| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hirendra Nath Banerjee, Millon Blackshear, Jordan Williams, Zack Hawkins, Crystal Sawyer, Vinod Manglik, Shailendra Gir. C-6 Ceramide Induces p53 Dependent Apoptosis in Human Astrocytoma Grade4 (Glioblastoma Multiforme) Cells. Journal of cancer science & therapy. vol 4. issue 2. 2021-10-21. PMID:24319543. |
since c6 ceramide induces apoptosis in glioblastoma cells, it may be employed in chemotherapeutic strategy to treat this highly malignant brain cancer. |
2021-10-21 |
2023-08-12 |
human |
| Xiao Xiao, Lijun Chen, Ying Ouyang, Wenbo Zhu, Pengxin Qiu, Xinwen Su, Yunling Dou, Lipeng Tang, Min Yan, Haipeng Zhang, Xiaoxiao Yang, Dong Xu, Guangmei Ya. Pregnenolone, a cholesterol metabolite, induces glioma cell apoptosis via activating extrinsic and intrinsic apoptotic pathways. Oncology letters. vol 8. issue 2. 2021-10-21. PMID:25013479. |
in the u-87 mg, ln-18 and c6 cell lines, the loss of cell viability resulted from cell apoptosis, which was evidenced by apoptotic nuclear morphology changes and caspase 3 activation. |
2021-10-21 |
2023-08-13 |
Not clear |
| Xiao Xiao, Lijun Chen, Ying Ouyang, Wenbo Zhu, Pengxin Qiu, Xinwen Su, Yunling Dou, Lipeng Tang, Min Yan, Haipeng Zhang, Xiaoxiao Yang, Dong Xu, Guangmei Ya. Pregnenolone, a cholesterol metabolite, induces glioma cell apoptosis via activating extrinsic and intrinsic apoptotic pathways. Oncology letters. vol 8. issue 2. 2021-10-21. PMID:25013479. |
in the c6 cells, upregulation of fas and fas ligand triggered the activation of the extrinsic pathway, whereas knockdown of fas significantly abrogated the cell apoptosis that was induced by pregnenolone. |
2021-10-21 |
2023-08-13 |
Not clear |
| Shaochun Dai, Changqing Xu, Ye Tian, Wen Cheng, Bo L. Oncology letters. vol 8. issue 4. 2021-10-21. PMID:25202390. |
the present study investigated enhancement of apoptosis induction and the mechanisms underlying calcium overload on c6 glioma cells |
2021-10-21 |
2023-08-13 |
Not clear |
| Ceyhan Hacioglu, Fatih Kar, Sedat Kacar, Varol Sahinturk, Gungor Kanba. Bexarotene inhibits cell proliferation by inducing oxidative stress, DNA damage and apoptosis via PPARγ/ NF-κB signaling pathway in C6 glioma cells. Medical oncology (Northwood, London, England). vol 38. issue 3. 2021-10-13. PMID:33599853. |
bexarotene inhibits cell proliferation by inducing oxidative stress, dna damage and apoptosis via pparγ/ nf-κb signaling pathway in c6 glioma cells. |
2021-10-13 |
2023-08-13 |
Not clear |
| Ceyhan Hacioglu, Fatih Kar, Sedat Kacar, Varol Sahinturk, Gungor Kanba. Bexarotene inhibits cell proliferation by inducing oxidative stress, DNA damage and apoptosis via PPARγ/ NF-κB signaling pathway in C6 glioma cells. Medical oncology (Northwood, London, England). vol 38. issue 3. 2021-10-13. PMID:33599853. |
in the study, first cytotoxic bexarotene concentrations for c6 cells were detected, and then apoptosis profile, reactive oxygen species (ros), total antioxidant (tas), 8-hydroxy-2'-deoxyguanosine (8-ohdg) and nuclear factor-κb (nf-κb) levels in the cells were determined. |
2021-10-13 |
2023-08-13 |
Not clear |
| Ceyhan Hacioglu, Fatih Kar, Sedat Kacar, Varol Sahinturk, Gungor Kanba. Bexarotene inhibits cell proliferation by inducing oxidative stress, DNA damage and apoptosis via PPARγ/ NF-κB signaling pathway in C6 glioma cells. Medical oncology (Northwood, London, England). vol 38. issue 3. 2021-10-13. PMID:33599853. |
in conclusion, bexarotene treatment in c6 glioma cells could modulate apoptosis profile, dna damage, ros production, and reduction of tas levels through inhibition of nf-κb by enhancing pparγ expression. |
2021-10-13 |
2023-08-13 |
Not clear |
| Zhangkai Yang, Hangyu Shi, Arunachalam Chinnathambi, Saleh H Salmen, Sulaiman A Alharbi, Vishnu Priya Veeraraghavan, Krishna Mohan Surapaneni, Palanisamy Arulselva. Arbutin exerts anticancer activity against rat C6 glioma cells by inducing apoptosis and inhibiting the inflammatory markers and P13/Akt/mTOR cascade. Journal of biochemical and molecular toxicology. vol 35. issue 9. 2021-09-29. PMID:34338399. |
arbutin exerts anticancer activity against rat c6 glioma cells by inducing apoptosis and inhibiting the inflammatory markers and p13/akt/mtor cascade. |
2021-09-29 |
2023-08-13 |
rat |
| Nak Yoon Sung, Deok Jeong, Youn Young Shim, Zubair Ahmed Ratan, Young-Jin Jang, Martin J T Reaney, Sarah Lee, Byoung-Hee Lee, Jong-Hoon Kim, Young-Su Yi, Jae Youl Ch. The Anti-Cancer Effect of Linusorb B3 from Flaxseed Oil through the Promotion of Apoptosis, Inhibition of Actin Polymerization, and Suppression of Src Activity in Glioblastoma Cells. Molecules (Basel, Switzerland). vol 25. issue 24. 2021-09-08. PMID:33322712. |
lob3 induced apoptosis and suppressed the proliferation of c6 cells by inhibiting the expression of anti-apoptotic genes, b cell lymphoma 2 (bcl-2) and p53, as well as promoting the activation of pro-apoptotic caspases, caspase-3 and -9. |
2021-09-08 |
2023-08-13 |
Not clear |
| Nak Yoon Sung, Deok Jeong, Youn Young Shim, Zubair Ahmed Ratan, Young-Jin Jang, Martin J T Reaney, Sarah Lee, Byoung-Hee Lee, Jong-Hoon Kim, Young-Su Yi, Jae Youl Ch. The Anti-Cancer Effect of Linusorb B3 from Flaxseed Oil through the Promotion of Apoptosis, Inhibition of Actin Polymerization, and Suppression of Src Activity in Glioblastoma Cells. Molecules (Basel, Switzerland). vol 25. issue 24. 2021-09-08. PMID:33322712. |
taken together, these results suggest that lob3 plays an anti-cancer role by inducing apoptosis and inhibiting the migration of c6 cells through the regulation of apoptosis-related molecules, actin polymerization, and proto-oncogenes. |
2021-09-08 |
2023-08-13 |
Not clear |
| Zhenqingyun Shuai, Yongxiang Zheng, Jia Jiang, Rong Yu, Chun Zhan. Design BH3 domain fusion protein as targeting pro-apoptotic self-assembling nanoparticles. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 141. 2021-09-08. PMID:34153848. |
the total apoptosis ratios (including necrosis) of c6 cells induced by rgd-bh3-hfn, bh3-hfn, and hfn proteins were 15.24%, 10.13% and 2.14%, respectively; those of bend.3 cells were 15.47%, 7.33% and 1.70%, respectively; while the total apoptosis rate (including necrosis) of mcf-7 cells were 3.24%, 4.9% and - 1.68%, respectively. |
2021-09-08 |
2023-08-13 |
Not clear |
| Zhenqingyun Shuai, Yongxiang Zheng, Jia Jiang, Rong Yu, Chun Zhan. Design BH3 domain fusion protein as targeting pro-apoptotic self-assembling nanoparticles. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 141. 2021-09-08. PMID:34153848. |
the results suggested self-assembling rgd-bh3-hfn could target to c6 cells and bend.3 cells, and enhance tumor cells apoptosis, its apoptosis effect against c6 cells was 7.11-fold that of hfn, and apoptosis effect against bend.3 cells was 9.08-fold that of hfn. |
2021-09-08 |
2023-08-13 |
Not clear |
| Maryam Alipour, Mohammad Reza Bigdeli, Hadi Aligholi, Bahram Rasoulian, Mojtaba Khaksaria. Sustained release of silibinin-loaded chitosan nanoparticle induced apoptosis in glioma cells. Journal of biomedical materials research. Part A. vol 108. issue 3. 2021-08-31. PMID:31657514. |
in this study, a chitosan nanoparticle formulation was synthesized for loading silibinin as a sustained-release drug system to evaluate its effects on apoptosis in c6 glioma cells. |
2021-08-31 |
2023-08-13 |
Not clear |
| Xiaohong Fan, Junfang Li, Lin Long, Tao Shi, Dan Liu, Wen Tan, Honghua Zhang, Xiaoyan Wu, Xiaoyong Lei, Zhen Wan. Design, synthesis and biological evaluation of N-anthraniloyl tryptamine derivatives as pleiotropic molecules for the therapy of malignant glioma. European journal of medicinal chemistry. vol 222. 2021-08-31. PMID:34091208. |
moreover, np16 downregulated the mmp-9 expression of bv2 cells in a co-culture system of bv2 and c6 glioma cells, abrogated the proliferative/invasive/migratory abilities of gbm cells, induced apoptosis by ros and the bcl-2-regulated apoptotic pathway, and induced obvious g |
2021-08-31 |
2023-08-13 |
Not clear |
| Fatih Kar, Sedat Kacar, Ceyhan Hacioglu, Gungor Kanbak, Varol Sahintur. Concanavalin A induces apoptosis in a dose-dependent manner by modulating thiol/disulfide homeostasis in C6 glioblastoma cells. Journal of biochemical and molecular toxicology. vol 35. issue 5. 2021-07-28. PMID:33604990. |
concanavalin a induces apoptosis in a dose-dependent manner by modulating thiol/disulfide homeostasis in c6 glioblastoma cells. |
2021-07-28 |
2023-08-13 |
rat |
| Fatih Kar, Sedat Kacar, Ceyhan Hacioglu, Gungor Kanbak, Varol Sahintur. Concanavalin A induces apoptosis in a dose-dependent manner by modulating thiol/disulfide homeostasis in C6 glioblastoma cells. Journal of biochemical and molecular toxicology. vol 35. issue 5. 2021-07-28. PMID:33604990. |
in the present study, it was aimed to decide the impacts of various doses of con a on c6 glioblastoma cells regarding cytotoxicity, thiol/disulfide homeostasis, apoptosis, and inflammation. |
2021-07-28 |
2023-08-13 |
rat |
| Fatih Kar, Sedat Kacar, Ceyhan Hacioglu, Gungor Kanbak, Varol Sahintur. Concanavalin A induces apoptosis in a dose-dependent manner by modulating thiol/disulfide homeostasis in C6 glioblastoma cells. Journal of biochemical and molecular toxicology. vol 35. issue 5. 2021-07-28. PMID:33604990. |
this study revealed that con a, known as carbohydrate-binding protein, generated oxidative damage, inflammation, and apoptosis in a dose-dependent manner by modulating thiol/disulfide homeostasis in c6 glioblastoma cells. |
2021-07-28 |
2023-08-13 |
rat |
| Madineh Mazarei, Pooria Mohammadi Arvejeh, M R Mozafari, Pegah Khosravian, Sorayya Ghasem. Anticancer Potential of Temozolomide-Loaded Eudragit-Chitosan Coated Selenium Nanoparticles: In Vitro Evaluation of Cytotoxicity, Apoptosis and Gene Regulation. Nanomaterials (Basel, Switzerland). vol 11. issue 7. 2021-07-27. PMID:34209471. |
this study aimed to investigate the possible effect of selenium-chitosan nanoparticles loaded with tmz on the efficacy of tmz on the expression of mgmt, e2f6, and rela genes and the rate of apoptosis in the c6 cell line. |
2021-07-27 |
2023-08-13 |
Not clear |
| Mengjie Huangfu, Riming Wei, Juan Wang, Jianli Qin, Dan Yu, Xiao Guan, Xumei Li, Minglei Fu, Haiping Liu, Xu Che. Osthole induces necroptosis via ROS overproduction in glioma cells. FEBS open bio. vol 11. issue 2. 2021-07-13. PMID:33350608. |
in this study, we found that osthole could induce necroptosis of glioma cell lines u87 and c6; such cell death was distinct from apoptosis induced by mg-132. |
2021-07-13 |
2023-08-13 |
Not clear |
| Firas Khathayer, Swapan K Ra. Diosgenin as a Novel Alternative Therapy for Inhibition of Growth, Invasion, and Angiogenesis Abilities of Different Glioblastoma Cell Lines. Neurochemical research. vol 45. issue 10. 2021-06-01. PMID:32683533. |
it also induced apoptosis in c6 and t98g cell lines and the molecular mechanisms involved in the induction of apoptosis included increase in pro-apoptotic bax protein and decrease in anti-apoptotic bcl-2 protein. |
2021-06-01 |
2023-08-13 |
human |