| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G-Y Han, J-H Cui, S Liang, H-L L. Increased miR-142 and decreased DJ-1 enhance the sensitivity of pancreatic cancer cell to adriamycin. European review for medical and pharmacological sciences. vol 22. issue 22. 2019-11-12. PMID:30536312. |
this investigation, therefore, aimed to study the role of mir-142 in the regulation of dj-1-pten/pi3k/akt/survivin signaling pathway as well as in pancreatic cancer cell proliferation, apoptosis, and adriamycin (adm) resistance. |
2019-11-12 |
2023-08-13 |
Not clear |
| Jiangwei Chen, Xuanyin Chen, Xiaodong Chen, Haiying Sun, Dong Yan. SM‑164 enhances the antitumor activity of adriamycin in human U2‑OS cells via downregulation of X‑linked inhibitor of apoptosis protein. Molecular medicine reports. vol 19. issue 6. 2019-09-10. PMID:31059038. |
in addition, cells treated with both sm‑164 and adm were further divided into three subgroups: sm‑164 + adm, sm‑164 + adm + vector and sm‑164 + adm + x‑linked inhibitor of apoptosis protein (xiap) silencing groups. |
2019-09-10 |
2023-08-13 |
human |
| Jiangwei Chen, Xuanyin Chen, Xiaodong Chen, Haiying Sun, Dong Yan. SM‑164 enhances the antitumor activity of adriamycin in human U2‑OS cells via downregulation of X‑linked inhibitor of apoptosis protein. Molecular medicine reports. vol 19. issue 6. 2019-09-10. PMID:31059038. |
compared with the control group, cell viability decreased, while apoptosis was increased in the adm and sm‑164‑treatment group. |
2019-09-10 |
2023-08-13 |
human |
| Jiangwei Chen, Xuanyin Chen, Xiaodong Chen, Haiying Sun, Dong Yan. SM‑164 enhances the antitumor activity of adriamycin in human U2‑OS cells via downregulation of X‑linked inhibitor of apoptosis protein. Molecular medicine reports. vol 19. issue 6. 2019-09-10. PMID:31059038. |
compared with adm + sm‑164 group, xiap silencing with adm + sm‑164 treatment further reduced cell viability, promoted apoptosis, increased caspase‑7, ‑9 and ‑3, and parp expression; however the expression of survivin and ciap‑1 were reduced. |
2019-09-10 |
2023-08-13 |
human |
| Xu-Na Wang, Kui-Yang Wang, Xue-Song Zhang, Chao Yang, Xue-Ying L. 4-Hydroxybenzoic acid (4-HBA) enhances the sensitivity of human breast cancer cells to adriamycin as a specific HDAC6 inhibitor by promoting HIPK2/p53 pathway. Biochemical and biophysical research communications. vol 504. issue 4. 2019-05-28. PMID:30217455. |
4-hba significantly promoted the anticancer effect of adm on apoptosis induction, as evidenced by the increased expressions of caspase-3 and parp cleavage, which was associated with the promotion p53 and homeodomain interacting protein kinase-2 (hipk2) expressions in adm-resistant breast cancer cells. |
2019-05-28 |
2023-08-13 |
human |
| Mengxia Zhang, Qi Liu, Lijun Li, Jing Ning, Jian Tu, Xiaoyong Lei, Zhongcheng Mo, Shengsong Tan. Cytoplasmic M‑CSF facilitates apoptosis resistance by inhibiting the HIF‑1α/BNIP3/Bax signalling pathway in MCF‑7 cells. Oncology reports. vol 41. issue 3. 2019-03-11. PMID:30592292. |
hoechst 33342 staining and flow cytometry were utilized to evaluate the effect of m‑csf on apoptosis in mcf‑7 cells treated with adm. |
2019-03-11 |
2023-08-13 |
human |
| Youxia Huang, Yingjian Cai, Ronggui Huang, Xingzhong Zhen. Rosmarinic Acid Combined with Adriamycin Induces Apoptosis by Triggering Mitochondria-Mediated Signaling Pathway in HepG2 and Bel-7402 Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-01-07. PMID:30391993. |
this study aimed to evaluate the anti-tumor effects of rosmarinic acid (rosa) combined with adriamycin (adm) on proliferation and apoptosis of hepatic carcinoma cell lines. |
2019-01-07 |
2023-08-13 |
human |
| Youxia Huang, Yingjian Cai, Ronggui Huang, Xingzhong Zhen. Rosmarinic Acid Combined with Adriamycin Induces Apoptosis by Triggering Mitochondria-Mediated Signaling Pathway in HepG2 and Bel-7402 Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-01-07. PMID:30391993. |
apoptosis rates in the rosa combined with adm group were significantly increased compared to the hepg2 or bel-7402 group (p<0.05). |
2019-01-07 |
2023-08-13 |
human |
| Youxia Huang, Yingjian Cai, Ronggui Huang, Xingzhong Zhen. Rosmarinic Acid Combined with Adriamycin Induces Apoptosis by Triggering Mitochondria-Mediated Signaling Pathway in HepG2 and Bel-7402 Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-01-07. PMID:30391993. |
conclusions rosa combined with adm damaged tumor cell morphologies, decreased cell viability, and induced apoptosis of hepg2 and bel-7402 by triggering the mitochondria-mediated signaling pathway. |
2019-01-07 |
2023-08-13 |
human |
| Lei Wang, Liang Liu, Yuetong Chen, Yu Du, Jing Wang, Jianghui Li. Correlation between adenosine triphosphate (ATP)-binding cassette transporter G2 (ABCG2) and drug resistance of esophageal cancer and reversal of drug resistance by artesunate. Pathology, research and practice. vol 214. issue 9. 2018-11-16. PMID:30104076. |
the volume and mass of the subcutaneously implanted tumors in the adm+art high- and low-dose groups were significantly decreased than that in the control group (p < 0.05), while the apoptosis rate of tumor cells and the cellular concentration of adm were increased significantly (p < 0.05), and the abcg2 protein expression in the tumor cells decreased significantly (p < 0.05). |
2018-11-16 |
2023-08-13 |
mouse |
| Xiang Sun, Longhua Lou, Kezhao Zhong, Lijuan Wa. MicroRNA-451 regulates chemoresistance in renal cell carcinoma by targeting ATF-2 gene. Experimental biology and medicine (Maywood, N.J.). vol 242. issue 12. 2018-10-24. PMID:28429654. |
overexpression of mir-451 strengthened drug resistance, decreased cell viability, and increased cell apoptosis of grc-1 pretreated by adm, while overexpressed atf-2 reversed the effect induced by mir-451 overexpression. |
2018-10-24 |
2023-08-13 |
human |
| Xiang Sun, Longhua Lou, Kezhao Zhong, Lijuan Wa. MicroRNA-451 regulates chemoresistance in renal cell carcinoma by targeting ATF-2 gene. Experimental biology and medicine (Maywood, N.J.). vol 242. issue 12. 2018-10-24. PMID:28429654. |
then mir-451 knockdown improved drug susceptibility, decreased cell apoptosis, and increased cell viability of achn induced by adm, however, atf-2 suppression reversed the low rate of cell apoptosis and high rate of cell viability induced by mir-451 knockdown. |
2018-10-24 |
2023-08-13 |
human |
| Guangshan Yang, Gaofei Fan, Tengyue Zhang, Kelong Ma, Jin Huang, Miao Liu, Xiaolu Teng, Kun Xu, Pingsheng Fan, Dongmiao Chen. Upregulation of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Mediates the Reversal Effect of Verapamil on Chemo-Resistance to Adriamycin of Hepatocellular Carcinoma. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-11. PMID:29627846. |
conclusions upregulation of uchl1 enhanced the reversal effect of ver on chemo-resistance to adm and promoted cell apoptosis. |
2018-09-11 |
2023-08-13 |
Not clear |
| Hongjin Si, Yao Zhang, Yuqing Song, Lili L. Overexpression of adrenomedullin protects mesenchymal stem cells against hypoxia and serum deprivation‑induced apoptosis via the Akt/GSK3β and Bcl‑2 signaling pathways. International journal of molecular medicine. vol 41. issue 6. 2018-09-10. PMID:29512737. |
the present study aimed to investigate the protective effects of adm on mscs against hypoxia and serum deprivation (h/sd)‑induced apoptosis, and to determine the potential underlying mechanisms. |
2018-09-10 |
2023-08-13 |
Not clear |
| Hongjin Si, Yao Zhang, Yuqing Song, Lili L. Overexpression of adrenomedullin protects mesenchymal stem cells against hypoxia and serum deprivation‑induced apoptosis via the Akt/GSK3β and Bcl‑2 signaling pathways. International journal of molecular medicine. vol 41. issue 6. 2018-09-10. PMID:29512737. |
the results indicated that adm overexpression could improve msc proliferation and viability, and protect mscs against h/sd‑induced apoptosis. |
2018-09-10 |
2023-08-13 |
Not clear |
| Hongjin Si, Yao Zhang, Yuqing Song, Lili L. Overexpression of adrenomedullin protects mesenchymal stem cells against hypoxia and serum deprivation‑induced apoptosis via the Akt/GSK3β and Bcl‑2 signaling pathways. International journal of molecular medicine. vol 41. issue 6. 2018-09-10. PMID:29512737. |
these results suggested that adm protects mscs against h/sd‑induced apoptosis, which may be mediated via the akt/gsk3β and bcl‑2 signaling pathways. |
2018-09-10 |
2023-08-13 |
Not clear |
| C-Q Liang, Y-M Fu, Z-Y Liu, B-R Xing, Y Jin, J-L Huan. The effect of miR-224 down-regulation on SW80 cell proliferation and apoptosis and weakening of ADM drug resistance. European review for medical and pharmacological sciences. vol 21. issue 21. 2018-08-07. PMID:29164556. |
the effect of mir-224 down-regulation on sw80 cell proliferation and apoptosis and weakening of adm drug resistance. |
2018-08-07 |
2023-08-13 |
Not clear |
| C-Q Liang, Y-M Fu, Z-Y Liu, B-R Xing, Y Jin, J-L Huan. The effect of miR-224 down-regulation on SW80 cell proliferation and apoptosis and weakening of ADM drug resistance. European review for medical and pharmacological sciences. vol 21. issue 21. 2018-08-07. PMID:29164556. |
this study investigated if mir-224 plays a role in mediating gsk-3β expression, wnt/β-catenin pathway activity, crc cell proliferation, apoptosis as well as drug sensitivity of adriamycin (adm). |
2018-08-07 |
2023-08-13 |
Not clear |
| Liang Liu, Yingchao Ju, Jing Wang, Rongmiao Zho. Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells. Pathology, research and practice. vol 213. issue 10. 2018-07-19. PMID:28964574. |
after treatment of eca109/abcg2 (an esophageal cancer multidrug resistance cell line) cells with adriamycin (adm) combined with egcg for 24h, the cellular apoptosis, mitochondrial membrane potential, adm concentration in cells and abcg2 protein expression were detected by flow cytometry. |
2018-07-19 |
2023-08-13 |
human |
| Liang Liu, Yingchao Ju, Jing Wang, Rongmiao Zho. Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells. Pathology, research and practice. vol 213. issue 10. 2018-07-19. PMID:28964574. |
the rate of apoptosis and adm concentration in the eca109/abcg2 cells following treatment with adm and egcg were higher than that with adm treatment alone, although the mitochondrial membrane potential was significantly lower (p<0.01). |
2018-07-19 |
2023-08-13 |
human |