| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tai Zhou, Lei Zhang, Li He, Yan Lan, Lei Ding, Li Li, Zhongcheng Wan. GSK-126 Attenuates Cell Apoptosis in Ischemic Brain Injury by Modulating the EZH2-H3K27me3-Bcl2l1 Axis. Molecular neurobiology. 2023-11-22. PMID:37989985. |
since the expression of many antiapoptotic genes is inhibited in the ischemic brains, here we aimed to offer an epigenetic solution to cell apoptosis after stroke by reversing h3k27me3 levels after ischemia. |
2023-11-22 |
2023-11-29 |
Not clear |
| Victoria Jiménez Carretero, Eva Ramos, Pedro Segura-Chama, Adan Hernández, Andrés M Baraibar, Iris Álvarez-Merz, Francisco López Muñoz, Javier Egea, José M Solís, Alejandro Romero, Jesús M Hernández-Guij. Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging. Antioxidants (Basel, Switzerland). vol 12. issue 10. 2023-10-30. PMID:37891922. |
they can attenuate oxidative stress, modulate calcium homeostasis, and inhibit apoptosis, thereby safeguarding neurons against damage induced by stroke and aging processes. |
2023-10-30 |
2023-11-08 |
Not clear |
| Hui Xu, Jiangtao Dong, Yang Li, Lei Zhang, Jiangwen Yin, Chao Zhu, Xu Wang, Kunhao Ren, Hao Zhang, Dong Zha. Neuritin has a neuroprotective role in the rat model of acute ischemia stroke by inhibiting neuronal apoptosis and NLRP3 inflammasome. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 32. issue 12. 2023-10-13. PMID:37832268. |
neuritin has a neuroprotective role in the rat model of acute ischemia stroke by inhibiting neuronal apoptosis and nlrp3 inflammasome. |
2023-10-13 |
2023-10-15 |
rat |
| Hui Xu, Jiangtao Dong, Yang Li, Lei Zhang, Jiangwen Yin, Chao Zhu, Xu Wang, Kunhao Ren, Hao Zhang, Dong Zha. Neuritin has a neuroprotective role in the rat model of acute ischemia stroke by inhibiting neuronal apoptosis and NLRP3 inflammasome. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 32. issue 12. 2023-10-13. PMID:37832268. |
this study explored the anti-inflammatory, anti-neuronal apoptosis, and neuroprotective effects of neuritin in rat models of acute ischemia stroke (ais). |
2023-10-13 |
2023-10-15 |
rat |
| Morgan J Rothschadl, Monica Sathyanesan, Samuel S Newto. Synergism of Carbamoylated Erythropoietin and Insulin-like Growth Factor-1 in Immediate Early Gene Expression. Life (Basel, Switzerland). vol 13. issue 9. 2023-09-28. PMID:37763230. |
previous preclinical studies have shown synergistic effects on decreasing apoptosis and improving behavioral performance after stroke when combining two such trophic factors, erythropoietin (epo) and insulin-like growth factor-1 (igf-1). |
2023-09-28 |
2023-10-07 |
rat |
| Fei Zhuang, Xin Shi, Sen Qiao, Bin Liu, Zhimei Wang, Huanhuan Huo, Feng Liang, Linghong Shen, Lijuan Zhu, Ben He, Hongmei Wan. Allicin promotes functional recovery in ischemic stroke via glutathione peroxidase-1 activation of Src-Akt-Erk. Cell death discovery. vol 9. issue 1. 2023-09-06. PMID:37673878. |
our results suggested that allicin could significantly ameliorate behavioral characteristics, cerebral infarct area, cell apoptosis, inflammatory factors, and lipid metabolic-related factors (arachidonic acid, 15-hydroperoxy-eicosatetraenoic acid (15s-hpete), palmitoylcarnitine, and acylcarnitine) by recalibrating astrocyte homeostasis in mice with photothrombotic stroke (pt). |
2023-09-06 |
2023-10-07 |
mouse |
| Li Wang, Wenzhan Tu, Xuqing Li, Caiyan Li, Junhong Lu, Peng Dai, Yuewei Chen, Meilin Gu, Ming Li, Songhe Jiang, Guanhu Yang, Shengcun L. Exercise improves cardiac function and attenuates myocardial inflammation and apoptosis by regulating APJ/STAT3 in mice with stroke. Life sciences. 2023-09-01. PMID:37657526. |
exercise improves cardiac function and attenuates myocardial inflammation and apoptosis by regulating apj/stat3 in mice with stroke. |
2023-09-01 |
2023-09-07 |
mouse |
| Li Wang, Wenzhan Tu, Xuqing Li, Caiyan Li, Junhong Lu, Peng Dai, Yuewei Chen, Meilin Gu, Ming Li, Songhe Jiang, Guanhu Yang, Shengcun L. Exercise improves cardiac function and attenuates myocardial inflammation and apoptosis by regulating APJ/STAT3 in mice with stroke. Life sciences. 2023-09-01. PMID:37657526. |
the results demonstrated that chronic exercise prevented myocardial inflammation, apoptosis and cardiac dysfunction after stroke. |
2023-09-01 |
2023-09-07 |
mouse |
| Li Wang, Wenzhan Tu, Xuqing Li, Caiyan Li, Junhong Lu, Peng Dai, Yuewei Chen, Meilin Gu, Ming Li, Songhe Jiang, Guanhu Yang, Shengcun L. Exercise improves cardiac function and attenuates myocardial inflammation and apoptosis by regulating APJ/STAT3 in mice with stroke. Life sciences. 2023-09-01. PMID:37657526. |
this study showed that exercise can maintain apj expression and inhibit p-stat3, thus, conferring protection against myocardial inflammation and apoptosis induced by stroke. |
2023-09-01 |
2023-09-07 |
mouse |
| Arshi Waseem, Abdul Quaiyoom Khan, Mohsin Ali Khan, Rehan Khan, Shahab Uddin, Johannes Boltze, Syed Shadab Raz. Unveiling the Therapeutic Potential of Non-coding RNAs in Stroke-Induced Tissue Regeneration. Stem cells (Dayton, Ohio). 2023-08-17. PMID:37591309. |
aberrant expression of various non-coding rnas (ncrnas) has been identified after stroke onset, impacting neurogenesis, angiogenesis, apoptosis and autophagy. |
2023-08-17 |
2023-09-07 |
Not clear |
| Minqi Zhou, Jiayu Xin, Jinyu Chen, Caiyun Sun, Bingyue Huo, Wenting Zhang, Xiangqian Li. Scientific Landscape of Oxidative Stress in Stroke: From a Bibliometric Analysis to an in-Depth Review. Neurochemical research. 2023-07-28. PMID:37505366. |
current key research areas of os in stroke may lie in the investigation of neuroinflammation, and interaction among multiple cell death mechanisms including apoptosis, autophagy, and ferroptosis to search for effective treatments. |
2023-07-28 |
2023-08-14 |
Not clear |
| Binhao Chen, Weifeng Ji. A comprehensive review of stroke-related signaling pathways and treatment in western medicine and traditional Chinese medicine. Frontiers in neuroscience. vol 17. 2023-06-23. PMID:37351420. |
the involvement of multiple signaling pathways, including sonic hedgehog (shh), nuclear factor erythroid 2-related factor 2 (nrf2)/antioxidant response element (are), hypoxia-inducible factor-1α (hif-1α), pi3k/akt, jak/stat, and ampk in pathophysiological mechanisms such as oxidative stress and apoptosis, highlights the complexity of stroke. |
2023-06-23 |
2023-08-14 |
Not clear |
| Pin Zhao, Jiapo Zhang, JianKe Kuai, Liya Li, Xuying Li, Namin Feng, Hailiang Du, Chen Li, Qiang Wang, Bin Den. TAT-PEP Alleviated Cognitive Impairment by Alleviating Neuronal Mitochondria Damage and Apoptosis After Cerebral Ischemic Reperfusion Injury. Molecular neurobiology. 2023-06-19. PMID:37335462. |
this study also suggests that tat-pep may be a potent neuroprotectant with therapeutic potential for stroke by reducing neuronal oxidative stress, mitochondrial damage, degeneration and apoptosis in ischemic stroke. |
2023-06-19 |
2023-08-14 |
Not clear |
| Shuai Li, Jingyuan Zhao, Yan Xi, Jiaqi Ren, Yanna Zhu, Yan Lu, Deshi Don. Dl-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282472. |
these findings suggest that dl-3-n-butylphthalide exhibits a neuroprotective effect on stroke by promoting hypoxia inducible factor-1α ubiquitination and degradation and inhibiting cell apoptosis. |
2023-06-07 |
2023-08-14 |
Not clear |
| Grazyna Lietzau, Waldemar Sienkiewicz, Zbigniew Karwacki, Jerzy Dziewiątkowski, Jerzy Kaleczyc, Przemysław Kowiańsk. The Effect of Simvastatin on the Dynamics of NF-κB-Regulated Neurodegenerative and Neuroprotective Processes in the Acute Phase of Ischemic Stroke. Molecular neurobiology. 2023-05-19. PMID:37204689. |
the nuclear factor-kappa b (nf-κb) transcription factor is involved in the regulation of apoptosis in stroke. |
2023-05-19 |
2023-08-14 |
rat |
| Kuo-Jen Wu, Tsai-Wei Hung, Yu-Syuan Wang, Yun-Hsiang Chen, Eun-Kyung Bae, Seong-Jin Y. Prosaposin PS18 reduces dopaminergic neurodegeneration in a 6-hydroxydopamine rat model of Parkinson's disease. Scientific reports. vol 13. issue 1. 2023-05-19. PMID:37208379. |
prosaposin or its analog prosaposin-derived 18-mer peptide (ps18) reduced neuronal damage in hippocampus and apoptosis in stroke brain. |
2023-05-19 |
2023-08-14 |
rat |
| Qian Suo, Lidong Deng, Tingting Chen, Shengju Wu, Lin Qi, Ze Liu, Tingting He, Heng-Li Tian, Wanlu Li, Yaohui Tang, Guo-Yuan Yang, Zhijun Zhan. Optogenetic Activation of Astrocytes Reduces Blood-Brain Barrier Disruption via IL-10 In Stroke. Aging and disease. 2023-05-17. PMID:37196130. |
moreover, photo-stimulation of astrocytes protected neurons against apoptosis and improved neurobehavioral outcomes in stroke rats compared to controls (p<0.05). |
2023-05-17 |
2023-08-14 |
rat |
| Neha Dhir, Ashish Jain, Amit Raj Sharma, Sunil Sharma, Dhruv Mahendru, Ajay Patial, Deepti Malik, Ajay Prakash, Savita Verma Attri, Shalmoli Bhattacharyya, Bishan Das Radotra, Bikash Medh. Rat BM-MSCs secretome alone and in combination with stiripentol and ISRIB, ameliorated microglial activation and apoptosis in experimental stroke. Behavioural brain research. 2023-05-05. PMID:37146724. |
rat bm-mscs secretome alone and in combination with stiripentol and isrib, ameliorated microglial activation and apoptosis in experimental stroke. |
2023-05-05 |
2023-08-14 |
rat |
| Mohammad Yusuf Hasan, Rosfaiizah Siran, Mohd Kaisan Mahad. The Effects of Vagus Nerve Stimulation on Animal Models of Stroke-Induced Injury: A Systematic Review. Biology. vol 12. issue 4. 2023-04-28. PMID:37106754. |
we concluded that vns yields stroke treatment potential by improving neurological deficit score, infarct volume, forelimb strength, inflammation, apoptosis, and angiogenesis. |
2023-04-28 |
2023-08-14 |
rat |
| Nan Qiao, Zhaohong An, Zeyu Fu, Xingyu Chen, Qingyi Tong, Yonghui Zhang, Hong Re. Kinsenoside alleviates oxidative stress-induced blood-brain barrier dysfunction via promoting Nrf2/HO-1 pathway in ischemic stroke. European journal of pharmacology. 2023-04-13. PMID:37054938. |
intracerebroventricular administration of kd upon reperfusion after 1 h ischemia decreased infarct volumes, neurological deficit, brain edema, neuronal loss, and apoptosis 72 h post-ischemic stroke. |
2023-04-13 |
2023-08-14 |
mouse |