| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Ozdemir, A Ertugrul, K Basar, E Sak. Differential effects of antipsychotics on hippocampal presynaptic protein expressions and recognition memory in a schizophrenia model in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 39. issue 1. 2013-01-21. PMID:22640753. |
we compared the effects of subchronic clozapine and haloperidol administration on the expression of snap-25 and synaptophysin in an animal model of schizophrenia based on the glutamatergic hypothesis. |
2013-01-21 |
2023-08-12 |
mouse |
| Rasmus Røge, Bjarne K Møller, Christian R Andersen, Christoph U Correll, Jimmi Nielse. Immunomodulatory effects of clozapine and their clinical implications: what have we learned so far? Schizophrenia research. vol 140. issue 1-3. 2013-01-18. PMID:22831769. |
to what degree the unique antipsychotic efficacy of clozapine in subgroups of schizophrenia patients is related to its immunomodulatory effects has not been studied. |
2013-01-18 |
2023-08-12 |
human |
| Rasmus Røge, Bjarne K Møller, Christian R Andersen, Christoph U Correll, Jimmi Nielse. Immunomodulatory effects of clozapine and their clinical implications: what have we learned so far? Schizophrenia research. vol 140. issue 1-3. 2013-01-18. PMID:22831769. |
research relating the immunomodulatory actions of clozapine and its early markers to clinically relevant adverse and therapeutic outcomes is hoped to provide new leads for the understanding of the pathophysiology of schizophrenia and aid the development of novel treatment targets. |
2013-01-18 |
2023-08-12 |
human |
| Catherine Frogley, David Taylor, Geoff Dickens, Marco Picchion. A systematic review of the evidence of clozapine's anti-aggressive effects. The international journal of neuropsychopharmacology. vol 15. issue 9. 2013-01-17. PMID:22339930. |
there is emerging evidence to suggest that the second-generation antipsychotic, clozapine, is effective at reducing this risk in patients with schizophrenia and some evidence to suggest that it may be best in selected patients. |
2013-01-17 |
2023-08-12 |
human |
| Catherine Frogley, David Taylor, Geoff Dickens, Marco Picchion. A systematic review of the evidence of clozapine's anti-aggressive effects. The international journal of neuropsychopharmacology. vol 15. issue 9. 2013-01-17. PMID:22339930. |
clozapine can reduce violence and persistent aggression in patients with schizophrenia and other psychiatric disorders. |
2013-01-17 |
2023-08-12 |
human |
| Dan Cohen, Jan P A M Bogers, Daniel van Dijk, Bert Bakker, Peter F J Schult. Beyond white blood cell monitoring: screening in the initial phase of clozapine therapy. The Journal of clinical psychiatry. vol 73. issue 10. 2013-01-17. PMID:23140648. |
clozapine is the preferred option for treatment-resistant schizophrenia. |
2013-01-17 |
2023-08-12 |
Not clear |
| Jimmi Nielsen, Rene Ernst Nielsen, Christoph U Correl. Predictors of clozapine response in patients with treatment-refractory schizophrenia: results from a Danish Register Study. Journal of clinical psychopharmacology. vol 32. issue 5. 2013-01-16. PMID:22926603. |
predictors of clozapine response in patients with treatment-refractory schizophrenia: results from a danish register study. |
2013-01-16 |
2023-08-12 |
Not clear |
| Jimmi Nielsen, Rene Ernst Nielsen, Christoph U Correl. Predictors of clozapine response in patients with treatment-refractory schizophrenia: results from a Danish Register Study. Journal of clinical psychopharmacology. vol 32. issue 5. 2013-01-16. PMID:22926603. |
the study was based on data from the danish psychiatric central research register and the national prescription database including schizophrenia patients initiating clozapine from 1997 to 2006. |
2013-01-16 |
2023-08-12 |
Not clear |
| Jimmi Nielsen, Rene Ernst Nielsen, Christoph U Correl. Predictors of clozapine response in patients with treatment-refractory schizophrenia: results from a Danish Register Study. Journal of clinical psychopharmacology. vol 32. issue 5. 2013-01-16. PMID:22926603. |
among 633 schizophrenia patients starting clozapine, shorter time to admission was predicted by increasing number of different antipsychotics (hazard ratio [hr], 1.08/trial; confidence interval [ci], 1.01-1.15/trial) and admissions (hr, 1.04/admission; ci, 1.03-1.05/admission) before first clozapine prescription, earlier onset of schizophrenia (hr, 0.98/y; ci, 0.96-0.99/y), and lower clozapine dose (hr, 0.07/100 mg; ci, 0.03-0.13/100 mg). |
2013-01-16 |
2023-08-12 |
Not clear |
| Megan Sherwood, Allen E Thornton, William G Hone. A quantitative review of the profile and time course of symptom change in schizophrenia treated with clozapine. Journal of psychopharmacology (Oxford, England). vol 26. issue 9. 2013-01-11. PMID:22465946. |
a quantitative review of the profile and time course of symptom change in schizophrenia treated with clozapine. |
2013-01-11 |
2023-08-12 |
human |
| Eric Hermes, Robert Rosenhec. Choice of randomization to clozapine versus other second generation antipsychotics in the CATIE schizophrenia trial. Journal of psychopharmacology (Oxford, England). vol 26. issue 9. 2013-01-11. PMID:22516668. |
choice of randomization to clozapine versus other second generation antipsychotics in the catie schizophrenia trial. |
2013-01-11 |
2023-08-12 |
Not clear |
| Eric Hermes, Robert Rosenhec. Choice of randomization to clozapine versus other second generation antipsychotics in the CATIE schizophrenia trial. Journal of psychopharmacology (Oxford, England). vol 26. issue 9. 2013-01-11. PMID:22516668. |
there is evidence to suggest that clozapine is underutilized in treatment-refractory schizophrenia. |
2013-01-11 |
2023-08-12 |
Not clear |
| Mie A Rizig, Andrew McQuillin, Aylwin Ng, Michelle Robinson, Andrew Harrison, Marketa Zvelebil, Steve P Hunt, Hugh M Gurlin. A gene expression and systems pathway analysis of the effects of clozapine compared to haloperidol in the mouse brain implicates susceptibility genes for schizophrenia. Journal of psychopharmacology (Oxford, England). vol 26. issue 9. 2013-01-11. PMID:22767372. |
a gene expression and systems pathway analysis of the effects of clozapine compared to haloperidol in the mouse brain implicates susceptibility genes for schizophrenia. |
2013-01-11 |
2023-08-12 |
mouse |
| Mie A Rizig, Andrew McQuillin, Aylwin Ng, Michelle Robinson, Andrew Harrison, Marketa Zvelebil, Steve P Hunt, Hugh M Gurlin. A gene expression and systems pathway analysis of the effects of clozapine compared to haloperidol in the mouse brain implicates susceptibility genes for schizophrenia. Journal of psychopharmacology (Oxford, England). vol 26. issue 9. 2013-01-11. PMID:22767372. |
several genes implicated genetically or functionally in schizophrenia such as frizzled homolog 3 (fzd3), u2af homology motif kinase 1 (uhmk1), pericentriolar material 1 (pcm1) and brain-derived neurotrophic factor (bdnf) were changed by clozapine but not by haloperidol. |
2013-01-11 |
2023-08-12 |
mouse |
| Tammie Lee Demler, Eileen Trigobof. Are clozapine blood dyscrasias associated with concomitant medications? Innovations in clinical neuroscience. vol 8. issue 4. 2013-01-09. PMID:21637633. |
clozapine is an atypical antipsychotic agent used for refractory schizophrenia. |
2013-01-09 |
2023-08-12 |
Not clear |
| Tammie Lee Demle. Challenging the hypothesized link to season of birth in patients with schizophrenia. Innovations in clinical neuroscience. vol 8. issue 9. 2013-01-09. PMID:22010060. |
there are over 200 studies exploring this issue at the writing of this article with most of the studies revealing a decrease in late summer births and an increase number of winter-spring births of those individuals with the disease.the primary objective of this study was to evaluate the seasonality of birth for 376 institutionalized patients with schizophrenia receiving clozapine treatment in a new york state psychiatric hospital. |
2013-01-09 |
2023-08-12 |
Not clear |
| Tammie Lee Demle. Challenging the hypothesized link to season of birth in patients with schizophrenia. Innovations in clinical neuroscience. vol 8. issue 9. 2013-01-09. PMID:22010060. |
the author chose to evaluate all 376 patients in the sample due to the introduction of clozapine therapy, which would substantiate the presence of a refractory psychotic disorder, such as schizophrenia. |
2013-01-09 |
2023-08-12 |
Not clear |
| Alison A Williams, Wendy M Ingram, Sarah Levine, Jack Resnik, Christy M Kamel, James R Lish, Diana I Elizalde, Scott A Janowski, Joseph Shoker, Alexey Kozlenkov, Javier González-Maeso, Amelia L Gallitan. Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 10. 2013-01-09. PMID:22692564. |
we have previously reported that egr3-deficient (egr3(-/-)) mice display reduced sensitivity to the sedating effects of clozapine compared with wild-type (wt) littermates, paralleling the heightened tolerance of schizophrenia patients to antipsychotic side effects. |
2013-01-09 |
2023-08-12 |
mouse |
| Eric Fakra, Jean-Michel Azori. Clozapine for the treatment of schizophrenia. Expert opinion on pharmacotherapy. vol 13. issue 13. 2013-01-07. PMID:22803789. |
clozapine for the treatment of schizophrenia. |
2013-01-07 |
2023-08-12 |
Not clear |
| Min Kyung Kim, Se Hyun Kim, Hyun Sook Yu, Hong Geun Park, Ung Gu Kang, Yong Min Ahn, Yong Sik Ki. The effect of clozapine on the AMPK-ACC-CPT1 pathway in the rat frontal cortex. The international journal of neuropsychopharmacology. vol 15. issue 7. 2012-12-11. PMID:21733226. |
clozapine is an antipsychotic drug that has a greater efficacy than other medications in some contexts, especially for the treatment of treatment-resistant schizophrenia. |
2012-12-11 |
2023-08-12 |
rat |