| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benjamin Uzan, Aude Villemin, Jean-Michel Garel, Michèle Cressen. Adrenomedullin is anti-apoptotic in osteoblasts through CGRP1 receptors and MEK-ERK pathway. Journal of cellular physiology. vol 215. issue 1. 2008-02-19. PMID:17941085. |
to address this question we have investigated its effect on the apoptosis of serum-deprived osteoblastic cells using mouse mc3t3-e1 cells which express both adm and adm receptors. |
2008-02-19 |
2023-08-12 |
mouse |
| Benjamin Uzan, Aude Villemin, Jean-Michel Garel, Michèle Cressen. Adrenomedullin is anti-apoptotic in osteoblasts through CGRP1 receptors and MEK-ERK pathway. Journal of cellular physiology. vol 215. issue 1. 2008-02-19. PMID:17941085. |
treatment with adm significantly blunted apoptosis, evaluated by caspase-3 activity, dna fragmentation quantification and annexin v-fitc labeling. |
2008-02-19 |
2023-08-12 |
mouse |
| Benjamin Uzan, Aude Villemin, Jean-Michel Garel, Michèle Cressen. Adrenomedullin is anti-apoptotic in osteoblasts through CGRP1 receptors and MEK-ERK pathway. Journal of cellular physiology. vol 215. issue 1. 2008-02-19. PMID:17941085. |
accordingly, neutralization of endogenous adm by a specific antibody enhanced apoptosis. |
2008-02-19 |
2023-08-12 |
mouse |
| Benjamin Uzan, Aude Villemin, Jean-Michel Garel, Michèle Cressen. Adrenomedullin is anti-apoptotic in osteoblasts through CGRP1 receptors and MEK-ERK pathway. Journal of cellular physiology. vol 215. issue 1. 2008-02-19. PMID:17941085. |
finally, the selective inhibitor of mapk kinase (mek), pd98059, abolished the apoptosis protective effect of adm and prevented adm activation of erk1/2. |
2008-02-19 |
2023-08-12 |
mouse |
| Wei Chang, Han-Ying Sun, Min Huang, Jian-Feng Zhou, Yi-Cheng Zhan. [Effect of adriamycin on Gfi-1 expression in K562 cells and its relationship with the relevant apoptotic genes]. Zhongguo shi yan xue ye xue za zhi. vol 15. issue 2. 2007-10-30. PMID:17493331. |
the apoptosis was assayed by flow cytometry (fcm) and the dna electrophoresis; the expression changes of gfi-1, bcl-2, bax mrna and protein were detected by rt-pcr and fcm after k562 cells were treated with different concentrations of adm for 24 hours. |
2007-10-30 |
2023-08-12 |
Not clear |
| Wei Chang, Han-Ying Sun, Min Huang, Jian-Feng Zhou, Yi-Cheng Zhan. [Effect of adriamycin on Gfi-1 expression in K562 cells and its relationship with the relevant apoptotic genes]. Zhongguo shi yan xue ye xue za zhi. vol 15. issue 2. 2007-10-30. PMID:17493331. |
it is concluded that at certain range of concentration, apoptosis or necrosis of k562 cells can be induced by adm, the percentage of apoptosis, the changes of expression of bcl-2, bax and gfi-1 depend on the dose of adm. |
2007-10-30 |
2023-08-12 |
Not clear |
| Wei Chang, Han-Ying Sun, Min Huang, Jian-Feng Zhou, Yi-Cheng Zhan. [Effect of adriamycin on Gfi-1 expression in K562 cells and its relationship with the relevant apoptotic genes]. Zhongguo shi yan xue ye xue za zhi. vol 15. issue 2. 2007-10-30. PMID:17493331. |
the mechanism of apoptosis in k562 cells induced by adm may be related to suppression of gfi-1 oncogene and activation of expression of bax gene. |
2007-10-30 |
2023-08-12 |
Not clear |
| Magdalena Olbryt, Michał Jarzab, Joanna Jazowiecka-Rakus, Krzysztof Simek, Stanisław Szala, Aleksander Sochani. Gene expression profile of B 16(F10) murine melanoma cells exposed to hypoxic conditions in vitro. Gene expression. vol 13. issue 3. 2007-01-25. PMID:17193925. |
we observed significant differences in expression levels of genes regulating glycolysis (pfkp, hk2, aldo3, eno2), apoptosis (bnip3, bnip31, cdknla), transcription (bhlhb2, sap30, atf3, mxil), angiogenesis (vegfa, adm, anxa2, ctgf), adhesion (pkp2, itga4, mcam), migration (cnn2, tmsb4x), and other processes. |
2007-01-25 |
2023-08-12 |
Not clear |
| Gaofeng Jiang, Jinlong Li, Zhaolei Zeng, Lijian Xia. Lentivirus-mediated gene therapy by suppressing survivin in BALB/c nude mice bearing oral squamous cell carcinoma. Cancer biology & therapy. vol 5. issue 4. 2007-01-23. PMID:16575205. |
the results showed that survivin was persistently and markedly reduced by lentivirus-mediated rna interference (rnai); the growth of kb cells was decreased by 34.2% on day 5; the apoptosis rate induced by vincristine (vcr) was increased by 29.8% and caspase-3 activity was also significantly increased; the ic(50) value of adriamycin (adm) were 0.09 mug/ml, which indicated that survivin-knockout kb cells were 2.1 times more susceptible to adm than the control; the clonogenic survival rate at 6 gy of x ray was 3.7%, less than 15.3% of the control. |
2007-01-23 |
2023-08-12 |
mouse |
| Fang Li, Li Meng, Hui Xing, Jianfeng Zhou, Shixuan Wang, Lei Huang, Gang Xu, Huaishi Zhu, Yunping Lu, Ding M. Essential role of c-Jun-NH2-terminal kinase on synergy induction of apoptosis by TRAIL plus ADM in ADM resistant MCF-7/ADM cells. Apoptosis : an international journal on programmed cell death. vol 11. issue 7. 2006-09-11. PMID:16703262. |
essential role of c-jun-nh2-terminal kinase on synergy induction of apoptosis by trail plus adm in adm resistant mcf-7/adm cells. |
2006-09-11 |
2023-08-12 |
Not clear |
| Lixin Qian, Hong Ding, Jianwei Zhou, Xinru Wang, Pengfei Shao, Shen Wu, Jie Yang, Jean M Feugang, Changping Zo. Intravesical N-(4-hydroxyphenyl) retinamide and adriamycin induces apoptosis in bladder cancer. Frontiers in bioscience : a journal and virtual library. vol 11. 2006-06-27. PMID:16720290. |
apoptosis occurred at a higher rate in the combination group than when 4-hpr or adm was used alone. |
2006-06-27 |
2023-08-12 |
rat |
| b' Benjamin Uzan, Hang-Korng Ea, Jean-Marie Launay, Jean-Michel Garel, Romuald Champy, Mich\\xc3\\xa8le Cressent, Fr\\xc3\\xa9d\\xc3\\xa9ric Liot\\xc3\\xa. A critical role for adrenomedullin-calcitonin receptor-like receptor in regulating rheumatoid fibroblast-like synoviocyte apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 176. issue 9. 2006-06-06. PMID:16622024.' |
adm dose-dependently inhibited ra-fls apoptosis, and this effect was reversed by the 22-52 adm antagonist peptide. |
2006-06-06 |
2023-08-12 |
Not clear |
| b' Benjamin Uzan, Hang-Korng Ea, Jean-Marie Launay, Jean-Michel Garel, Romuald Champy, Mich\\xc3\\xa8le Cressent, Fr\\xc3\\xa9d\\xc3\\xa9ric Liot\\xc3\\xa. A critical role for adrenomedullin-calcitonin receptor-like receptor in regulating rheumatoid fibroblast-like synoviocyte apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 176. issue 9. 2006-06-06. PMID:16622024.' |
adm inhibited ra-fls apoptosis triggered by extrinsic and intrinsic pathways. |
2006-06-06 |
2023-08-12 |
Not clear |
| b' Benjamin Uzan, Hang-Korng Ea, Jean-Marie Launay, Jean-Michel Garel, Romuald Champy, Mich\\xc3\\xa8le Cressent, Fr\\xc3\\xa9d\\xc3\\xa9ric Liot\\xc3\\xa. A critical role for adrenomedullin-calcitonin receptor-like receptor in regulating rheumatoid fibroblast-like synoviocyte apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 176. issue 9. 2006-06-06. PMID:16622024.' |
our data suggest that adm may prevent or reduce ra-fls apoptosis, via up-regulation of its functional receptor crlr/ramp-2. |
2006-06-06 |
2023-08-12 |
Not clear |
| Li Sun, Yongquan Shi, Changcun Guo, Liping Yao, Tao Lin, Jingping Du, Quanli Han, Ying Han, Daiming Fa. Regulation of multidrug resistance by MGr1-antigen in gastric cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 27. issue 1. 2006-01-25. PMID:16340247. |
overexpression of exogenous mgr1-ag may promote the mdr phenotype of gastric cancer cells, decrease intracellular adm accumulation and protect gastric cancer cells from adm-induced apoptosis, whereas downregulation of mgr1-ag had reverse effects. |
2006-01-25 |
2023-08-12 |
Not clear |
| Zhi-Yong Yu, Wen-Shu Zuo, Ling Wei, Pei-Ying Shan, Xian-Rang Song, Yu-Tan Liu, Yan-Song Liu, Zheng-Bo Zhou, Zhi-Min Sha. [Inhibitory and apoptosis regulating effects of adriamycin on different human breast cancer cell lines]. Zhonghua yi xue za zhi. vol 85. issue 1. 2005-11-22. PMID:15808069. |
to investigate the inhibitory and apoptosis regulating effects of adriamycin (adm) on different human breast cancer cell lines and to evaluate the value of apoptosis in breast cancer treatment. |
2005-11-22 |
2023-08-12 |
human |
| A Bravo-Cuellar, P C Gómez-Contreras, J M Lerma-Díaz, G Hernández-Flores, J R Domínguez-Rodríguez, P Ortíz-Lazareno, R Cervantes-Munguia, S Orbach-Arbouy. In vivo modification of adriamycin-induced apoptosis in L-5178Y lymphoma cell-bearing mice by (+)-alpha-tocopherol and superoxide dismutase. Cancer letters. vol 229. issue 1. 2005-11-14. PMID:16157219. |
apoptosis was followed in l5178y lymphoma cell-bearing mice at different times after intraperitoneal injections of adriamycin (adm). |
2005-11-14 |
2023-08-12 |
mouse |
| A Bravo-Cuellar, P C Gómez-Contreras, J M Lerma-Díaz, G Hernández-Flores, J R Domínguez-Rodríguez, P Ortíz-Lazareno, R Cervantes-Munguia, S Orbach-Arbouy. In vivo modification of adriamycin-induced apoptosis in L-5178Y lymphoma cell-bearing mice by (+)-alpha-tocopherol and superoxide dismutase. Cancer letters. vol 229. issue 1. 2005-11-14. PMID:16157219. |
apoptosis was observed 36h after injection of 5mg/kg adm (apoptotic cell index 64.2+/-5.6 vs. 1.5+/-2.1 from the untreated group) and confirmed by dna electrophoresis. |
2005-11-14 |
2023-08-12 |
mouse |
| Ryuji Ikeda, Xiao-Fang Che, Tatsuya Yamaguchi, Mina Ushiyama, Chun-Lei Zheng, Hiroshi Okumura, Yasuo Takeda, Yoshihiko Shibayama, Kazuo Nakamura, Hei-Cheul Jeung, Tatsuhiko Furukawa, Tomoyuki Sumizawa, Misako Haraguchi, Shin-ichi Akiyama, Katsushi Yamad. Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer science. vol 96. issue 6. 2005-08-04. PMID:15958061. |
it has also been found that cepharanthine enhanced sensitivity to doxorubicin (adm) and vincristine (vcr), and enhanced apoptosis induced by adm and vcr of p-gp negative k562 cells. |
2005-08-04 |
2023-08-12 |
Not clear |
| Ryungsa Kim, Kazuaki Tanabe, Manabu Emi, Yoko Uchida, Akihiko Osaki, Tetsuya Tog. Rationale for sequential tamoxifen and anticancer drugs in adjuvant setting for patients with node- and receptor-positive breast cancer. International journal of oncology. vol 26. issue 4. 2005-07-28. PMID:15753998. |
estradiol decreased sensitivity to adm, mmc, and txl in mcf-7 and mda-mb-231 breast cancer cells, and this was associated in part with an increase in the amount of bcl-2 protein, and decreases in levels of bax and cytochrome c leading to apoptosis. |
2005-07-28 |
2023-08-12 |
Not clear |