| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R A Morrisett, R S Jope, O C Snea. Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats. Experimental neurology. vol 97. issue 1. 1987-07-17. PMID:3582562. |
thus, status epilepticus induced by lithium and pilocarpine provides a seizure model that is not responsive to conventional anticonvulsants. |
1987-07-17 |
2023-08-11 |
rat |
| G G Buterbaugh, H B Michelson, D O Keyse. Status epilepticus facilitated by pilocarpine in amygdala-kindled rats. Experimental neurology. vol 94. issue 1. 1986-11-18. PMID:3758290. |
status epilepticus facilitated by pilocarpine in amygdala-kindled rats. |
1986-11-18 |
2023-08-11 |
rat |
| G G Buterbaugh, H B Michelson, D O Keyse. Status epilepticus facilitated by pilocarpine in amygdala-kindled rats. Experimental neurology. vol 94. issue 1. 1986-11-18. PMID:3758290. |
animals that had been partially kindled to stage ii seizures did not develop status epilepticus after stimulation when pretreated with pilocarpine, indicating that prior kindling is integral to the development of status epilepticus in this model. |
1986-11-18 |
2023-08-11 |
rat |
| R S Jope, R A Morriset. Neurochemical consequences of status epilepticus induced in rats by coadministration of lithium and pilocarpine. Experimental neurology. vol 93. issue 2. 1986-09-17. PMID:3015661. |
neurochemical consequences of status epilepticus induced in rats by coadministration of lithium and pilocarpine. |
1986-09-17 |
2023-08-11 |
rat |
| R S Jope, R A Morriset. Neurochemical consequences of status epilepticus induced in rats by coadministration of lithium and pilocarpine. Experimental neurology. vol 93. issue 2. 1986-09-17. PMID:3015661. |
status epilepticus was produced in rats by administering pilocarpine (30 mg/kg, s.c.) 16 h after treatment with licl (3 meq/kg, i.p.). |
1986-09-17 |
2023-08-11 |
rat |
| L Turski, E A Cavalheiro, W A Turski, B S Meldru. Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate. Neuroscience. vol 18. issue 1. 1986-09-17. PMID:3016600. |
pilocarpine, 380 mg/kg, produces a sequence of behavioural and electroencephalographic alterations indicative of motor limbic seizures and status epilepticus, which is followed by widespread damage to the limbic forebrain resembling that occurring subsequent to prolonged intractable seizures. |
1986-09-17 |
2023-08-11 |
rat |
| L Turski, E A Cavalheiro, W A Turski, B S Meldru. Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate. Neuroscience. vol 18. issue 1. 1986-09-17. PMID:3016600. |
in rats pretreated with microinjections of n-methyl-d-aspartate into the substantia nigra pars reticulata, a non-convulsive dose of pilocarpine, 100 mg/kg, results in recurrent motor limbic seizures and status epilepticus. |
1986-09-17 |
2023-08-11 |
rat |
| L Turski, E A Cavalheiro, W A Turski, B S Meldru. Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate. Neuroscience. vol 18. issue 1. 1986-09-17. PMID:3016600. |
morphological examination of brains from rats treated with n-methyl-d-aspartate in the substantia nigra pars reticulata and subsequently given pilocarpine, 100 mg/kg, which underwent status epilepticus, reveals widespread damage to the amygdala, thalamus, olfactory cortex, substantia nigra, neocortex, and hippocampus. |
1986-09-17 |
2023-08-11 |
rat |
| L Turski, E A Cavalheiro, M Schwarz, W A Turski, L E De Moraes Mello, Z A Bortolotto, T Klockgether, K H Sonta. Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or gamma-vinyl-GABA into the substantia nigra. Brain research. vol 370. issue 2. 1986-06-27. PMID:3708328. |
in animals pretreated with microinjections of isoniazid, 150 micrograms, an inhibitor of activity of the gaba-synthesizing enzyme, l-glutamic acid decarboxylase, into the substantia nigra pars reticulata (snr), bilaterally, non-convulsant doses of pilocarpine, 100 and 200 mg/kg, resulted in severe motor limbic seizures and status epilepticus. |
1986-06-27 |
2023-08-11 |
rat |
| R S Jope, R A Morrisett, O C Snea. Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats. Experimental neurology. vol 91. issue 3. 1986-04-01. PMID:3948956. |
subcutaneous administration of pilocarpine to rats that were pretreated with a small dose of lithium chloride results in the evolution of generalized convulsive status epilepticus. |
1986-04-01 |
2023-08-11 |
rat |
| W A Turski, E A Cavalheiro, C Ikonomidou, L E Mello, Z A Bortolotto, L Tursk. Effects of aminophylline and 2-chloroadenosine on seizures produced by pilocarpine in rats: morphological and electroencephalographic correlates. Brain research. vol 361. issue 1-2. 1986-03-24. PMID:3936592. |
in animals pretreated with aminophylline at doses of 25-100 mg/kg, non-convulsant dose of pilocarpine, 100 mg/kg, resulted in severe motor limbic seizures, which rapidly developed into the status epilepticus. |
1986-03-24 |
2023-08-11 |
rat |
| W A Turski, E A Cavalheiro, Z A Bortolotto, L M Mello, M Schwarz, L Tursk. Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis. Brain research. vol 321. issue 2. 1985-01-24. PMID:6498517. |
at doses of 300, 325 and 350 mg/kg, pilocarpine produced a sequence of behavioral alterations including staring spells, limbic gustatory automatisms and motor limbic seizures that developed over 15-30 min and built up progressively into a limbic status epilepticus lasting for several hours. |
1985-01-24 |
2023-08-12 |
mouse |
| W A Turski, E A Cavalheiro, M Schwarz, S J Czuczwar, Z Kleinrok, L Tursk. Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behavioural brain research. vol 9. issue 3. 1984-01-07. PMID:6639740. |
at the dose of 400 mg/kg pilocarpine produced a sequence of behavioural alterations including staring spells, olfactory and gustatory automatisms and motor limbic seizures that developed over 1-2 h and built up progressively into limbic status epilepticus. |
1984-01-07 |
2023-08-12 |
rat |
| W A Turski, E A Cavalheiro, M Schwarz, S J Czuczwar, Z Kleinrok, L Tursk. Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behavioural brain research. vol 9. issue 3. 1984-01-07. PMID:6639740. |
these results show that systemic pilocarpine in rats selectively elaborates epileptiform activity in the limbic structures accompanied by motor limbic seizures, limbic status epilepticus and widespread brain damage. |
1984-01-07 |
2023-08-12 |
rat |