| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Künig, O Pogarell, J C Möller, M Delf, W H Oerte. Pramipexole, a nonergot dopamine agonist, is effective against rest tremor in intermediate to advanced Parkinson's disease. Clinical neuropharmacology. vol 22. issue 5. 1999-11-04. PMID:10516884. |
pramipexole, a nonergot dopamine agonist, is effective against rest tremor in intermediate to advanced parkinson's disease. |
1999-11-04 |
2023-08-12 |
Not clear |
| M D Lindner, C K Cain, M A Plone, B R Frydel, T J Blaney, D F Emerich, M R Hoan. Incomplete nigrostriatal dopaminergic cell loss and partial reductions in striatal dopamine produce akinesia, rigidity, tremor and cognitive deficits in middle-aged rats. Behavioural brain research. vol 102. issue 1-2. 1999-09-10. PMID:10403011. |
incomplete nigrostriatal dopaminergic cell loss and partial reductions in striatal dopamine produce akinesia, rigidity, tremor and cognitive deficits in middle-aged rats. |
1999-09-10 |
2023-08-12 |
rat |
| M D Lindner, C K Cain, M A Plone, B R Frydel, T J Blaney, D F Emerich, M R Hoan. Incomplete nigrostriatal dopaminergic cell loss and partial reductions in striatal dopamine produce akinesia, rigidity, tremor and cognitive deficits in middle-aged rats. Behavioural brain research. vol 102. issue 1-2. 1999-09-10. PMID:10403011. |
akinesia, rigidity, tremor and visuospatial cognitive deficits) can be quantified in rats with incomplete nigrostriatal dopaminergic cell loss and partial reductions in striatal dopamine levels (2) parkinsonian symptoms were more evident in middle-aged rats with 6-ohda infusions, and (3) there was evidence of substantial neuroplasticity in the older rats, but regardless of the age of the animal, endogenous compensatory mechanisms were unable to maintain striatal dopamine levels after rapid, lesion-induced nigrostriatal cell loss. |
1999-09-10 |
2023-08-12 |
rat |
| A Schrag, L Schelosky, U Scholz, W Poew. Reduction of Parkinsonian signs in patients with Parkinson's disease by dopaminergic versus anticholinergic single-dose challenges. Movement disorders : official journal of the Movement Disorder Society. vol 14. issue 2. 1999-06-15. PMID:10091618. |
in only one patient was tremor reduced by the dopamine agonist but not by the anticholinergic. |
1999-06-15 |
2023-08-12 |
Not clear |
| N Hayase, N Miyashita, K Endo, H Narabayash. Neuronal activity in GP and Vim of parkinsonian patients and clinical changes of tremor through surgical interventions. Stereotactic and functional neurosurgery. vol 71. issue 1. 1999-04-27. PMID:10072670. |
basal ganglia pathology due to dopamine depletion could generate oscillatory neuronal activity in gpi, which may cause tremor. |
1999-04-27 |
2023-08-12 |
human |
| J D Salamone, A J Mayorga, J T Trevitt, M S Cousins, A Conlan, A Nawa. Tremulous jaw movements in rats: a model of parkinsonian tremor. Progress in neurobiology. vol 56. issue 6. 1999-03-23. PMID:9871939. |
although the clinical significance of these movements has been a subject of some debate, considerable evidence indicates that the non-directed, chewing-like movements induced by cholinomimetics, dopamine antagonists and dopamine depletions have many of the characteristics of parkinsonian tremor. |
1999-03-23 |
2023-08-12 |
human |
| M Finn, A Jassen, P Baskin, J D Salamon. Tremulous characteristics of the vacuous jaw movements induced by pilocarpine and ventrolateral striatal dopamine depletions. Pharmacology, biochemistry, and behavior. vol 57. issue 1-2. 1997-07-30. PMID:9164578. |
these experiments indicate that vacuous jaw movements induced by pilocarpine and striatal dopamine depletion occur in a frequency range similar to that shown in parkinsonian tremor. |
1997-07-30 |
2023-08-12 |
rat |
| J M Delfs, V M Ciaramitaro, J J Soghomonian, M F Chessele. Unilateral nigrostriatal lesions induce a bilateral increase in glutamate decarboxylase messenger RNA in the reticular thalamic nucleus. Neuroscience. vol 71. issue 2. 1997-03-13. PMID:9053794. |
in view of the role of the reticular thalamic nucleus in tremor and attentional processes, which are altered in parkinson's disease, this effect may contribute to the clinical manifestations of nigrostriatal dopamine depletion. |
1997-03-13 |
2023-08-12 |
rat |
| H Ima. Clinicophysiological features of akinesia. European neurology. vol 36 Suppl 1. 1996-12-03. PMID:8791015. |
in 1972 barbeau first described pure akinesia without rigidity or tremor responsive to l-dopa therapy, that is, akinesia due to striatal dopamine deficiency. |
1996-12-03 |
2023-08-12 |
Not clear |
| M Ebadi, S K Srinivasan, M D Bax. Oxidative stress and antioxidant therapy in Parkinson's disease. Progress in neurobiology. vol 48. issue 1. 1996-10-16. PMID:8830346. |
parkinson's disease, known also as striatal dopamine deficiency syndrome, is a degenerative disorder of the central nervous system characterized by akinesia, muscular rigidity, tremor at rest, and postural abnormalities. |
1996-10-16 |
2023-08-12 |
human |
| L Smith, M De Salvia, P Jenner, C D Marsde. An appraisal of the antiparkinsonian activity of piribedil in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets. Movement disorders : official journal of the Movement Disorder Society. vol 11. issue 2. 1996-08-16. PMID:8684381. |
the d2 dopamine agonist piribedil is not widely used in the treatment of parkinson's disease because it was thought to be effective mainly on parkinsonian tremor and to produce a high incidence of peripheral side effects, particular nausea. |
1996-08-16 |
2023-08-12 |
marmoset |
| H Narabayash. The neural mechanisms and progressive nature of symptoms of Parkinson's disease--based on clinical, neurophysiological and morphological studies. Journal of neural transmission. Parkinson's disease and dementia section. vol 10. issue 1. 1996-06-18. PMID:8619910. |
the neural mechanism of parkinsonian motor symptoms, i.e., rigidity, tremor and akinesia, which are the result of nigrostriatal dopamine deficiency, is interpreted from long-term observations on the effect of surgical and pharmacological treatment of the disease in relation to the neuropathological findings within the substantia nigra zona compacta (snc). |
1996-06-18 |
2023-08-12 |
Not clear |
| F Cardos. [Treatment of Parkinson disease]. Arquivos de neuro-psiquiatria. vol 53. issue 1. 1995-11-07. PMID:7575192. |
other drugs that may be used are anticholinergic agents, useful for tremor; amantadine, for rigidity and bradykinesia; dopamine agonists, for the management of levodopa complications; and selegiline which may be a neuroprotector agent. |
1995-11-07 |
2023-08-12 |
Not clear |
| L V Laitine. Ventroposterolateral pallidotomy. Stereotactic and functional neurosurgery. vol 62. issue 1-4. 1995-09-07. PMID:7631088. |
recent laboratory experiments have produced increasing evidence that nigral-striatal dopamine deficiency causes an inhibitory hyperactivity in the medial globus pallidus (mgp), where it freezes the initiation of movement and thus causes bradykinesia, rigidity and tremor. |
1995-09-07 |
2023-08-12 |
Not clear |
| X D Zhu, E Giacobini, J M Hornsperge. Effect of MDL 73,745 on acetylcholine and biogenic amine levels in rat cortex. European journal of pharmacology. vol 276. issue 1-2. 1995-07-18. PMID:7781701. |
the increases of norepinephrine and dopamine levels reached a maximum of 124% and 370%, respectively, and continued for a period of at least 8 h. cholinergic side-effects were most marked at the 10 mg/kg dose but were also noticeable at the 2 mg/kg dose in the form of fasciculations, tremor and splay. |
1995-07-18 |
2023-08-12 |
rat |
| P Remy, A de Recondo, G Defer, C Loc'h, P Amarenco, V Planté-Bordeneuve, M H Dao-Castellana, B Bendriem, C Crouzel, M Clane. Peduncular 'rubral' tremor and dopaminergic denervation: a PET study. Neurology. vol 45. issue 3 Pt 1. 1995-04-27. PMID:7898699. |
our results indicate an important involvement of the nigral dopaminergic system in peduncular tremors that appears to be independent of postsynaptic dopamine receptors. |
1995-04-27 |
2023-08-12 |
Not clear |
| M Hara, M Sasa, A Kawabata, T Serikawa, T Yamada, J Yamada, S Takaor. Decreased dopamine and increased norepinephrine levels in the spontaneously epileptic rat, a double mutant rat. Epilepsia. vol 34. issue 3. 1993-07-08. PMID:8504778. |
dopamine (da) and norepinephrine (ne) brain levels and turnover rate were examined in the spontaneously epileptic rat (ser: zi/zi, tm/tm), a double mutant rat obtained by mating tremor heterozygotes (tm/+) with zitter homozygotes associated with epileptic seizures composed of spontaneously occurring tonic convulsion and absence-like seizure. |
1993-07-08 |
2023-08-12 |
rat |
| P Rondot, M Ziegle. Activity and acceptability of piribedil in Parkinson's disease: a multicentre study. Journal of neurology. vol 239 Suppl 1. 1992-08-25. PMID:1634909. |
several controlled trials have shown that the dopamine agonist, trivastal (piribedil), is active in the treatment of parkinson's disease, particularly with regard to tremor. |
1992-08-25 |
2023-08-11 |
Not clear |
| M Stacy, J Jankovi. Tardive tremor. Movement disorders : official journal of the Movement Disorder Society. vol 7. issue 1. 1992-05-04. PMID:1348352. |
we describe five patients in whom tremor occurred after chronic treatment with neuroleptics, was aggravated by and persisted after neuroleptic withdrawal, and improved after treatment with the dopamine depleting drug tetrabenazine. |
1992-05-04 |
2023-08-11 |
Not clear |
| A Battista, K Fuxe, M Goldstein, T Miyamot. Effect of ventromedial tegmental lesions on central catecholamine neurons of monkey brain: involvement of dopamine pathways in tremor and involuntary movements. Medical biology. vol 52. issue 1. 1991-04-11. PMID:4220350. |
effect of ventromedial tegmental lesions on central catecholamine neurons of monkey brain: involvement of dopamine pathways in tremor and involuntary movements. |
1991-04-11 |
2023-08-11 |
monkey |