| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Albert J Lyons, Neha S Gandhi, Ricardo L Mancer. Molecular dynamics simulation of the phosphorylation-induced conformational changes of a tau peptide fragment. Proteins. vol 82. issue 9. 2015-06-08. PMID:24577753. |
aggregation of the microtubule associated protein tau (mapt) within neurons of the brain is the leading cause of tauopathies such as alzheimer's disease. |
2015-06-08 |
2023-08-12 |
Not clear |
| Chun-Wei Chang, Wen-Chuin Hsu, Alan Pittman, Yih-Ru Wu, John Hardy, Hon-Chung Fun. Structural study of the microtubule-associated protein tau locus of Alzheimer's disease in Taiwan. Biomedical journal. vol 37. issue 3. 2015-05-15. PMID:24923570. |
haplotype structure of the microtubule-associated protein tau (mapt) gene is associated with various tauopathies in the caucasian population. |
2015-05-15 |
2023-08-13 |
Not clear |
| Michiaki Okuda, Ichiro Hijikuro, Yuki Fujita, Xiaofeng Wu, Shinichi Nakayama, Yoko Sakata, Yuji Noguchi, Makoto Ogo, Shigeru Akasofu, Yoshimasa Ito, Yoshiyuki Soeda, Nobuhiko Tsuchiya, Naoki Tanaka, Takashi Takahashi, Hachiro Sugimot. PE859, a novel tau aggregation inhibitor, reduces aggregated tau and prevents onset and progression of neural dysfunction in vivo. PloS one. vol 10. issue 2. 2015-03-30. PMID:25659102. |
in tauopathies, a neural microtubule-associated protein tau (mapt) is abnormally aggregated and forms neurofibrillary tangle. |
2015-03-30 |
2023-08-13 |
mouse |
| Naomi Kouri, Yari Carlomagno, Matthew Baker, Amanda M Liesinger, Richard J Caselli, Zbigniew K Wszolek, Leonard Petrucelli, Bradley F Boeve, Joseph E Parisi, Keith A Josephs, Ryan J Uitti, Owen A Ross, Neill R Graff-Radford, Michael A DeTure, Dennis W Dickson, Rosa Rademaker. Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration. Acta neuropathologica. vol 127. issue 2. 2014-09-30. PMID:24121548. |
our findings show that mutations in mapt can cause cbd and mapt non-coding variants may increase the risk of complex 4r tauopathies. |
2014-09-30 |
2023-08-12 |
Not clear |
| Giacomina Rossi, Antonio Bastone, Elena Piccoli, Michela Morbin, Giulia Mazzoleni, Valeria Fugnanesi, Marten Beeg, Elena Del Favero, Laura Cantù, Simona Motta, Ettore Salsano, Davide Pareyson, Alessandra Erbetta, Antonio Emanuele Elia, Francesca Del Sorbo, Vincenzo Silani, Claudia Morelli, Mario Salmona, Fabrizio Tagliavin. Different mutations at V363 MAPT codon are associated with atypical clinical phenotypes and show unusual structural and functional features. Neurobiology of aging. vol 35. issue 2. 2014-08-25. PMID:24018212. |
in particular, mapt mutations give rise to the subgroup of tauopathies. |
2014-08-25 |
2023-08-12 |
Not clear |
| Reeteka Sud, Evan T Geller, Gerard D Schellenber. Antisense-mediated Exon Skipping Decreases Tau Protein Expression: A Potential Therapy For Tauopathies. Molecular therapy. Nucleic acids. vol 3. 2014-07-30. PMID:25072694. |
we propose that reducing mapt expression and thus the amount of tau protein made could prevent aggregation, and potentially be an approach to treat tauopathies. |
2014-07-30 |
2023-08-13 |
mouse |
| Marie-Laure Caillet-Boudin, Francisco-Jose Fernandez-Gomez, Hélène Tran, Claire-Marie Dhaenens, Luc Buee, Nicolas Sergean. Brain pathology in myotonic dystrophy: when tauopathy meets spliceopathy and RNAopathy. Frontiers in molecular neuroscience. vol 6. 2014-06-24. PMID:24409116. |
tauopathies are a group of nearly 30 neurodegenerative diseases that are characterized by intraneuronal protein aggregates of the microtubule-associated protein tau (mapt) in patient brains. |
2014-06-24 |
2023-08-12 |
Not clear |
| Joaquín Goñi, Sebastián Cervantes, Gonzalo Arrondo, Isabel Lamet, Pau Pastor, María A Pasto. Selective brain gray matter atrophy associated with APOE ε4 and MAPT H1 in subjects with mild cognitive impairment. Journal of Alzheimer's disease : JAD. vol 33. issue 4. 2013-10-17. PMID:23064258. |
the pattern of frontal gray matter loss observed among mci mapt h1/h1 carriers has also been found in other tauopathies, suggesting that mci may share etiological factors with other tauopathies. |
2013-10-17 |
2023-08-12 |
human |
| Ismael Santa-Maria, Aya Haggiagi, Xinmin Liu, Jessica Wasserscheid, Peter T Nelson, Ken Dewar, Lorraine N Clark, John F Crar. The MAPT H1 haplotype is associated with tangle-predominant dementia. Acta neuropathologica. vol 124. issue 5. 2013-03-25. PMID:22802095. |
haplotype analysis demonstrates a strong association between tpd and the mapt h1 haplotype, a genomic inversion associated with some tauopathies and parkinson disease (pd), when compared to age-matched control subjects with mild degenerative changes, i.e., successful cerebral aging. |
2013-03-25 |
2023-08-12 |
human |
| Daniah Trabzuni, Selina Wray, Jana Vandrovcova, Adaikalavan Ramasamy, Robert Walker, Colin Smith, Connie Luk, J Raphael Gibbs, Allissa Dillman, Dena G Hernandez, Sampath Arepalli, Andrew B Singleton, Mark R Cookson, Alan M Pittman, Rohan de Silva, Michael E Weale, John Hardy, Mina Ryte. MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies. Human molecular genetics. vol 21. issue 18. 2013-01-17. PMID:22723018. |
mapt expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies. |
2013-01-17 |
2023-08-12 |
human |
| Tara M Caffrey, Richard Wade-Martin. The role of MAPT sequence variation in mechanisms of disease susceptibility. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817717. |
the microtubule-associated protein tau (mapt or tau) is of great interest in the field of neurodegeneration as there is a well-established genetic link between the mapt gene locus and tauopathies, a diverse group of neurodegenerative dementias and movement disorders. |
2012-12-07 |
2023-08-12 |
Not clear |
| Eleanna Kara, Helen Ling, Alan M Pittman, Karen Shaw, Rohan de Silva, Roberto Simone, Janice L Holton, Jason D Warren, Jonathan D Rohrer, Georgia Xiromerisiou, Andrew Lees, John Hardy, Henry Houlden, Tamas Reves. The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features. Neurobiology of aging. vol 33. issue 9. 2012-11-29. PMID:22595371. |
the mapt p.a152t variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features. |
2012-11-29 |
2023-08-12 |
Not clear |
| Eleanna Kara, Helen Ling, Alan M Pittman, Karen Shaw, Rohan de Silva, Roberto Simone, Janice L Holton, Jason D Warren, Jonathan D Rohrer, Georgia Xiromerisiou, Andrew Lees, John Hardy, Henry Houlden, Tamas Reves. The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features. Neurobiology of aging. vol 33. issue 9. 2012-11-29. PMID:22595371. |
microtubule-associated protein tau (mapt) mutations have been shown to underlie frontotemporal dementia and a variety of additional sporadic tauopathies. |
2012-11-29 |
2023-08-12 |
Not clear |
| Natalia Crespo-Biel, Clara Theunis, Fred Van Leuve. Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22720188. |
the microtubule-associated protein tau (mapt) is a major component of the pathogenesis of a wide variety of brain-damaging disorders, known as tauopathies. |
2012-08-23 |
2023-08-12 |
human |
| Hans H Jung, Juliane Bremer, Johannes Streffer, Kanwar Virdee, Maria Grazia Spillantini, R Anthony Crowther, Peter Brugger, Christine Van Broeckhoven, Adriano Aguzzi, Markus Tolna. Phenotypic variation of autosomal-dominant corticobasal degeneration. European neurology. vol 67. issue 3. 2012-07-16. PMID:22261560. |
neurodegenerative tauopathies may be inherited as autosomal-dominant disorders with variable clinicopathological phenotypes, and causative mutations in the microtubule-associated protein tau (mapt) gene are not regularly seen. |
2012-07-16 |
2023-08-12 |
Not clear |
| Diana A T Nijholt, Elise S van Haastert, Annemieke J M Rozemuller, Wiep Scheper, Jeroen J M Hoozeman. The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. The Journal of pathology. vol 226. issue 5. 2012-04-27. PMID:22102449. |
the aim of the present study is to investigate upr activation in sporadic tauopathies like progressive supranuclear palsy (psp) and pick's disease (pid), and familial cases with frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) which carry mutations in the gene encoding for tau (mapt). |
2012-04-27 |
2023-08-12 |
Not clear |
| Dennis W Dickson, Naomi Kouri, Melissa E Murray, Keith A Joseph. Neuropathology of frontotemporal lobar degeneration-tau (FTLD-tau). Journal of molecular neuroscience : MN. vol 45. issue 3. 2012-03-19. PMID:21720721. |
tauopathies are subclassified according to the predominant species of tau that accumulates, with respect to alternative splicing of mapt, with tau proteins containing three (3r) or four repeats (4r) of ~32 amino acids in the microtubule binding domain. |
2012-03-19 |
2023-08-12 |
Not clear |
| J Vandrovcova, F Anaya, V Kay, A Lees, J Hardy, R de Silv. Disentangling the role of the tau gene locus in sporadic tauopathies. Current Alzheimer research. vol 7. issue 8. 2011-11-23. PMID:20704554. |
however, in the sporadic tauopathies such as progressive supranuclear palsy (psp) and corticobasal degeneration (cbd) where mapt mutation is absent, common variation in mapt that defines the h1 and h2 haplotype clades strongly influences disease risk. |
2011-11-23 |
2023-08-12 |
Not clear |
| Sara J Johnson, Richard Wade-Martin. A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2, SNCA and MAPT BAC-transgenic mice. Biochemical Society transactions. vol 39. issue 4. 2011-11-15. PMID:21787314. |
the present review discusses results of recent studies investigating pd (parkinson's disease) and tauopathies using bac-transgenic mice carrying either the lrrk2 (leucine-rich repeat kinase 2), α-synuclein (snca) or mapt (microtubule-associated protein tau) genes. |
2011-11-15 |
2023-08-12 |
mouse |
| Shufen Chen, Kirk Townsend, Terry E Goldberg, Peter Davies, Concepcion Conejero-Goldber. MAPT isoforms: differential transcriptional profiles related to 3R and 4R splice variants. Journal of Alzheimer's disease : JAD. vol 22. issue 4. 2011-05-25. PMID:20930284. |
the predominant aggregation of certain mapt (tau gene) isoforms, either the 4-repeat (4r tau) or the 3-repeat (3r tau) isoform has been widely described in tauopathies. |
2011-05-25 |
2023-08-12 |
human |