| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Longwei Hu, Jing Han, Xi Yang, Yang Wang, Hongya Pan, Liqun X. Apoptosis repressor with caspase recruitment domain enhances survival and promotes osteogenic differentiation of human osteoblast cells under Zoledronate treatment. Molecular medicine reports. vol 14. issue 4. 2017-04-13. PMID:27573706. |
apoptosis repressor with caspase recruitment domain (arc) is a multifunctional inhibitor of apoptosis that is physiologically expressed predominantly in post‑mitotic cells such as cardiomyocytes, neurons and skeletal muscle cells. |
2017-04-13 |
2023-08-13 |
mouse |
| Longwei Hu, Jing Han, Xi Yang, Yang Wang, Hongya Pan, Liqun X. Apoptosis repressor with caspase recruitment domain enhances survival and promotes osteogenic differentiation of human osteoblast cells under Zoledronate treatment. Molecular medicine reports. vol 14. issue 4. 2017-04-13. PMID:27573706. |
arc is additionally able to promote osteogenic differentiation of osteoblasts and inhibit their apoptosis. |
2017-04-13 |
2023-08-13 |
mouse |
| Glenda C Gobe, Keng Lim Ng, David M Small, David A Vesey, David W Johnson, Hemamali Samaratunga, Kimberley Oliver, Simon Wood, Johanna L Barclay, Retnagowri Rajandram, Li Li, Christudas Morai. Decreased apoptosis repressor with caspase recruitment domain confers resistance to sunitinib in renal cell carcinoma through alternate angiogenesis pathways. Biochemical and biophysical research communications. vol 473. issue 1. 2016-09-21. PMID:26995091. |
apoptosis repressor with caspase recruitment domain (arc), an endogenous inhibitor of apoptosis, is upregulated in a number of human cancers, thereby conferring drug resistance and giving a rationale for the inhibition of arc to overcome drug resistance. |
2016-09-21 |
2023-08-13 |
human |
| Csaba Tóth, Jeannine Meinrath, Esther Herpel, Jutta Derix, Jochen Fries, Reinhard Buettner, Peter Schirmacher, Sebastian Heikau. Expression of the apoptosis repressor with caspase recruitment domain (ARC) in liver metastasis of colorectal cancer and its correlation with DNA mismatch repair proteins and p53. Journal of cancer research and clinical oncology. vol 142. issue 5. 2016-08-30. PMID:26721253. |
expression of the apoptosis repressor with caspase recruitment domain (arc) in liver metastasis of colorectal cancer and its correlation with dna mismatch repair proteins and p53. |
2016-08-30 |
2023-08-13 |
Not clear |
| Jianxun Wang, Chang Feng, Yuqi He, Wei Ding, Jianqiu Sheng, Muhammad Arshad, Xiaojie Zhang, Peifeng L. Phosphorylation of apoptosis repressor with caspase recruitment domain by protein kinase CK2 contributes to chemotherapy resistance by inhibiting doxorubicin induced apoptosis. Oncotarget. vol 6. issue 29. 2016-08-16. PMID:26172393. |
here, we identified that the phosphorylation of apoptosis repressor with caspase recruitment domain (arc) at threonine 149 was essential to inhibit doxorubicin (dox) induced apoptosis and mitochondrial fission in cancer cells. |
2016-08-16 |
2023-08-13 |
Not clear |
| Jianxun Wang, Chang Feng, Yuqi He, Wei Ding, Jianqiu Sheng, Muhammad Arshad, Xiaojie Zhang, Peifeng L. Phosphorylation of apoptosis repressor with caspase recruitment domain by protein kinase CK2 contributes to chemotherapy resistance by inhibiting doxorubicin induced apoptosis. Oncotarget. vol 6. issue 29. 2016-08-16. PMID:26172393. |
our further study showed that casein kinase ii (ck2) inhibitors could decrease the phosphorylation levels of arc and make cancer cells sensitive to undergoing apoptosis. |
2016-08-16 |
2023-08-13 |
Not clear |
| Jianxun Wang, Chang Feng, Yuqi He, Wei Ding, Jianqiu Sheng, Muhammad Arshad, Xiaojie Zhang, Peifeng L. Phosphorylation of apoptosis repressor with caspase recruitment domain by protein kinase CK2 contributes to chemotherapy resistance by inhibiting doxorubicin induced apoptosis. Oncotarget. vol 6. issue 29. 2016-08-16. PMID:26172393. |
taken together, our results revealed that ck2-mediated phosphorylation of arc contributed to chemotherapy resistance by inhibiting dox induced apoptosis and combining dox with ck2 inhibitor could induce apoptosis of cancer cells synergistically by down-regulating the phosphorylation of arc. |
2016-08-16 |
2023-08-13 |
Not clear |
| Tae-ho Jang, Seong Hyun Kim, Jae-Hee Jeong, Sunghwan Kim, Yeon-Gil Kim, Hyun Ho Par. Corrigendum: Crystal structure of caspase recruiting domain (CARD) of apoptosis repressor with CARD (ARC) and its implication in inhibition of apoptosis. Scientific reports. vol 5. 2016-06-30. PMID:26680499. |
corrigendum: crystal structure of caspase recruiting domain (card) of apoptosis repressor with card (arc) and its implication in inhibition of apoptosis. |
2016-06-30 |
2023-08-13 |
Not clear |
| Tae-ho Jang, Seong Hyun Kim, Jae-Hee Jeong, Sunghwan Kim, Yeon-Gil Kim, Yeun Gil Kim, Hyun Ho Par. Crystal structure of caspase recruiting domain (CARD) of apoptosis repressor with CARD (ARC) and its implication in inhibition of apoptosis. Scientific reports. vol 5. 2016-03-24. PMID:26038885. |
crystal structure of caspase recruiting domain (card) of apoptosis repressor with card (arc) and its implication in inhibition of apoptosis. |
2016-03-24 |
2023-08-13 |
human |
| Tae-ho Jang, Seong Hyun Kim, Jae-Hee Jeong, Sunghwan Kim, Yeon-Gil Kim, Yeun Gil Kim, Hyun Ho Par. Crystal structure of caspase recruiting domain (CARD) of apoptosis repressor with CARD (ARC) and its implication in inhibition of apoptosis. Scientific reports. vol 5. 2016-03-24. PMID:26038885. |
apoptosis repressor with caspase recruiting domain (arc) is a multifunctional inhibitor of apoptosis that is unusually over-expressed or activated in various cancers and in the state of the pulmonary hypertension. |
2016-03-24 |
2023-08-13 |
human |
| Tae-ho Jang, Seong Hyun Kim, Jae-Hee Jeong, Sunghwan Kim, Yeon-Gil Kim, Yeun Gil Kim, Hyun Ho Par. Crystal structure of caspase recruiting domain (CARD) of apoptosis repressor with CARD (ARC) and its implication in inhibition of apoptosis. Scientific reports. vol 5. 2016-03-24. PMID:26038885. |
arc inhibits the extrinsic apoptosis pathway by interfering with disc formation. |
2016-03-24 |
2023-08-13 |
human |
| Benjamin T Barnes, Amy L Confides, Mark M Rich, Esther E Dupont-Versteegde. Distinct muscle apoptotic pathways are activated in muscles with different fiber types in a rat model of critical illness myopathy. Journal of muscle research and cell motility. vol 36. issue 3. 2016-03-07. PMID:25740800. |
anti-apoptotic proteins hsp70, -27, and apoptosis repressor with a caspase recruitment domain (arc) were elevated in soleus compared to ta muscle and arc was significantly decreased with induction of dsim in soleus. |
2016-03-07 |
2023-08-13 |
rat |
| Azzurra Stefanucci, Jesús Mosquera, Eugènio Vázquez, José L Mascareñas, Ettore Novellino, Adriano Mollic. Synthesis, Characterization, and DNA Binding Profile of a Macrocyclic β-Sheet Analogue of ARC Protein. ACS medicinal chemistry letters. vol 6. issue 12. 2015-12-29. PMID:26713108. |
arc repressor (apoptosis repressor with caspase recruitment domain) is a protein which binds selectively to a specific sequence of dna. |
2015-12-29 |
2023-08-13 |
Not clear |
| J-X Wang, X-J Zhang, C Feng, T Sun, K Wang, Y Wang, L-Y Zhou, P-F L. MicroRNA-532-3p regulates mitochondrial fission through targeting apoptosis repressor with caspase recruitment domain in doxorubicin cardiotoxicity. Cell death & disease. vol 6. 2015-12-22. PMID:25766316. |
here we observed that apoptosis repressor with caspase recruitment domain (arc) was downregulated in mouse heart and cardiomyocytes upon dox treatment. |
2015-12-22 |
2023-08-13 |
mouse |
| J-X Wang, X-J Zhang, C Feng, T Sun, K Wang, Y Wang, L-Y Zhou, P-F L. MicroRNA-532-3p regulates mitochondrial fission through targeting apoptosis repressor with caspase recruitment domain in doxorubicin cardiotoxicity. Cell death & disease. vol 6. 2015-12-22. PMID:25766316. |
furthermore, enforced expression of arc attenuated dox-induced cardiomyocyte mitochondrial fission and apoptosis. |
2015-12-22 |
2023-08-13 |
mouse |
| J-X Wang, X-J Zhang, C Feng, T Sun, K Wang, Y Wang, L-Y Zhou, P-F L. MicroRNA-532-3p regulates mitochondrial fission through targeting apoptosis repressor with caspase recruitment domain in doxorubicin cardiotoxicity. Cell death & disease. vol 6. 2015-12-22. PMID:25766316. |
in elucidating the molecular mechanism by which arc was downregulated upon dox treatment, mir-532-3p was found to directly target arc and participated in dox-induced mitochondrial fission and apoptosis. |
2015-12-22 |
2023-08-13 |
mouse |
| Jena R White, Amy L Confides, Stephanie Moore-Reed, Johanna M Hoch, Esther E Dupont-Versteegde. Regrowth after skeletal muscle atrophy is impaired in aged rats, despite similar responses in signaling pathways. Experimental gerontology. vol 64. 2015-11-30. PMID:25681639. |
protein abundance of apoptosis repressor with caspase-recruitment domain (arc), cytosolic endog, as well as cytosolic and nuclear apoptosis inducing factor (aif) were lower in muscle from old rats, and there was no age-related difference in the response to atrophy or regrowth. |
2015-11-30 |
2023-08-13 |
rat |
| Andrew S Mitchell, Ian C Smith, Daniel Gamu, Stefan Donath, A Russell Tupling, Joe Quadrilater. Functional, morphological, and apoptotic alterations in skeletal muscle of ARC deficient mice. Apoptosis : an international journal on programmed cell death. vol 20. issue 3. 2015-11-16. PMID:25596718. |
apoptosis repressor with caspase recruitment domain (arc) is a potent anti-apoptotic protein that is highly expressed in skeletal muscle; however, its role in this tissue has yet to be elucidated. |
2015-11-16 |
2023-08-13 |
mouse |
| Andrew S Mitchell, Ian C Smith, Daniel Gamu, Stefan Donath, A Russell Tupling, Joe Quadrilater. Functional, morphological, and apoptotic alterations in skeletal muscle of ARC deficient mice. Apoptosis : an international journal on programmed cell death. vol 20. issue 3. 2015-11-16. PMID:25596718. |
however, cytosolic fractions of red muscle from arc ko mice had higher apoptosis inducing factor content, suggesting increased mitochondrial-mediated, caspase-independent apoptotic signaling. |
2015-11-16 |
2023-08-13 |
mouse |
| Seong Hyun Kim, Hyun Ho Par. Crystallization and preliminary X-ray crystallographic analysis of the CARD domain of apoptosis repressor with CARD (ARC). Acta crystallographica. Section F, Structural biology communications. vol 71. issue Pt 1. 2015-10-01. PMID:25615975. |
crystallization and preliminary x-ray crystallographic analysis of the card domain of apoptosis repressor with card (arc). |
2015-10-01 |
2023-08-13 |
human |