| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kiran Bhaskar, Megan Konerth, Olga N Kokiko-Cochran, Astrid Cardona, Richard M Ransohoff, Bruce T Lam. Regulation of tau pathology by the microglial fractalkine receptor. Neuron. vol 68. issue 1. 2010-10-22. PMID:20920788. |
aggregates of the hyperphosphorylated microtubule-associated protein tau (mapt) are an invariant neuropathological feature of tauopathies. |
2010-10-22 |
2023-08-12 |
mouse |
| Mathias Dutschmann, Clement Menuet, Georg M Stettner, Christian Gestreau, Peter Borghgraef, Herman Devijver, Lies Gielis, Gerard Hilaire, Fred Van Leuve. Upper airway dysfunction of Tau-P301L mice correlates with tauopathy in midbrain and ponto-medullary brainstem nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 5. 2010-03-05. PMID:20130190. |
some primary tauopathies are linked to mutations in the mapt gene coding for protein tau, but most are sporadic with unknown causes. |
2010-03-05 |
2023-08-12 |
mouse |
| Jesse B G Hayesmoore, Nicholas J Bray, William C Cross, Michael J Owen, Michael C O'Donovan, Huw R Morri. The effect of age and the H1c MAPT haplotype on MAPT expression in human brain. Neurobiology of aging. vol 30. issue 10. 2009-10-30. PMID:18276036. |
the mapt h1c haplotype is a risk factor for the neurodegenerative tauopathies progressive supranuclear palsy (psp) and alzheimer's disease. |
2009-10-30 |
2023-08-12 |
human |
| Anna Kowalsk. [The genetics of dementias. Part 1: Molecular basis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)]. Postepy higieny i medycyny doswiadczalnej (Online). vol 63. 2009-10-27. PMID:19535823. |
in contrast to alzheimer's disease(ad), there are neither senile plaques nor neurofibrillary tangles in the brains of ftd patients.frontotemporal dementias are tauopathies, a group of disorders caused by aberrant metabolism of tau protein, a family of proteins associated with microtubules (mapt: macro-tubule-associated tau protein). |
2009-10-27 |
2023-08-12 |
human |
| Qin Shen, Xusheng Wang, Ying Chen, Lingli Xu, Xiaodong Wang, Lu L. Expression QTL and regulatory network analysis of microtubule-associated protein tau gene. Parkinsonism & related disorders. vol 15. issue 7. 2009-10-12. PMID:19233709. |
numerous studies have shown that the microtubule-associated protein tau (mapt) gene plays an important role in tauopathies. |
2009-10-12 |
2023-08-12 |
mouse |
| Jana Vandrovcova, Alan M Pittman, Elke Malzer, Patrick M Abou-Sleiman, Andrew J Lees, Nicholas W Wood, Rohan de Silv. Association of MAPT haplotype-tagging SNPs with sporadic Parkinson's disease. Neurobiology of aging. vol 30. issue 9. 2009-10-09. PMID:18162161. |
in addition, the mapt h1-clade specific sub-haplotype, h1c, has been strongly associated with the tauopathies, progressive supranuclear palsy (psp) and corticobasal degeneration (cbd) and, to a lesser extent, with alzheimer's disease (ad). |
2009-10-09 |
2023-08-12 |
Not clear |
| Kallirhoe Kalinderi, Liana Fidani, Sevasti Bostantjopoulo. From 1997 to 2007: a decade journey through the H1 haplotype on 17q21 chromosome. Parkinsonism & related disorders. vol 15. issue 1. 2009-03-26. PMID:18424220. |
initially, a dinucleotide polymorphism was detected in the tau (mapt) gene and was subsequently found to be in linkage disequilibrium (ld) with other polymorphisms, forming the mapt h1 haplotype, a risk factor for many neurological diseases, considered as tauopathies. |
2009-03-26 |
2023-08-12 |
Not clear |
| Kallirhoe Kalinderi, Liana Fidani, Sevasti Bostantjopoulo. From 1997 to 2007: a decade journey through the H1 haplotype on 17q21 chromosome. Parkinsonism & related disorders. vol 15. issue 1. 2009-03-26. PMID:18424220. |
currently, the h1 haplotype extends beyond the outer edges of mapt encompassing multiple genes on chromosome 17 and thus increasing the number of candidate genes implicated in the pathogenesis of tauopathies. |
2009-03-26 |
2023-08-12 |
Not clear |
| Anna-Lotta Kaivorinne, Johanna Krüger, Katja Kuivaniemi, Hannu Tuominen, Virpi Moilanen, Kari Majamaa, Anne M Reme. Role of MAPT mutations and haplotype in frontotemporal lobar degeneration in Northern Finland. BMC neurology. vol 8. 2009-02-27. PMID:19091059. |
the h1 haplotype of mapt has been found to be closely associated with tauopathies and with sporadic ftld. |
2009-02-27 |
2023-08-12 |
Not clear |
| Franziska Denk, Richard Wade-Martin. Knock-out and transgenic mouse models of tauopathies. Neurobiology of aging. vol 30. issue 1. 2009-02-19. PMID:17590238. |
tauopathies, characterized by the dysfunction and aggregation of the microtubule-associated protein tau (mapt), represent some of the most devastating neurodegenerative disorders afflicting the elderly, including alzheimer's disease and progressive supranuclear palsy. |
2009-02-19 |
2023-08-12 |
mouse |
| Franziska Denk, Richard Wade-Martin. Knock-out and transgenic mouse models of tauopathies. Neurobiology of aging. vol 30. issue 1. 2009-02-19. PMID:17590238. |
finally, we discuss potential future mapt genomic dna models to investigate the importance of alternative splicing of the mapt locus and its role in sporadic tauopathies. |
2009-02-19 |
2023-08-12 |
mouse |
| S M Laws, P Friedrich, J Diehl-Schmid, J Müller, B Ibach, J Bäuml, T Eisele, H Förstl, A Kurz, M Riemenschneide. Genetic analysis of MAPT haplotype diversity in frontotemporal dementia. Neurobiology of aging. vol 29. issue 8. 2008-08-21. PMID:17386961. |
the h1 haplotype of the tau gene, mapt, has been linked to the sporadic tauopathies corticobasal degeneration and progressive supranuclear palsy; however, there have been inconsistent findings regarding association with frontotemporal dementia (ftd). |
2008-08-21 |
2023-08-12 |
Not clear |
| S M Laws, P Friedrich, J Diehl-Schmid, J Müller, B Ibach, J Bäuml, T Eisele, H Förstl, A Kurz, M Riemenschneide. Genetic analysis of MAPT haplotype diversity in frontotemporal dementia. Neurobiology of aging. vol 29. issue 8. 2008-08-21. PMID:17386961. |
these findings do not support an association of mapt with ftd but do not rule out its association with other tauopathies. |
2008-08-21 |
2023-08-12 |
Not clear |
| Rebecca F Rosen, Aaron S Farberg, Marla Gearing, Jeromy Dooyema, Patrick M Long, Daniel C Anderson, Jeremy Davis-Turak, Giovanni Coppola, Daniel H Geschwind, Jean-Francois Paré, Timothy Q Duong, William D Hopkins, Todd M Preuss, Lary C Walke. Tauopathy with paired helical filaments in an aged chimpanzee. The Journal of comparative neurology. vol 509. issue 3. 2008-07-15. PMID:18481275. |
the neurodegenerative tauopathies are typified by the intracellular aggregation of hyperphosphorylated microtubule-associated protein tau (mapt) and the dysfunction and death of affected neurons. |
2008-07-15 |
2023-08-12 |
human |
| Rebecca F Rosen, Aaron S Farberg, Marla Gearing, Jeromy Dooyema, Patrick M Long, Daniel C Anderson, Jeremy Davis-Turak, Giovanni Coppola, Daniel H Geschwind, Jean-Francois Paré, Timothy Q Duong, William D Hopkins, Todd M Preuss, Lary C Walke. Tauopathy with paired helical filaments in an aged chimpanzee. The Journal of comparative neurology. vol 509. issue 3. 2008-07-15. PMID:18481275. |
sequencing of the exons and flanking intronic regions in the genomic mapt locus disclosed no mutations that are associated with the known human hereditary tauopathies, nor any polymorphisms of obvious functional significance. |
2008-07-15 |
2023-08-12 |
human |
| Nigel J Cairns, Eileen H Bigio, Ian R A Mackenzie, Manuela Neumann, Virginia M-Y Lee, Kimmo J Hatanpaa, Charles L White, Julie A Schneider, Lea Tenenholz Grinberg, Glenda Halliday, Charles Duyckaerts, James S Lowe, Ida E Holm, Markus Tolnay, Koichi Okamoto, Hideaki Yokoo, Shigeo Murayama, John Woulfe, David G Munoz, Dennis W Dickson, Paul G Ince, John Q Trojanowski, David M A Man. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta neuropathologica. vol 114. issue 1. 2007-11-27. PMID:17579875. |
the proposed criteria for ftld are based on existing criteria, which include the tauopathies [ftld with pick bodies, corticobasal degeneration, progressive supranuclear palsy, sporadic multiple system tauopathy with dementia, argyrophilic grain disease, neurofibrillary tangle dementia, and ftd with microtubule-associated tau (mapt) gene mutation, also called ftd with parkinsonism linked to chromosome 17 (ftdp-17)]. |
2007-11-27 |
2023-08-12 |
Not clear |
| Simon M Laws, Robert Perneczky, Alexander Drzezga, Janine Diehl-Schmid, Bernd Ibach, Josef Bäuml, Tamara Eisele, Hans Förstl, Alexander Kurz, Matthias Riemenschneide. Association of the tau haplotype H2 with age at onset and functional alterations of glucose utilization in frontotemporal dementia. The American journal of psychiatry. vol 164. issue 10. 2007-11-01. PMID:17898350. |
the microtubule-associated protein tau gene (mapt) contains two extended haplotypes, h1 and h2, which have been linked with sporadic tauopathies. |
2007-11-01 |
2023-08-12 |
Not clear |
| John Hardy, Alan Pittman, Amanda Myers, Hon Chung Fung, Rohan de Silva, Jaime Duckwort. Tangle diseases and the tau haplotypes. Alzheimer disease and associated disorders. vol 20. issue 1. 2006-07-03. PMID:16493238. |
we discuss the reason for this disequilibrium, its evolutionary history, and the role of genetic variability at mapt in the etiology of tauopathies. |
2006-07-03 |
2023-08-12 |
Not clear |
| R Rademakers, M Cruts, C van Broeckhove. The role of tau (MAPT) in frontotemporal dementia and related tauopathies. Human mutation. vol 24. issue 4. 2005-03-31. PMID:15365985. |
the role of tau (mapt) in frontotemporal dementia and related tauopathies. |
2005-03-31 |
2023-08-12 |
mouse |
| Alan M Pittman, Amanda J Myers, Jaime Duckworth, Leslie Bryden, Melissa Hanson, Patrick Abou-Sleiman, Nicholas W Wood, John Hardy, Andrew Lees, Rohan de Silv. The structure of the tau haplotype in controls and in progressive supranuclear palsy. Human molecular genetics. vol 13. issue 12. 2004-12-22. PMID:15115761. |
the group of neurodegenerative diseases collectively known as tauopathies are characterized by hallmark lesions consisting of fibrillar aggregates of the microtubule-associated protein, tau (mapt). |
2004-12-22 |
2023-08-12 |
Not clear |