| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Indranil Banerjee, Kakali De, Dibyanti Mukherjee, Goutam Dey, Sankha Chattopadhyay, Manabendra Mukherjee, Mahitosh Mandal, Amal Kumar Bandyopadhyay, Amit Gupta, Santanu Ganguly, Mridula Misr. Paclitaxel-loaded solid lipid nanoparticles modified with Tyr-3-octreotide for enhanced anti-angiogenic and anti-glioma therapy. Acta biomaterialia. vol 38. 2017-10-12. PMID:27109765. |
in rat c6 glioma cells, psm improved ptx induced apoptosis. |
2017-10-12 |
2023-08-13 |
rat |
| Paulo L C Coelho, Mona N Oliveira, Alessandra B da Silva, Bruno P S Pitanga, Victor D A Silva, Giselle P Faria, Geraldo P Sampaio, Maria de Fatima D Costa, Suzana Braga-de-Souza, Silvia L Cost. The flavonoid apigenin from Croton betulaster Mull inhibits proliferation, induces differentiation and regulates the inflammatory profile of glioma cells. Anti-cancer drugs. vol 27. issue 10. 2017-09-20. PMID:27622606. |
even after c6 cells were treated with apigenin for 48 h, high proportions of c6 cells entered apoptosis (39.56%) and autophagy (22%) as shown by flow cytometry using annexin v/propidium iodide and acridine orange staining, respectively. |
2017-09-20 |
2023-08-13 |
rat |
| Paulo L C Coelho, Mona N Oliveira, Alessandra B da Silva, Bruno P S Pitanga, Victor D A Silva, Giselle P Faria, Geraldo P Sampaio, Maria de Fatima D Costa, Suzana Braga-de-Souza, Silvia L Cost. The flavonoid apigenin from Croton betulaster Mull inhibits proliferation, induces differentiation and regulates the inflammatory profile of glioma cells. Anti-cancer drugs. vol 27. issue 10. 2017-09-20. PMID:27622606. |
because apigenin can induce differentiation, apoptosis, and autophagy, can alter the profile of cytokines involved in regulating the immune response, and can reduce the survival, growth, proliferation, and migration of c6 cells, this flavonoid may be considered a potential antitumor drug for the adjuvant treatment of malignant gliomas. |
2017-09-20 |
2023-08-13 |
rat |
| Sung-Jo Kim, Eunmi Hwang, Sun Shin Yi, Ki Duk Song, Hak-Kyo Lee, Tae-Hwe Heo, Sang-Kyu Park, Yun Joo Jung, Hyun Sik Ju. Sea Buckthorn Leaf Extract Inhibits Glioma Cell Growth by Reducing Reactive Oxygen Species and Promoting Apoptosis. Applied biochemistry and biotechnology. vol 182. issue 4. 2017-09-08. PMID:28181191. |
the present study examined whether sbt leaf extract could inhibit proliferation and promote apoptosis of rat glioma c6 cells. |
2017-09-08 |
2023-08-13 |
rat |
| Sung-Jo Kim, Eunmi Hwang, Sun Shin Yi, Ki Duk Song, Hak-Kyo Lee, Tae-Hwe Heo, Sang-Kyu Park, Yun Joo Jung, Hyun Sik Ju. Sea Buckthorn Leaf Extract Inhibits Glioma Cell Growth by Reducing Reactive Oxygen Species and Promoting Apoptosis. Applied biochemistry and biotechnology. vol 182. issue 4. 2017-09-08. PMID:28181191. |
all of these results suggest that sbt leaf extract could inhibit the rapid proliferation of rat c6 glioma cells, possibly by inducing the early events of apoptosis. |
2017-09-08 |
2023-08-13 |
rat |
| Wei-Chen Hou, Xiao-Hui Miao, Lian-Jun Ma, Xiao-Xue Bai, Qun Liu, Lei Son. WITHAFERIN A INDUCES APOPTOSIS IN RAT C6 GLIOMA CELLS THROUGH REGULATING NF-KB NUCLEAR TRANSLOCATION AND ACTIVATION OF CASPASE CASCADE. African journal of traditional, complementary, and alternative medicines : AJTCAM. vol 14. issue 2. 2017-08-16. PMID:28573248. |
withaferin a induces apoptosis in rat c6 glioma cells through regulating nf-kb nuclear translocation and activation of caspase cascade. |
2017-08-16 |
2023-08-13 |
rat |
| Caixia Wang, Heyu Chen, Mingchao Zhang, Jie Zhang, Xunbin Wei, Weihai Yin. Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis. Cancer letters. vol 378. issue 1. 2017-07-17. PMID:27157912. |
we found that aoaa, a widely used mas inhibitor, led to decreased intracellular atp levels, altered cell cycle and increased apoptosis and necrosis of c6 glioma cells, without affecting the survival of primary astrocyte cultures. |
2017-07-17 |
2023-08-13 |
Not clear |
| Yahua Wang, Xue Ying, Haolun Xu, Helu Yan, Xia Li, Hui Tan. The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals. International journal of nanomedicine. vol 12. 2017-05-02. PMID:28260885. |
the functional curcumin liposomes induce apoptosis in c6 glioblastoma cells and c6 glioblastoma stem cells in vitro and in animals. |
2017-05-02 |
2023-08-13 |
Not clear |
| Can Chen, Sarah Zingales, Ting Wang, Mingyong Yuan, Dan Wang, Lulu Cai, Qinglin Jian. Synthesis and in vitro evaluation of 4-substituted furano[3,2-c] tetrahydroquinolines as potential anti-cancer agents. Journal of enzyme inhibition and medicinal chemistry. vol 31. issue 5. 2017-03-24. PMID:26207511. |
in addition, 10a induced murine c6 glioma cell apoptosis in a dose-dependent manner by up-regulating the expression of bax, caspase-3, and caspase-9, and by down-regulating bcl-2. |
2017-03-24 |
2023-08-13 |
Not clear |
| Kai Yao, Junfeng Wu, Jianfeng Zhang, Jimei Bo, Zhen Hong, Hengbing Z. Protective Effect of DHT on Apoptosis Induced by U18666A via PI3K/Akt Signaling Pathway in C6 Glial Cell Lines. Cellular and molecular neurobiology. vol 36. issue 5. 2017-03-24. PMID:26340949. |
protective effect of dht on apoptosis induced by u18666a via pi3k/akt signaling pathway in c6 glial cell lines. |
2017-03-24 |
2023-08-13 |
Not clear |
| Kai Yao, Junfeng Wu, Jianfeng Zhang, Jimei Bo, Zhen Hong, Hengbing Z. Protective Effect of DHT on Apoptosis Induced by U18666A via PI3K/Akt Signaling Pathway in C6 Glial Cell Lines. Cellular and molecular neurobiology. vol 36. issue 5. 2017-03-24. PMID:26340949. |
apoptosis of c6 cells was detected by hoechst 33258 fluorescent staining and flow cytometry with annexin v-fitc/pi dual staining. |
2017-03-24 |
2023-08-13 |
Not clear |
| Jian Ma, Yan-Ru Yang, Wei Chen, Mei-Hua Chen, Hao Wang, Xiao-Dan Wang, Li-Li Sun, Feng-Ze Wang, De-Cai Wan. Fluoxetine synergizes with temozolomide to induce the CHOP-dependent endoplasmic reticulum stress-related apoptosis pathway in glioma cells. Oncology reports. vol 36. issue 2. 2017-03-08. PMID:27278525. |
flt treatment increased the early apoptosis rate, induced typical apoptotic morphology in the c6 cells and activated caspase-3 with no change in the mitochondrial membrane potential. |
2017-03-08 |
2023-08-13 |
rat |
| Jian Ma, Yan-Ru Yang, Wei Chen, Mei-Hua Chen, Hao Wang, Xiao-Dan Wang, Li-Li Sun, Feng-Ze Wang, De-Cai Wan. Fluoxetine synergizes with temozolomide to induce the CHOP-dependent endoplasmic reticulum stress-related apoptosis pathway in glioma cells. Oncology reports. vol 36. issue 2. 2017-03-08. PMID:27278525. |
knockdown of chop expression abolished the synergistic effect of flt and tmz in the c6 cells, which suggests that flt may sensitize glioma cells to tmz through activation of the chop-dependent apoptosis pathway. |
2017-03-08 |
2023-08-13 |
rat |
| Arabinda Das, Daniel G McDonald, Yaenette N Dixon-Mah, Dustin J Jacqmin, Vikram N Samant, William A Vandergrift, Scott M Lindhorst, David Cachia, Abhay K Varma, Kenneth N Vanek, Naren L Banik, Joseph M Jenrette, Jeffery J Raizer, Pierre Giglio, Sunil J Pate. RIP1 and RIP3 complex regulates radiation-induced programmed necrosis in glioblastoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 6. 2017-02-14. PMID:26684801. |
here, we compare the molecular mechanism of cell death (apoptosis or necrosis) of c6 glioma cells in both in vitro and in vivo (c6 othotopically allograft) models in response to low and high doses of x-ray radiation. |
2017-02-14 |
2023-08-13 |
Not clear |
| Xin Sui, Xiao-Hua Li, Ming-Hua Duan, Ai-Ling Jia, Ye Wang, Da Liu, Yi-Ping Li, Zhi-Dong Qi. Investigation of the anti-glioma activity of Oviductus ranae protein hydrolysate. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 81. 2017-01-31. PMID:27261592. |
this study aimed to investigate the effects of oviductus ranae protein hydrolysate (orph) on human glioma c6 cell proliferation and apoptosis in vitro and in vivo. |
2017-01-31 |
2023-08-13 |
human |
| Shravan Kumar Sriraman, Jiayi Pan, Can Sarisozen, Ed Luther, Vladimir Torchili. Enhanced Cytotoxicity of Folic Acid-Targeted Liposomes Co-Loaded with C6 Ceramide and Doxorubicin: In Vitro Evaluation on HeLa, A2780-ADR, and H69-AR Cells. Molecular pharmaceutics. vol 13. issue 2. 2016-12-20. PMID:26702994. |
overall, this study clearly shows that the co-delivery of c6 ceramide and dox using a liposomal platform significantly correlates with an antiproliferative effect due to cell cycle regulation and subsequent induction of apoptosis and thus warrants its further evaluation in preclinical animal models. |
2016-12-20 |
2023-08-13 |
Not clear |
| Eun-Ok Choi, Jin-Woo Jeong, Cheol Park, Su Hyun Hong, Gi-Young Kim, Hye-Jin Hwang, Eun-Ju Cho, Yung Hyun Cho. Baicalein protects C6 glial cells against hydrogen peroxide-induced oxidative stress and apoptosis through regulation of the Nrf2 signaling pathway. International journal of molecular medicine. vol 37. issue 3. 2016-12-19. PMID:26796879. |
baicalein protects c6 glial cells against hydrogen peroxide-induced oxidative stress and apoptosis through regulation of the nrf2 signaling pathway. |
2016-12-19 |
2023-08-13 |
Not clear |
| Cíntia J Kiekow, Fabrício Figueiró, Fabrícia Dietrich, Luciana Dalla Vechia, Elisa N S Pires, Elisa H F Jandrey, Simone C B Gnoatto, Christianne G Salbego, Ana Maria O Battastini, Grace Gosman. Quercetin derivative induces cell death in glioma cells by modulating NF-κB nuclear translocation and caspase-3 activation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 84. 2016-12-13. PMID:26802551. |
cell cycle and apoptotic death analyses on c6 glioma cells were also performed, and chalcone 2 increased the apoptosis of the cells but did not alter the cell cycle progression. |
2016-12-13 |
2023-08-13 |
Not clear |
| Songping Zheng, Xiang Gao, Xiaoxiao Liu, Ting Yu, Tianying Zheng, Yi Wang, Chao Yo. Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo. International journal of nanomedicine. vol 11. 2016-12-13. PMID:27354801. |
the cur-loaded mpeg-pla micelles (cur/mpeg-pla micelles) exhibited an enhanced toxicity on c6 and u251 glioma cells and induced more apoptosis on c6 glioma cells compared with free cur. |
2016-12-13 |
2023-08-13 |
mouse |
| Lanfu Zhao, Yuan Wang, Quan Yan, Wenhai Lv, Yufu Zhang, Shiming H. Exogenous hydrogen sulfide exhibits anti-cancer effects though p38 MAPK signaling pathway in C6 glioma cells. Biological chemistry. vol 396. issue 11. 2016-08-17. PMID:26040007. |
this work demonstrated that nahs could reduce cell number and induce apoptosis of c6 gliomas cells. |
2016-08-17 |
2023-08-13 |
Not clear |