| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qingxiu Liu, Leli Wang, Lei An, Yafei Liu, Honglei Qu, Shimeng Huang, Lihong Zhao, Yulong Yin, Qiugang M. Vitamin E Mitigates Apoptosis in Ovarian Granulosa Cells by Inhibiting Zearalenone-Induced Activation of the PERK/eIF-2α/ATF4/Chop Signaling Pathway. Journal of agricultural and food chemistry. 2024-11-29. PMID:39610174. |
ve supplementation reduced apoptosis in gcs and decreased the expression of p-eif-2α, atf4, and chop. |
2024-11-29 |
2024-12-01 |
mouse |
| Xiaojuan Xu, Chaochao Ge, Senzhen Wang, Lei Gao, Chaojie Wang, Fujun Dai, Yuxia Wang, Songqiang Xi. Polyamine-modified naphthalimide derivative 9C inhibits colorectal cancer through ROS-mediated ER stress, migration and invasion. Toxicology in vitro : an international journal published in association with BIBRA. 2024-11-25. PMID:39586364. |
removal of ros using n-acetyl-l-cysteine (nac) attenuated the expression of atf4, chop, death receptors, e-cadherin, and the apoptosis and autophagy related proteins. |
2024-11-25 |
2024-11-28 |
Not clear |
| Saba Qureshi, Stephanie Lee, Lukas Ritzer, Stefan Y Kim, William Steidl, Gayle Joliet Krest, Anisha Kasi, Varun Kuma. ATF4 regulates mitochondrial dysfunction, mitophagy, and autophagy, contributing to corneal endothelial apoptosis under chronic ER stress in Fuchs' dystrophy. bioRxiv : the preprint server for biology. 2024-11-21. PMID:39569143. |
atf4 regulates mitochondrial dysfunction, mitophagy, and autophagy, contributing to corneal endothelial apoptosis under chronic er stress in fuchs' dystrophy. |
2024-11-21 |
2024-11-23 |
Not clear |
| Saba Qureshi, Stephanie Lee, Lukas Ritzer, Stefan Y Kim, William Steidl, Gayle Joliet Krest, Anisha Kasi, Varun Kuma. ATF4 regulates mitochondrial dysfunction, mitophagy, and autophagy, contributing to corneal endothelial apoptosis under chronic ER stress in Fuchs' dystrophy. bioRxiv : the preprint server for biology. 2024-11-21. PMID:39569143. |
the purpose of this study is to explore the role of atf4 in regulating mitochondrial dysfunction and mitophagy/autophagy, leading to cenc apoptosis in fecd. |
2024-11-21 |
2024-11-23 |
Not clear |
| Thi-Huong Nguyen, Huey-Jiun Ko, Po-Yu Tsai, Tai-Shan Cheng, Thu-Ha Tran, Ly Hien Doan, Michael Hsiao, Peter Mu-Hsin Chang, Hsiao-Sheng Liu, Yi-Ren Hong, Chi-Ying F Huan. Dehydroepiandrosterone suppresses human colorectal cancer progression through ER stress-mediated autophagy and apoptosis in a p53-independent manner. Frontiers in pharmacology. vol 15. 2024-10-21. PMID:39431156. |
further study reveals that dhea induces endoplasmic reticulum (er) stress and triggers perk/eif2/atf4/chop upr signaling pathway to activate autophagy followed by apoptosis, which was confirmed by suppression of 4-phenylbutyric acid (an er stress inhibitor) or knockdown either atf4 or chop. |
2024-10-21 |
2024-10-23 |
human |
| Xunqi Zhang, Yanxiao Han, Chenliu Fan, Yang Jiang, Wen Jiang, Chengyun Zhen. Epigallocatechin gallate induces apoptosis in multiple myeloma cells through endoplasmic reticulum stress induction and cytoskeletal disruption. International immunopharmacology. vol 141. 2024-08-19. PMID:39159563. |
subsequently, mrna sequencing of egcg-treated mm.1s cells revealed a significant upregulation of genes associated with endoplasmic reticulum stress (ers), including p-eif2α (phosphorylation-eukaryotic translation initiation factor 2 alpha), atf4 (activating transcription factor 4), chop (c/ebp homologous protein, ddit3), and puma (p53 upregulated modulator of apoptosis, bbc3), which were confirmed at the protein level by western blotting. |
2024-08-19 |
2024-08-22 |
mouse |
| Ju Zheng, Yixin Li, Ting Zhang, Yanlin Fu, Peiyan Long, Xiao Gao, Zhengwei Wang, Zhizhong Guan, Xiaolan Qi, Wei Hong, Yan Xia. Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury: PERK as a potential target for intervention. Neural regeneration research. vol 20. issue 5. 2024-07-30. PMID:39075912. |
we found that prolongation of oxygen-glucose deprivation activated the er stress pathway protein kinase-like endoplasmic reticulum kinase (perk)/eukaryotic translation initiation factor 2 subunit alpha (eif2α)-activating transcription factor 4 (atf4)-c/ebp homologous protein (chop), increased neuronal apoptosis, and induced autophagy. |
2024-07-30 |
2024-08-02 |
Not clear |
| Ruohan Cheng, Yihan Jiang, Yue Zhang, Mohammed Ismail, Luyong Zhang, Zhenzhou Jiang, Qinwei Y. Proteasome activity inhibition mediates endoplasmic reticulum stress-apoptosis in triptolide/lipopolysaccharide-induced hepatotoxicity. Cell biology and toxicology. vol 40. issue 1. 2024-07-29. PMID:39073694. |
moreover, 4-phenylbutyric acid (4-pba), an ers inhibitor, was able to alleviate tp/lps-induced hepatotoxicity by reducing ers-related apoptosis protein expression (grp78, p-eif2α/eif2α, atf4, chop, cleaved caspase-3 and cleaved parp) and ros levels, with atf4 being an indispensable mediator. |
2024-07-29 |
2024-08-02 |
Not clear |
| Ruohan Cheng, Yihan Jiang, Yue Zhang, Mohammed Ismail, Luyong Zhang, Zhenzhou Jiang, Qinwei Y. Proteasome activity inhibition mediates endoplasmic reticulum stress-apoptosis in triptolide/lipopolysaccharide-induced hepatotoxicity. Cell biology and toxicology. vol 40. issue 1. 2024-07-29. PMID:39073694. |
in summary, we propose that tp/lps may upregulate the activation of ers-associated apoptosis by inhibiting proteasome activity and enhancing ros production through atf4. |
2024-07-29 |
2024-08-02 |
Not clear |
| Ying Cui, Guang Yang, Hong Li, Jianying Sun, Xiaoman Liu, Xiaohan Xi. Reduced expression of NUPR1 alleviates epilepsy progression via attenuating ER stress. Biochemical and biophysical research communications. vol 730. 2024-07-12. PMID:38996786. |
in vitro experiments showed that the absence of nupr1 reduced the expression of atf4, chop, and cleaved caspase-12 in hippocampal neurons and inhibited the neuron apoptosis. |
2024-07-12 |
2024-07-15 |
mouse |
| Xiaodong Gu, Fei Li, Xianda Che, Xiaochun Wei, Pengcui L. HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model. BMC musculoskeletal disorders. vol 25. issue 1. 2024-06-16. PMID:38879481. |
hdac4 represses er stress induced chondrocyte apoptosis by inhibiting atf4 and attenuates cartilage degeneration in an osteoarthritis rat model. |
2024-06-16 |
2024-06-18 |
human |
| Xiaodong Gu, Fei Li, Xianda Che, Xiaochun Wei, Pengcui L. HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model. BMC musculoskeletal disorders. vol 25. issue 1. 2024-06-16. PMID:38879481. |
the present study evaluated whether the lack of histone deacetylase 4 (hdac4) increases endoplasmic reticulum stress-induced chondrocyte apoptosis by releasing activating transcription factor 4 (atf4) in human osteoarthritis (oa) cartilage degeneration. |
2024-06-16 |
2024-06-18 |
human |
| Huey-Liang Kuo, Haw-Ling Chuang, Chang-Mu Chen, Yu-Ya Chen, Yu-Syuan Chen, Ssu-Chia Lin, Pei-Yu Weng, Ting-Chun Liu, Pei-Yun Wang, Chun-Fa Huang, Siao-Syun Guan, Shing-Hwa Liu, Shun-Fa Yang, Cheng-Tien W. Wogonin ameliorates ER stress-associated inflammatory response, apoptotic death and renal fibrosis in a unilateral ureteral obstruction mouse model. European journal of pharmacology. vol 977. 2024-06-08. PMID:38815787. |
furthermore, wogonin treatment mitigated endoplasmic reticulum (er) stress-associated molecular markers (grp78, grp94, atf4, chop, and the caspase cascade) and suppressed apoptosis. |
2024-06-08 |
2024-06-11 |
mouse |
| Jiawei Chen, Xiaopeng Huang, Shuai Zhang, Xiaodong Zh. ATF4 inhibits tumor development and mediates p-GCN2/ASNS upregulation in colon cancer. Scientific reports. vol 14. issue 1. 2024-06-06. PMID:38844625. |
cell counting kit-8 (cck-8), clone formation, transwell, and flow cytometry assays were conducted to assess cell viability, clonogenicity, migration, invasion, cell cycle, and apoptosis, respectively, in the atf4 knockdown and overexpression sw480 cell lines. |
2024-06-06 |
2024-06-10 |
Not clear |
| Jiawei Chen, Xiaopeng Huang, Shuai Zhang, Xiaodong Zh. ATF4 inhibits tumor development and mediates p-GCN2/ASNS upregulation in colon cancer. Scientific reports. vol 14. issue 1. 2024-06-06. PMID:38844625. |
atf4 knockdown promoted cell proliferation, invasion, and s-phase cell cycle and inhibited apoptosis in sw480 cells. |
2024-06-06 |
2024-06-10 |
Not clear |
| Jiawei Chen, Xiaopeng Huang, Shuai Zhang, Xiaodong Zh. ATF4 inhibits tumor development and mediates p-GCN2/ASNS upregulation in colon cancer. Scientific reports. vol 14. issue 1. 2024-06-06. PMID:38844625. |
atf4 inhibited cc cell viability, clone formation ability, migration, and invasion and promoted apoptosis, possibly by regulating the expression of p-gcn2 and asns. |
2024-06-06 |
2024-06-10 |
Not clear |
| Young Yun Jung, Ninh The Son, Chakrabhavi Dhananjaya Mohan, Jairo Kenupp Bastos, Nguyen Dinh Luyen, Le Mai Huong, Kwang Seok Ah. Kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ROS production, SHP-1 expression, and the STAT3 pathway. IUBMB life. 2024-05-06. PMID:38708996. |
it also downmodulated the expression of alix (an intracellular inhibitor of paraptosis) and increased the expression of chop and atf4 (transcription factors that promote paraptosis) indicating that kf promotes apoptosis as well as paraptosis. |
2024-05-06 |
2024-05-08 |
Not clear |
| Huimin Liu, Ye Zheng, Shaoning Kan, Ming Hao, Huan Jiang, Shuangji Li, Rong Li, Yinyu Wang, Dongxu Wang, Weiwei Li. Melatonin inhibits tongue squamous cell carcinoma: Interplay of ER stress-induced apoptosis and autophagy with cell migration. Heliyon. vol 10. issue 8. 2024-04-22. PMID:38644851. |
mt also promoted the expression of atf4, atf6, bip, bap31 and chop in crl-1623 cells leading to endoplasmic reticulum stress, and induced autophagy and apoptosis in crl-1623 cells. |
2024-04-22 |
2024-04-24 |
Not clear |
| Er-Ying Hao, Xue-Lu Liu, Xiang-Yu Chen, Han Xue, Bo-Fei Su, Yi-Fan Chen, De-He Wang, Lei Shi, Kang Bai, Fei Hou, Jian-Ku Hou, Hui-Ling Bao, Hui Che. Melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating ATF4 to activate mTOR signaling pathway in chickens. Poultry science. vol 103. issue 6. 2024-04-07. PMID:38583308. |
melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating atf4 to activate mtor signaling pathway in chickens. |
2024-04-07 |
2024-04-10 |
Not clear |
| Er-Ying Hao, Xue-Lu Liu, Xiang-Yu Chen, Han Xue, Bo-Fei Su, Yi-Fan Chen, De-He Wang, Lei Shi, Kang Bai, Fei Hou, Jian-Ku Hou, Hui-Ling Bao, Hui Che. Melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating ATF4 to activate mTOR signaling pathway in chickens. Poultry science. vol 103. issue 6. 2024-04-07. PMID:38583308. |
this study aimed to investigate whether mel inhibits ers and follicular granulosa cell apoptosis by regulating atf4 to activate mtor signaling pathway in chickens. |
2024-04-07 |
2024-04-10 |
Not clear |