| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Georgina Perez-Garcia, Mesude Bicak, Jean-Vianney Haure-Mirande, Gissel M Perez, Alena Otero-Pagan, Miguel A Gama Sosa, Rita De Gasperi, Mary Sano, Carrolee Barlow, Fred H Gage, Benjamin Readhead, Michelle E Ehrlich, Sam Gandy, Gregory A Elde. BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPT Neuroscience letters. 2023-01-19. PMID:36657633. |
bci-838, an orally active mglur2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the ps19 mapt tauopathies are a heterogeneous group of neurodegenerative disorders that are clinically and pathologically distinct from alzheimer's disease (ad) having tau inclusions in neurons and/or glia as their most prominent neuropathological feature. |
2023-01-19 |
2023-08-14 |
Not clear |
| Hannah Mein, Yu Jing, Faraz Ahmad, Hu Zhang, Ping Li. Altered Brain Arginine Metabolism and Polyamine System in a P301S Tauopathy Mouse Model: A Time-Course Study. International journal of molecular sciences. vol 23. issue 11. 2022-06-10. PMID:35682712. |
altered arginine metabolism (including the polyamine system) has recently been implicated in the pathogenesis of tauopathies, characterised by hyperphosphorylated and aggregated microtubule-associated protein tau (mapt) accumulation in the brain. |
2022-06-10 |
2023-08-14 |
mouse |
| Justin R Welden, Giorgi Margvelani, Chi Jing Leow, Jessica Blackburn, Peter T Nelson, Stefan Stam. Proteins translated from tau circular RNAs as drivers for Alzheimer's disease and frontotemporal dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109060. |
neurofibrillary tangles formed by the microtubule protein tau (mapt) are the pathologic hallmark of tauopathies, including alzheimer's disease and ∼1/2 of frontotemporal lobar degeneration (ftld-tau) cases. |
2022-02-03 |
2023-08-13 |
mouse |
| Rita Martinez, Shan Jiang, Jacob Marsh, Oscar Harari, Carlos Cruchaga, Alison M Goate, Sally Temple, Celeste M Karc. Stem cell models of primary tauopathies reveal defects in synaptic function. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109113. |
primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (mapt) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. |
2022-02-03 |
2023-08-13 |
Not clear |
| Tara E Tracy, Jesus Madero-Pérez, Danielle L Swaney, Timothy S Chang, Michelle Moritz, Csaba Konrad, Michael E Ward, Erica Stevenson, Ruth Hüttenhain, Grant Kauwe, Maria Mercedes, Lauren Sweetland-Martin, Xu Chen, Sue-Ann Mok, Man Ying Wong, Maria Telpoukhovskaia, Sang-Won Min, Chao Wang, Peter Dongmin Sohn, Jordie Martin, Yungui Zhou, Wenjie Luo, John Q Trojanowski, Virginia M Y Lee, Shiaoching Gong, Giovanni Manfredi, Giovanni Coppola, Nevan J Krogan, Daniel H Geschwind, Li Ga. Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Cell. 2022-01-22. PMID:35063084. |
tau (mapt) drives neuronal dysfunction in alzheimer disease (ad) and other tauopathies. |
2022-01-22 |
2023-08-13 |
human |
| Elahe Zarini-Gakiye, Gholamhassan Vaezi, Kazem Parivar, Nima Sanadgo. Age and Dose-Dependent Effects of Alpha-Lipoic Acid on Human Microtubule- Associated Protein Tau-Induced Endoplasmic Reticulum Unfolded Protein Response: Implications for Alzheimer's Disease. CNS & neurological disorders drug targets. vol 20. issue 5. 2021-12-09. PMID:33573583. |
in human tauopathies, pathological aggregation of misfolded/unfolded proteins, particularly microtubule-associated protein tau (mapt, tau) is considered to be an essential mechanism that triggers the induction of endoplasmic reticulum (er) stress. |
2021-12-09 |
2023-08-13 |
human |
| Ana Damianich, Carolina Lucia Facal, Javier Andrés Muñiz, Camilo Mininni, Mariano Soiza-Reilly, Magdalena Ponce De León, Leandro Urrutia, German Falasco, Juan Esteban Ferrario, María Elena Aval. Tau mis-splicing correlates with motor impairments and striatal dysfunction in a model of tauopathy. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:34059893. |
tauopathies are neurodegenerative diseases caused by the abnormal metabolism of the microtubule associated protein tau (mapt), which is highly expressed in neurons and critically involved in microtubule dynamics. |
2021-12-08 |
2023-08-13 |
mouse |
| Gesine Respondek, Lea Krey, Meret Huber, Henning Pflugrad, Florian Wegner, Günter U Höglinge. [Neuroprotective treatment of tauopathies]. Der Nervenarzt. vol 92. issue 12. 2021-12-07. PMID:34652482. |
primary tauopathies include progressive supranuclear palsy, corticobasal degeneration, pick's disease and rare hereditary tauopathies, which are referred to as frontotemporal lobar degeneration with microtubule-associated protein tau (mapt) mutation. |
2021-12-07 |
2023-08-13 |
Not clear |
| Mette Habekost, Per Qvist, Mark Denham, Ida E Holm, Arne Lund Jørgense. Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration. Molecular neurobiology. vol 58. issue 5. 2021-11-19. PMID:33415685. |
to model alzheimer's disease and other tauopathies, it is essential that alternative splicing of the mapt transcript in these neurons produces the relevant tau isoforms. |
2021-11-19 |
2023-08-13 |
human |
| Faraz Ahmad, Hannah Mein, Yu Jing, Hu Zhang, Ping Li. Behavioural Functions and Cerebral Blood Flow in a P301S Tauopathy Mouse Model: A Time-Course Study. International journal of molecular sciences. vol 22. issue 18. 2021-10-28. PMID:34575885. |
tauopathies refer to a group of neurodegenerative diseases with intracellular accumulation of hyperphosphorylated and aggregated microtubule-associated protein tau (mapt) in neurons and glial cells. |
2021-10-28 |
2023-08-13 |
mouse |
| Umesh K Jinwal, John Koren, John C O'Leary, Jeffrey R Jones, Jose F Abisambra, Chad A Dicke. Hsp70 ATPase Modulators as Therapeutics for Alzheimer's and other Neurodegenerative Diseases. Molecular and cellular pharmacology. vol 2. issue 2. 2021-10-20. PMID:20523917. |
neurodegenerative diseases caused by abnormal accumulation of the microtubule associated protein tau (mapt, tau) are collectively called tauopathies. |
2021-10-20 |
2023-08-12 |
Not clear |
| Etienne Leveille, Owen A Ross, Ziv Gan-O. Tau and MAPT genetics in tauopathies and synucleinopathies. Parkinsonism & related disorders. vol 90. 2021-10-11. PMID:34593302. |
tau and mapt genetics in tauopathies and synucleinopathies. |
2021-10-11 |
2023-08-13 |
Not clear |
| Etienne Leveille, Owen A Ross, Ziv Gan-O. Tau and MAPT genetics in tauopathies and synucleinopathies. Parkinsonism & related disorders. vol 90. 2021-10-11. PMID:34593302. |
mapt variations are a cause or risk factors for many tauopathies and synucleinopathies and are associated with certain clinical and pathological features in affected individuals. |
2021-10-11 |
2023-08-13 |
Not clear |
| Etienne Leveille, Owen A Ross, Ziv Gan-O. Tau and MAPT genetics in tauopathies and synucleinopathies. Parkinsonism & related disorders. vol 90. 2021-10-11. PMID:34593302. |
understanding the role of mapt variations in tauopathies and synucleinopathies is therefore essential to elucidate the role of tau in the pathogenesis and phenotype of those disorders, and ultimately to develop targeted therapies. |
2021-10-11 |
2023-08-13 |
Not clear |
| Etienne Leveille, Owen A Ross, Ziv Gan-O. Tau and MAPT genetics in tauopathies and synucleinopathies. Parkinsonism & related disorders. vol 90. 2021-10-11. PMID:34593302. |
in this review, we describe the role of mapt genetic variations in tauopathies and synucleinopathies, several genotype-phenotype and pathological features, and discuss their implications for the classification and treatment of those disorders. |
2021-10-11 |
2023-08-13 |
Not clear |
| Maria Stamelou, Gesine Respondek, Nikolaos Giagkou, Jennifer L Whitwell, Gabor G Kovacs, Günter U Höglinge. Evolving concepts in progressive supranuclear palsy and other 4-repeat tauopathies. Nature reviews. Neurology. vol 17. issue 10. 2021-09-29. PMID:34426686. |
those in which four-repeat (4r) tau predominates are known as 4r-tauopathies, and include progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease, globular glial tauopathies and conditions associated with specific mapt mutations. |
2021-09-29 |
2023-08-13 |
Not clear |
| Qiong Feng, Yu Luo, Xiang-Nan Zhang, Xi-Fei Yang, Xiao-Yue Hong, Dong-Shen Sun, Xia-Chun Li, Yu Hu, Xiao-Guang Li, Jun-Fei Zhang, Xiao Li, Ying Yang, Qun Wang, Gong-Ping Liu, Jian-Zhi Wan. MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration. Autophagy. vol 16. issue 4. 2021-06-07. PMID:31223056. |
macroautophagy/autophagy deficit induces intracellular mapt/tau accumulation, the hallmark pathology in alzheimer disease (ad) and other tauopathies; however, the reverse role of mapt accumulation in autophagy and neurodegeneration is not clear. |
2021-06-07 |
2023-08-13 |
human |
| Elena Britti, Joaquim Ros, Noemi Esteras, Andrey Y Abramo. Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death. Cell calcium. vol 86. 2021-06-01. PMID:31918031. |
aggregation or phosphorylation of the microtubule-associated protein tau is the pathological hallmark in a number of diseases termed tauopathies, which include the most common neurodegenerative disorder, alzheimer's disease; or frontotemporal dementia, linked to mutations in the gene mapt encoding tau. |
2021-06-01 |
2023-08-13 |
Not clear |
| Kunie Ando, Robert De Decker, Cristina Vergara, Zehra Yilmaz, Salwa Mansour, Valérie Suain, Kristel Sleegers, Marie-Ange de Fisenne, Sarah Houben, Marie-Claude Potier, Charles Duyckaerts, Toshio Watanabe, Luc Buée, Karelle Leroy, Jean-Pierre Brio. Picalm reduction exacerbates tau pathology in a murine tauopathy model. Acta neuropathologica. vol 139. issue 4. 2021-05-17. PMID:31925534. |
we have previously reported that soluble picalm protein level is reduced in correlation with abnormalities of autophagy markers in the affected brain areas of neurodegenerative diseases including ad, sporadic tauopathies and familial cases of frontotemporal lobar degeneration with tau-immunoreactive inclusions (ftld-tau) with mutations in the microtubule-associated protein tau (mapt) gene. |
2021-05-17 |
2023-08-13 |
mouse |
| Jianfeng Zhao, Hongrong Wu, Xiao-Qing Tan. Tau internalization: A complex step in tau propagation. Ageing research reviews. vol 67. 2021-04-19. PMID:33571704. |
aggregation of microtubule-associated protein tau (mapt) may underlie abnormalities of the intracellular matrix and neuronal death in tauopathies. |
2021-04-19 |
2023-08-13 |
Not clear |