| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simon Dujardin, Séverine Bégard, Raphaëlle Caillierez, Cédrick Lachaud, Sébastien Carrier, Sarah Lieger, Jose A Gonzalez, Vincent Deramecourt, Nicole Déglon, Claude-Alain Maurage, Matthew P Frosch, Bradley T Hyman, Morvane Colin, Luc Bué. Different tau species lead to heterogeneous tau pathology propagation and misfolding. Acta neuropathologica communications. vol 6. issue 1. 2019-06-03. PMID:30497516. |
most of them are sporadic but certain tauopathies rely on tau gene (mapt) mutations. |
2019-06-03 |
2023-08-13 |
human |
| Shelley L Forrest, Jillian J Kril, Claire H Stevens, John B Kwok, Marianne Hallupp, Woojin S Kim, Yue Huang, Ciara V McGinley, Hellen Werka, Matthew C Kiernan, Jürgen Götz, Maria Grazia Spillantini, John R Hodges, Lars M Ittner, Glenda M Hallida. Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies. Brain : a journal of neurology. vol 141. issue 2. 2019-05-30. PMID:29253099. |
retiring the term ftdp-17 as mapt mutations are genetic forms of sporadic frontotemporal tauopathies. |
2019-05-30 |
2023-08-13 |
Not clear |
| Kevin H Strang, Cara L Croft, Zachary A Sorrentino, Paramita Chakrabarty, Todd E Golde, Benoit I Giasso. Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies. The Journal of biological chemistry. vol 293. issue 7. 2019-02-05. PMID:29259137. |
the accumulation of aberrantly aggregated mapt (microtubule-associated protein tau) defines a spectrum of tauopathies, including alzheimer's disease. |
2019-02-05 |
2023-08-13 |
Not clear |
| María José Gil, María Sagrario Manzano, María Luz Cuadrado, Cristina Fernández, Elena Góméz, Carmen Matesanz, Miguel Calero, Alberto Rában. Frontotemporal lobar degeneration: Study of a clinicopathological cohort. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 58. 2018-12-21. PMID:30348585. |
h1/h1 haplotype of the mapt gene was the most frequent and appeared in relationship with 4r tauopathies. |
2018-12-21 |
2023-08-13 |
Not clear |
| Justin R Welden, Jacob van Doorn, Peter T Nelson, Stefan Stam. The human MAPT locus generates circular RNAs. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 9 Pt B. 2018-12-11. PMID:29729314. |
the microtubule-associated protein tau, generated by the mapt gene is involved in dozens of neurodegenerative conditions ("tauopathies"), including alzheimer's disease (ad) and frontotemporal lobar degeneration/frontotemporal dementia (ftld/ftd). |
2018-12-11 |
2023-08-13 |
human |
| Sandra Köglsberger, Maria Lorena Cordero-Maldonado, Paul Antony, Julia Ilona Forster, Pierre Garcia, Manuel Buttini, Alexander Crawford, Enrico Glaa. Gender-Specific Expression of Ubiquitin-Specific Peptidase 9 Modulates Tau Expression and Phosphorylation: Possible Implications for Tauopathies. Molecular neurobiology. vol 54. issue 10. 2018-07-27. PMID:27878758. |
overall, the analyses suggest usp9 may contribute to molecular gender differences observed in tauopathies and provide a new target for intervention strategies to modulate mapt expression. |
2018-07-27 |
2023-08-13 |
human |
| Lindsey B Shelton, Jeremy D Baker, Dali Zheng, Leia E Sullivan, Parth K Solanki, Jack M Webster, Zheying Sun, Jonathan J Sabbagh, Bryce A Nordhues, John Koren, Suman Ghosh, Brian S J Blagg, Laura J Blair, Chad A Dicke. Hsp90 activator Aha1 drives production of pathological tau aggregates. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 36. 2018-06-04. PMID:28827321. |
the microtubule-associated protein tau (mapt, tau) forms neurotoxic aggregates that promote cognitive deficits in tauopathies, the most common of which is alzheimer's disease (ad). |
2018-06-04 |
2023-08-13 |
mouse |
| Carol Dobson-Stone, John B J Kwo. Finding MAPT Mutations in Frontotemporal Dementia and Other Tauopathies. Methods in molecular biology (Clifton, N.J.). vol 1523. 2018-01-22. PMID:27975259. |
finding mapt mutations in frontotemporal dementia and other tauopathies. |
2018-01-22 |
2023-08-13 |
human |
| Jeremy D Baker, Lindsey B Shelton, Dali Zheng, Filippo Favretto, Bryce A Nordhues, April Darling, Leia E Sullivan, Zheying Sun, Parth K Solanki, Mackenzie D Martin, Amirthaa Suntharalingam, Jonathan J Sabbagh, Stefan Becker, Eckhard Mandelkow, Vladimir N Uversky, Markus Zweckstetter, Chad A Dickey, John Koren, Laura J Blai. Human cyclophilin 40 unravels neurotoxic amyloids. PLoS biology. vol 15. issue 6. 2017-10-02. PMID:28654636. |
the aberrant accumulation of the microtubule associating protein tau (mapt, tau) into toxic oligomers and amyloid deposits is a primary pathology in tauopathies, the most common of which is alzheimer's disease (ad). |
2017-10-02 |
2023-08-13 |
mouse |
| Ghulam Jeelani Pir, Bikash Choudhary, Eckhard Mandelkow, Eva-Maria Mandelko. Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model. Molecular neurodegeneration. vol 11. 2016-11-08. PMID:27118310. |
a certain number of mutations in the microtubule-associated protein tau (mapt) gene have been identified in individuals with high risk to develop neurodegenerative diseases, collectively called tauopathies. |
2016-11-08 |
2023-08-13 |
caenorhabditis_elegans |
| Magdalena Maj, Gregor Hoermann, Sazan Rasul, Wolfgang Base, Ludwig Wagner, Johannes Attem. The Microtubule-Associated Protein Tau and Its Relevance for Pancreatic Beta Cells. Journal of diabetes research. vol 2016. 2016-10-25. PMID:26824039. |
structural and biochemical alterations of the microtubule-associated protein tau (mapt) are associated with degenerative disorders referred to as tauopathies. |
2016-10-25 |
2023-08-13 |
human |
| Seyedeh Maryam Alavi Naini, Nadia Soussi-Yanicosta. Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies? Oxidative medicine and cellular longevity. vol 2015. 2016-07-25. PMID:26576216. |
however, although mutations of the mapt gene have been detected in familial early-onset tauopathies, causative events in the more frequent sporadic late-onset forms and relationships between tau hyperphosphorylation and neurodegeneration remain largely elusive. |
2016-07-25 |
2023-08-13 |
Not clear |
| Melissa C Wren, Jing Zhao, Chia-Chen Liu, Melissa E Murray, Yuka Atagi, Mary D Davis, Yuan Fu, Hirotaka J Okano, Kotaro Ogaki, Audrey J Strongosky, Pawel Tacik, Rosa Rademakers, Owen A Ross, Dennis W Dickson, Zbigniew K Wszolek, Takahisa Kanekiyo, Guojun B. Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells. Molecular neurodegeneration. vol 10. 2016-03-21. PMID:26373282. |
although mutations in the mapt gene have been linked to multiple tauopathies including alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy, knowledge regarding how tau n279k mutation causes ppnd/ftdp-17 is limited. |
2016-03-21 |
2023-08-13 |
Not clear |
| Yutaro Komuro, Guixiang Xu, Kiran Bhaskar, Bruce T Lam. Human tau expression reduces adult neurogenesis in a mouse model of tauopathy. Neurobiology of aging. vol 36. issue 6. 2016-03-17. PMID:25863528. |
accumulation of hyperphosphorylated and aggregated microtubule-associated protein tau (mapt) is a central feature of a class of neurodegenerative diseases termed tauopathies. |
2016-03-17 |
2023-08-13 |
mouse |
| Yutaro Komuro, Guixiang Xu, Kiran Bhaskar, Bruce T Lam. Human tau expression reduces adult neurogenesis in a mouse model of tauopathy. Neurobiology of aging. vol 36. issue 6. 2016-03-17. PMID:25863528. |
taken together, these studies provide evidence that altered adult neurogenesis is a robust and early marker of altered, cell-autonomous function of mapt in the htau mouse mode of tauopathy and that altered adult neurogenesis should be examined as a potential marker and therapeutic target for human tauopathies. |
2016-03-17 |
2023-08-13 |
mouse |
| Mariangela Iovino, Sylvia Agathou, Ana González-Rueda, Martin Del Castillo Velasco-Herrera, Barbara Borroni, Antonella Alberici, Timothy Lynch, Sean O'Dowd, Imbisaat Geti, Daniel Gaffney, Ludovic Vallier, Ole Paulsen, Ragnhildur Thóra Káradóttir, Maria Grazia Spillantin. Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations. Brain : a journal of neurology. vol 138. issue Pt 11. 2016-02-09. PMID:26220942. |
tauopathies, such as alzheimer's disease, some cases of frontotemporal dementia, corticobasal degeneration and progressive supranuclear palsy, are characterized by aggregates of the microtubule-associated protein tau, which are linked to neuronal death and disease development and can be caused by mutations in the mapt gene. |
2016-02-09 |
2023-08-13 |
human |
| Camilla N Clark, Tammaryn Lashley, Colin J Mahoney, Jason D Warren, Tamas Revesz, Jonathan D Rohre. Temporal Variant Frontotemporal Dementia is Associated with Globular Glial Tauopathy. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. vol 28. issue 2. 2016-01-12. PMID:26102999. |
for patients with temporal variant ftd, the most common cause found on post-mortem examination has been a tdp-43 (transactive response dna-binding protein 43 kda) proteinopathy, but tauopathies have also been described, including pick's disease and mutations in the microtubule-associated protein tau (mapt) gene. |
2016-01-12 |
2023-08-13 |
Not clear |
| Hong Xu, Thomas W Rösler, Thomas Carlsson, Anderson de Andrade, Ondrej Fiala, Matthias Hollerhage, Wolfgang H Oertel, Michel Goedert, Achim Aigner, Gunter U Höglinge. Tau silencing by siRNA in the P301S mouse model of tauopathy. Current gene therapy. vol 14. issue 5. 2015-10-13. PMID:25687501. |
our data suggest that sirna against mapt can serve as a potential tool for gene therapy in tauopathies. |
2015-10-13 |
2023-08-13 |
mouse |
| Nicole Maphis, Guixiang Xu, Olga N Kokiko-Cochran, Astrid E Cardona, Richard M Ransohoff, Bruce T Lamb, Kiran Bhaska. Loss of tau rescues inflammation-mediated neurodegeneration. Frontiers in neuroscience. vol 9. 2015-06-19. PMID:26089772. |
activated microglia spatially coexist with microtubule-associated protein tau (mapt or tau)-burdened neurons in the brains of human ad and non-ad tauopathies. |
2015-06-19 |
2023-08-13 |
mouse |
| Albert J Lyons, Neha S Gandhi, Ricardo L Mancer. Molecular dynamics simulation of the phosphorylation-induced conformational changes of a tau peptide fragment. Proteins. vol 82. issue 9. 2015-06-08. PMID:24577753. |
aggregation of the microtubule associated protein tau (mapt) within neurons of the brain is the leading cause of tauopathies such as alzheimer's disease. |
2015-06-08 |
2023-08-12 |
Not clear |