| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G C Ormandy, R S Jope, O C Snea. Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats. Experimental neurology. vol 106. issue 2. 1989-12-12. PMID:2553470. |
third, although it is relatively easy to block seizures induced by lithium and pilocarpine by administration of anticonvulsants prior to pilocarpine, it is more difficult to terminate ongoing status epilepticus and block the lethality of the seizures. |
1989-12-12 |
2023-08-11 |
rat |
| G C Ormandy, R S Jope, O C Snea. Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats. Experimental neurology. vol 106. issue 2. 1989-12-12. PMID:2553470. |
administration of mk-801 30 or 60 min after pilocarpine, i.e., during status epilepticus, gradually reduced electrical and behavioral seizure activity and greatly enhanced the survival rate. |
1989-12-12 |
2023-08-11 |
rat |
| G C Ormandy, R S Jope, O C Snea. Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats. Experimental neurology. vol 106. issue 2. 1989-12-12. PMID:2553470. |
this was further supported by results showing that nonconvulsive doses of nmda and pilocarpine were synergistic, resulting in status epilepticus and subsequent mortality. |
1989-12-12 |
2023-08-11 |
rat |
| H B Michelson, J Kapur, E W Lothma. Reduction of paired pulse inhibition in the CA1 region of the hippocampus by pilocarpine in naive and in amygdala-kindled rats. Experimental neurology. vol 104. issue 3. 1989-07-07. PMID:2721629. |
subconvulsant doses (20 mg/kg) of pilocarpine administered to a kindled rat convert a kindled seizure to status epilepticus. |
1989-07-07 |
2023-08-11 |
rat |
| H B Michelson, J Kapur, E W Lothma. Reduction of paired pulse inhibition in the CA1 region of the hippocampus by pilocarpine in naive and in amygdala-kindled rats. Experimental neurology. vol 104. issue 3. 1989-07-07. PMID:2721629. |
these findings suggest that the ability of subconvulsive doses of pilocarpine to change a discrete kindled seizure triggered by one stimulus to status epilepticus depends on the suppression of gabaergic inhibition below a critical level. |
1989-07-07 |
2023-08-11 |
rat |
| L Turski, E A Cavalheiro, S J Czuczwar, W A Turski, Z Kleinro. The seizures induced by pilocarpine: behavioral, electroencephalographic and neuropathological studies in rodents. Polish journal of pharmacology and pharmacy. vol 39. issue 5. 1989-03-27. PMID:3333612. |
developmental studies show age-dependent differences in the convulsant response of rats to pilocarpine and status epilepticus are first noted in 2-3 week-old rats, but there is no clear-cut correlation between seizures and evolution of brain damage at this age. |
1989-03-27 |
2023-08-11 |
mouse |
| C Ikonomidou-Turski, E A Cavalheiro, L Turski, Z A Bortolotto, Z Kleinrok, L S Calderazzo-Filho, W A Tursk. Differential effects of non-steroidal anti-inflammatory drugs on seizures produced by pilocarpine in rats. Brain research. vol 462. issue 2. 1989-01-11. PMID:3191389. |
the muscarinic cholinergic agonist pilocarpine induces in rats seizures and status epilepticus followed by widespread damage to the forebrain. |
1989-01-11 |
2023-08-11 |
rat |
| N Y Walton, D M Treima. Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam. Experimental neurology. vol 101. issue 2. 1988-09-07. PMID:3396644. |
response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam. |
1988-09-07 |
2023-08-11 |
rat |
| N Y Walton, D M Treima. Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam. Experimental neurology. vol 101. issue 2. 1988-09-07. PMID:3396644. |
status epilepticus (se) was induced in rats by administration of 3 mmol/kg lithium chloride followed 24 h later by injection of 25 mg/kg pilocarpine. |
1988-09-07 |
2023-08-11 |
rat |
| E A Cavalheiro, D F Silva, W A Turski, L S Calderazzo-Filho, Z A Bortolotto, L Tursk. The susceptibility of rats to pilocarpine-induced seizures is age-dependent. Brain research. vol 465. issue 1-2. 1988-04-19. PMID:3440212. |
more intense behavioral signs evolving in some animals to limbic seizures and status epilepticus occurred when pilocarpine was administered in 12-day-old-rats. |
1988-04-19 |
2023-08-11 |
rat |
| E A Cavalheiro, D F Silva, W A Turski, L S Calderazzo-Filho, Z A Bortolotto, L Tursk. The susceptibility of rats to pilocarpine-induced seizures is age-dependent. Brain research. vol 465. issue 1-2. 1988-04-19. PMID:3440212. |
akinesia, tremor and head bobbing progressed in 15-21-day-old rats given pilocarpine, 100-380 mg/kg, to motor limbic seizures and status epilepticus. |
1988-04-19 |
2023-08-11 |
rat |
| E A Cavalheiro, D F Silva, W A Turski, L S Calderazzo-Filho, Z A Bortolotto, L Tursk. The susceptibility of rats to pilocarpine-induced seizures is age-dependent. Brain research. vol 465. issue 1-2. 1988-04-19. PMID:3440212. |
morphological analysis of frontal forebrain sections in 15-21-day-old rats which underwent status epilepticus after pilocarpine revealed no damage or an attenuated pattern of damage. |
1988-04-19 |
2023-08-11 |
rat |
| R A Morrisett, R S Jope, O C Snea. Status epilepticus is produced by administration of cholinergic agonists to lithium-treated rats: comparison with kainic acid. Experimental neurology. vol 98. issue 3. 1987-12-24. PMID:2824229. |
electroencephalographic techniques were used to study generalized convulsive status epilepticus induced by administration of subconvulsive doses of cholinomimetics (e.g., pilocarpine) to rats pretreated with lithium chloride. |
1987-12-24 |
2023-08-11 |
rat |
| R A Morrisett, R S Jope, O C Snea. Status epilepticus is produced by administration of cholinergic agonists to lithium-treated rats: comparison with kainic acid. Experimental neurology. vol 98. issue 3. 1987-12-24. PMID:2824229. |
lithium/pilocarpine-induced status epilepticus developed within 10 min of initial paroxysmal spike activity, 24 +/- 1 min (n = 20) after administration of pilocarpine, and continued uninterrupted for more than 3 h. kainic acid (10 mg/kg)-induced status epilepticus developed approximately 60 min after initial spike activity, 96 +/- 3 min (n = 7) after kainate administration, and continued for 0.5 h. thus, the interval of intermittent seizure activity and the duration of status epilepticus differed markedly between these two models. |
1987-12-24 |
2023-08-11 |
rat |
| R S Jope, M Simonato, K Lall. Acetylcholine content in rat brain is elevated by status epilepticus induced by lithium and pilocarpine. Journal of neurochemistry. vol 49. issue 3. 1987-09-23. PMID:3612132. |
acetylcholine content in rat brain is elevated by status epilepticus induced by lithium and pilocarpine. |
1987-09-23 |
2023-08-11 |
rat |
| R S Jope, M Simonato, K Lall. Acetylcholine content in rat brain is elevated by status epilepticus induced by lithium and pilocarpine. Journal of neurochemistry. vol 49. issue 3. 1987-09-23. PMID:3612132. |
generalized convulsive status epilepticus was induced by the administration of pilocarpine to lithium-treated rats. |
1987-09-23 |
2023-08-11 |
rat |
| R A Morrisett, R S Jope, O C Snea. Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats. Experimental neurology. vol 97. issue 1. 1987-07-17. PMID:3582562. |
effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats. |
1987-07-17 |
2023-08-11 |
rat |
| R A Morrisett, R S Jope, O C Snea. Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats. Experimental neurology. vol 97. issue 1. 1987-07-17. PMID:3582562. |
the ability of various drugs to prevent the onset of status epilepticus induced by administration of the muscarinic agonist, pilocarpine, to lithium-pretreated rats was determined. |
1987-07-17 |
2023-08-11 |
rat |
| R A Morrisett, R S Jope, O C Snea. Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats. Experimental neurology. vol 97. issue 1. 1987-07-17. PMID:3582562. |
motor limbic seizures and status epilepticus occurred in 100% of rats administered pilocarpine (30 mg/kg, s.c.) 20 h after pretreatment with lithium (3 meq/kg, i.p.). |
1987-07-17 |
2023-08-11 |
rat |
| R A Morrisett, R S Jope, O C Snea. Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats. Experimental neurology. vol 97. issue 1. 1987-07-17. PMID:3582562. |
atropine, diazepam, phenobarbital, phenytoin, sodium valproate, l-pia, and carbamazepine did not interrupt seizure activity when administered 60 min after pilocarpine (approximately 35 min after initiation of status epilepticus). |
1987-07-17 |
2023-08-11 |
rat |