| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maxwell J Roeske, Christine Konradi, Stephan Heckers, Alan S Lewi. Hippocampal volume and hippocampal neuron density, number and size in schizophrenia: a systematic review and meta-analysis of postmortem studies. Molecular psychiatry. vol 26. issue 7. 2021-10-16. PMID:32724199. |
reduced hippocampal volume is a consistent finding in neuroimaging studies of individuals with schizophrenia. |
2021-10-16 |
2023-08-13 |
human |
| Maxwell J Roeske, Christine Konradi, Stephan Heckers, Alan S Lewi. Hippocampal volume and hippocampal neuron density, number and size in schizophrenia: a systematic review and meta-analysis of postmortem studies. Molecular psychiatry. vol 26. issue 7. 2021-10-16. PMID:32724199. |
here we use a meta-analytic approach to synthesize the extant literature of hippocampal subfield volume and cellular composition in schizophrenia patients and healthy control subjects. |
2021-10-16 |
2023-08-13 |
human |
| Maxwell J Roeske, Christine Konradi, Stephan Heckers, Alan S Lewi. Hippocampal volume and hippocampal neuron density, number and size in schizophrenia: a systematic review and meta-analysis of postmortem studies. Molecular psychiatry. vol 26. issue 7. 2021-10-16. PMID:32724199. |
following pre-registration (prospero crd42019138280), pubmed, web of science, and psycinfo were searched using the term: (schizophrenia or schizoaffective) and (post-mortem or postmortem) and hippocampus. |
2021-10-16 |
2023-08-13 |
human |
| Maxwell J Roeske, Christine Konradi, Stephan Heckers, Alan S Lewi. Hippocampal volume and hippocampal neuron density, number and size in schizophrenia: a systematic review and meta-analysis of postmortem studies. Molecular psychiatry. vol 26. issue 7. 2021-10-16. PMID:32724199. |
subjects were adult men and women with schizophrenia or schizoaffective disorder or non-psychiatric control subjects, and key outcomes, stratified by hippocampal hemisphere and subfield, were volume, neuron number, neuron density, and neuron size. |
2021-10-16 |
2023-08-13 |
human |
| Maxwell J Roeske, Christine Konradi, Stephan Heckers, Alan S Lewi. Hippocampal volume and hippocampal neuron density, number and size in schizophrenia: a systematic review and meta-analysis of postmortem studies. Molecular psychiatry. vol 26. issue 7. 2021-10-16. PMID:32724199. |
these results extend neuroimaging findings of smaller hippocampal volume in schizophrenia patients and further our understanding of regional and cellular neuropathology in schizophrenia. |
2021-10-16 |
2023-08-13 |
human |
| Wenwen Gao, Guangfei Li, Xiaowei Han, Zeyu Song, Shuai Zhao, Feiyi Sun, Hong Ma, Ailing Cui, Yige Wang, Xiuxiu Liu, Yue Chen, Lu Zhang, Guolin Ma, Xiaoying Tan. Regional brain network and behavioral alterations in EGR3 gene transfected rat model of schizophrenia. Brain imaging and behavior. vol 15. issue 5. 2021-10-12. PMID:33723811. |
a rat model of schizophrenia was previously established by transfecting egr3 gene into the hippocampus of rats. |
2021-10-12 |
2023-08-13 |
rat |
| Zixuan Lin, Yicheng Long, Zhipeng Wu, Zhibiao Xiang, Yumeng Ju, Zhening Li. Associations between brain abnormalities and common genetic variants for schizophrenia: a narrative review of structural and functional neuroimaging findings. Annals of palliative medicine. vol 10. issue 9. 2021-10-12. PMID:34412503. |
in summary, the current investigations have reported effects of these genetic variants on both structural and functional brain abnormalities (e.g., altered grey matter volumes, white matter integrity and functional connectivity patterns) in schizophrenia within multiple brain regions, especially the frontal, temporal and hippocampal areas. |
2021-10-12 |
2023-08-13 |
Not clear |
| Sebastian Walther, Stephanie Lefebvre, Frauke Conring, Nicole Gangl, Niluja Nadesalingam, Danai Alexaki, Florian Wüthrich, Maximilian Rüter, Petra V Viher, Andrea Federspiel, Roland Wiest, Katharina Stegmaye. Limbic links to paranoia: increased resting-state functional connectivity between amygdala, hippocampus and orbitofrontal cortex in schizophrenia patients with paranoia. European archives of psychiatry and clinical neuroscience. 2021-10-12. PMID:34636951. |
limbic links to paranoia: increased resting-state functional connectivity between amygdala, hippocampus and orbitofrontal cortex in schizophrenia patients with paranoia. |
2021-10-12 |
2023-08-13 |
human |
| Jessica Marie Perez, Stefano Berto, Kelly Gleason, Subroto Ghose, Chunfeng Tan, Tae-Kyung Kim, Genevieve Konopka, Carol A Tamming. Hippocampal subfield transcriptome analysis in schizophrenia psychosis. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:32152472. |
hippocampal subfield transcriptome analysis in schizophrenia psychosis. |
2021-10-11 |
2023-08-13 |
Not clear |
| Jessica Marie Perez, Stefano Berto, Kelly Gleason, Subroto Ghose, Chunfeng Tan, Tae-Kyung Kim, Genevieve Konopka, Carol A Tamming. Hippocampal subfield transcriptome analysis in schizophrenia psychosis. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:32152472. |
we have previously demonstrated functional and molecular changes in hippocampal subfields in individuals with schizophrenia (sz) psychosis associated with hippocampal excitability. |
2021-10-11 |
2023-08-13 |
Not clear |
| Stephanie M Perez, Daniel J Lodg. Orexin Modulation of VTA Dopamine Neuron Activity: Relevance to Schizophrenia. The international journal of neuropsychopharmacology. vol 24. issue 4. 2021-10-06. PMID:33587746. |
the hippocampus is a region consistently implicated in schizophrenia and has been advanced as a therapeutic target for positive, negative, and cognitive deficits associated with the disease. |
2021-10-06 |
2023-08-13 |
Not clear |
| Dennis Kätzel, Amy R Wolff, Alexei M Bygrave, David M Bannerma. Hippocampal Hyperactivity as a Druggable Circuit-Level Origin of Aberrant Salience in Schizophrenia. Frontiers in pharmacology. vol 11. 2021-09-24. PMID:33178010. |
hippocampal hyperactivity as a druggable circuit-level origin of aberrant salience in schizophrenia. |
2021-09-24 |
2023-08-13 |
Not clear |
| Dennis Kätzel, Amy R Wolff, Alexei M Bygrave, David M Bannerma. Hippocampal Hyperactivity as a Druggable Circuit-Level Origin of Aberrant Salience in Schizophrenia. Frontiers in pharmacology. vol 11. 2021-09-24. PMID:33178010. |
imaging studies in humans have implicated a hyperactivity of the hippocampus as a robust and early endophenotype in schizophrenia. |
2021-09-24 |
2023-08-13 |
Not clear |
| Mohamed A Sherif, Samuel A Neymotin, William W Lytto. In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia. NPJ schizophrenia. vol 6. issue 1. 2021-09-21. PMID:32958782. |
in silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia. |
2021-09-21 |
2023-08-13 |
Not clear |
| Xinrui Wang, Zhiyang Yin, Qikun Sun, Xiaowei Jiang, Li Chao, Xu Dai, Yanqing Tan. Comparative Study on the Functional Connectivity of Amygdala and Hippocampal Neural Circuits in Patients With First-Episode Schizophrenia and Other High-Risk Populations. Frontiers in psychiatry. vol 12. 2021-09-21. PMID:34539456. |
comparative study on the functional connectivity of amygdala and hippocampal neural circuits in patients with first-episode schizophrenia and other high-risk populations. |
2021-09-21 |
2023-08-13 |
Not clear |
| Matthew M Nour, Yunzhe Liu, Atheeshaan Arumuham, Zeb Kurth-Nelson, Raymond J Dola. Impaired neural replay of inferred relationships in schizophrenia. Cell. vol 184. issue 16. 2021-09-20. PMID:34197734. |
schizophrenia is proposed to reflect a compromise in structured mental representations, with animal models reporting abnormalities in hippocampal replay and associated ripple activity during rest. |
2021-09-20 |
2023-08-13 |
human |
| James P Bauer, Sarah L Rader, Max E Joffe, Wooseok Kwon, Juliana Quay, Leann Seanez, Chengwen Zhou, P Jeffrey Conn, Alan S Lewi. Modeling intrahippocampal effects of anterior hippocampal hyperactivity relevant to schizophrenia using chemogenetic excitation of long axis-projecting mossy cells in the mouse dentate gyrus. Biological psychiatry global open science. vol 1. issue 2. 2021-09-10. PMID:34414387. |
modeling intrahippocampal effects of anterior hippocampal hyperactivity relevant to schizophrenia using chemogenetic excitation of long axis-projecting mossy cells in the mouse dentate gyrus. |
2021-09-10 |
2023-08-13 |
mouse |
| James P Bauer, Sarah L Rader, Max E Joffe, Wooseok Kwon, Juliana Quay, Leann Seanez, Chengwen Zhou, P Jeffrey Conn, Alan S Lewi. Modeling intrahippocampal effects of anterior hippocampal hyperactivity relevant to schizophrenia using chemogenetic excitation of long axis-projecting mossy cells in the mouse dentate gyrus. Biological psychiatry global open science. vol 1. issue 2. 2021-09-10. PMID:34414387. |
the anterior hippocampus of individuals with early psychosis or schizophrenia is hyperactive, as is the ventral hippocampus in many rodent models for schizophrenia risk. |
2021-09-10 |
2023-08-13 |
mouse |
| Keaton A Unroe, Matthew E Glover, Elizabeth A Shupe, Ningping Feng, Sarah M Clinto. Perinatal SSRI Exposure Disrupts G Protein-coupled Receptor BAI3 in Developing Dentate Gyrus and Adult Emotional Behavior: Relevance to Psychiatric Disorders. Neuroscience. vol 471. 2021-08-25. PMID:34293414. |
to determine translational implications of this work, we examined expression of bai3 and related molecules in hippocampus and prefrontal cortex from patients that suffered with depression or schizophrenia relative to healthy control subjects. |
2021-08-25 |
2023-08-13 |
human |
| Keaton A Unroe, Matthew E Glover, Elizabeth A Shupe, Ningping Feng, Sarah M Clinto. Perinatal SSRI Exposure Disrupts G Protein-coupled Receptor BAI3 in Developing Dentate Gyrus and Adult Emotional Behavior: Relevance to Psychiatric Disorders. Neuroscience. vol 471. 2021-08-25. PMID:34293414. |
together these results suggest that abnormal bai3 signaling may contribute to molecular mechanisms that drive adverse effects of perinatal ssri exposure, and show evidence for alterations of bai3 signaling in the hippocampus of patients that suffer depression and schizophrenia. |
2021-08-25 |
2023-08-13 |
human |