| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lyndsey E Collins, Daniel J Galtieri, Lise T Brennum, Thomas N Sager, Jörg Hockemeyer, Christa E Müller, James R Hinman, James J Chrobak, John D Salamon. Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX. Pharmacology, biochemistry, and behavior. vol 94. issue 4. 2010-04-29. PMID:19958787. |
tremulous jaw movements in rats, which can be induced by dopamine (da) antagonists, da depletion, and cholinomimetics, have served as a useful model for studies of tremor. |
2010-04-29 |
2023-08-12 |
rat |
| Kenya Nishioka, Mounir Kefi, Barbara Jasinska-Myga, Christian Wider, Carles Vilariño-Güell, Owen A Ross, Michael G Heckman, Lefkos T Middleton, Lianna Ishihara-Paul, Rachel A Gibson, Rim Amouri, Samia Ben Yahmed, Samia Ben Sassi, Mourad Zouari, Ghada El Euch, Matthew J Farrer, Faycal Hentat. A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. vol 81. issue 4. 2010-04-26. PMID:19726410. |
in comparison with genetically undefined patients, lrrk2 mutation carriers had more severe motor symptoms (median unified parkinson's disease rating scale scores approximately 1.6 times higher, p<0.001), a higher rate of dyskinesia (or 4.21, p=0.002) and use of dopamine agonists (or 3.64, p<0.001), and less postural tremor (or 0.21, p<0.001). |
2010-04-26 |
2023-08-12 |
Not clear |
| Jose Luis Ordoñez-Librado, Veronica Anaya-Martinez, Ana Luisa Gutierrez-Valdez, Enrique Montiel-Flores, David Reyes Corona, Daniel Martinez-Fong, Maria Rosa Avila-Cost. L-DOPA treatment reverses the motor alterations induced by manganese exposure as a Parkinson disease experimental model. Neuroscience letters. vol 471. issue 2. 2010-04-16. PMID:20079802. |
after 5 months of mn-mixture inhalation striatal dopamine content decreased 71%, mice developed evident deficits in motor performance manifested as akinesia, postural instability and action tremor; these alterations were reverted with l-dopa treatment. |
2010-04-16 |
2023-08-12 |
mouse |
| Fabiana Novellino, Gennarina Arabia, Antonio Bagnato, Giuseppe Lucio Cascini, Maria Salsone, Giuseppe Nicoletti, Demetrio Messina, Maurizio Morelli, Sandra Paglionico, Laura Giofrè, Antonino Restuccia, Giusi Torchia, Francesca Condino, Aldo Quattron. Combined use of DAT-SPECT and cardiac MIBG scintigraphy in mixed tremors. Movement disorders : official journal of the Movement Disorder Society. vol 24. issue 15. 2010-02-17. PMID:19795467. |
twenty-two patients with mixed tremor and additional mild extrapyramidal features, such as bradykinesia and rigidity, 20 patients with probable pd, 10 patients with probable et, and 18 controls were investigated through the combined use of dopamine transporter (123)i-fp-cit-single-photon emission tomography (dat-spect) and cardiac (123)metaiodobenzylguanidine (migb) scintigraphy. |
2010-02-17 |
2023-08-12 |
Not clear |
| Helen Ling, Andrew J Lee. How can neuroimaging help in the diagnosis of movement disorders? Neuroimaging clinics of North America. vol 20. issue 1. 2010-02-11. PMID:19959023. |
dopamine transporter spect imaging is helpful in distinguishing benign tremulous parkinson disease from atypical tremor syndromes and other clinical scenarios where the demonstration of nigrostriatal dopamine denervation is helpful. |
2010-02-11 |
2023-08-12 |
Not clear |
| Rubing Zhao-Shea, Bruce N Cohen, Herwig Just, Tristan McClure-Begley, Paul Whiteaker, Sharon R Grady, Outi Salminen, Paul D Gardner, Henry A Lester, Andrew R Tappe. Dopamine D2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive {alpha}4 nicotinic receptors via a cholinergic-dependent mechanism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 1. 2010-02-02. PMID:19720621. |
dopamine d2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive {alpha}4 nicotinic receptors via a cholinergic-dependent mechanism. |
2010-02-02 |
2023-08-12 |
mouse |
| Christoph Scherfler, Michael Nocke. Dopamine transporter SPECT: how to remove subjectivity? Movement disorders : official journal of the Movement Disorder Society. vol 24 Suppl 2. 2010-01-26. PMID:19877234. |
single photon emission computed tomography (spect) investigating the striatal dopamine transporter (dat) status have been suggested to increase the diagnostic accuracy in uncertain parkinsonian syndromes such as isolated tremor symptoms not fulfilling essential tremor criteria, as well as drug-induced, vascular and psychogenetic parkinsonism. |
2010-01-26 |
2023-08-12 |
Not clear |
| J Trevitt, K Kawa, A Jalali, C Larse. Differential effects of adenosine antagonists in two models of parkinsonian tremor. Pharmacology, biochemistry, and behavior. vol 94. issue 1. 2009-12-17. PMID:19602422. |
furthermore they indicate that dopamine antagonist-induced tremor models and acetylcholine agonist-induced tremor models are not entirely similar, and caution should be taken when using these models to evaluate novel therapeutics. |
2009-12-17 |
2023-08-12 |
Not clear |
| Yueh-Feng Sung, Yaw-Don Hsu, Wen-Sheng Huan. (99m)Tc-TRODAT-1 SPECT study in evaluation of Holmes tremor after thalamic hemorrhage. Annals of nuclear medicine. vol 23. issue 6. 2009-11-24. PMID:19455387. |
the (99m)tc-trodat-1 spect study is a useful and convenient tool for evaluating the nigrostriatal dopamine function in patients with holmes tremor. |
2009-11-24 |
2023-08-12 |
Not clear |
| Neil E Paterson, Sam A Malekiani, Mark M Foreman, Berend Olivier, Taleen Hanani. Pharmacological characterization of harmaline-induced tremor activity in mice. European journal of pharmacology. vol 616. issue 1-3. 2009-10-19. PMID:19497322. |
the dopamine reuptake inhibitor gbr12909 and the dopamine d(1)/d(2) receptor agonist apomorphine attenuated harmaline-induced tremor. |
2009-10-19 |
2023-08-12 |
mouse |
| Neil E Paterson, Sam A Malekiani, Mark M Foreman, Berend Olivier, Taleen Hanani. Pharmacological characterization of harmaline-induced tremor activity in mice. European journal of pharmacology. vol 616. issue 1-3. 2009-10-19. PMID:19497322. |
further, these data provide additional evidence for the roles of ionotropic glutamate, gaba(a) and dopamine d(2)/d(3) receptors in the neurobiology of harmaline-induced tremor. |
2009-10-19 |
2023-08-12 |
mouse |
| S Seidel, G Kasprian, F Leutmezer, D Prayer, E Auf. Disruption of nigrostriatal and cerebellothalamic pathways in dopamine responsive Holmes' tremor. Journal of neurology, neurosurgery, and psychiatry. vol 80. issue 8. 2009-07-30. PMID:18450789. |
disruption of nigrostriatal and cerebellothalamic pathways in dopamine responsive holmes' tremor. |
2009-07-30 |
2023-08-12 |
Not clear |
| David H Benninger, Sebastian Thees, Spyros S Kollias, Claudio L Bassetti, Daniel Waldvoge. Morphological differences in Parkinson's disease with and without rest tremor. Journal of neurology. vol 256. issue 2. 2009-07-14. PMID:19219572. |
nigro-striatal dopamine deficiency correlates best with bradykinesia, but not with tremor. |
2009-07-14 |
2023-08-12 |
Not clear |
| Roberto Ceravolo, Angelo Antonini, Duccio Volterrani, Carlo Rossi, Lorenzo Kiferle, Daniela Frosini, Claudio Lucetti, Ioannis U Isaias, Riccardo Benti, Luigi Murri, Ubaldo Bonuccell. Predictive value of nigrostriatal dysfunction in isolated tremor: a clinical and SPECT study. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 14. 2009-04-08. PMID:18759337. |
we investigated dopamine transporter binding in 61 subjects presenting with isolated atypical tremors defined as unilateral either postural, resting, or mixed (i.e. |
2009-04-08 |
2023-08-12 |
human |
| M Weinberger, W D Hutchison, A M Lozano, M Hodaie, J O Dostrovsk. Increased gamma oscillatory activity in the subthalamic nucleus during tremor in Parkinson's disease patients. Journal of neurophysiology. vol 101. issue 2. 2009-03-26. PMID:19004998. |
rest tremor is one of the main symptoms in parkinson's disease (pd), although in contrast to rigidity and akinesia, the severity of the tremor does not correlate well with the degree of dopamine deficiency or the progression of the disease. |
2009-03-26 |
2023-08-12 |
human |
| John D Salamone, Keita Ishiwari, Adrienne J Betz, Andrew M Farrar, Susana M Mingote, Laura Font, Jörg Hockemeyer, Christa E Müller, Mercè Corre. Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism. Parkinsonism & related disorders. vol 14 Suppl 2. 2008-12-12. PMID:18585081. |
recent experiments studied the ability of msx-3 (an adenosine a(2a) antagonist) to reverse the locomotor suppression and tremor produced by dopamine antagonists in rats. |
2008-12-12 |
2023-08-12 |
rat |
| Colleen M Niswender, Kari A Johnson, C David Weaver, Carrie K Jones, Zixiu Xiang, Qingwei Luo, Alice L Rodriguez, Joy E Marlo, Tomas de Paulis, Analisa D Thompson, Emily L Days, Tasha Nalywajko, Cheryl A Austin, Michael Baxter Williams, Jennifer E Ayala, Richard Williams, Craig W Lindsley, P Jeffrey Con. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Molecular pharmacology. vol 74. issue 5. 2008-11-17. PMID:18664603. |
parkinson's disease (pd) is caused by the death of dopamine neurons in the basal ganglia and results in motor symptoms such as tremor and bradykinesia. |
2008-11-17 |
2023-08-12 |
human |
| N J Ray, N Jenkinson, S Wang, P Holland, J S Brittain, C Joint, J F Stein, T Azi. Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation. Experimental neurology. vol 213. issue 1. 2008-09-15. PMID:18619592. |
depth recordings after this procedure have revealed excessive activity at frequencies between 8 and 35 hz (brown et al., 2001; kuhn et al., 2004; priori et al., 2004) that are reduced by dopamine therapy in tandem with improvements in bradykinesia/rigidity, but not tremor (kuhn et al., 2006). |
2008-09-15 |
2023-08-12 |
Not clear |
| N Simola, M Morelli, A Pinn. Adenosine A2A receptor antagonists and Parkinson's disease: state of the art and future directions. Current pharmaceutical design. vol 14. issue 15. 2008-07-24. PMID:18537671. |
furthermore, adenosine a(2a) receptor antagonists appear to exert a marked efficacy on pd tremor and in reducing the progress of underlying neurodegeneration and maladaptive neuroplasticity that complicates standard dopamine replacement treatments in pd. |
2008-07-24 |
2023-08-12 |
Not clear |
| John T Gale, Ramin Amirnovin, Ziv M Williams, Alice W Flaherty, Emad N Eskanda. From symphony to cacophony: pathophysiology of the human basal ganglia in Parkinson disease. Neuroscience and biobehavioral reviews. vol 32. issue 3. 2008-05-27. PMID:17466375. |
among these are the antagonist balance hypothesis wherein increased firing rates in the indirect pathway inhibits movement; the selectivity hypothesis wherein loss of neuronal selectivity leads to an inability to select or initiate movements; the firing pattern hypothesis wherein increased oscillation and synchronization contribute to tremor and disrupt information flow; and the learning hypothesis, wherein the basal ganglia are conceived as playing an important role in learning sensory-motor associations which is disrupted by the loss of dopamine. |
2008-05-27 |
2023-08-12 |
human |