladin-1, survivin, XIAP, bax, and bcl-xl expression through a rapid PI3-K/Akt signaling in C6 glial cell lines. Neurochemical research. vol 40. issue 1. 2015-11-10. PMID:25347962. |
collectively, in a c6 glial cell model, we firstly found that dht inhibits aβ25-35-induced apoptosis by a rapid nongenic pi-3k/akt activation as well as regulation of seladin-1, survivin, xiap, bcl-xl, and bax proteins. |
2015-11-10 |
2023-08-13 |
Not clear |
| Y Zhou, F Li, X Tian, B Wang, M Ding, H Pan. Changes in phosphatidylinositol 3-kinase 55 kDa gamma expression and subcellular localization may be caspase 6 dependent in paraquat-induced SH-SY5Y apoptosis. Human & experimental toxicology. vol 33. issue 7. 2015-10-21. PMID:24130211. |
thus, p55pik could be a substrate of activated c6 during apoptosis, leading to loss of original biological functions and redistribution to disturb cell cycle progression. |
2015-10-21 |
2023-08-12 |
human |
| Jin Yao, Hui-E Bi, Yi Sheng, Li-Bo Cheng, Ri-Le Wendu, Cheng-Hu Wang, Guo-Fan Cao, Qin Jian. Ultraviolet (UV) and hydrogen peroxide activate ceramide-ER stress-AMPK signaling axis to promote retinal pigment epithelium (RPE) cell apoptosis. International journal of molecular sciences. vol 14. issue 5. 2015-10-19. PMID:23685869. |
conversely, cell permeable short-chain c6 ceramide and ampk activator aicar (5-amino-1-β-d-ribofuranosyl-imidazole-4-carboxamide) mimicked uv and h2o2's effects and promoted rpe cell apoptosis. |
2015-10-19 |
2023-08-12 |
Not clear |
| Xing-Qi Li, Zhi-Gang Ouyang, Sheng-Hua Zhang, Hong Liu, Yue Shang, Yi Li, Yong-Su Zhe. Synergy of enediyne antibiotic lidamycin and temozolomide in suppressing glioma growth with potentiated apoptosis induction. Journal of neuro-oncology. vol 119. issue 1. 2015-10-19. PMID:24842385. |
in addition, ldm also potentiated the apoptosis inductions by tmz in rat c6 cells and human u87 cells. |
2015-10-19 |
2023-08-13 |
human |
| Xing-Qi Li, Zhi-Gang Ouyang, Sheng-Hua Zhang, Hong Liu, Yue Shang, Yi Li, Yong-Su Zhe. Synergy of enediyne antibiotic lidamycin and temozolomide in suppressing glioma growth with potentiated apoptosis induction. Journal of neuro-oncology. vol 119. issue 1. 2015-10-19. PMID:24842385. |
as determined by western blot, apoptosis signal pathways in c6 cells and u87 cells were markedly affected by the synergistic alteration of p53, bax, procaspase 3, and bcd-2 expression. |
2015-10-19 |
2023-08-13 |
human |