| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jorge R Domínguez-Rodríguez, Veronica Chaparro-Huerta, Georgina Hernández-Flores, Piedad C Gómez-Contreras, José M Lerma-Dáz, Pablo C Ortiz-Lazareno, Ramón Cervantes-Munguia, Simone Orbach-Arbouys, Daniel Scott-Algara, Alejandro Bravo Cuella. In vivo adriamycin-induced apoptosis in peritoneal murine macrophages: partial participation of a caspase cascade. Anticancer research. vol 24. issue 5A. 2004-12-10. PMID:15517873. |
adriamycin (adm) is a potent antitumor drug that induces apoptosis (ap) in tumor cells. |
2004-12-10 |
2023-08-12 |
mouse |
| V N Bilim, Y Tomita, T Kawasaki, M Takeda, K Takahash. Adriamycin (ADM) induced apoptosis in transitional cell cancer (TCC) cell lines accompanied by p21 WAF1/CIP1 induction. Apoptosis : an international journal on programmed cell death. vol 2. issue 2. 2003-12-23. PMID:14646556. |
adriamycin (adm) induced apoptosis in transitional cell cancer (tcc) cell lines accompanied by p21 waf1/cip1 induction. |
2003-12-23 |
2023-08-12 |
human |
| V N Bilim, Y Tomita, T Kawasaki, M Takeda, K Takahash. Adriamycin (ADM) induced apoptosis in transitional cell cancer (TCC) cell lines accompanied by p21 WAF1/CIP1 induction. Apoptosis : an international journal on programmed cell death. vol 2. issue 2. 2003-12-23. PMID:14646556. |
here we studied adriamycin (adm)-induced apoptosis in four human bladder cancer cell lines in respect of p53, p21waf1/cip1 and bcl-2 family proteins. |
2003-12-23 |
2023-08-12 |
human |
| V N Bilim, Y Tomita, T Kawasaki, M Takeda, K Takahash. Adriamycin (ADM) induced apoptosis in transitional cell cancer (TCC) cell lines accompanied by p21 WAF1/CIP1 induction. Apoptosis : an international journal on programmed cell death. vol 2. issue 2. 2003-12-23. PMID:14646556. |
after adm, treatment bladder cancer cells underwent dose-dependent cell death with typical morphologic features of apoptosis. |
2003-12-23 |
2023-08-12 |
human |
| V N Bilim, Y Tomita, T Kawasaki, M Takeda, K Takahash. Adriamycin (ADM) induced apoptosis in transitional cell cancer (TCC) cell lines accompanied by p21 WAF1/CIP1 induction. Apoptosis : an international journal on programmed cell death. vol 2. issue 2. 2003-12-23. PMID:14646556. |
among four cell lines rt4 with wt p53, low ratio of bcl-2 to bax and induction of p21waf1/cip1 after adm treatment, was the most sensitive to induction of apoptosis. |
2003-12-23 |
2023-08-12 |
human |
| V N Bilim, Y Tomita, T Kawasaki, M Takeda, K Takahash. Adriamycin (ADM) induced apoptosis in transitional cell cancer (TCC) cell lines accompanied by p21 WAF1/CIP1 induction. Apoptosis : an international journal on programmed cell death. vol 2. issue 2. 2003-12-23. PMID:14646556. |
thus, p53, p21waf1/cip1, bcl-2 and bax status might determine susceptibility of bladder cancer cells to adm induced apoptosis. |
2003-12-23 |
2023-08-12 |
human |
| Hong-Ling Li, Xian-Da Ren, Hai-Wei Zhang, Chun-Ling Ye, Jun-Hua Lv, Pei-E Zhen. Synergism between heparin and adriamycin on cell proliferation and apoptosis in human nasopharyngeal carcinoma CNE2 cells. Acta pharmacologica Sinica. vol 23. issue 2. 2003-09-16. PMID:11866879. |
to measure the effect of addition of heparin to adriamycin (adm) on cell proliferation and apoptosis in cne2 cells and investigate the possible molecular mechanisms of heparin and adm interactions. |
2003-09-16 |
2023-08-12 |
human |
| Ken-Ichi Kiyomiya, Masaru Kurebe, Hiroshi Nakagawa, Saburou Matsu. The role of the proteasome in apoptosis induced by anthracycline anticancer agents. International journal of oncology. vol 20. issue 6. 2002-08-29. PMID:12012000. |
exposure of l1210 mouse lymphocytic leukemia cells to adriamycin (adm) or 4'-o-tetrahydropyranyladriamycin (thp) resulted in apoptosis in a dose-dependent manner: 5 microm adm and 0.5 microm thp induced apoptosis efficiently, but the effects of 10 microm adm and 5 microm thp were markedly decreased or completely absent. |
2002-08-29 |
2023-08-12 |
mouse |
| A S Belloni, G Albertin, M L Forneris, G G Nussdorfe. Proadrenomedullin-derived peptides as autocrine-paracrine regulators of cell growth. Histology and histopathology. vol 16. issue 4. 2002-03-21. PMID:11642745. |
these last two effects are mediated by calcitonin gene-related peptide type 1 (cgrp1) receptors coupled to the adenylate cyclase (ac)/protein kinase (pk) a-dependent cascade; 2) inhibits proliferation and enhances apoptosis of kidney mesangial cells, through the modulation of mitogen-activated pk (mapk) cascades; 3) stimulates proliferation of adrenal zona glomerulosa cells, acting via cgrp1 receptor coupled to the tyrosine kinase-dependent mapk cascade, thereby possibly being involved in the maintenance and stimulation of adrenal growth; 4) enhances proliferation of skin and mucosa epithelial cells and fibroblasts, by activating cgrp1 receptor coupled to the ac/pka signaling pathway; and 5) enhances proliferation of several tumor-cell lines through the activation of the ac/pka cascade, which suggests a potential role for adm as promoter of neoplastic growth. |
2002-03-21 |
2023-08-12 |
Not clear |
| Piera Rebuffat, Myriam L Forneris, Francesco Aragona, Agnieszka Ziolkowska, Ludwik K Malendowicz, Gastone G Nussdorfe. Adrenomedullin and its receptors are expressed in the zona glomerulosa of human adrenal gland: evidence that ADM enhances proliferation and decreases apoptosis in cultured ZG cells. International journal of molecular medicine. vol 9. issue 2. 2002-02-19. PMID:11786920. |
adrenomedullin and its receptors are expressed in the zona glomerulosa of human adrenal gland: evidence that adm enhances proliferation and decreases apoptosis in cultured zg cells. |
2002-02-19 |
2023-08-12 |
human |
| Piera Rebuffat, Myriam L Forneris, Francesco Aragona, Agnieszka Ziolkowska, Ludwik K Malendowicz, Gastone G Nussdorfe. Adrenomedullin and its receptors are expressed in the zona glomerulosa of human adrenal gland: evidence that ADM enhances proliferation and decreases apoptosis in cultured ZG cells. International journal of molecular medicine. vol 9. issue 2. 2002-02-19. PMID:11786920. |
in conclusion our study provides evidence that i) human zg cells express adm and adm receptors of both l1 and crlr/pamp2,3 subtypes; and ii) through the activation of these receptors, adm exerts an aldosterone antisecretagogue action and a growth promoting effect on cultured zg cells, the latter an effect which includes both stimulation of proliferation and inhibition of apoptosis. |
2002-02-19 |
2023-08-12 |
human |
| Z H Li, Y J Zhu, L S Chao, X T L. [Wild-type p53 stimulates vincristine-induced apoptosis]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 32. issue 8. 2001-11-01. PMID:11596302. |
recent studies indicate that wild-type p53 can trigger cell apoptosis induced by many chemotherapeutic agents which induce dna damage or cause disruptions of dna metabolism, such as adm, 5-fu, vp-16 and radiation. |
2001-11-01 |
2023-08-12 |
Not clear |
| V Bilim, T Kawasaki, K Takahashi, Y Tomit. Adriamycin induced G2/M cell cycle arrest in transitional cell cancer cells with wt p53 and p21(WAF1/CIP1) genes. Journal of experimental & clinical cancer research : CR. vol 19. issue 4. 2001-07-19. PMID:11277327. |
adriamycin (adm), widely used for systemic and local treatment of bladder tumors, triggers apoptosis in bladder cancer cells. |
2001-07-19 |
2023-08-12 |
Not clear |
| M K Oehler, C Norbury, S Hague, M C Rees, R Bicknel. Adrenomedullin inhibits hypoxic cell death by upregulation of Bcl-2 in endometrial cancer cells: a possible promotion mechanism for tumour growth. Oncogene. vol 20. issue 23. 2001-07-19. PMID:11420706. |
here we report for the first time that adm treated or stably transfected ishikawa cells overexpressing adm show increased resistance to hypoxia induced apoptosis. |
2001-07-19 |
2023-08-12 |
Not clear |
| R Kim, Y Ohi, H Inoue, T Tog. Enhancement of chemotherapeutic agents induced-apoptosis associated with activation of c-Jun N-terminal kinase 1 and caspase 3 (CPP32) in bax-transfected gastric cancer cells. Anticancer research. vol 20. issue 1A. 2000-05-11. PMID:10769693. |
apoptosis in the bax-transfected gastric cancer cells was enhanced following the treatment of various chemotherapeutic agents including adriamycin (adm), cisplatin (cddp), etoposide (vp-16) and taxotere (txt) as compared to those of neo gene-transfected cells. |
2000-05-11 |
2023-08-12 |
mouse |
| R Kim, Y Ohi, H Inoue, T Tog. Enhancement of chemotherapeutic agents induced-apoptosis associated with activation of c-Jun N-terminal kinase 1 and caspase 3 (CPP32) in bax-transfected gastric cancer cells. Anticancer research. vol 20. issue 1A. 2000-05-11. PMID:10769693. |
the enhancement of apoptosis was coincident with the increase of sensitivity in the ratio of ic50 value, that was 1.3-fold in adm, 4.4-fold in cddp, 4.6-fold in vp-16 and 2.5-fold in txt, respectively. |
2000-05-11 |
2023-08-12 |
mouse |
| M Takahashi, S Kataoka, E Kobayashi, Y Udagawa, D Aoki, S Oie, A Kozu, S Nozaw. Differences in apoptosis induced by anticancer drugs in sublines (SKG-3a, SKG-3b) from a human uterine cervical epidermoid carcinoma. Oncology research. vol 11. issue 2. 1999-11-02. PMID:10489162. |
skg-3b cells treated with cddp, adm, vp-16, and taxol showed the apoptotic cell death, whereas apoptosis in skg-3a cells was not induced by these anticancer drugs. |
1999-11-02 |
2023-08-12 |
human |
| Y Ch. [Roles of p53 in adriamycin-induced cell death and in acquisition of adriamycin resistance in adult T-cell leukemia (ATL) cells]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 74. issue 3. 1999-09-14. PMID:10422567. |
these findings suggest that p53 does not play a leading part either in the apoptosis induced by adm, or in the acquisition of resistance to adm in atl cells, and that adm-induced apoptosis is mediated by multiple pathways leading to the activation of effector molecules. |
1999-09-14 |
2023-08-12 |
Not clear |
| T Shirahama, E A Sweeney, C Sakakura, A K Singhal, K Nishiyama, S Akiyama, S Hakomori, Y Igarash. In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 3. issue 2. 1999-02-16. PMID:9815681. |
adriamycin (adm) induced apoptosis in kb-3-1 cells but not in kb-c2 mdr cells at the concentration of 50 microg/ml. |
1999-02-16 |
2023-08-12 |
human |
| T Shirahama, E A Sweeney, C Sakakura, A K Singhal, K Nishiyama, S Akiyama, S Hakomori, Y Igarash. In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 3. issue 2. 1999-02-16. PMID:9815681. |
these results suggested that kb-c2 mdr cells were resistant to apoptosis induction by adm but sensitive to that by sphingosine and dms. |
1999-02-16 |
2023-08-12 |
human |