| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianfeng Zhao, Hongrong Wu, Xiao-Qing Tan. Tau internalization: A complex step in tau propagation. Ageing research reviews. vol 67. 2021-04-19. PMID:33571704. |
aggregation of microtubule-associated protein tau (mapt) may underlie abnormalities of the intracellular matrix and neuronal death in tauopathies. |
2021-04-19 |
2023-08-13 |
Not clear |
| Madhuri Chakravarthy, Suxiang Chen, Tao Wang, Rakesh N Veed. Development of Novel Chemically-Modified Nucleic Acid Molecules for Efficient Inhibition of Human Genes. vol 11. issue 6. 2021-03-18. PMID:32575375. |
it has been hypothesized that the reduction of mapt would result in depolymerizing neurofibrillary tangles and could be a potential strategy for the treatment of alzheimer's disease and other tauopathies. |
2021-03-18 |
2023-08-13 |
human |
| M Catarina Silva, Stephen J Haggart. Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies. International journal of molecular sciences. vol 21. issue 23. 2021-03-05. PMID:33255694. |
tauopathies are neurodegenerative diseases characterized by the pathological accumulation of microtubule-associated protein tau (mapt) in the form of neurofibrillary tangles and paired helical filaments in neurons and glia, leading to brain cell death. |
2021-03-05 |
2023-08-13 |
Not clear |
| David N Soleimani-Meigooni, Leonardo Iaccarino, Renaud La Joie, Suzanne Baker, Viktoriya Bourakova, Adam L Boxer, Lauren Edwards, Rana Eser, Maria-Luisa Gorno-Tempini, William J Jagust, Mustafa Janabi, Joel H Kramer, Orit H Lesman-Segev, Taylor Mellinger, Bruce L Miller, Julie Pham, Howard J Rosen, Salvatore Spina, William W Seeley, Amelia Strom, Lea T Grinberg, Gil D Rabinovic. 18F-flortaucipir PET to autopsy comparisons in Alzheimer's disease and other neurodegenerative diseases. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33141172. |
eight patients had primary alzheimer's disease pathology, nine had non-alzheimer tauopathies (progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease, and frontotemporal lobar degeneration with mapt mutations), and three had non-tau frontotemporal lobar degeneration. |
2021-03-01 |
2023-08-13 |
Not clear |
| Giacomo Siano, Mariachiara Micaelli, Arianna Scarlatti, Valentina Quercioli, Cristina Di Primio, Antonino Cattane. The Q336H MAPT Mutation Linked to Pick's Disease Leads to Increased Binding of Tau to the Microtubule Network Frontiers in molecular neuroscience. vol 13. 2021-01-27. PMID:33343296. |
the q336h mapt mutation linked to pick's disease leads to increased binding of tau to the microtubule network tauopathies are neurodegenerative disorders characterized by tau aggregation. |
2021-01-27 |
2023-08-13 |
Not clear |
| Shanya Jiang, Kiran Bhaska. Degradation and Transmission of Tau by Autophagic-Endolysosomal Networks and Potential Therapeutic Targets for Tauopathy. Frontiers in molecular neuroscience. vol 13. 2020-11-14. PMID:33177989. |
tauopathies are a class of neurodegenerative diseases, including alzheimer's disease (ad), frontotemporal dementia (ftd), progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and many others where microtubule-associated protein tau (mapt or tau) is hyperphosphorylated and aggregated to form insoluble paired helical filaments (phfs) and ultimately neurofibrillary tangles (nfts). |
2020-11-14 |
2023-08-13 |
Not clear |
| Alena Michalicova, Petra Majerova, Andrej Kova. Tau Protein and Its Role in Blood-Brain Barrier Dysfunction. Frontiers in molecular neuroscience. vol 13. 2020-10-28. PMID:33100967. |
tauopathies represent a heterogeneous group of around 20 different neurodegenerative diseases characterized by abnormal deposition of the mapt in cells of the nervous system. |
2020-10-28 |
2023-08-13 |
Not clear |
| Seyedeh Maryam Alavi Naini, Nadia Soussi-Yanicosta. Heparan Sulfate as a Therapeutic Target in Tauopathies: Insights From Zebrafish. Frontiers in cell and developmental biology. vol 6. 2020-10-01. PMID:30619849. |
microtubule-associated protein tau (mapt) hyperphosphorylation and aggregation, are two hallmarks of a family of neurodegenerative disorders collectively referred to as tauopathies. |
2020-10-01 |
2023-08-13 |
zebrafish |
| Nicole M Maphis, Shanya Jiang, Jessica Binder, Carrie Wright, Banu Gopalan, Bruce T Lamb, Kiran Bhaska. Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology. Frontiers in molecular neuroscience. vol 10. 2020-09-28. PMID:28367114. |
increasing evidence suggests that hyperphosphorylation and aggregation of microtubule-associated protein tau (mapt or tau) correlates with the development of cognitive impairment in alzheimer's disease (ad) and related tauopathies. |
2020-09-28 |
2023-08-13 |
mouse |
| Shelley L Forrest, Jillian J Kril, Glenda M Hallida. Cellular and regional vulnerability in frontotemporal tauopathies. Acta neuropathologica. vol 138. issue 5. 2020-09-15. PMID:31203391. |
the findings show that diverse clinical phenotypes relate most to the brain region degenerating rather than the type of pathology involved, that different regions on the mapt gene and novel risk genes are associated with specific tau pathologies, that the 4-repeat glial tauopathies do not follow individual patterns of spreading as identified for neuronal pathologies, and that genetic and pathological data indicate that neuroinflammatory mechanisms are involved. |
2020-09-15 |
2023-08-13 |
Not clear |
| Saif Zaman, Boris I Chobrutskiy, Dhiraj Sikaria, George Blanc. MAPT (Tau) expression is a biomarker for an increased rate of survival for low‑grade glioma. Oncology reports. vol 41. issue 2. 2020-09-11. PMID:30535461. |
the association of mapt (tau) with various tauopathies and other neurological disorders has long been established. |
2020-09-11 |
2023-08-13 |
Not clear |
| Sachiko Nakayama, Shotaro Shimonaka, Montasir Elahi, Kenya Nishioka, Yutaka Oji, Shin-Ei Matsumoto, Yuanzhe Li, Hiroyo Yoshino, Kaoru Mogushi, Taku Hatano, Takeshi Sato, Teikichi Ikura, Nobutoshi Ito, Yumiko Motoi, Nobutaka Hattor. Tau aggregation and seeding analyses of two novel MAPT variants found in patients with motor neuron disease and progressive parkinsonism. Neurobiology of aging. vol 84. 2020-08-04. PMID:31027853. |
variants in the microtubule-associated protein tau (mapt) gene cause the genetic tauopathies, a subgroup of frontotemporal dementia (ftd) disorders. |
2020-08-04 |
2023-08-13 |
Not clear |
| Sachiko Nakayama, Shotaro Shimonaka, Montasir Elahi, Kenya Nishioka, Yutaka Oji, Shin-Ei Matsumoto, Yuanzhe Li, Hiroyo Yoshino, Kaoru Mogushi, Taku Hatano, Takeshi Sato, Teikichi Ikura, Nobutoshi Ito, Yumiko Motoi, Nobutaka Hattor. Tau aggregation and seeding analyses of two novel MAPT variants found in patients with motor neuron disease and progressive parkinsonism. Neurobiology of aging. vol 84. 2020-08-04. PMID:31027853. |
through genetic screening of 165 cases possibly associated with tauopathies, including 88 alzheimer's disease, 26 behavioral variant ftd, eight primary progressive aphasia, nine ftd with motor neuron disease, 21 progressive supranuclear palsy, and 13 corticobasal syndrome, we identified two novel mapt variants: a heterozygous missense variant, p.p160s, in a patient with ftd with motor neuron disease and a heterozygous insertional variant, p.k298_h299insq, in three patients with familial progressive supranuclear palsy. |
2020-08-04 |
2023-08-13 |
Not clear |
| Celeste M Karch, Aimee W Kao, Anna Karydas, Khadijah Onanuga, Rita Martinez, Andrea Argouarch, Chao Wang, Cindy Huang, Peter Dongmin Sohn, Kathryn R Bowles, Salvatore Spina, M Catarina Silva, Jacob A Marsh, Simon Hsu, Derian A Pugh, Nupur Ghoshal, Joanne Norton, Yadong Huang, Suzee E Lee, William W Seeley, Panagiotis Theofilas, Lea T Grinberg, Fermin Moreno, Kathryn McIlroy, Bradley F Boeve, Nigel J Cairns, John F Crary, Stephen J Haggarty, Justin K Ichida, Kenneth S Kosik, Bruce L Miller, Li Gan, Alison M Goate, Sally Templ. A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies. Stem cell reports. vol 13. issue 5. 2020-06-29. PMID:31631020. |
primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (mapt) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. |
2020-06-29 |
2023-08-13 |
Not clear |
| Changyi Ji, Maoping Tang, Claudia Zeidler, Jörg Höhfeld, Gail Vw Johnso. BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes. Autophagy. vol 15. issue 7. 2020-06-15. PMID:30744518. |
given that accumulation of hyperphosphorylated mapt contributes to the pathogenesis of alzheimer disease and other tauopathies, decreasing endogenous mapt levels has been shown to be beneficial to neuronal health in models of these diseases. |
2020-06-15 |
2023-08-13 |
Not clear |
| Yin Xu, Sheng Zhang, Hui Zhen. The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau). Autophagy. vol 15. issue 4. 2020-05-11. PMID:30290707. |
accumulating evidence suggests that misfolded mapt (microtubule associated protein tau), the main component of neurofibrillary tangles in tauopathies, is subject to degradation by the autophagy-lysosomal pathway. |
2020-05-11 |
2023-08-13 |
mouse |
| Ilie-Cosmin Stancu, Mattia Ferraiolo, Dick Terwel, Ilse Dewachte. Tau Interacting Proteins: Gaining Insight into the Roles of Tau in Health and Disease. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096036. |
however, mutations in mapt have been identified which are autosomal dominantly linked to tauopathies, including ftdp, psp and cbd [94, 163, 185] (alzforum, https://www.alzforum.org/mutations/mapt ). |
2020-04-08 |
2023-08-13 |
human |
| Saif Zaman, Boris I Chobrutskiy, George Blanc. MAPT (Tau) expression is a biomarker for an increased rate of survival in pediatric neuroblastoma. Cell cycle (Georgetown, Tex.). vol 17. issue 21-22. 2019-11-18. PMID:30394813. |
although the impact of mapt (tau) expression has been well documented for neuronal cells in the context of tauopathies and neurodegenerative diseases, the impact and role of tau expression in cancer, and specifically cancers of neuronal origin, is in its infancy. |
2019-11-18 |
2023-08-13 |
human |
| Federica Morelli, Margherita Romeo, Maria Monica Barzago, Marco Bolis, Davide Mattioni, Giacomina Rossi, Fabrizio Tagliavini, Antonio Bastone, Mario Salmona, Luisa Diomed. V363I and V363A mutated tau affect aggregation and neuronal dysfunction differently in C. elegans. Neurobiology of disease. vol 117. 2019-09-06. PMID:29936232. |
mutations in the microtubule-associated protein tau (mapt) gene have been linked to a heterogeneous group of progressive neurodegenerative disorders commonly called tauopathies. |
2019-09-06 |
2023-08-13 |
caenorhabditis_elegans |
| Olga N Kokiko-Cochran, Maha Saber, Shweta Puntambekar, Shane M Bemiller, Atsuko Katsumoto, Yu-Shang Lee, Kiran Bhaskar, Richard M Ransohoff, Bruce T Lam. Traumatic Brain Injury in hTau Model Mice: Enhanced Acute Macrophage Response and Altered Long-Term Recovery. Journal of neurotrauma. vol 35. issue 1. 2019-07-08. PMID:28859549. |
traumatic brain injury (tbi) induces widespread neuroinflammation and accumulation of microtubule associated protein tau (mapt): two key pathological features of tauopathies. |
2019-07-08 |
2023-08-13 |
mouse |