| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Golo Kronenberg, Karen Gertz, Ria Uhlemann, Melanie T C Kuffner, Imke Kirste, Junfeng An, Nafisa M Jadavji, Bjoern H Schott, Thomas Scheffel, Matthias Endres, Rainer Hellweg, Christoph Harm. Reduced Hippocampal Neurogenesis in Mice Deficient in Apoptosis Repressor with Caspase Recruitment Domain (ARC). Neuroscience. vol 416. 2020-09-24. PMID:31356897. |
reduced hippocampal neurogenesis in mice deficient in apoptosis repressor with caspase recruitment domain (arc). |
2020-09-24 |
2023-08-13 |
mouse |
| Golo Kronenberg, Karen Gertz, Ria Uhlemann, Melanie T C Kuffner, Imke Kirste, Junfeng An, Nafisa M Jadavji, Bjoern H Schott, Thomas Scheffel, Matthias Endres, Rainer Hellweg, Christoph Harm. Reduced Hippocampal Neurogenesis in Mice Deficient in Apoptosis Repressor with Caspase Recruitment Domain (ARC). Neuroscience. vol 416. 2020-09-24. PMID:31356897. |
the apoptosis repressor with caspase recruitment domain (arc), encoded by the nol3 gene, is a potent and multifunctional death repressor that inhibits both death receptor and mitochondrial apoptotic signaling. |
2020-09-24 |
2023-08-13 |
mouse |
| Yuanyuan Tu, Lele Li, Bai Qin, Jian Wu, Tianyu Cheng, Lihua Kang, Huaijin Gua. Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract. Molecular vision. vol 25. 2020-06-19. PMID:31814699. |
the apoptosis of lens epithelial cells (lecs) induced by oxidative damage is a major contributing factor to arc. |
2020-06-19 |
2023-08-13 |
Not clear |
| Weimei Huang, Geng Su, Xiaoxian Huang, Angru Zou, Jingfang Wu, Yunchu Yang, Yaru Zhu, Shumei Liang, Deyu Li, Feng Ma, Linlang Gu. Long noncoding RNA PCAT6 inhibits colon cancer cell apoptosis by regulating anti-apoptotic protein ARC expression via EZH2. Cell cycle (Georgetown, Tex.). vol 18. issue 1. 2020-02-17. PMID:30569799. |
long noncoding rna pcat6 inhibits colon cancer cell apoptosis by regulating anti-apoptotic protein arc expression via ezh2. |
2020-02-17 |
2023-08-13 |
Not clear |
| Weimei Huang, Geng Su, Xiaoxian Huang, Angru Zou, Jingfang Wu, Yunchu Yang, Yaru Zhu, Shumei Liang, Deyu Li, Feng Ma, Linlang Gu. Long noncoding RNA PCAT6 inhibits colon cancer cell apoptosis by regulating anti-apoptotic protein ARC expression via EZH2. Cell cycle (Georgetown, Tex.). vol 18. issue 1. 2020-02-17. PMID:30569799. |
mechanistically, pcat6 enhanced the coenrichment of ezh2 and h3k4me3 at the apoptosis repressor with caspase recruitment domain (arc) genomic region, promoting the transcriptional activity of arc. |
2020-02-17 |
2023-08-13 |
Not clear |
| Weimei Huang, Geng Su, Xiaoxian Huang, Angru Zou, Jingfang Wu, Yunchu Yang, Yaru Zhu, Shumei Liang, Deyu Li, Feng Ma, Linlang Gu. Long noncoding RNA PCAT6 inhibits colon cancer cell apoptosis by regulating anti-apoptotic protein ARC expression via EZH2. Cell cycle (Georgetown, Tex.). vol 18. issue 1. 2020-02-17. PMID:30569799. |
our data highlighted that pcat6 acts as a key activator of arc expression by forming a complex with ezh2, inhibiting cell apoptosis and contributing to colon cancer progression. |
2020-02-17 |
2023-08-13 |
Not clear |
| Shu Zhu, Zhe Zhang, Lian-Qun Jia, Kai-Xuan Zhan, Li-Jun Wang, Nan Song, Yue Liu, Yan-Yan Cheng, Yong-Ju Yang, Le Guan, Dong-Yu Min, Guan-Lin Yan. Valproic acid attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-pyroptosis pathways. Neurochemistry international. vol 124. 2019-12-24. PMID:30611759. |
in addition, western blot and real-time pcr analysis revealed that vpa modulated the protein expression of apoptosis repressor with caspase recruitment domain (arc), caspase-1 and il-1β/il-18. |
2019-12-24 |
2023-08-13 |
Not clear |
| Bing Z Carter, Po Yee Mak, Xiangmeng Wang, Wenjing Tao, Vivian Ruvolo, Duncan Mak, Hong Mu, Jared K Burks, Michael Andreef. An ARC-Regulated IL1β/Cox-2/PGE2/β-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML. Cancer research. vol 79. issue 6. 2019-12-18. PMID:30674535. |
the apoptosis repressor with caspase recruitment domain (arc) protein is a strong independent adverse prognostic marker in acute myeloid leukemia (aml). |
2019-12-18 |
2023-08-13 |
mouse |
| Fan Fan, Jianhui Zhuang, Peng Zhou, Xin Liu, Yi Lu. MicroRNA-34a promotes mitochondrial dysfunction-induced apoptosis in human lens epithelial cells by targeting Notch2. Oncotarget. vol 8. issue 66. 2019-11-20. PMID:29299142. |
human lens epithelial cell (hlec) apoptosis is a common pathogenic mechanism in age-related cataracts (arc). |
2019-11-20 |
2023-08-13 |
human |
| Qi Li, Jun Yang, Jian Yang, Ying Yan. [Advances in the Apoptosis Repressor with Caspase Recruitment Domain in Cardiovascular Diseases]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 41. issue 4. 2019-09-30. PMID:31484618. |
apoptosis plays important roles in maintaining normal development and homeostasis and in the pathophysiological processes of various diseases.previous studies have shown that cardiomyocyte apoptosis is involved in the development of various cardiovascular diseases.the apoptosis repressor with caspase recruitment domain(arc)is abundantly expressed in heart,which makes arc a unique and central cardioprotective factor via anti-apoptotic pathway.this article reviews the structure and characteristics of arc as well as the roles and mechanisms of arc in cardiovascular diseases. |
2019-09-30 |
2023-08-13 |
Not clear |
| Ke Yingjie, Yan Haihong, Chen Lingwei, Zhong Sen, Dai Yuanting, Cai Shasha, Pan Liutong, Wang Ying, Zhou Mi. Apoptosis repressor with caspase recruitment domain deficiency accelerates ischemia/reperfusion (I/R)-induced acute kidney injury by suppressing inflammation and apoptosis: The role of AKT/mTOR signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 112. 2019-09-03. PMID:30970510. |
apoptosis repressor with caspase recruitment domain (arc) is abundantly expressed in various tissues, and has been reported to play a strong protective role during pathological processes. |
2019-09-03 |
2023-08-13 |
mouse |
| Ke Yingjie, Yan Haihong, Chen Lingwei, Zhong Sen, Dai Yuanting, Cai Shasha, Pan Liutong, Wang Ying, Zhou Mi. Apoptosis repressor with caspase recruitment domain deficiency accelerates ischemia/reperfusion (I/R)-induced acute kidney injury by suppressing inflammation and apoptosis: The role of AKT/mTOR signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 112. 2019-09-03. PMID:30970510. |
arc deficiency markedly accelerated renal dysfunction, promoted reperfusion-regulated tubular epithelial cell apoptosis, and enhanced the vulnerability of kidney to i/r damage. |
2019-09-03 |
2023-08-13 |
mouse |
| Ke Yingjie, Yan Haihong, Chen Lingwei, Zhong Sen, Dai Yuanting, Cai Shasha, Pan Liutong, Wang Ying, Zhou Mi. Apoptosis repressor with caspase recruitment domain deficiency accelerates ischemia/reperfusion (I/R)-induced acute kidney injury by suppressing inflammation and apoptosis: The role of AKT/mTOR signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 112. 2019-09-03. PMID:30970510. |
of note, blocking akt/mtor signaling markedly attenuated inflammation, mitochondrial damage and apoptosis stimulated by h/r in arc knockdown cells. |
2019-09-03 |
2023-08-13 |
mouse |
| Weifeng Gong, Jie Li, Yongcheng Wang, Jia Meng, Guangying Zhen. miR-221 promotes lens epithelial cells apoptosis through interacting with SIRT1 and E2F3. Chemico-biological interactions. vol 306. 2019-06-05. PMID:30926320. |
we concluded that mir-221 promoted lens epithelial cells apoptosis through regulating sirt1 and e2f3, providing a novel biomarker for treatment of arc. |
2019-06-05 |
2023-08-13 |
human |
| Tao Xu, Wei Ding, Xiang Ao, Xianming Chu, Qinggong Wan, Yu Wang, Dandan Xiao, Wanpeng Yu, Mengyang Li, Fei Yu, Jianxun Wan. ARC regulates programmed necrosis and myocardial ischemia/reperfusion injury through the inhibition of mPTP opening. Redox biology. vol 20. 2019-03-21. PMID:30415165. |
in this study, we showed that apoptosis repressor with caspase recruitment domain (arc) participated in the mitochondrial intrinsic pathway and inhibited myocardial necrosis by preventing the opening of the mitochondrial permeability transition pore (mptp). |
2019-03-21 |
2023-08-13 |
Not clear |
| Yuan Zhong, Yitong Zhu, Ting He, Wei Li, Qinjie Li, Ya Mia. Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30365051. |
exposure of the hippocampal neurons to high glucose (75 mm for 72 h) resulted in cell apoptosis, decreased mrna and protein expression levels of three synaptic plasticity‑related proteins (syn, arc and cyclic amp response element‑binding protein), and changes in the cellular distribution of syn, indicating loss of synaptic density. |
2019-03-05 |
2023-08-13 |
rat |
| Wendy M McKimpson, Min Zheng, Streamson C Chua, Jeffrey E Pessin, Richard N Kitsi. ARC is essential for maintaining pancreatic islet structure and β-cell viability during type 2 diabetes. Scientific reports. vol 7. issue 1. 2019-02-27. PMID:28765602. |
apoptosis repressor with card (arc) is a cell death inhibitor that antagonizes multiple death programs. |
2019-02-27 |
2023-08-13 |
mouse |
| Liying Lv, Jinping Liu, Zunshu Du, Yizhi Song, Hui Li, Xue Li, Lirong Chang, Yan W. Expression alterations of apoptosis repressor with caspase recruitment domain in Aβ25-35-induced hippocampal neurotoxicity. Neuroreport. vol 30. issue 1. 2019-02-13. PMID:30395005. |
as the first identified antiapoptotic protein, apoptosis repressor with caspase recruitment domain (arc) is highly expressed in terminally differentiated cells, and its functions and expressions in striated muscles and cancer cells have been widely studied. |
2019-02-13 |
2023-08-13 |
Not clear |
| Kira Vorobej, Andrew S Mitchell, Ian C Smith, Stefan Donath, A Russell Tupling, Joe Quadrilater. The effect of ARC ablation on skeletal muscle morphology, function, and apoptotic signaling during aging. Experimental gerontology. vol 101. 2018-12-20. PMID:29056555. |
apoptosis repressor with caspase recruitment domain (arc) is an anti-apoptotic protein highly expressed in skeletal muscle. |
2018-12-20 |
2023-08-13 |
mouse |
| Kira Vorobej, Andrew S Mitchell, Ian C Smith, Stefan Donath, A Russell Tupling, Joe Quadrilater. The effect of ARC ablation on skeletal muscle morphology, function, and apoptotic signaling during aging. Experimental gerontology. vol 101. 2018-12-20. PMID:29056555. |
here we examined the role of arc on age-related skeletal muscle apoptosis and wasting by utilizing an arc-deficient mouse model. |
2018-12-20 |
2023-08-13 |
mouse |