| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hidetomo Tanaka, Seojin Lee, Ivan Martinez-Valbuena, Blas Couto, Maria Carmela Tartaglia, Javier Sanchez-Ruiz de Gordoa, M Elena Erro, Anthony E Lang, Shelley L Forrest, Gabor G Kovac. Ageing-related tau astrogliopathy severely affecting the substantia nigra. Neuropathology and applied neurobiology. vol 50. issue 4. 2024-07-22. PMID:39036836. |
astrocytic tau pathology is a major feature of tauopathies and ageing-related tau astrogliopathy (artag). |
2024-07-22 |
2024-07-24 |
Not clear |
| Davide Di Lorenz. Tau Protein and Tauopathies: Exploring Tau Protein-Protein and Microtubule Interactions, Cross-Interactions and Therapeutic Strategies. ChemMedChem. 2024-07-20. PMID:39031682. |
tau protein and tauopathies: exploring tau protein-protein and microtubule interactions, cross-interactions and therapeutic strategies. |
2024-07-20 |
2024-07-24 |
Not clear |
| Davide Di Lorenz. Tau Protein and Tauopathies: Exploring Tau Protein-Protein and Microtubule Interactions, Cross-Interactions and Therapeutic Strategies. ChemMedChem. 2024-07-20. PMID:39031682. |
however, aberrant modifications and pathological aggregations of tau are implicated in various neurodegenerative disorders, collectively known as tauopathies. |
2024-07-20 |
2024-07-24 |
Not clear |
| Panos Theofilas, Chao Wang, David Butler, Dulce O Morales, Cathrine Petersen, Andrew Ambrose, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Rakez Kayed, Celeste M Karch, Bruce L Miller, Jason E Gestwicki, Li Gan, Sally Temple, Michelle R Arkin, Lea T Grinber. iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death. Molecular and cellular neurosciences. 2024-07-20. PMID:39032719. |
tau post-translational modifications (ptms) result in the gradual build-up of abnormal tau and neuronal degeneration in tauopathies, encompassing variants of frontotemporal lobar degeneration (ftld) and alzheimer's disease (ad). |
2024-07-20 |
2024-07-24 |
Not clear |
| Panos Theofilas, Chao Wang, David Butler, Dulce O Morales, Cathrine Petersen, Andrew Ambrose, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Rakez Kayed, Celeste M Karch, Bruce L Miller, Jason E Gestwicki, Li Gan, Sally Temple, Michelle R Arkin, Lea T Grinber. iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death. Molecular and cellular neurosciences. 2024-07-20. PMID:39032719. |
therefore, therapeutic strategies against caspase cleaved-tau pathology could be necessary to modulate the extent of tau abnormalities in ad and other tauopathies. |
2024-07-20 |
2024-07-24 |
Not clear |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
tau protein profiling in tauopathies: a human brain study. |
2024-07-19 |
2024-07-21 |
human |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
abnormal accumulation of misfolded and hyperphosphorylated tau protein in brain is the defining feature of several neurodegenerative diseases called tauopathies, including alzheimer's disease (ad). |
2024-07-19 |
2024-07-21 |
human |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
interestingly, despite tau pathology being at the core of all tauopathies, csf tau biomarkers remain unchanged in certain tauopathies, e.g., progressive supranuclear palsy (psp), pick's disease (pid), and corticobasal neurodegeneration (cbd). |
2024-07-19 |
2024-07-21 |
human |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
to better understand commonalities and differences between tauopathies, we report a multiplex assay combining immunoprecipitation and high-resolution mass spectrometry capable of detecting and quantifying peptides from different tau protein isoforms as well as non-phosphorylated and phosphorylated peptides, including those carrying multiple phosphorylations. |
2024-07-19 |
2024-07-21 |
human |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
we investigated the tau proteoforms in soluble and insoluble fractions of brain tissue from subjects with autopsy-confirmed tauopathies, including sporadic ad (n = 10), psp (n = 11), pid (n = 10), and cbd (n = 10), and controls (n = 10). |
2024-07-19 |
2024-07-21 |
human |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
our results demonstrate that non-phosphorylated tau profiles differ across tauopathies, generally showing high abundance of microtubule-binding region (mtbr)-containing peptides in insoluble protein fractions compared with controls; the ad group showed 12-72 times higher levels of mtbr-containing aggregates. |
2024-07-19 |
2024-07-21 |
human |
| Celeste Parra Bravo, Sarah A Naguib, Li Ga. Cellular and pathological functions of tau. Nature reviews. Molecular cell biology. 2024-07-16. PMID:39014245. |
tauopathies are neurodegenerative diseases marked by the abnormal accumulation of tau protein aggregates in neurons, as seen, for example, in conditions such as frontotemporal dementia and alzheimer disease. |
2024-07-16 |
2024-07-19 |
human |
| Saskia J Pollack, Dina Dakkak, Tong Guo, George Chennell, Patricia Gomez-Suaga, Wendy Noble, Maria Jimenez-Sanchez, Diane P Hange. Truncated tau interferes with the autophagy and endolysosomal pathway and results in lipid accumulation. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-07-15. PMID:39009859. |
the autophagy-lysosomal pathway plays a critical role in the clearance of tau protein aggregates that deposit in the brain in tauopathies, and defects in this system are associated with disease pathogenesis. |
2024-07-15 |
2024-07-18 |
Not clear |
| Despoina Goniotaki, Francesco Tamagnini, Luca Biasetti, Svenja-Lotta Rumpf, Claire Troakes, Saskia J Pollack, Shalom Ukwesa, Haoyue Sun, Igor Kraev, Louise C Serpell, Wendy Noble, Kevin Staras, Diane P Hange. Tau-mediated synaptic dysfunction is coupled with HCN channelopathy. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-07-12. PMID:38994745. |
in tauopathies, altered tau processing correlates with impairments in synaptic density and function. |
2024-07-12 |
2024-07-14 |
Not clear |
| Moumita Majumder, Debashis Dutt. Oligodendrocyte Dysfunction in Tauopathy: A Less Explored Area in Tau-Mediated Neurodegeneration. Cells. vol 13. issue 13. 2024-07-12. PMID:38994964. |
aggregation of the microtubule-associated protein tau (mapt) is the hallmark pathology in a spectrum of neurodegenerative disorders collectively called tauopathies. |
2024-07-12 |
2024-07-14 |
Not clear |
| Moumita Majumder, Debashis Dutt. Oligodendrocyte Dysfunction in Tauopathy: A Less Explored Area in Tau-Mediated Neurodegeneration. Cells. vol 13. issue 13. 2024-07-12. PMID:38994964. |
oligodendrocyte-specific tau pathology, in the form of fibrils and coiled coils, is evident in major tauopathies including progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and pick's disease (pid). |
2024-07-12 |
2024-07-14 |
Not clear |
| Yiyang Zhu, Wade K Self, David M Holtzma. An emerging role for the gut microbiome in tauopathy. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-07-04. PMID:38964948. |
tauopathies constitute a group of neurodegenerative diseases characterized by abnormal aggregation of the protein tau, progressive neuronal and synaptic loss, and eventual cognitive and motor impairment. |
2024-07-04 |
2024-07-11 |
human |
| Sagar Gaikwad, Nicha Puangmalai, Minal Sonawane, Mauro Montalbano, Rachel Price, Malini S Iyer, Anamika Ray, Sandra Moreno, Rakez Kaye. Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice. Science translational medicine. vol 16. issue 754. 2024-07-03. PMID:38959324. |
pathological tau aggregates cause cognitive decline in neurodegenerative tauopathies, including alzheimer's disease (ad). |
2024-07-03 |
2024-07-10 |
mouse |
| Sagar Gaikwad, Nicha Puangmalai, Minal Sonawane, Mauro Montalbano, Rachel Price, Malini S Iyer, Anamika Ray, Sandra Moreno, Rakez Kaye. Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice. Science translational medicine. vol 16. issue 754. 2024-07-03. PMID:38959324. |
this study could be valuable in designing effective tau immunotherapies for ad and other tauopathies. |
2024-07-03 |
2024-07-10 |
mouse |
| Jing-Fen Su, Yue Xiao, Lin-Yu Wei, Hui-Yang Lei, Fei Sun, Wei-Xia Wang, Shi-Hong Li, Xiao-Chuan Wang, Jie Zheng, Jian-Zhi Wan. A new tau dephosphorylation-targeting chimera for the treatment of tauopathies. Acta pharmacologica Sinica. 2024-07-02. PMID:38956416. |
a new tau dephosphorylation-targeting chimera for the treatment of tauopathies. |
2024-07-02 |
2024-07-06 |
mouse |