| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin-Qiong Zhan, Chun-Nuan Chen, Si-Xian Wu, Han-Jun Wu, Ke Zou, Jian-Wen Xiong, Bo Wei, Yuan-Jian Yan. Flavonoid fisetin reverses impaired hippocampal synaptic plasticity and cognitive function by regulating the function of AMPARs in a male rat model of schizophrenia. Journal of neurochemistry. vol 158. issue 2. 2021-11-12. PMID:33882624. |
collectively, our findings demonstrate that fisetin treatment can reverse the deficits of hippocampal synaptic plasticity and memory in a male rat model of schizophrenia by restoring the phosphorylation and surface expression of ampar glua1 subunit, suggesting fisetin as a promising therapeutic candidate for schizophrenia-associated cognitive deficits. |
2021-11-12 |
2023-08-13 |
rat |
| John Wang, Kamber L Hart, Wei Qi, Babak A Ardekani, Chenxiang Li, Julia Marx, Oliver Freudenreich, Corinne Cather, Daphne Holt, Iruma Bello, Erica D Diminich, Yingying Tang, Michelle Worthington, Botao Zeng, Renrong Wu, Xiaoduo Fan, Jingping Zhao, Jijun Wang, Donald C Gof. Association of Aripiprazole With Reduced Hippocampal Atrophy During Maintenance Treatment of First-Episode Schizophrenia. Journal of clinical psychopharmacology. vol 41. issue 3. 2021-11-09. PMID:33814546. |
association of aripiprazole with reduced hippocampal atrophy during maintenance treatment of first-episode schizophrenia. |
2021-11-09 |
2023-08-13 |
Not clear |
| John Wang, Kamber L Hart, Wei Qi, Babak A Ardekani, Chenxiang Li, Julia Marx, Oliver Freudenreich, Corinne Cather, Daphne Holt, Iruma Bello, Erica D Diminich, Yingying Tang, Michelle Worthington, Botao Zeng, Renrong Wu, Xiaoduo Fan, Jingping Zhao, Jijun Wang, Donald C Gof. Association of Aripiprazole With Reduced Hippocampal Atrophy During Maintenance Treatment of First-Episode Schizophrenia. Journal of clinical psychopharmacology. vol 41. issue 3. 2021-11-09. PMID:33814546. |
hippocampal volume loss in early schizophrenia has been linked with markers of inflammation and oxidative stress, and with less response of negative symptoms. |
2021-11-09 |
2023-08-13 |
Not clear |
| Xianjin Zho. Over-representation of potential SP4 target genes within schizophrenia-risk genes. Molecular psychiatry. 2021-11-09. PMID:34750502. |
reduction of sp4 expression causes age-dependent hippocampal vacuolization and many other intermediate phenotypes of schizophrenia in sp4 hypomorphic mice. |
2021-11-09 |
2023-08-13 |
mouse |
| Eric A Nelson, Nina V Kraguljac, Jose O Maximo, Frederic Briend, William Armstrong, Lawrence W Ver Hoef, Victoria Johnson, Adrienne C Laht. Hippocampal Dysconnectivity and Altered Glutamatergic Modulation of the Default Mode Network: A Combined Resting-State Connectivity and Magnetic Resonance Spectroscopy Study in Schizophrenia. Biological psychiatry. Cognitive neuroscience and neuroimaging. 2021-11-07. PMID:32684484. |
hippocampal dysconnectivity and altered glutamatergic modulation of the default mode network: a combined resting-state connectivity and magnetic resonance spectroscopy study in schizophrenia. |
2021-11-07 |
2023-08-13 |
Not clear |
| Eric A Nelson, Nina V Kraguljac, Jose O Maximo, Frederic Briend, William Armstrong, Lawrence W Ver Hoef, Victoria Johnson, Adrienne C Laht. Hippocampal Dysconnectivity and Altered Glutamatergic Modulation of the Default Mode Network: A Combined Resting-State Connectivity and Magnetic Resonance Spectroscopy Study in Schizophrenia. Biological psychiatry. Cognitive neuroscience and neuroimaging. 2021-11-07. PMID:32684484. |
converging lines of evidence point to hippocampal dysfunction in schizophrenia. |
2021-11-07 |
2023-08-13 |
Not clear |
| Amanda Kiemes, Felipe V Gomes, Diana Cash, Daniela L Uliana, Camilla Simmons, Nisha Singh, Anthony C Vernon, Federico Turkheimer, Cathy Davies, James M Stone, Anthony A Grace, Gemma Modino. GABA Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021-11-07. PMID:34743200. |
gaba hippocampal hyperactivity driven by gabaergic interneuron deficits and nmda receptor hypofunction is associated with the hyperdopaminergic state often observed in schizophrenia. |
2021-11-07 |
2023-08-13 |
rat |
| Giuliana S Zuccoli, Guilherme Reis-de-Oliveira, Bruna Garbes, Peter Falkai, Andrea Schmitt, Helder I Nakaya, Daniel Martins-de-Souz. Linking proteomic alterations in schizophrenia hippocampus to NMDAr hypofunction in human neurons and oligodendrocytes. European archives of psychiatry and clinical neuroscience. vol 271. issue 8. 2021-11-03. PMID:33751207. |
linking proteomic alterations in schizophrenia hippocampus to nmdar hypofunction in human neurons and oligodendrocytes. |
2021-11-03 |
2023-08-13 |
human |
| Giuliana S Zuccoli, Guilherme Reis-de-Oliveira, Bruna Garbes, Peter Falkai, Andrea Schmitt, Helder I Nakaya, Daniel Martins-de-Souz. Linking proteomic alterations in schizophrenia hippocampus to NMDAr hypofunction in human neurons and oligodendrocytes. European archives of psychiatry and clinical neuroscience. vol 271. issue 8. 2021-11-03. PMID:33751207. |
glutamatergic neurotransmission dysfunction and the early involvement of the hippocampus have been proposed to be important aspects of the pathophysiology of schizophrenia. |
2021-11-03 |
2023-08-13 |
human |
| Giuliana S Zuccoli, Guilherme Reis-de-Oliveira, Bruna Garbes, Peter Falkai, Andrea Schmitt, Helder I Nakaya, Daniel Martins-de-Souz. Linking proteomic alterations in schizophrenia hippocampus to NMDAr hypofunction in human neurons and oligodendrocytes. European archives of psychiatry and clinical neuroscience. vol 271. issue 8. 2021-11-03. PMID:33751207. |
here, we performed proteomic analysis of hippocampus postmortem samples from schizophrenia patients as well as neural cells-neurons and oligodendrocytes-treated with mk-801, an nmda receptor antagonist. |
2021-11-03 |
2023-08-13 |
human |
| Kazutaka Ohi, Kiyotaka Nemoto, Yuzuru Kataoka, Shunsuke Sugiyama, Yukimasa Muto, Toshiki Shioiri, Yasuhiro Kawasak. Alterations in hippocampal subfield volumes among schizophrenia patients, their first-degree relatives and healthy subjects. Progress in neuro-psychopharmacology & biological psychiatry. vol 110. 2021-11-01. PMID:33662534. |
alterations in hippocampal subfield volumes among schizophrenia patients, their first-degree relatives and healthy subjects. |
2021-11-01 |
2023-08-13 |
human |
| Kazutaka Ohi, Kiyotaka Nemoto, Yuzuru Kataoka, Shunsuke Sugiyama, Yukimasa Muto, Toshiki Shioiri, Yasuhiro Kawasak. Alterations in hippocampal subfield volumes among schizophrenia patients, their first-degree relatives and healthy subjects. Progress in neuro-psychopharmacology & biological psychiatry. vol 110. 2021-11-01. PMID:33662534. |
reduced hippocampal volumes feature prominently in schizophrenia patients (scz). |
2021-11-01 |
2023-08-13 |
human |
| Min Tae M Park, Peter Jeon, Ali R Khan, Kara Dempster, M Mallar Chakravarty, Jason P Lerch, Michael MacKinley, Jean Théberge, Lena Palaniyappa. Hippocampal neuroanatomy in first episode psychosis: A putative role for glutamate and serotonin receptors. Progress in neuro-psychopharmacology & biological psychiatry. vol 110. 2021-11-01. PMID:33691200. |
we demonstrate a putative glutamate-driven hippocampal variability in fep through a serotonin receptor-density gated mechanism, thus outlining a mechanistic interplay between serotonin and glutamate in determining the hippocampal morphology in schizophrenia. |
2021-11-01 |
2023-08-13 |
human |
| Nikolai Gobshtis, Matanel Tfilin, Vadim E Fraifeld, Gadi Turgema. Transplantation of mesenchymal stem cells causes long-term alleviation of schizophrenia-like behaviour coupled with increased neurogenesis. Molecular psychiatry. vol 26. issue 8. 2021-10-28. PMID:31827249. |
in the present study, we utilized intracerebroventricular transplantation of bone marrow-derived mesenchymal stem cells (msc) as a means to enhance hippocampal neurogenesis in the ketamine-induced neurodevelopmental murine model for schizophrenia. |
2021-10-28 |
2023-08-13 |
mouse |
| Nami Mohammadian Khonsari, Rahim Badrfam, Mohammad Reza Mohammdi, Hadith Rastad, Fateme Etemadi, Zahra Vafaei, Atefeh Zandifa. Effect of Aerobic Exercise as Adjunct Therapy on the Improvement of Negative Symptoms and Cognitive Impairment in Patients With Schizophrenia: A Randomized, Case-Control Clinical Trial. Journal of psychosocial nursing and mental health services. 2021-10-22. PMID:34677118. |
the current study aimed to evaluate the effects of exercise on negative and cognitive symptoms and simultaneous evaluation of brain and hippocampus volume in patients with schizophrenia. |
2021-10-22 |
2023-08-13 |
Not clear |
| Suzanne N Avery, Lisa E Williams, Austin A Woolard, Stephan Hecker. Relational memory and hippocampal function in psychotic bipolar disorder. European archives of psychiatry and clinical neuroscience. 2021-10-21. PMID:24022592. |
specifically, both bipolar disorder and schizophrenia are characterized by interneuron dysfunction within the hippocampus, an essential structure for relational memory. |
2021-10-21 |
2023-08-12 |
human |
| Alan S Brown, Karin Borgmann-Winter, Chang-Gyu Hahn, Lorna Role, David Talmage, Raquel Gur, Jacky Chow, Patric Prado, Thelma McCloskey, Yuanyuan Bao, J Chloe Bulinski, Andrew J Dwor. Increased stability of microtubules in cultured olfactory neuroepithelial cells from individuals with schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 48. 2021-10-21. PMID:24513021. |
while we cannot rule out a possible confounding effect of antipsychotic medications, these findings may reflect analogous neurobiological events in at least a subset of immature neurons or other cell types during gestation, or newly generated cells destined for the olfactory bulb or hippocampus, suggesting a mechanism that underlies findings of postmortem and neuroimaging investigations of schizophrenia. |
2021-10-21 |
2023-08-12 |
human |
| Sherry Leonard, Sharon Mexal, Robert Freedma. Smoking, Genetics and Schizophrenia: Evidence for Self Medication. Journal of dual diagnosis. vol 3. issue 3-4. 2021-10-20. PMID:19122786. |
smoking changes gene expression for more than 200 genes in human hippocampus, and differentially normalizes aberrant gene expression in schizophrenia. |
2021-10-20 |
2023-08-12 |
human |
| Xiaoyan Shi, Joseph G Ibrahim, Jeffrey Lieberman, Martin Styner, Hongtu Zh. TWO-STAGE EMPIRICAL LIKELIHOOD FOR LONGITUDINAL NEUROIMAGING DATA. The annals of applied statistics. vol 5. issue 2B. 2021-10-20. PMID:21765885. |
we demonstrate the application of our statistical methods to the detection of the difference in the morphological changes of the hippocampus across time between schizophrenia patients and healthy subjects in a longitudinal schizophrenia study. |
2021-10-20 |
2023-08-12 |
human |
| Maxwell J Roeske, Christine Konradi, Stephan Heckers, Alan S Lewi. Hippocampal volume and hippocampal neuron density, number and size in schizophrenia: a systematic review and meta-analysis of postmortem studies. Molecular psychiatry. vol 26. issue 7. 2021-10-16. PMID:32724199. |
hippocampal volume and hippocampal neuron density, number and size in schizophrenia: a systematic review and meta-analysis of postmortem studies. |
2021-10-16 |
2023-08-13 |
human |