| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen Nie, Xin Zan, Ting Yu, Mengni Ran, Zehua Hong, Yihong He, Tingting Yang, Yan Ju, Xiang Ga. Synergetic therapy of glioma mediated by a dual delivery system loading α-mangostin and doxorubicin through cell cycle arrest and apoptotic pathways. Cell death & disease. vol 11. issue 10. 2021-05-17. PMID:33116114. |
based on the in vitro results, mpeg-pcl loaded with α-m and dox (α-m-dox/m) with a size of 25.68 nm and a potential of -1.51 mv was demonstrated to significantly inhibit the growth and promote apoptosis in gl261, c6 and u87 cells, and the effects of the combination were better than each compound alone. |
2021-05-17 |
2023-08-13 |
mouse |
| Jingjing Zhu, Ying Zhang, Xiaojie Chen, Yue Zhang, Ke Zhang, Hongyue Zheng, Yinghui Wei, Hangsheng Zheng, Jiazhen Zhu, Fang Wu, Ji-Gang Piao, Zhihong Zhu, Fanzhu L. Angiopep-2 modified lipid-coated mesoporous silica nanoparticles for glioma targeting therapy overcoming BBB. Biochemical and biophysical research communications. vol 534. 2021-04-20. PMID:33162028. |
in vitro experiments demonstrated that the targeting efficiency of ptx was enhanced by ang-lp-msn-ptx with higher penetration ability (10.74%) and causing more c6 cell apoptosis. |
2021-04-20 |
2023-08-13 |
rat |
| Julia Ketteler, Alina Wittka, Daniela Leonetti, Victoria Veas Roy, Hala Estephan, Patrick Maier, Henning Reis, Carsten Herskind, Verena Jendrossek, Francois Paris, Diana Klei. Caveolin-1 regulates the ASMase/ceramide-mediated radiation response of endothelial cells in the context of tumor-stroma interactions. Cell death & disease. vol 11. issue 4. 2021-04-08. PMID:32273493. |
exogenous c6 and c16 ceramide treatment in parallel increased the growth delay of pca spheroids and induced pca cell apoptosis. |
2021-04-08 |
2023-08-13 |
human |
| Wanna Sa-Nongdej, Sukumal Chongthammakun, Chanchai Songthaveesi. Nutrient starvation induces apoptosis and autophagy in C6 glioma stem-like cells. Heliyon. vol 7. issue 2. 2021-03-16. PMID:33718649. |
nutrient starvation induces apoptosis and autophagy in c6 glioma stem-like cells. |
2021-03-16 |
2023-08-13 |
Not clear |
| Wanna Sa-Nongdej, Sukumal Chongthammakun, Chanchai Songthaveesi. Nutrient starvation induces apoptosis and autophagy in C6 glioma stem-like cells. Heliyon. vol 7. issue 2. 2021-03-16. PMID:33718649. |
western blots detected cleaved caspase-3 (an apoptosis marker) and phospho-beclin 1, lc 3b-i, lc 3b-ii (autophagy markers) in c6 gscs after nutrient starvation for 1, 3, 4, and 5 days. |
2021-03-16 |
2023-08-13 |
Not clear |
| Wanna Sa-Nongdej, Sukumal Chongthammakun, Chanchai Songthaveesi. Nutrient starvation induces apoptosis and autophagy in C6 glioma stem-like cells. Heliyon. vol 7. issue 2. 2021-03-16. PMID:33718649. |
this study demonstrated that nutrient starvation decreases proliferation by approximately 81%, while increasing apoptosis (99.9%) and autophagy (94.6%) in c6 gscs by the fifth day. |
2021-03-16 |
2023-08-13 |
Not clear |
| Li Li, Yuelong Xu, Meng Zhao, Zhiqiang Ga. Neuro-protective roles of long non-coding RNA MALAT1 in Alzheimer's disease with the involvement of the microRNA-30b/CNR1 network and the following PI3K/AKT activation. Experimental and molecular pathology. vol 117. 2021-02-02. PMID:32976819. |
it increased viability and decreased apoptosis in injured pc12 and c6 cells, and decreased the secretion of pro-inflammatory factor il-6 and tnf-α but increased il-10 production. |
2021-02-02 |
2023-08-13 |
rat |
| Firas Khathayer, Matthew A Taylor, Swapan K Ra. Synergism of 4HPR and SAHA increases anti-tumor actions in glioblastoma cells. Apoptosis : an international journal on programmed cell death. vol 25. issue 3-4. 2021-01-08. PMID:32006189. |
the results from molecular studies indicated that cell death occurred via activation of the extrinsic and intrinsic pathways of apoptosis in both c6 and t98g cells. |
2021-01-08 |
2023-08-13 |
human |
| Ana Dácil Marrero, Laura Castilla, José L Espartero, Andrés Madrona, Ana R Quesada, Miguel Ángel Medina, Beatriz Martínez-Poved. A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers. Food chemistry. vol 333. 2021-01-06. PMID:32688305. |
in these assays, hydroxytyrosyl hexyl ether (ht c6) exhibited the most potent inhibitory activity in vitro, activating as well apoptosis in endothelial cells. |
2021-01-06 |
2023-08-13 |
chicken |
| Juzheng Zhang, Zhenlei Zhang, Ming Jiang, Shanhe Li, Haoliang Yuan, Hongbin Sun, Feng Yang, Hong Lian. Developing a Novel Gold(III) Agent to Treat Glioma Based on the Unique Properties of Apoferritin Nanoparticles: Inducing Lethal Autophagy and Apoptosis. Journal of medicinal chemistry. vol 63. issue 22. 2020-12-31. PMID:33185442. |
moreover, we confirmed that c6 kills glioma cells by inducing lethal autophagy and apoptosis. |
2020-12-31 |
2023-08-13 |
Not clear |
| Sakine Shirvalilou, Samideh Khoei, Sepideh Khoee, Seied Rabi Mahdavi, Nida Jamali Raoufi, Manijeh Motevalian, Mohammad Yahya Karim. Enhancement radiation-induced apoptosis in C6 glioma tumor-bearing rats via pH-responsive magnetic graphene oxide nanocarrier. Journal of photochemistry and photobiology. B, Biology. vol 205. 2020-11-19. PMID:32120183. |
enhancement radiation-induced apoptosis in c6 glioma tumor-bearing rats via ph-responsive magnetic graphene oxide nanocarrier. |
2020-11-19 |
2023-08-13 |
rat |
| Liany Luna-Dulcey, James A da Silva, Marcia R Cominett. SSi6 promotes cell death by apoptosis through cell cycle arrest and inhibits migration and invasion of MDA-MB-231 human breast cancer cells. Anti-cancer drugs. vol 31. issue 1. 2020-10-16. PMID:31490285. |
cell cycle and apoptosis assay were analyzed using flow cytometer accuri c6 and analysis of proteins as retinoblastoma rb and kinases cdk4/6 were analyzed by western blotting. |
2020-10-16 |
2023-08-13 |
human |
| Elena Capoccia, Carla Cirillo, Annalisa Marchetto, Samanta Tiberi, Youssef Sawikr, Marcella Pesce, Alessandra D'Alessandro, Caterina Scuderi, Giovanni Sarnelli, Rosario Cuomo, Luca Steardo, Giuseppe Esposit. S100B-p53 disengagement by pentamidine promotes apoptosis and inhibits cellular migration via aquaporin-4 and metalloproteinase-2 inhibition in C6 glioma cells. Oncology letters. vol 9. issue 6. 2020-10-01. PMID:26137161. |
s100b-p53 disengagement by pentamidine promotes apoptosis and inhibits cellular migration via aquaporin-4 and metalloproteinase-2 inhibition in c6 glioma cells. |
2020-10-01 |
2023-08-13 |
rat |
| Elena Capoccia, Carla Cirillo, Annalisa Marchetto, Samanta Tiberi, Youssef Sawikr, Marcella Pesce, Alessandra D'Alessandro, Caterina Scuderi, Giovanni Sarnelli, Rosario Cuomo, Luca Steardo, Giuseppe Esposit. S100B-p53 disengagement by pentamidine promotes apoptosis and inhibits cellular migration via aquaporin-4 and metalloproteinase-2 inhibition in C6 glioma cells. Oncology letters. vol 9. issue 6. 2020-10-01. PMID:26137161. |
thus, the aim of the present study was to evaluate the effect of pentamidine on rat c6 glioma cell proliferation, migration and apoptosis |
2020-10-01 |
2023-08-13 |
rat |
| Pengguo Zhang, Qingwei Zhou, Lin Tian, Xiangyu Zhou, Yue Zhou, Jiajun Che. Experimental study of a novel tumstatin on C6 brain glioma Oncology letters. vol 14. issue 3. 2020-10-01. PMID:28928823. |
novel tumstatin had an evident inhibitory effect on c6 glioma cells, and the most notable impact emerged after 48 h. the following were observed under the fluorescence microscope: characteristic morphological changes of cell apoptosis were typically observed in the novel tumstatin (2,000 µg/ml) group; mitochondrial membrane potential decreased significantly (p<0.05); the cells in the g0/g1 phase significantly increased (p<0.05); and the number of cells in the s phase was reduced. |
2020-10-01 |
2023-08-13 |
Not clear |
| Safia Ladha, Xiaofan Qiu, Lorenzo Casal, Nicholas S Caron, Dagmar E Ehrnhoefer, Michael R Hayde. Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli. Cell death discovery. vol 4. 2020-10-01. PMID:29560279. |
in addition to apoptosis, c6 has been shown to regulate b-cell activation and differentiation in plasma cells as well as macrophage activation. |
2020-10-01 |
2023-08-13 |
mouse |
| Chanchai Songthaveesin, Wanna Sa-Nongdej, Tanapol Limboonreung, Sukumal Chongthammaku. Combination of metformin and 9-cis retinoic acid increases apoptosis in C6 glioma stem-like cells. Heliyon. vol 4. issue 5. 2020-10-01. PMID:29872770. |
combination of metformin and 9-cis retinoic acid increases apoptosis in c6 glioma stem-like cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Gökhan Kuş, Mete Özkurt, Pınar Öztopcu Vatan, Nilüfer Erkasap, Ruhi Uyar, Selda Kabader. Comparison of a ceramidase inhibitor (ceranib-2) with C2 ceramide and cisplatin on cytotoxicity and apoptosis of glioma cells. Turkish journal of biology = Turk biyoloji dergisi. vol 42. issue 3. 2020-10-01. PMID:30814888. |
ceranib-2 had the most growth-suppressive activity on human t-98g cells with an ic50 of 7 µm for 24 h and 0.9 µm for 48 h. only the 25 µm dose of ceranib-2 induced apoptosis of human t-98g and u-87mg cells after 24 h of treatment; however, it increased apoptosis of c6 cells dose- and time-dependently. |
2020-10-01 |
2023-08-13 |
human |
| Hidetomo Niwa, Ken-Ichi Furukawa, Kazuhiko Seya, Kazuyoshi Hirot. Ketamine suppresses the proliferation of rat C6 glioma cells. Oncology letters. vol 14. issue 4. 2020-09-30. PMID:29085500. |
terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) assays were performed following cell incubation with/without ketamine, to confirm if the ketamine-induced cell death of c6 glioma and rnb cells were due to apoptosis. |
2020-09-30 |
2023-08-13 |
human |
| Guocai Guo, Ang Tian, Xiaolei Lan, Changqing Fu, Zhiyong Yan, Chao Wan. Nano hydroxyapatite induces glioma cell apoptosis by suppressing NF-κB signaling pathway. Experimental and therapeutic medicine. vol 17. issue 5. 2020-09-29. PMID:30988786. |
rat glioma c6 cells and human glioma u87mg atcc cells were exposed to nha (20-100 µg/ml), and its effects on cell morphology, viability, apoptosis, cell cycle, invasion and nuclear factor (nf)-κb signaling were analyzed. |
2020-09-29 |
2023-08-13 |
human |