| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helle Bogetofte, Arezo Alamyar, Morten Blaabjerg, Morten Meye. Levodopa Therapy for Parkinson's Disease: History, Current Status and Perspectives. CNS & neurological disorders drug targets. vol 19. issue 8. 2021-11-02. PMID:32703142. |
this results in a profound decrease of striatal dopamine (da) levels, which in turn leads to the cardinal motor symptoms of pd; muscle rigidity, hypo- and bradykinesia and resting tremor. |
2021-11-02 |
2023-08-13 |
Not clear |
| Don Gueu Park, Young Sil An, Jung Han Yoo. Serial 18F-FP-CIT and FDG PET in Fulminant Corticobasal Syndrome. Clinical nuclear medicine. vol 46. issue 9. 2021-10-15. PMID:34374680. |
we experienced a rapidly progressing cbs patient (onset to bed-ridden within 2 years) presenting only with resting tremor but showing complete unilateral loss of dopamine transporter binding. |
2021-10-15 |
2023-08-13 |
Not clear |
| Daniele Caligiore, Francesco Montedori, Silvia Buscaglione, Adriano Capirchi. Increasing Serotonin to Reduce Parkinsonian Tremor. Frontiers in systems neuroscience. vol 15. 2021-08-07. PMID:34354572. |
this lack of consistency could be explained by considering recent evidence suggesting that pd resting tremor can be divided into different partially overlapping phenotypes based on the dopamine response. |
2021-08-07 |
2023-08-13 |
human |
| Daniele Caligiore, Francesco Montedori, Silvia Buscaglione, Adriano Capirchi. Increasing Serotonin to Reduce Parkinsonian Tremor. Frontiers in systems neuroscience. vol 15. 2021-08-07. PMID:34354572. |
the simulations run with the model demonstrate that a physiological serotonin increase can partially recover dopamine levels at the early stages of the disease before the manifestation of overt tremor. |
2021-08-07 |
2023-08-13 |
human |
| Daniele Caligiore, Francesco Montedori, Silvia Buscaglione, Adriano Capirchi. Increasing Serotonin to Reduce Parkinsonian Tremor. Frontiers in systems neuroscience. vol 15. 2021-08-07. PMID:34354572. |
the simulations also show the effectiveness of a new pharmacological treatment for tremor that acts on serotonin to recover dopamine levels. |
2021-08-07 |
2023-08-13 |
human |
| Alessandro F Fois, Florence Cf Chang, Robert Barnett, Kevin London, Neil Mahant, Ainhi Ha, Zakiyah Aldaajani, Belinda Cruse, Hugo Morales-Briceno, Kit Kwan Ma, David Farlow, Victor Sc Fun. Rest tremor correlates with reduced contralateral striatal dopamine transporter binding in Parkinson's disease. Parkinsonism & related disorders. vol 85. 2021-07-22. PMID:33799200. |
rest tremor correlates with reduced contralateral striatal dopamine transporter binding in parkinson's disease. |
2021-07-22 |
2023-08-13 |
Not clear |
| Alessandro F Fois, Florence Cf Chang, Robert Barnett, Kevin London, Neil Mahant, Ainhi Ha, Zakiyah Aldaajani, Belinda Cruse, Hugo Morales-Briceno, Kit Kwan Ma, David Farlow, Victor Sc Fun. Rest tremor correlates with reduced contralateral striatal dopamine transporter binding in Parkinson's disease. Parkinsonism & related disorders. vol 85. 2021-07-22. PMID:33799200. |
bradykinesia, rigidity, hypomimia) correlate well with reduced striatal dopamine transporter binding, the same relationship has not been demonstrated for tremor. |
2021-07-22 |
2023-08-13 |
Not clear |
| Alessandro F Fois, Florence Cf Chang, Robert Barnett, Kevin London, Neil Mahant, Ainhi Ha, Zakiyah Aldaajani, Belinda Cruse, Hugo Morales-Briceno, Kit Kwan Ma, David Farlow, Victor Sc Fun. Rest tremor correlates with reduced contralateral striatal dopamine transporter binding in Parkinson's disease. Parkinsonism & related disorders. vol 85. 2021-07-22. PMID:33799200. |
we investigated the relationship between striatal dopamine transporter binding and quantitative measures of tremor. |
2021-07-22 |
2023-08-13 |
Not clear |
| Amy Bullock, Inder Kaul, Sigui Li, Christopher Silber, James Doherty, Stephen J Kane. Zuranolone as an oral adjunct to treatment of Parkinsonian tremor: A phase 2, open-label study. Journal of the neurological sciences. vol 421. 2021-05-14. PMID:33387701. |
among cardinal symptoms of this disorder, tremor is the least responsive to dopamine replacement therapy and is often undertreated. |
2021-05-14 |
2023-08-13 |
Not clear |
| Maham Sanawar, Uzma Saleem, Fareeha Anwar, Samra Nazir, Muhammad Furqan Akhtar, Bashir Ahmad, Tariq Ismai. Investigation of anti-Parkinson activity of dicyclomine. The International journal of neuroscience. 2021-05-10. PMID:32847457. |
anticholinergics act by normalizing the disequilibrium between striatal dopamine and acetylcholine-resulted reduction in tremors. |
2021-05-10 |
2023-08-13 |
Not clear |
| Annelies J van Nuland, Rick C Helmich, Michiel F Dirkx, Heidemarie Zach, Ivan Toni, Roshan Cools, Hanneke E M den Oude. Effects of dopamine on reinforcement learning in Parkinson's disease depend on motor phenotype. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33147621. |
this variability in tremor relates to variation in cognitive/motivational impairment, as well as the spatial distribution of neurodegeneration in the midbrain and dopamine depletion in the striatum. |
2021-03-01 |
2023-08-13 |
human |
| Annelies J van Nuland, Rick C Helmich, Michiel F Dirkx, Heidemarie Zach, Ivan Toni, Roshan Cools, Hanneke E M den Oude. Effects of dopamine on reinforcement learning in Parkinson's disease depend on motor phenotype. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33147621. |
here we ask whether interindividual heterogeneity in tremor symptoms could account for the puzzlingly large variability in the effects of dopaminergic medication on reinforcement learning, a fundamental cognitive function known to rely on dopamine. |
2021-03-01 |
2023-08-13 |
human |
| Sanjay G Manoha. Tremor in Parkinson's disease inverts the effect of dopamine on reinforcement. Brain : a journal of neurology. vol 143. issue 11. 2021-02-22. PMID:33278817. |
tremor in parkinson's disease inverts the effect of dopamine on reinforcement. |
2021-02-22 |
2023-08-13 |
Not clear |
| Fillipe M de Araújo, Lorena Cuenca-Bermejo, Emiliano Fernández-Villalba, Silvia L Costa, Victor Diogenes A Silva, Maria Trinidad Herrer. Role of Microgliosis and NLRP3 Inflammasome in Parkinson's Disease Pathogenesis and Therapy. Cellular and molecular neurobiology. 2021-01-02. PMID:33387119. |
parkinson's disease (pd) is a neurodegenerative disorder marked primarily by motor symptoms such as rigidity, bradykinesia, postural instability and resting tremor associated with dopaminergic neuronal loss in the substantia nigra pars compacta (snpc) and deficit of dopamine in the basal ganglia. |
2021-01-02 |
2023-08-13 |
Not clear |
| Jincheol Seo, Jinyoung Won, Keonwoo Kim, Junghyung Park, Hyeon-Gu Yeo, Yu Gyeong Kim, Seung Ho Baek, Hoonwon Lee, Chang-Yeop Jeon, Won Seok Choi, Sangil Lee, Ki Jin Kim, Sung-Hyun Park, Yeonghoon Son, Kang Jin Jeong, Kyung Seob Lim, Philyong Kang, Hwal-Yong Lee, Hee-Chang Son, Jae-Won Huh, Young-Hyun Kim, Dong-Seok Lee, Sang-Rae Lee, Ji-Woong Choi, Youngjeon Le. Impaired Hand Dexterity Function in a Non-human Primate Model with Chronic Parkinson's Disease. Experimental neurobiology. vol 29. issue 5. 2020-11-14. PMID:33154199. |
to validate this assessment, we analyzed the alteration in parkinsonian tremor signs and the functionality of presynaptic dopaminergic neuron using positron emission tomography imaging of dopamine transporters in these models. |
2020-11-14 |
2023-08-13 |
Not clear |
| Dirk Balke, Lars Tatenhorst, Vivian Dambeck, Vinicius Toledo Ribas, Björn F Vahsen, Uwe Michel, Mathias Bähr, Paul Lingo. AAV-Mediated Expression of Dominant-Negative ULK1 Increases Neuronal Survival and Enhances Motor Performance in the MPTP Mouse Model of Parkinson's Disease. Molecular neurobiology. vol 57. issue 2. 2020-11-05. PMID:31446549. |
loss of nigrostriatal projections by axonal degeneration is a key early event in parkinson's disease (pd) pathophysiology, being accountable for the lack of dopamine in the nigrostriatal system and resulting in motor symptoms such as bradykinesia, rigidity, and tremor. |
2020-11-05 |
2023-08-13 |
mouse |
| Heidemarie Zach, Michiel F Dirkx, Dominik Roth, Jaco W Pasman, Bastiaan R Bloem, Rick C Helmic. Dopamine-responsive and dopamine-resistant resting tremor in Parkinson disease. Neurology. vol 95. issue 11. 2020-11-04. PMID:32651292. |
we also investigated whether this pattern is specific to tremor by comparing interindividual differences in the dopamine response of tremor to that of bradykinesia. |
2020-11-04 |
2023-08-13 |
Not clear |
| Michinori Koebisu, Takayuki Ishid. [Safinamide Mesilate (Equfina Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 155. issue 4. 2020-11-02. PMID:32612042. |
dopamine deficiency is thought to disrupt motor control of the basal ganglia and cause characteristic motor symptoms in parkinson's disease such as bradykinesia, akinesia, and tremor. |
2020-11-02 |
2023-08-13 |
rat |
| Khadga Raj, Pooja Chawla, Shamsher Sing. Neurobehavioral Consequences Associated with Long Term Tramadol Utilization and Pathological Mechanisms. CNS & neurological disorders drug targets. vol 18. issue 10. 2020-10-13. PMID:31721720. |
the reduced level of dopamine may produce bradykinesia and tremors which are chief motor abnormalities in parkinson's disease (pd). |
2020-10-13 |
2023-08-13 |
Not clear |
| Daniele Caligiore, Francesco Mannella, Gianluca Baldassarr. Different Dopaminergic Dysfunctions Underlying Parkinsonian Akinesia and Tremor. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31191237. |
as a consequence, current dopamine medications cannot be tailored to the specific dysfunctions of patients with the result that generic drug therapies produce different effects on akinesia and tremor. |
2020-09-30 |
2023-08-13 |
Not clear |