| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manuel Menéndez-González, Francisco Tavares, Nahla Zeidan, José M Salas-Pacheco, Oscar Arias-Carrió. Diagnoses behind patients with hard-to-classify tremor and normal DaT-SPECT: a clinical follow up study. Frontiers in aging neuroscience. vol 6. 2014-04-18. PMID:24744729. |
the [(123)i]ioflupane-a dopamine transporter radioligand-spect (dat-spect) has proven to be useful in the differential diagnosis of tremor. |
2014-04-18 |
2023-08-13 |
Not clear |
| Marla B Bruns, Keith A Joseph. Neuropsychiatry of corticobasal degeneration and progressive supranuclear palsy. International review of psychiatry (Abingdon, England). vol 25. issue 2. 2014-01-06. PMID:23611349. |
corticobasal syndrome (cbs) and progressive supranuclear palsy syndrome (psps) are two of the atypical parkinsonism syndromes, in that patients exhibit rigidity, occasional tremor and postural instability, but do not symptomatically respond to dopamine replacement. |
2014-01-06 |
2023-08-12 |
Not clear |
| Pedro Porto Alegre Baptista, Priscylla Nunes de Senna, Mariana Fontoura Paim, Lisiani Saur, Martina Blank, Patricia do Nascimento, Jocemar Ilha, Mônica Ryff Moreira Vianna, Régis Gemerasca Mestriner, Matilde Achaval, Léder Leal Xavie. Physical exercise down-regulated locomotor side effects induced by haloperidol treatment in Wistar rats. Pharmacology, biochemistry, and behavior. vol 104. 2013-09-17. PMID:23290938. |
extra-pyramidal symptoms (eps) such as akinesia, dystonia, gait alteration and tremors are observed when dopamine d2-receptors are blocked by pharmacological agents such as haloperidol. |
2013-09-17 |
2023-08-12 |
rat |
| Scott Ayton, Jessica L George, Paul A Adlard, Ashley I Bush, Robert A Cherny, David I Finkelstei. The effect of dopamine on MPTP-induced rotarod disability. Neuroscience letters. vol 543. 2013-09-06. PMID:23562518. |
dopamine depletion in parkinson's disease (pd) results in bradykinesia and tremor. |
2013-09-06 |
2023-08-12 |
mouse |
| Alessandro Stefani, Francesco Marzetti, Mariangela Pierantozzi, Simona Petrucci, Enrica Olivola, Salvatore Galati, Mario Stampanoni Bassi, Paola Imbriani, Enza Maria Valente, Francesco Saverio Pastor. Successful subthalamic stimulation, but levodopa-induced dystonia, in a genetic Parkinson's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 3. 2013-09-04. PMID:22437494. |
before surgery, the combination of ld and dopamine agonists failed to handle tremor unless administered at doses, which induced undesirable adverse events. |
2013-09-04 |
2023-08-12 |
Not clear |
| N P S Bajaj, L Wang, V Gontu, D G Grosset, P G Bai. Accuracy of subjective and objective handwriting assessment for differentiating Parkinson's disease from tremulous subjects without evidence of dopaminergic deficits (SWEDDs): an FP-CIT-validated study. Journal of neurology. vol 259. issue 11. 2013-08-22. PMID:22532169. |
we analyzed the accuracy of subjective and objective assessment of handwriting samples for distinguishing 27 pd cases, 22 with tremulous pd, and five with akinetic-rigid pd, from 39 movement-disorder patients with normal presynaptic dopamine imaging (subjects without evidence of dopamine deficiency or swedds; 31 with dystonic tremor (dt), six indeterminate tremor syndrome, one essential tremor, one vascular parkinsonism). |
2013-08-22 |
2023-08-12 |
human |
| Wacław Kolasiewicz, Katarzyna Kuter, Klemencja Berghauzen, Przemysław Nowak, Gert Schulze, Krystyna Ossowsk. 6-OHDA injections into A8-A9 dopaminergic neurons modelling early stages of Parkinson's disease increase the harmaline-induced tremor in rats. Brain research. vol 1477. 2013-02-27. PMID:22902616. |
in the caudate-putamen, the ipsi/contra ratio of dopamine level correlated negatively, while that of dopamine turnover positively with the tremor intensity. |
2013-02-27 |
2023-08-12 |
rat |
| Rick C Helmich, Mark Hallett, Günther Deuschl, Ivan Toni, Bastiaan R Bloe. Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits? Brain : a journal of neurology. vol 135. issue Pt 11. 2013-02-04. PMID:22382359. |
pathophysiologically, tremor is linked to altered activity in not one, but two distinct circuits: the basal ganglia, which are primarily affected by dopamine depletion in parkinson's disease, and the cerebello-thalamo-cortical circuit, which is also involved in many other tremors. |
2013-02-04 |
2023-08-12 |
Not clear |
| Yasushi Takagi, Jun Takahash. Primate embryonic stem cells as a source of dopaminergic neurons: A novel transplantation for Parkinson's disease. Discovery medicine. vol 5. issue 26. 2012-10-02. PMID:20704914. |
while being the precursor to dopamine synthesis, l-dihydroxyphenylalanine (l-dopa) can initially improve the symptoms of the disease, such as resting tremor and a poverty of movement, its effectiveness diminishes with time. |
2012-10-02 |
2023-08-12 |
Not clear |
| Garrett E Alexande. Biology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder. Dialogues in clinical neuroscience. vol 6. issue 3. 2012-09-10. PMID:22033559. |
the characteristic motor impairments - bradykinesia, rigidity, and resting tremor - result from degenerative loss of midbrain dopamine (da) neurons in the substantia nigra, and are responsive to symptomatic treatment with dopaminergic medications and functional neurosurgery. |
2012-09-10 |
2023-08-12 |
human |
| Mark Hallet. Parkinson's disease tremor: pathophysiology. Parkinsonism & related disorders. vol 18 Suppl 1. 2012-08-27. PMID:22166464. |
as a manifestation of parkinson's disease, it is separate from bradykinesia and rigidity as the magnitude of tremor is not related to dopamine deficiency nor does it respond readily to dopamine treatment. |
2012-08-27 |
2023-08-12 |
Not clear |
| Chun-Yi Lin, Chung-Hsin Yeh, Tien-Tien Chang, Chia-Hong Kao, Song-Yen Tsa. Smoking, dopamine transporter, and hand tremor. Clinical nuclear medicine. vol 37. issue 1. 2012-04-18. PMID:22157025. |
smoking, dopamine transporter, and hand tremor. |
2012-04-18 |
2023-08-12 |
Not clear |
| Anthony H V Schapir. Monoamine oxidase B inhibitors for the treatment of Parkinson's disease: a review of symptomatic and potential disease-modifying effects. CNS drugs. vol 25. issue 12. 2012-04-04. PMID:22133327. |
although the resulting dopamine deficiency is the cause of the typical motor features of parkinson's disease (bradykinesia, rigidity, tremor), additional non-motor symptoms appear at various timepoints and are the result of non-dopamine nerve degeneration. |
2012-04-04 |
2023-08-12 |
Not clear |
| Jeffrey L Cummings, Claire Henchcliffe, Sharon Schaier, Tanya Simuni, Alan Waxman, Paul Kem. The role of dopaminergic imaging in patients with symptoms of dopaminergic system neurodegeneration. Brain : a journal of neurology. vol 134. issue Pt 11. 2012-01-18. PMID:21810889. |
in patients in whom there was diagnostic uncertainty between degenerative parkinsonism and non-degenerative tremor disorders, baseline imaging with the dopamine transporter ligand [(123)i]ioflupane (datscan™) has shown 78% sensitivity and 97% specificity with reference to clinical diagnosis at 3 years, versus 93% and 46%, respectively, for baseline clinical diagnosis. |
2012-01-18 |
2023-08-12 |
Not clear |
| José Luis Ordoñez-Librado, Verónica Anaya-Martínez, Ana Luisa Gutierrez-Valdez, Laura Colín-Barenque, Enrique Montiel-Flores, Maria Rosa Avila-Cost. Manganese inhalation as a Parkinson disease model. Parkinson's disease. vol 2011. 2011-07-14. PMID:21209715. |
after 5 months of mn mixture inhalation, striatal dopamine content decreased 71%, the snc showed important reduction in the number of th-immunopositive neurons, mice developed akinesia, postural instability, and action tremor; these motor alterations were reverted with l-dopa treatment. |
2011-07-14 |
2023-08-12 |
mouse |
| Frederick P Bellinger, Miyoko T Bellinger, Lucia A Seale, Andrea S Takemoto, Arjun V Raman, Takanori Miki, Amy B Manning-Boğ, Marla J Berry, Lon R White, G Webster Ros. Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain. Molecular neurodegeneration. vol 6. issue 1. 2011-07-14. PMID:21255396. |
parkinson's disease is a neurodegenerative disorder characterized pathologically by the loss of nigrostriatal dopamine neurons that project from the substantia nigra in the midbrain to the putamen and caudate nuclei, leading to the clinical features of bradykinesia, rigidity, and rest tremor. |
2011-07-14 |
2023-08-12 |
Not clear |
| Claire Delaville, Philippe De Deurwaerdère, Abdelhamid Benazzou. Noradrenaline and Parkinson's disease. Frontiers in systems neuroscience. vol 5. 2011-07-14. PMID:21647359. |
parkinson's disease (pd) is characterized by the degeneration of dopamine (da) neurons in the substantia nigra pars compacta, and motor symptoms including bradykinesia, rigidity, and tremor at rest. |
2011-07-14 |
2023-08-12 |
Not clear |
| Rick C Helmich, Marcel J R Janssen, Wim J G Oyen, Bastiaan R Bloem, Ivan Ton. Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor. Annals of neurology. vol 69. issue 2. 2011-05-11. PMID:21387372. |
parkinson disease (pd) is characterized by striatal dopamine depletion, which explains clinical symptoms such as bradykinesia and rigidity, but not resting tremor. |
2011-05-11 |
2023-08-12 |
Not clear |
| Ioannis U Isaias, Giorgio Marotta, Shigeki Hirano, Margherita Canesi, Riccardo Benti, Andrea Righini, Chengke Tang, Roberto Cilia, Gianni Pezzoli, David Eidelberg, Angelo Antonin. Imaging essential tremor. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 6. 2010-07-28. PMID:20437537. |
however, mild impairment of dopamine transporter in the caudate nucleus may contribute to tremor onset in et. |
2010-07-28 |
2023-08-12 |
human |
| Petra Schwingenschuh, Diane Ruge, Mark J Edwards, Carmen Terranova, Petra Katschnig, Fatima Carrillo, Laura Silveira-Moriyama, Susanne A Schneider, Georg Kägi, Francisco J Palomar, Penelope Talelli, John Dickson, Andrew J Lees, Niall Quinn, Pablo Mir, John C Rothwell, Kailash P Bhati. Distinguishing SWEDDs patients with asymmetric resting tremor from Parkinson's disease: a clinical and electrophysiological study. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 5. 2010-07-23. PMID:20131394. |
electrophysiological tremor parameters and also response to a cortical plasticity protocol using paired associative stimulation (pas) was studied in 9 patients with swedds, 9 with tremor-dominant pd (with abnormal dopamine transporter single photon emission computed tomography findings), 8 with segmental dystonia, and 8 with essential tremor (et). |
2010-07-23 |
2023-08-12 |
Not clear |