| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Refaat A Ei. Acylated ghrelin protection inhibits apoptosis in the remote myocardium post-myocardial infarction by inhibiting calcineurin and activating ARC. Archives of physiology and biochemistry. 2021-12-29. PMID:34965150. |
this study investigated if acylated ghrelin (ag) could inhibit myocardial infarction (mi)-induced apoptosis in the left ventricles (lv) of male rats and tested if this protection involves modulating arc anti-apoptotic protein. |
2021-12-29 |
2023-08-13 |
rat |
| Andrew T Templin, Christine Schmidt, Meghan F Hogan, Nathalie Esser, Richard N Kitsis, Rebecca L Hull, Sakeneh Zraika, Steven E Kah. Loss of apoptosis repressor with caspase recruitment domain (ARC) worsens high fat diet-induced hyperglycemia in mice. The Journal of endocrinology. vol 251. issue 2. 2021-12-11. PMID:34382577. |
loss of apoptosis repressor with caspase recruitment domain (arc) worsens high fat diet-induced hyperglycemia in mice. |
2021-12-11 |
2023-08-13 |
mouse |
| Andrew T Templin, Christine Schmidt, Meghan F Hogan, Nathalie Esser, Richard N Kitsis, Rebecca L Hull, Sakeneh Zraika, Steven E Kah. Loss of apoptosis repressor with caspase recruitment domain (ARC) worsens high fat diet-induced hyperglycemia in mice. The Journal of endocrinology. vol 251. issue 2. 2021-12-11. PMID:34382577. |
apoptosis repressor with caspase recruitment domain (arc) is an endogenous inhibitor of cell death signaling that is expressed in insulin-producing β cells. |
2021-12-11 |
2023-08-13 |
mouse |
| Cuiyun Zhou, Xiaoqiong Huang, Xia Li, Yan Xion. Circular RNA erythrocyte membrane protein band 4.1 assuages ultraviolet irradiation-induced apoptosis of lens epithelial cells by stimulating 5'-bisphosphate nucleotidase 1 in a miR-24-3p-dependent manner. Bioengineered. vol 12. issue 1. 2021-11-23. PMID:34652259. |
apoptosis of lens epithelial cells contributed to the formation of age-related cataract (arc), and previous data revealed that circular rna (circrna) was responsible for the underneath mechanism. |
2021-11-23 |
2023-08-13 |
Not clear |
| Cuiyun Zhou, Xiaoqiong Huang, Xia Li, Yan Xion. Circular RNA erythrocyte membrane protein band 4.1 assuages ultraviolet irradiation-induced apoptosis of lens epithelial cells by stimulating 5'-bisphosphate nucleotidase 1 in a miR-24-3p-dependent manner. Bioengineered. vol 12. issue 1. 2021-11-23. PMID:34652259. |
taken together, the enforced expression of circ_epb41 ameliorated uv irradiation-induced apoptosis of lens epithelial cells by mir-24-3p/bpnt1 pathway, providing us with a potential target for the therapy of uv-caused arc. |
2021-11-23 |
2023-08-13 |
Not clear |
| Jing Zhang, Xianxin Zheng, Peiyan Wang, Jianxun Wang, Wei Din. Role of apoptosis repressor with caspase recruitment domain (ARC) in cell death and cardiovascular disease. Apoptosis : an international journal on programmed cell death. vol 26. issue 1-2. 2021-11-22. PMID:33604728. |
role of apoptosis repressor with caspase recruitment domain (arc) in cell death and cardiovascular disease. |
2021-11-22 |
2023-08-13 |
Not clear |
| Jing Zhang, Xianxin Zheng, Peiyan Wang, Jianxun Wang, Wei Din. Role of apoptosis repressor with caspase recruitment domain (ARC) in cell death and cardiovascular disease. Apoptosis : an international journal on programmed cell death. vol 26. issue 1-2. 2021-11-22. PMID:33604728. |
apoptosis repressor with caspase recruitment domain (arc) is a highly effective and multifunctional inhibitor of apoptosis that is mainly expressed in postmitotic cells such as cardiomyocytes and skeletal muscle cells. |
2021-11-22 |
2023-08-13 |
Not clear |
| Jing Zhang, Xianxin Zheng, Peiyan Wang, Jianxun Wang, Wei Din. Role of apoptosis repressor with caspase recruitment domain (ARC) in cell death and cardiovascular disease. Apoptosis : an international journal on programmed cell death. vol 26. issue 1-2. 2021-11-22. PMID:33604728. |
initially, the inhibitory effect of arc was only found in apoptosis, however, it was later found that arc also played a regulatory role in other types of cell death. |
2021-11-22 |
2023-08-13 |
Not clear |
| Jing Zhang, Xianxin Zheng, Peiyan Wang, Jianxun Wang, Wei Din. Role of apoptosis repressor with caspase recruitment domain (ARC) in cell death and cardiovascular disease. Apoptosis : an international journal on programmed cell death. vol 26. issue 1-2. 2021-11-22. PMID:33604728. |
arc can reduce the cardiomyocyte apoptotic response to various stresses and injuries, including extrinsic apoptosis induced by death receptor ligands, cellular ca |
2021-11-22 |
2023-08-13 |
Not clear |
| Kaiyun Zhang, Yue Yin, Cheng Pei, Changrui W. MicroRNA-124 regulates lens epithelial cell apoptosis by affecting Fas alternative splicing by targeting polypyrimidine tract-binding protein in age-related cataract. Clinical & experimental ophthalmology. vol 49. issue 6. 2021-09-16. PMID:34008270. |
this study aimed to investigate whether microrna (mirna)-124 can regulate lec apoptosis by targeting polypyrimidine tract-binding protein (ptb) and thereby affecting fas alternative splicing in arc. |
2021-09-16 |
2023-08-13 |
Not clear |
| Shengqun Jiang, Jiansu Che. WRN inhibits oxidative stress-induced apoptosis of human lensepithelial cells through ATM/p53 signaling pathway and its expression is downregulated by DNA methylation. Molecular medicine (Cambridge, Mass.). vol 26. issue 1. 2021-09-08. PMID:32640976. |
apoptosis and oxidative stress are the main etiology of age related cataract (arc). |
2021-09-08 |
2023-08-13 |
human |
| Wendy M McKimpson, Yun Chen, James A Irving, Min Zheng, Jeremy Weinberger, Wilson Lek Wen Tan, Zenia Tiang, Alistair M Jagger, Streamson C Chua, Jeffrey E Pessin, Roger S-Y Foo, David A Lomas, Richard N Kitsi. Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes. Developmental cell. vol 56. issue 6. 2021-08-30. PMID:33667344. |
while cytoplasmic arc maintains β cell viability and pancreatic architecture, a pool of arc relocates to the nucleus to induce β cell apoptosis in humans with diabetes and several pathophysiologically distinct mouse models. |
2021-08-30 |
2023-08-13 |
mouse |
| Toshiharu Onodera, Philipp E Schere. From friend to foe: Pro-apoptotic action of nuclear ARC in diabetes. Developmental cell. vol 56. issue 6. 2021-08-19. PMID:33756115. |
apoptosis repressor with caspase recruitment domain (arc) is an established cytoplasmic anti-apoptotic factor relevant for cancer and metabolic disease. |
2021-08-19 |
2023-08-13 |
Not clear |
| Mengxin Liu, Tao Yu, Mengyang Li, Xinyu Fang, Bo Hou, Gaoli Liu, Jianxun Wan. Apoptosis repressor with caspase recruitment domain promotes cell proliferation and phenotypic modulation through 14-3-3ε/YAP signaling in vascular smooth muscle cells. Journal of molecular and cellular cardiology. vol 147. 2021-07-28. PMID:32771410. |
apoptosis repressor with caspase recruitment domain (arc) was initially discovered as an endogenous apoptosis inhibitor, but whether arc plays a role in vsmcs and whether it can participate in the regulation of atherosclerosis are unknown. |
2021-07-28 |
2023-08-13 |
Not clear |
| Zeze Wang, Yi Liu, Xuehui Liu, Lixiao Zhou, Xindi Ma, Junyao Liu, Lei Wang, Huicai Gu. Activation of forkhead box O3a by mono(2-ethylhexyl)phthalate and its role in protection against mono(2-ethylhexyl)phthalate-induced oxidative stress and apoptosis in human cardiomyocytes. Journal of applied toxicology : JAT. vol 41. issue 4. 2021-07-16. PMID:33029813. |
the expression of foxo3a and its target genes, mitochondrial superoxide dismutase (mn-sod) and apoptosis repressor with caspase recruitment domain (arc), increased after mehp exposure, but the expression of p-foxo3a protein was decreased. |
2021-07-16 |
2023-08-13 |
human |
| Zeze Wang, Yi Liu, Xuehui Liu, Lixiao Zhou, Xindi Ma, Junyao Liu, Lei Wang, Huicai Gu. Activation of forkhead box O3a by mono(2-ethylhexyl)phthalate and its role in protection against mono(2-ethylhexyl)phthalate-induced oxidative stress and apoptosis in human cardiomyocytes. Journal of applied toxicology : JAT. vol 41. issue 4. 2021-07-16. PMID:33029813. |
overexpression of foxo3a decreased the production of ros and the apoptosis rate induced by mehp, and the expression of mn-sod and arc was further increased after mehp exposure. |
2021-07-16 |
2023-08-13 |
human |
| Zeze Wang, Yi Liu, Xuehui Liu, Lixiao Zhou, Xindi Ma, Junyao Liu, Lei Wang, Huicai Gu. Activation of forkhead box O3a by mono(2-ethylhexyl)phthalate and its role in protection against mono(2-ethylhexyl)phthalate-induced oxidative stress and apoptosis in human cardiomyocytes. Journal of applied toxicology : JAT. vol 41. issue 4. 2021-07-16. PMID:33029813. |
in contrast, knockdown of foxo3a resulted in increased ros production and apoptosis and suppressed the expression of mn-sod and arc in the presence of mehp. |
2021-07-16 |
2023-08-13 |
human |
| Zeze Wang, Yi Liu, Xuehui Liu, Lixiao Zhou, Xindi Ma, Junyao Liu, Lei Wang, Huicai Gu. Activation of forkhead box O3a by mono(2-ethylhexyl)phthalate and its role in protection against mono(2-ethylhexyl)phthalate-induced oxidative stress and apoptosis in human cardiomyocytes. Journal of applied toxicology : JAT. vol 41. issue 4. 2021-07-16. PMID:33029813. |
activation of foxo3a defends against mehp-induced oxidative stress and apoptosis by upregulating the expression of mn-sod and arc in ac16 cardiomyocytes. |
2021-07-16 |
2023-08-13 |
human |
| Christoph Roser, Csaba Tóth, Marcus Renner, Esther Herpel, Peter Schirmache. Expression of apoptosis repressor with caspase recruitment domain (ARC) in familial adenomatous polyposis (FAP) adenomas and its correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2 and beta-catenin. Cell communication and signaling : CCS. vol 19. issue 1. 2021-07-15. PMID:33579312. |
expression of apoptosis repressor with caspase recruitment domain (arc) in familial adenomatous polyposis (fap) adenomas and its correlation with dna mismatch repair proteins, p53, bcl-2, cox-2 and beta-catenin. |
2021-07-15 |
2023-08-13 |
Not clear |
| Christoph Roser, Csaba Tóth, Marcus Renner, Esther Herpel, Peter Schirmache. Expression of apoptosis repressor with caspase recruitment domain (ARC) in familial adenomatous polyposis (FAP) adenomas and its correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2 and beta-catenin. Cell communication and signaling : CCS. vol 19. issue 1. 2021-07-15. PMID:33579312. |
one of the key regulatory proteins involved in apoptosis is apoptosis repressor with caspase recruitment domain (arc). |
2021-07-15 |
2023-08-13 |
Not clear |