| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Wang, Xiaojun Xu, Ruiqing Zhou, Kunyun Gu. [Effects of itraconazole plus doxorubicin on proliferation and apoptosis in acute myeloid leukemia cells]. Zhonghua yi xue za zhi. vol 95. issue 4. 2015-11-14. PMID:25877249. |
to explore the effects of itraconazole (itc) plus adriamycin (adm) on proliferation and apoptosis of acute myeloid leukemia cells in vitro. |
2015-11-14 |
2023-08-13 |
Not clear |
| Qian Wang, Jian Zou, Xiufen Zhang, Huijun Mu, Ying Yin, Ping Xi. Glucosylceramide synthase promotes Bcl-2 expression via the ERK signaling pathway in the K562/A02 leukemia drug-resistant cell line. International journal of hematology. vol 100. issue 6. 2015-08-18. PMID:25281403. |
our results indicate that the inhibition of gcs caused downregulation of bcl-2 as well as apoptosis enhancement in response to adm via the erk pathway, while jnk or p38 mapk signaling appeared to play less significant roles in the regulation of apoptosis and mdr in k562/a02 cells. |
2015-08-18 |
2023-08-13 |
Not clear |
| Katja Wagner, Ulrich Wachter, Josef A Vogt, Angelika Scheuerle, Oscar McCook, Sandra Weber, Michael Gröger, Bettina Stahl, Michael Georgieff, Peter Möller, Andreas Bergmann, Frauke Hein, Enrico Calzia, Peter Radermacher, Florian Wagne. Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock. Intensive care medicine experimental. vol 1. issue 1. 2015-08-13. PMID:26266790. |
adrenomedullin (adm) has been referred to as a double-edged sword during septic shock: on one hand, adm supplementation improved organ perfusion and function, attenuated systemic inflammation, and ultimately reduced tissue apoptosis and mortality. |
2015-08-13 |
2023-08-13 |
Not clear |
| Dong Wang, Nan Zhang, Yintao Ye, Junqiang Qian, Yu Zhu, Chen Wan. Role and mechanisms of microRNA‑503 in drug resistance reversal in HepG2/ADM human hepatocellular carcinoma cells. Molecular medicine reports. vol 10. issue 6. 2015-06-19. PMID:25269574. |
in conclusion, mir‑503 was observed to reverse adm resistance in hepg2/adm cells by inhibiting drug efflux, downregulating the expression of drug resistance‑related proteins, blocking the cell cycle and promoting cell apoptosis. |
2015-06-19 |
2023-08-13 |
human |
| Lei Yuan, Ran-Ran Shi, Shu-Mei Rao, Jin-Ling Song, Ming-Chen Cu. [Reversal of resistance to adriamycin in human breast cancer cell line MCF-7/ADM by silencing AEG-1 gene and its mechanism]. Sheng li xue bao : [Acta physiologica Sinica]. vol 66. issue 5. 2015-05-16. PMID:25332010. |
aeg-1 gene silencing induced cell apoptosis and enhanced the pro-apoptotic effect of adm on mcf-7/adm cells. |
2015-05-16 |
2023-08-13 |
human |
| Lei Yuan, Ran-Ran Shi, Shu-Mei Rao, Jin-Ling Song, Ming-Chen Cu. [Reversal of resistance to adriamycin in human breast cancer cell line MCF-7/ADM by silencing AEG-1 gene and its mechanism]. Sheng li xue bao : [Acta physiologica Sinica]. vol 66. issue 5. 2015-05-16. PMID:25332010. |
in conclusion, the results suggest that aeg-1 gene silencing can reverse the adm resistance in human breast cancer cell line mcf-7/adm by means of inducing apoptosis and down-regulating the protein level of mdr1. |
2015-05-16 |
2023-08-13 |
human |
| Fenbao Li, Ruimin Yang, Xizhong Zhang, Aiguang Liu, Yongli Zhao, Yingchang Gu. Silencing of hypoxia‑inducible adrenomedullin using RNA interference attenuates hepatocellular carcinoma cell growth in vivo. Molecular medicine reports. vol 10. issue 3. 2015-05-13. PMID:24927229. |
in addition, knockdown of adm expression using short hairpin rna (shrna) in smmc‑7721 cells resulted in apoptosis that was not observed in untransfected cells. |
2015-05-13 |
2023-08-13 |
human |
| Ying Wang, Yu-Xiang Han, Zhi-Yun Niu, Xing-Zhe Wang, Huan Hua, Yin-Tao Shang, Fu-Xu Wang, Xue-Jun Zhang, Jian-Min Lu. [BMMSC from blastic phase CML down-regulate leukemia cell apoptosis]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 5. 2015-03-30. PMID:25338597. |
the results showed that the cml-bp bmmsc could enhance the survival rate of k562 cells treated with adviamycin (adm) and display protective effect on k562 cells and primary cml-bp mononuctear cells, inhibited adm-induced leukimia cell apoptosis (p < 0.05); as compared with cml-chronic phase (cml-cp) bmmsc and normal bmmsc, the cml-bp bmmsc showed the highest protective effect on leukemic cells, the mitochondrial membrane potential of co-cultured cells slightly droped (p < 0.05). |
2015-03-30 |
2023-08-13 |
Not clear |
| John P Morris, Renee Greer, Holger A Russ, Guido von Figura, Grace E Kim, Anke Busch, Jonghyeob Lee, Klemens J Hertel, Seung Kim, Michael McManus, Matthias Hebro. Dicer regulates differentiation and viability during mouse pancreatic cancer initiation. PloS one. vol 9. issue 5. 2014-12-18. PMID:24788257. |
however, unconstrained adm also displays high levels of apoptosis. |
2014-12-18 |
2023-08-13 |
mouse |
| Li-Hui Wang, Jing-Yu Yang, Sheng-Nan Yang, Yi Li, Guan-Fang Ping, Yue Hou, Wei Cui, Zhen-Zhong Wang, Wei Xiao, Chun-Fu W. Suppression of NF-κB signaling and P-glycoprotein function by gambogic acid synergistically potentiates adriamycin -induced apoptosis in lung cancer. Current cancer drug targets. vol 14. issue 1. 2014-09-30. PMID:24245692. |
the critical role of nf-κb was further confirmed by using pdtc, a nf-κb inhibitor, which significantly increased apoptosis induction by the combination of ga and adm and inhibited adm-induced abcb1 upregulation. |
2014-09-30 |
2023-08-12 |
Not clear |
| Wesley W Hsiao, Hsien-Shun Liao, Hsing-Hung Lin, Yueh-Lun Lee, Chia-Kwung Fan, Chien-Wei Liao, Po-Yen Lin, En-Te Hwu, Chia-Seng Chan. Biophysical analysis of astrocytes apoptosis triggered by larval E/S antigen from cerebral toxocarosis-causing pathogen Toxocara canis. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. vol 29. issue 9. 2014-09-16. PMID:24025572. |
we propose an alternation detection method, a combination of the astigmatic detection microscopy (adm) and atomic force microscopy (afm) techniques, to investigate the apoptosis of astrocytes triggered with t. canis larval excretory/secretory (tc e/s) antigen. |
2014-09-16 |
2023-08-12 |
Not clear |
| Ni-sha Wang, Min Wei, Wen-li Ma, Wei Meng, Wen-ling Zhen. Knockdown of CD44 enhances chemosensitivity of acute myeloid leukemia cells to ADM and Ara-C. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 4. 2014-06-09. PMID:24375249. |
cell apoptosis and intracellular adm accumulation were detected by flow cytometry. |
2014-06-09 |
2023-08-12 |
Not clear |
| Ni-sha Wang, Min Wei, Wen-li Ma, Wei Meng, Wen-ling Zhen. Knockdown of CD44 enhances chemosensitivity of acute myeloid leukemia cells to ADM and Ara-C. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 4. 2014-06-09. PMID:24375249. |
sirna/cd44 substantially induces cell apoptosis, inhibits cell proliferation, enhances susceptibility to adm and ara-c, and at the same time increases intracellular adm accumulation even reverses chemoresistance to adm and ara-c. |
2014-06-09 |
2023-08-12 |
Not clear |
| Xiaohui Cai, Xiaohui Cai, Chunling Wang, Baoan Chen, Weijun Hua, Fei Shen, Liang Yu, Zhengmei He, Yuye Shi, Yue Chen, Guohua Xia, Wen Bao, Yu Zhang, Xuemei Wan. Antitumor efficacy of DMSA modified Fe3O4 magnetic nanoparticles combined with arsenic trioxide and adriamycin in Raji cells. Journal of biomedical nanotechnology. vol 10. issue 2. 2014-05-06. PMID:24738333. |
further, apoptosis of cells and intracellular concentration of adm were detected by flow cytometry (fcm). |
2014-05-06 |
2023-08-13 |
Not clear |
| Ai-guang Liu, Xi-zhong Zhang, Fen-bao Li, Yong-li Zhao, Ying-chang Guo, Rui-min Yan. RNA interference targeting adrenomedullin induces apoptosis and reduces the growth of human bladder urothelial cell carcinoma. Medical oncology (Northwood, London, England). vol 30. issue 3. 2014-04-17. PMID:23715749. |
adm signaling is of particular significance in endothelial cell biology because the peptide protects cells from apoptosis, and adm has been shown to be pro-tumorigenic in that it stimulates tumor cell growth and angiogenesis. |
2014-04-17 |
2023-08-12 |
human |
| Ai-guang Liu, Xi-zhong Zhang, Fen-bao Li, Yong-li Zhao, Ying-chang Guo, Rui-min Yan. RNA interference targeting adrenomedullin induces apoptosis and reduces the growth of human bladder urothelial cell carcinoma. Medical oncology (Northwood, London, England). vol 30. issue 3. 2014-04-17. PMID:23715749. |
furthermore, the knockdown of adm by shrna in t24 cells showed obvious apoptosis compared to untransfected controls (p < 0.0001). |
2014-04-17 |
2023-08-12 |
human |
| Liangjing Wang, Manish Gala, Masayoshi Yamamoto, Maria S Pino, Hirotoshi Kikuchi, Daniel S Shue, Senji Shirasawa, Thomas R Austin, Maureen P Lynch, Bo R Rueda, Lawrence R Zukerberg, Daniel C Chun. Adrenomedullin is a therapeutic target in colorectal cancer. International journal of cancer. vol 134. issue 9. 2014-04-02. PMID:24519534. |
knockdown of adm in colon tumor xenografts blocked angiogenesis and stimulated apoptosis, resulting in tumor suppression. |
2014-04-02 |
2023-08-12 |
Not clear |
| Miao He, Hai-Gang Sun, Jun-Ying Hao, Yan-Lin Li, Jian-Kun Yu, Yuan-Yuan Yan, Lin Zhao, Na Li, Yan Wang, Xue-Feng Bai, Zhao-Jin Yu, Zhi-Hong Zheng, Xiao-Yi Mi, En-Hua Wang, Min-Jie We. RNA interference-mediated FANCF silencing sensitizes OVCAR3 ovarian cancer cells to adriamycin through increased adriamycin-induced apoptosis dependent on JNK activation. Oncology reports. vol 29. issue 5. 2014-03-05. PMID:23440494. |
furthermore, silencing of fancf increased cell apoptosis of ovcar3 cells which was caused by decreased mitochondrial membrane potential (mmp)-induced dna damage, activated jun n-terminal kinase (jnk), increased release of cytochrome c, increased expression of cleaved caspase-3 and poly(adp-ribose) polymerase (parp) dependent on jnk activation following treatment of adm. |
2014-03-05 |
2023-08-12 |
Not clear |
| Ai-Mei Gao, Zun-Ping Ke, Jia-Ning Wang, Jian-Ye Yang, Shi-You Chen, Hui Che. Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway. Carcinogenesis. vol 34. issue 8. 2014-02-20. PMID:23563091. |
in bel-7402 xenografts, apg and adm cotreatment inhibited tumor growth, reduced cell proliferation and induced apoptosis more substantially when compared with adm treatment alone. |
2014-02-20 |
2023-08-12 |
Not clear |
| Kai Tang, Yi Lin, Li-Ming L. The role of phenethyl isothiocyanate on bladder cancer ADM resistance reversal and its molecular mechanism. Anatomical record (Hoboken, N.J. : 2007). vol 296. issue 6. 2014-01-30. PMID:23495258. |
in this report, we identified the role of peitc on adm resistance reversal of human bladder carcinoma t24/adm cells, including an increased drug sensitivity to adm, cell apoptosis rates, intracellular accumulation of rhodamine-123 (rh-123), an increased expression of dna topoisomerase ii (topo-ii), and a decreased expression of multidrug resistance gene (mdr1), multidrug resistance-associated protein (mrp1), bcl-2 and glutathione s transferase π (gst-π).we also found that there was a decreased expression of nf-κb, survivin, twist, and p-akt, and an increased expression of pten and p-jnk after peitc treatment for t24/ adm cells. |
2014-01-30 |
2023-08-12 |
human |