| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu-Zhen Li, Dao-Yuan Lu, Wei-Qi Tan, Jian-Xun Wang, Pei-Feng L. p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC. Molecular and cellular biology. vol 28. issue 2. 2008-01-29. PMID:17998337. |
p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein arc. |
2008-01-29 |
2023-08-12 |
Not clear |
| Yu-Zhen Li, Dao-Yuan Lu, Wei-Qi Tan, Jian-Xun Wang, Pei-Feng L. p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC. Molecular and cellular biology. vol 28. issue 2. 2008-01-29. PMID:17998337. |
here, we report that p53 can transcriptionally target the antiapoptotic protein, apoptosis repressor with caspase recruitment domain (arc). |
2008-01-29 |
2023-08-12 |
Not clear |
| Yu-Zhen Li, Dao-Yuan Lu, Wei-Qi Tan, Jian-Xun Wang, Pei-Feng L. p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC. Molecular and cellular biology. vol 28. issue 2. 2008-01-29. PMID:17998337. |
thus, our data reveal a novel p53 apoptotic pathway in which it initiates apoptosis by transcriptionally repressing arc. |
2008-01-29 |
2023-08-12 |
Not clear |
| Roger S-Y Foo, Young-Jae Nam, Marc Jason Ostreicher, Mark D Metzl, Russell S Whelan, Chang-Fu Peng, Anthony W Ashton, Weimin Fu, Kartik Mani, Suet-Feung Chin, Elena Provenzano, Ian Ellis, Nichola Figg, Sarah Pinder, Martin R Bennett, Carlos Caldas, Richard N Kitsi. Regulation of p53 tetramerization and nuclear export by ARC. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 52. 2008-01-15. PMID:18087040. |
here, we demonstrate a mechanism for p53 inactivation by apoptosis repressor with caspase recruitment domain (arc), a protein induced in multiple cancer cells. |
2008-01-15 |
2023-08-12 |
human |
| Rachel A Hill, Jenny Chow, Karlheinrich Fritzemeier, Evan R Simpson, Wah Chin Boo. Fas/FasL-mediated apoptosis in the arcuate nucleus and medial preoptic area of male ArKO mice is ameliorated by selective estrogen receptor alpha and estrogen receptor beta agonist treatment, respectively. Molecular and cellular neurosciences. vol 36. issue 2. 2008-01-09. PMID:17716913. |
our previous analysis revealed apoptosis of dopaminergic neurons in the arcuate nucleus (arc) and medial preoptic area (mpo) of 1-year-old male arko mice. |
2008-01-09 |
2023-08-12 |
mouse |
| Qun Li, Jun Re. Influence of cardiac-specific overexpression of insulin-like growth factor 1 on lifespan and aging-associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression. Aging cell. vol 6. issue 6. 2007-12-31. PMID:17973971. |
pro- and anti-apoptotic proteins including bax, p53, pp53, bcl2, omi/htra2, apoptosis repressor with caspase recruitment domain (arc) and x-linked inhibitor of apoptosis protein (xiap) were assessed by western blot. |
2007-12-31 |
2023-08-12 |
mouse |
| Yu Zhen Li, Xiu Hua Liu, Xiao Mei Zhu, Li Rong Ca. ARC contributes to the inhibitory effect of preconditioning on cardiomyocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 12. issue 9. 2007-10-26. PMID:17594520. |
arc contributes to the inhibitory effect of preconditioning on cardiomyocyte apoptosis. |
2007-10-26 |
2023-08-12 |
rat |
| Yu Zhen Li, Xiu Hua Liu, Xiao Mei Zhu, Li Rong Ca. ARC contributes to the inhibitory effect of preconditioning on cardiomyocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 12. issue 9. 2007-10-26. PMID:17594520. |
apoptosis repressor with caspase recruitment domain (arc) possesses the ability to block hypoxia-induced cardiomyocyte apoptosis. |
2007-10-26 |
2023-08-12 |
rat |
| Yu Zhen Li, Xiu Hua Liu, Xiao Mei Zhu, Li Rong Ca. ARC contributes to the inhibitory effect of preconditioning on cardiomyocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 12. issue 9. 2007-10-26. PMID:17594520. |
we tested whether arc contributes to the inhibitory effect of preconditioning on cardiomyocyte apoptosis. |
2007-10-26 |
2023-08-12 |
rat |
| Yu Zhen Li, Xiu Hua Liu, Xiao Mei Zhu, Li Rong Ca. ARC contributes to the inhibitory effect of preconditioning on cardiomyocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 12. issue 9. 2007-10-26. PMID:17594520. |
inhibition of endogenous arc expression by arc antisense oligonucleotides reduced the inhibitory effect of preconditioning on apoptosis. |
2007-10-26 |
2023-08-12 |
rat |
| H A Kim, F J Blanc. Cell death and apoptosis in osteoarthritic cartilage. Current drug targets. vol 8. issue 2. 2007-05-31. PMID:17305511. |
finally, the regulation of the natural inhibitors of apoptosis (c-flip, bar, arc and hc-gp39) could complement the other strategies to reduce cartilage degradation. |
2007-05-31 |
2023-08-12 |
Not clear |
| C Baudoui. [A new approach for better comprehension of diseases of the ocular surface]. Journal francais d'ophtalmologie. vol 30. issue 3. 2007-05-01. PMID:17417148. |
cell damage in the cornea and conjunctiva, by means of apoptosis and direct mechanical and/or osmotic stress, will stimulate the reflex neurosensory arc, in turn stimulating lacrimal gland and neurogenic inflammation, with inflammatory cytokine release, mmp activation, and inflammatory involvement of the conjunctival epithelium. |
2007-05-01 |
2023-08-12 |
Not clear |
| Young-Jae Nam, Kartik Mani, Lily Wu, Chang-Fu Peng, John W Calvert, Roger S-Y Foo, Barath Krishnamurthy, Wenfeng Miao, Anthony W Ashton, David J Lefer, Richard N Kitsi. The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant. The Journal of biological chemistry. vol 282. issue 8. 2007-04-17. PMID:17142452. |
the apoptosis inhibitor arc undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant. |
2007-04-17 |
2023-08-12 |
mouse |
| Young-Jae Nam, Kartik Mani, Lily Wu, Chang-Fu Peng, John W Calvert, Roger S-Y Foo, Barath Krishnamurthy, Wenfeng Miao, Anthony W Ashton, David J Lefer, Richard N Kitsi. The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant. The Journal of biological chemistry. vol 282. issue 8. 2007-04-17. PMID:17142452. |
arc (apoptosis repressor with caspase recruitment domain) is an endogenous inhibitor of apoptosis that antagonizes both central apoptosis pathways. |
2007-04-17 |
2023-08-12 |
mouse |
| Young-Jae Nam, Kartik Mani, Lily Wu, Chang-Fu Peng, John W Calvert, Roger S-Y Foo, Barath Krishnamurthy, Wenfeng Miao, Anthony W Ashton, David J Lefer, Richard N Kitsi. The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant. The Journal of biological chemistry. vol 282. issue 8. 2007-04-17. PMID:17142452. |
the mechanisms that mediate decreases in arc protein levels during apoptosis and whether these decreases initiate the subsequent cell death are not known. |
2007-04-17 |
2023-08-12 |
mouse |
| Young-Jae Nam, Kartik Mani, Lily Wu, Chang-Fu Peng, John W Calvert, Roger S-Y Foo, Barath Krishnamurthy, Wenfeng Miao, Anthony W Ashton, David J Lefer, Richard N Kitsi. The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant. The Journal of biological chemistry. vol 282. issue 8. 2007-04-17. PMID:17142452. |
rather, pulse-chase experiments show that decreases in steady state arc protein levels during apoptosis result from marked destabilization of arc protein. |
2007-04-17 |
2023-08-12 |
mouse |
| Young-Jae Nam, Kartik Mani, Lily Wu, Chang-Fu Peng, John W Calvert, Roger S-Y Foo, Barath Krishnamurthy, Wenfeng Miao, Anthony W Ashton, David J Lefer, Richard N Kitsi. The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant. The Journal of biological chemistry. vol 282. issue 8. 2007-04-17. PMID:17142452. |
arc protein destabilization, in turn, is mediated by the ubiquitin-proteasomal pathway, as mutation of arc ubiquitin acceptor residues stabilizes arc protein and preserves its steady state levels during apoptosis. |
2007-04-17 |
2023-08-12 |
mouse |
| Roger S-Y Foo, Lennard K W Chan, Richard N Kitsis, Martin R Bennet. Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2. The Journal of biological chemistry. vol 282. issue 8. 2007-04-17. PMID:17142834. |
arc (apoptosis repressor with caspase recruitment domain) is an anti-apoptotic protein that is found abundantly in terminally differentiated cells such as cardiomyocytes. |
2007-04-17 |
2023-08-12 |
mouse |
| Roger S-Y Foo, Lennard K W Chan, Richard N Kitsis, Martin R Bennet. Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2. The Journal of biological chemistry. vol 282. issue 8. 2007-04-17. PMID:17142834. |
proteasomal inhibitors rescued both mdm2 and h(2)o(2)-induced degradation of arc and inhibited cardiomyocyte apoptosis. |
2007-04-17 |
2023-08-12 |
mouse |
| Roger S-Y Foo, Lennard K W Chan, Richard N Kitsis, Martin R Bennet. Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2. The Journal of biological chemistry. vol 282. issue 8. 2007-04-17. PMID:17142834. |
prevention of mdm2-induced degradation of arc represents a potential therapeutic target to prevent cardiomyocyte apoptosis. |
2007-04-17 |
2023-08-12 |
mouse |