| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yin Yang, Tomas Ondrejcak, Neng-Wei Hu, Igor Klyubin, Michael J Rowa. Divergent disruptive effects of soluble recombinant tau assemblies on synaptic plasticity in vivo. Molecular brain. vol 18. issue 1. 2025-04-19. PMID:40251677. |
we conclude that otau and sτas provide useful means to explore ways of targeting different synaptotoxic soluble tau species in tauopathies. |
2025-04-19 |
2025-04-21 |
rat |
| Angelique D Gonzalez, Yannick N Wadop, Benjamin Danner, Kyra M Clarke, Matthew B Dopler, Ali Ghaseminejad-Bandpey, Sahana Babu, Julie Parker-Garza, Cole Corbett, Mohammad Alhneif, Mallory Keating, Kevin F Bieniek, Gladys E Maestre, Sudha Seshadri, Shahroo Etemadmoghadam, Bernard Fongang, Margaret E Flanaga. Digital pathology in tau research: A comparison of QuPath and HALO. Journal of neuropathology and experimental neurology. 2025-04-16. PMID:40238207. |
this study evaluated halo and qupath tau quantification performance in the hippocampus and mid-frontal gyrus across various tauopathies. |
2025-04-16 |
2025-04-19 |
human |
| Xudong Han, Yichi Zhang, Jillian N Petrosky, Sarah Bald, Richard M Sherva, Adam Labadorf, Jonathan D Cherry, Jaeyoon Chung, Kurt Farrell, Bobak Abdolmohammadi, Shruti Durape, Brett M Martin, Joseph N Palmisano, John J Farrell, Victor E Alvarez, Bertrand R Huber, Brigid Dwyer, Daniel H Daneshvar, Kristen Dams-O'Connor, Gyungah R Jun, Kathryn L Lunetta, Lee E Goldstein, Douglas I Katz, Robert C Cantu, Martha E Shenton, Jeffrey L Cummings, Eric M Reiman, Robert A Stern, Michael L Alosco, Yorghos Tripodis, Lindsay A Farrer, Thor D Stein, John F Crary, Ann C McKee, Jesse Me. A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes. Cell reports. Medicine. 2025-04-16. PMID:40239644. |
genetic variation in the 17q21.31 region, containing microtubule-associated protein tau (mapt), has been implicated in tauopathies but has not been investigated in cte. |
2025-04-16 |
2025-04-19 |
Not clear |
| Martin Bolin, Sangram Nag, Ryosuke Arakawa, Andrea Varrone, Lars Farde, Laurent Martarello, Maciej A Kaliszczak, Christer Halldin, Anton Forsberg Moré. In vivo quantification of [ Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2025-04-12. PMID:40219925. |
in vivo quantification of [ neurofibrillary tangles (nfts), composed of aggregated tau protein, in the brain is a neuropathological hallmark and feature of alzheimer's disease (ad) and other tauopathies. |
2025-04-12 |
2025-04-15 |
Not clear |
| Nicolò Bisi, Luca Pinzi, Giulio Rastell. Selective imaging probes for differential detection of pathological tau polymorphs in tauopathies. Drug discovery today. 2025-04-11. PMID:40216294. |
selective imaging probes for differential detection of pathological tau polymorphs in tauopathies. |
2025-04-11 |
2025-04-14 |
Not clear |
| Nicolò Bisi, Luca Pinzi, Giulio Rastell. Selective imaging probes for differential detection of pathological tau polymorphs in tauopathies. Drug discovery today. 2025-04-11. PMID:40216294. |
tauopathies, including alzheimer's disease (ad), pick's disease (pid), progressive supranuclear palsy (psp) and corticobasal degeneration (cbd), are characterized by the misfolding and pathological aggregation of the tau protein, leading to neurodegeneration. |
2025-04-11 |
2025-04-14 |
Not clear |
| Nicolò Bisi, Luca Pinzi, Giulio Rastell. Selective imaging probes for differential detection of pathological tau polymorphs in tauopathies. Drug discovery today. 2025-04-11. PMID:40216294. |
tau inclusions are not the same in terms of structure and morphology, and different tauopathies are characterized by different polymorphs. |
2025-04-11 |
2025-04-14 |
Not clear |
| Nicolò Bisi, Luca Pinzi, Giulio Rastell. Selective imaging probes for differential detection of pathological tau polymorphs in tauopathies. Drug discovery today. 2025-04-11. PMID:40216294. |
this review discusses recent advances in the development of imaging probes designed for the selective detection of pathological tau forms associated with specific tauopathies. |
2025-04-11 |
2025-04-14 |
Not clear |
| Kuniyuki Iwata-Endo, Kentaro Sahashi, Kaori Kawai, Yusuke Fujioka, Yohei Okada, Eri Watanabe, Nobuyuki Iwade, Minaka Ishibashi, Moniruzzaman Mohammad, Asraa Faris Aldoghachi, Dilina Tuerde, Tsuyoshi Fujiwara, Shinobu Hirai, Haruo Okado, Masahisa Katsuno, Hirohisa Watanabe, Kayoko Kanamitsu, Masahiro Neya, Shinsuke Ishigaki, Gen Sobu. Correcting tau isoform ratios with a long-acting antisense oligonucleotide alleviates 4R-tauopathy phenotypes. Molecular therapy. Nucleic acids. vol 36. issue 2. 2025-04-10. PMID:40206658. |
tau, a microtubule-binding protein linked to tauopathies like alzheimer's disease and frontotemporal lobar degeneration (ftld), has 3-repeat (3r) and 4-repeat (4r) isoforms. |
2025-04-10 |
2025-04-12 |
mouse |
| Shan Xu, Kangyan Liu, Shiyan Qian, Jingying Wu, Jialing Hu, Dongming Zhou, Tingting Zhen. Mechanism of Tau Protein Incorporation into Exosomes via Cooperative Recognition of KFERQ-like Motifs by LAMP2A and HSP70. Neurochemistry international. 2025-04-05. PMID:40187566. |
aggregates of the tau protein is a well-known hallmark of alzheimer's disease (ad) and other tauopathies, such as frontotemporal dementia (ftd). |
2025-04-05 |
2025-04-08 |
human |
| Shan Xu, Kangyan Liu, Shiyan Qian, Jingying Wu, Jialing Hu, Dongming Zhou, Tingting Zhen. Mechanism of Tau Protein Incorporation into Exosomes via Cooperative Recognition of KFERQ-like Motifs by LAMP2A and HSP70. Neurochemistry international. 2025-04-05. PMID:40187566. |
these findings revealed the presence of a novel mechanism by which release of tau through exosome secretion pathway and that lamp2a may play an important role in the regulation of exosome-mediated secretion of tau, which may become a potential therapeutic target for ad or other tauopathies. |
2025-04-05 |
2025-04-08 |
human |
| Elena Vacchi, Iñigo Ruiz-Barrio, Giorgia Mell. Tau biomarkers for neurodegenerative diseases: Current state and perspectives. Parkinsonism & related disorders. 2025-04-04. PMID:40185651. |
tauopathies are characterized by progressive neuronal damage and intracellular deposits of hyperphosphorylated tau. |
2025-04-04 |
2025-04-08 |
Not clear |
| Elena Vacchi, Iñigo Ruiz-Barrio, Giorgia Mell. Tau biomarkers for neurodegenerative diseases: Current state and perspectives. Parkinsonism & related disorders. 2025-04-04. PMID:40185651. |
advances in tau biomarkers and imaging have facilitated targeted alzheimer's disease therapies, but progress for other tauopathies remains inadequate. |
2025-04-04 |
2025-04-08 |
Not clear |
| Anna-Lisa Fischer, Matthias Schmitz, Tobias Thom, Saima Zafar, Neelam Younas, Susana da Silva Correia, Angela da Silva Correia, Sezgi Canaslan Eyyuboglu, Inga Zer. Alpha-Synuclein Demonstrates Varying Binding Affinities With Different Tau Isoforms. Journal of neurochemistry. vol 169. issue 4. 2025-04-01. PMID:40165586. |
for instance, lewy bodies are reported in tauopathies and neurofibrillary tau-tangles are detected in synucleinopathies, suggesting a potential co-existence or crosstalk of misfolded asyn and tau. |
2025-04-01 |
2025-04-03 |
Not clear |
| Hong-Ru Chen, Hsiao-Tien Hagar, Kuan-Wei Wang, Stacy Hovde, Hsiang-Ying Lin, Min-Hsuan Lin, Cheng-Chun Chang, Ching-Yung Wang, Chia-Yen Chen, Emily J Bian, Melissa M Kinkaid, Min-Hao Kuo, Chia-Yi Kua. Intrahippocampal delivery of hyperphosphorylated human tau oligomers induces neurodegeneration in non-transgenic wildtype mice. bioRxiv : the preprint server for biology. 2025-03-31. PMID:40161714. |
hyperphosphorylated tau (p-tau) forms neurofibrillary tangles, a key biomarker for alzheimer's disease and additional neurodegenerative tauopathies. |
2025-03-31 |
2025-04-03 |
mouse |
| Karthikeyan Tangavelou, Shanya Jiang, Somayeh Dadras, Jonathan P Hulse, Kathryn Sanchez, Virginie Bondu, Zachary Villaseñor, Michael Mandell, Julianne Peabody, Bryce Chackerian, Kiran Bhaska. Pathological tau activates inflammatory nuclear factor-kappa B (NF-κB) and pT181-Qβ vaccine attenuates NF-κB in PS19 tauopathy mice. bioRxiv : the preprint server for biology. 2025-03-31. PMID:40161741. |
however, longitudinal nf-κb activation in tauopathies and whether pathological tau (ptau) contributes to nf-κb activity is unknown. |
2025-03-31 |
2025-04-03 |
mouse |
| Lathan Lucas, Phoebe S Tsoi, Josephine C Ferreon, Allan Chris M Ferreo. Tau Oligomers Resist Phase Separation. Biomolecules. vol 15. issue 3. 2025-03-28. PMID:40149872. |
llps has also been implicated in pathological tau aggregation, which contributes to tauopathies such as alzheimer's disease. |
2025-03-28 |
2025-03-30 |
Not clear |
| Lathan Lucas, Phoebe S Tsoi, Josephine C Ferreon, Allan Chris M Ferreo. Tau Oligomers Resist Phase Separation. Biomolecules. vol 15. issue 3. 2025-03-28. PMID:40149872. |
these findings underscore the need to further explore llps as a likely modulator of tau pathogenesis and distinct pathogenic oligomers as viable therapeutic targets in tauopathies. |
2025-03-28 |
2025-03-30 |
Not clear |
| Indalo Domene-Serrano, Raquel Cuadros, Vega García-Escudero, Francisco Vallejo-Bedia, Ismael Santa-María, Laura Vallés-Saiz, Félix Hernandez, Jesús Avil. Shapeshifter W-Tau Peptide Inhibits Tau Aggregation and Disintegrates Paired Helical Filaments. Biochemistry. 2025-03-27. PMID:40140976. |
tauopathies comprise a range of neurodegenerative conditions characterized by the aberrant accumulation of tau protein clumps in the brain. |
2025-03-27 |
2025-03-30 |
Not clear |
| Nicole M Maphis, Jonathan Hulse, Julianne Peabody, Somayeh Dadras, Madelin J Whelpley, Manas Kandath, Colin Wilson, Sasha Hobson, Jeff Thompson, Suttinee Poolsup, Danielle Beckman, Sean P Ott, Jennifer W Watanabe, Jodie L Usachenko, Koen K Van Rompay, John Morrison, Reed Selwyn, Gary Rosenberg, Janice Knoefel, Bryce Chackerian, Kiran Bhaska. Targeting of phosphorylated tau at threonine 181 by a Qβ virus-like particle vaccine is safe, highly immunogenic, and reduces disease severity in mice and rhesus macaques. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 21. issue 3. 2025-03-27. PMID:40145301. |
pathological accumulation of tau (ptau) contributes to various tauopathies, including alzheimer's disease (ad), and correlates with cognitive decline. |
2025-03-27 |
2025-03-30 |
mouse |