| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Ekhterae, Z Lin, M S Lundberg, M T Crow, F C Brosius, G Núñe. ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells. Circulation research. vol 85. issue 12. 1999-12-21. PMID:10590251. |
in the present study, we examined the ability of arc to protect rat embryonic heart-derived h9c2 cells from apoptosis induced by hypoxia, a component of ischemia. |
1999-12-21 |
2023-08-12 |
rat |
| D Ekhterae, Z Lin, M S Lundberg, M T Crow, F C Brosius, G Núñe. ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells. Circulation research. vol 85. issue 12. 1999-12-21. PMID:10590251. |
we found that h9c2 cells express arc and that exposure to hypoxia substantially reduces arc expression while inducing apoptosis. |
1999-12-21 |
2023-08-12 |
rat |
| D Ekhterae, Z Lin, M S Lundberg, M T Crow, F C Brosius, G Núñe. ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells. Circulation research. vol 85. issue 12. 1999-12-21. PMID:10590251. |
transfected h9c2 cells in which cytosolic arc protein levels remain elevated during hypoxia were significantly more resistant to hypoxia-induced apoptosis than parental h9c2 cells or h9c2 cells transfected with a control vector. |
1999-12-21 |
2023-08-12 |
rat |
| D Ekhterae, Z Lin, M S Lundberg, M T Crow, F C Brosius, G Núñe. ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells. Circulation research. vol 85. issue 12. 1999-12-21. PMID:10590251. |
in contrast, caspase inhibitors prevented parp cleavage but not cytochrome c release, suggesting that exogenously expressed arc acts upstream of caspase activation in this model of apoptosis. |
1999-12-21 |
2023-08-12 |
rat |
| D Ekhterae, Z Lin, M S Lundberg, M T Crow, F C Brosius, G Núñe. ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells. Circulation research. vol 85. issue 12. 1999-12-21. PMID:10590251. |
these results demonstrate that arc can protect heart myogenic h9c2 cells from hypoxia-induced apoptosis, and that arc prevents cytochrome c release by acting upstream of caspase activation, perhaps at the mitochondrial level. |
1999-12-21 |
2023-08-12 |
rat |
| T Koseki, N Inohara, S Chen, R Carrio, J Merino, M O Hottiger, G J Nabel, G Núñe. CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10. The Journal of biological chemistry. vol 274. issue 15. 1999-05-03. PMID:10187770. |
ciper formed homodimers via its card and interacted with viral e10 but not with several apoptosis regulators containing cards including arc, raidd, rick, caspase-2, caspase-9, or apaf-1. |
1999-05-03 |
2023-08-12 |
Not clear |
| C Voiculescu, C Avramescu, E Radu, M Bălăşoiu, A Turculean. Expression of activation surface markers, interleukin-2 synthesis and apoptosis rate in fresh or cultured lymphocytes from HIV-infected children. Roumanian archives of microbiology and immunology. vol 57. issue 1. 1998-10-08. PMID:9745333. |
in 2 groups of hiv-infected children aged from 7 to 10 years (arc and aids, respectively) the following immune markers: % expression of cd69, cd25, hla-dr activation surface determinants, il-2 synthesis, rate of apoptosis were tested in non stimulated, pha-stimulated or pha and il-12-stimulated t cell cultures. |
1998-10-08 |
2023-08-12 |
Not clear |
| T Koseki, N Inohara, S Chen, G Núñe. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 9. 1998-06-04. PMID:9560245. |
arc, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. |
1998-06-04 |
2023-08-12 |
human |
| T Koseki, N Inohara, S Chen, G Núñe. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 9. 1998-06-04. PMID:9560245. |
we have identified and characterized arc, apoptosis repressor with caspase recruitment domain (card). |
1998-06-04 |
2023-08-12 |
human |
| T Koseki, N Inohara, S Chen, G Núñe. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 9. 1998-06-04. PMID:9560245. |
arc inhibited apoptosis induced by caspase-8 and ced-3 but not that mediated by caspase-9. |
1998-06-04 |
2023-08-12 |
human |
| T Koseki, N Inohara, S Chen, G Núñe. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 9. 1998-06-04. PMID:9560245. |
consistent with the inhibition of caspase-8, arc attenuated apoptosis induced by fadd and tradd and that triggered by stimulation of death receptors coupled to caspase-8, including cd95/fas, tumor necrosis factor-r1, and tramp/dr3. |
1998-06-04 |
2023-08-12 |
human |
| T Koseki, N Inohara, S Chen, G Núñe. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 9. 1998-06-04. PMID:9560245. |
thus, arc represents an inhibitor of apoptosis expressed in muscle that appears to selectively target caspases. |
1998-06-04 |
2023-08-12 |
human |