| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Morris, T Hogan, A McGuir. The cost-effectiveness of clozapine: a survey of the literature. Clinical drug investigation. vol 15. issue 2. 2012-10-02. PMID:18370477. |
furthermore, the evidence indicates that, for many patients, clozapine may substantially reduce costs associated with treatment-resistant schizophrenia. |
2012-10-02 |
2023-08-12 |
Not clear |
| H Meltze. Multiple-outcome criteria in schizophrenia: an overview of outcome with clozapine. European psychiatry : the journal of the Association of European Psychiatrists. vol 10 Suppl 1. 2012-10-02. PMID:19698385. |
multiple-outcome criteria in schizophrenia: an overview of outcome with clozapine. |
2012-10-02 |
2023-08-12 |
Not clear |
| A Deutc. Mechanisms of action of clozapine in the treatment of neuroleptic-resistant and neuroleptic-intolerant schizophrenia. European psychiatry : the journal of the Association of European Psychiatrists. vol 10 Suppl 1. 2012-10-02. PMID:19698391. |
mechanisms of action of clozapine in the treatment of neuroleptic-resistant and neuroleptic-intolerant schizophrenia. |
2012-10-02 |
2023-08-12 |
human |
| J Vanell. Refractory schizophrenia: Historical and currently prevailing criteria and definitions. European psychiatry : the journal of the Association of European Psychiatrists. vol 12 Suppl 5. 2012-10-02. PMID:19698587. |
interest in treatment-refractory schizophrenia was stimulated by several studies in the period 1985-1990, including a pivotal study of clozapine. |
2012-10-02 |
2023-08-12 |
Not clear |
| G Cassano, A Ciapparelli, M Vill. Clozapine as a treatment tool: only in resistant schizophrenic patients? European psychiatry : the journal of the Association of European Psychiatrists. vol 12 Suppl 5. 2012-10-02. PMID:19698590. |
evidence indicates that clozapine is effective in the management of treatment-resistant schizophrenia and in affective psychoses. |
2012-10-02 |
2023-08-12 |
Not clear |
| M Moldavsky, D Stein, R Benatov, P Sirota, A Elizur, Y Matzner, A Weizma. Combined clozapine-lithium treatment for schizophrenia and schizoaffective disorder. European psychiatry : the journal of the Association of European Psychiatrists. vol 13. issue 2. 2012-10-02. PMID:19698608. |
three adolescent and two adult patients suffering from chronic excited psychoses (either schizophrenia or schizoaffective disorder) resistant to traditional neuroleptics and clozapine were treated with combined clozapine-lithium. |
2012-10-02 |
2023-08-12 |
Not clear |
| N C Moore, P A Lewitt, S Gersho. Reduction of dyskinesias and psychiatric disability with clozapine over different time courses. Journal of psychopharmacology (Oxford, England). vol 6. issue 4. 2012-10-02. PMID:22291400. |
nine subjects with schizophrenia or schizoaffective disorder were treated with clozapine, 500 mg/day for at least 3 months. |
2012-10-02 |
2023-08-12 |
human |
| D Geane. Clozapine can cause hallucinations by inducing complex partial seizures of temporal lobe origin (temporal lobe epilepsy). A potentially serious complication in the management of schizophrenia with clozapine. Journal of psychopharmacology (Oxford, England). vol 9. issue 1. 2012-10-02. PMID:22298695. |
a potentially serious complication in the management of schizophrenia with clozapine. |
2012-10-02 |
2023-08-12 |
Not clear |
| D Geane. Clozapine can cause hallucinations by inducing complex partial seizures of temporal lobe origin (temporal lobe epilepsy). A potentially serious complication in the management of schizophrenia with clozapine. Journal of psychopharmacology (Oxford, England). vol 9. issue 1. 2012-10-02. PMID:22298695. |
a young man with schizophrenia had persistent auditory hallucinations which responded well to clozapine but subsequently developed a different pattern of brief, joint visual and auditory hallucinations which were confirmed as being due to complex partial seizures of temporal lobe origin. |
2012-10-02 |
2023-08-12 |
Not clear |
| I Theochari, C Boulas, A Chaidemeno. [Use of antiepileptic drugs in schizophrenia: A review of recent evidence]. Psychiatrike = Psychiatriki. vol 18. issue 3. 2012-10-02. PMID:22466630. |
adjunctive lamotrigine appears effective when added to clozapine even in cases of treatment resistant schizophrenia. |
2012-10-02 |
2023-08-12 |
Not clear |
| Nurith Amitai, Ronald Kuczenski, M Margarita Behrens, Athina Marko. Repeated phencyclidine administration alters glutamate release and decreases GABA markers in the prefrontal cortex of rats. Neuropharmacology. vol 62. issue 3. 2012-09-27. PMID:21238466. |
all of the observed pcp effects were attenuated by chronic treatment with clozapine, an atypical antipsychotic that has partial effectiveness on cognitive impairment in schizophrenia. |
2012-09-27 |
2023-08-12 |
rat |
| Sabita Dihingia, Kamala Deka, Dhrubajyoti Bhuyan, Supriya Kumar Monda. Life-threatening thrombocytosis following GCSF treatment in a case of clozapine-induced agranulocytosis. General hospital psychiatry. vol 34. issue 3. 2012-09-27. PMID:22018773. |
clozapine was introduced in european market in 1972 as an effective treatment for schizophrenia without extrapyramidal side effects. |
2012-09-27 |
2023-08-12 |
Not clear |
| Y-J Liou, Y M Bai, E Lin, J-Y Chen, T-T Chen, C-J Hong, S-J Tsa. Gene-gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics. The pharmacogenomics journal. vol 12. issue 1. 2012-09-24. PMID:20877301. |
the study included 456 schizophrenia patients treated with clozapine (n=171), olanzapine (n=91) and risperidone (n=194), for an average of 45.5±27.6 months. |
2012-09-24 |
2023-08-12 |
human |
| Manfred Ackenheil, Klaus Webe. Developments in antipsychotic therapy with regard to hypotheses for schizophrenia. Dialogues in clinical neuroscience. vol 4. issue 4. 2012-09-10. PMID:22034064. |
this unique feature of clozapine significantly broadened understanding of the mode of action of antipsychotics, and created new hypotheses for schizophrenia. |
2012-09-10 |
2023-08-12 |
Not clear |
| Asaf Caspi, Michael Davidson, Carol A Tamming. Treatment-refractory schizophrenia. Dialogues in clinical neuroscience. vol 6. issue 1. 2012-09-10. PMID:22034144. |
for patients who do not respond to the first prescribed antipsychotic drug, current clinical practice is to switch to a second and a third drug, and eventually to clozapine, the only antipsychotic drug proven to be effective in treatment-refractory schizophrenia (trs). |
2012-09-10 |
2023-08-12 |
Not clear |
| Frederike Schirmbeck, Mathias Zin. Clozapine-induced obsessive-compulsive symptoms in schizophrenia: a critical review. Current neuropharmacology. vol 10. issue 1. 2012-09-06. PMID:22942882. |
based on long-term case observations, one hypothesis assumes that second-onset ocs in the course of schizophrenia might be a side effect of second generation antipsychotics (sga), most importantly clozapine (clz). |
2012-09-06 |
2023-08-12 |
Not clear |
| Beppe Micallef-Trigona, Joseph Spiter. Maintenance electroconvulsive therapy in a patient with treatment-resistant paranoid schizophrenia and comorbid epilepsy. Case reports in psychiatry. vol 2012. 2012-09-06. PMID:22953149. |
the treatment of choice for acute schizophrenia is antipsychotic drug treatment and electroconvulsive therapy (ect) and should only be considered as an option for treatment-resistant schizophrenia, where treatment with clozapine has already proven ineffective or intolerable. |
2012-09-06 |
2023-08-12 |
Not clear |
| Aleksandar Chanachev, Nicolas Ansermot, Séverine Crettol Wavre, Ute Nowotka, Maria-Eleni Stamatopoulou, Philippe Conus, Chin B Ea. Addition of aripiprazole to the clozapine may be useful in reducing anxiety in treatment-resistant schizophrenia. Case reports in psychiatry. vol 2011. 2012-08-31. PMID:22937411. |
addition of aripiprazole to the clozapine may be useful in reducing anxiety in treatment-resistant schizophrenia. |
2012-08-31 |
2023-08-12 |
Not clear |
| Hanan Munit. [Clozapine--the neglected potential]. Harefuah. vol 151. issue 5. 2012-08-30. PMID:22844735. |
clozapine also has antiaggression and antisuicide effects, as well as specific effects on the negative symptoms of schizophrenia. |
2012-08-30 |
2023-08-12 |
Not clear |
| Khalid Abou Farha, Andre van Vliet, Henderikus Knegtering, Richard Bruggema. The Value of Desmethylclozapine and Serum CRP in Clozapine Toxicity: A Case Report. Case reports in psychiatry. vol 2012. 2012-08-30. PMID:22934219. |
clozapine, an atypical antipsychotic, has proved to be superior to other antipsychotics in treating patients with refractory schizophrenia. |
2012-08-30 |
2023-08-12 |
Not clear |