| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sophie E Legge, Marian Hamshere, Richard D Hayes, Johnny Downs, Michael C O'Donovan, Michael J Owen, James T R Walters, James H MacCab. Reasons for discontinuing clozapine: A cohort study of patients commencing treatment. Schizophrenia research. vol 174. issue 1-3. 2018-01-05. PMID:27211516. |
clozapine is uniquely effective in the management of treatment-resistant schizophrenia (trs). |
2018-01-05 |
2023-08-13 |
Not clear |
| Inti Qurashi, Simon Chu, Nusrat Husain, Richard J Drake, Imran Chaudhry, J F W Deaki. Glycopyrrolate in comparison to hyoscine hydrobromide and placebo in the treatment of hypersalivation induced by clozapine (GOTHIC1): study protocol for a randomised controlled feasibility study. Trials. vol 17. issue 1. 2018-01-05. PMID:27871302. |
clozapine is the only medication licensed for the treatment of resistant schizophrenia in the uk. |
2018-01-05 |
2023-08-13 |
Not clear |
| Vilte E Barakauskas, Annie Moradian, Alasdair M Barr, Clare L Beasley, Gorazd Rosoklija, J John Mann, Boro Ilievski, Aleksandar Stankov, Andrew J Dwork, Peter Falkai, Gregg B Morin, William G Hone. Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia. Schizophrenia research. vol 177. issue 1-3. 2018-01-02. PMID:26971072. |
administration of haloperidol or clozapine to rats did not mimic the changes found in schizophrenia. |
2018-01-02 |
2023-08-13 |
rat |
| Takanobu Nakazawa, Masataka Kikuchi, Mitsuru Ishikawa, Hidenaga Yamamori, Kazuki Nagayasu, Takuya Matsumoto, Michiko Fujimoto, Yuka Yasuda, Mikiya Fujiwara, Shota Okada, Kensuke Matsumura, Atsushi Kasai, Atsuko Hayata-Takano, Norihito Shintani, Shusuke Numata, Kazuhiro Takuma, Wado Akamatsu, Hideyuki Okano, Akihiro Nakaya, Hitoshi Hashimoto, Ryota Hashimot. Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. Schizophrenia research. vol 181. 2018-01-02. PMID:28277309. |
differential gene expression profiles in neurons generated from lymphoblastoid b-cell line-derived ips cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. |
2018-01-02 |
2023-08-13 |
Not clear |
| Takanobu Nakazawa, Masataka Kikuchi, Mitsuru Ishikawa, Hidenaga Yamamori, Kazuki Nagayasu, Takuya Matsumoto, Michiko Fujimoto, Yuka Yasuda, Mikiya Fujiwara, Shota Okada, Kensuke Matsumura, Atsushi Kasai, Atsuko Hayata-Takano, Norihito Shintani, Shusuke Numata, Kazuhiro Takuma, Wado Akamatsu, Hideyuki Okano, Akihiro Nakaya, Hitoshi Hashimoto, Ryota Hashimot. Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. Schizophrenia research. vol 181. 2018-01-02. PMID:28277309. |
clozapine is the most effective antipsychotic drug for treatment-resistant schizophrenia; however, clozapine has rare but serious side-effects. |
2018-01-02 |
2023-08-13 |
Not clear |
| Takanobu Nakazawa, Masataka Kikuchi, Mitsuru Ishikawa, Hidenaga Yamamori, Kazuki Nagayasu, Takuya Matsumoto, Michiko Fujimoto, Yuka Yasuda, Mikiya Fujiwara, Shota Okada, Kensuke Matsumura, Atsushi Kasai, Atsuko Hayata-Takano, Norihito Shintani, Shusuke Numata, Kazuhiro Takuma, Wado Akamatsu, Hideyuki Okano, Akihiro Nakaya, Hitoshi Hashimoto, Ryota Hashimot. Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. Schizophrenia research. vol 181. 2018-01-02. PMID:28277309. |
these results, which contribute to the current understanding of the molecular mechanisms of clozapine action, establish a new strategy for the use of monozygotic twin studies in schizophrenia research. |
2018-01-02 |
2023-08-13 |
Not clear |
| J-P Klemettilä, O Kampman, A Solismaa, L-P Lyytikäinen, N Seppälä, M Viikki, M Hämäläinen, E Moilanen, N Mononen, T Lehtimäki, E Leinone. Association study of arcuate nucleus neuropeptide Y neuron receptor gene variation and serum NPY levels in clozapine treated patients with schizophrenia. European psychiatry : the journal of the Association of European Psychiatrists. vol 40. 2017-12-20. PMID:27837667. |
association study of arcuate nucleus neuropeptide y neuron receptor gene variation and serum npy levels in clozapine treated patients with schizophrenia. |
2017-12-20 |
2023-08-13 |
Not clear |
| Yusuke Nakata, Nobuhisa Kanahara, Hiroshi Kimura, Hiroyuki Watanabe, Masaomi Iy. Efficacy of clozapine on dopamine supersensitivity psychosis in schizophrenia. International clinical psychopharmacology. vol 32. issue 3. 2017-12-18. PMID:28067751. |
efficacy of clozapine on dopamine supersensitivity psychosis in schizophrenia. |
2017-12-18 |
2023-08-13 |
Not clear |
| Yusuke Nakata, Nobuhisa Kanahara, Hiroshi Kimura, Hiroyuki Watanabe, Masaomi Iy. Efficacy of clozapine on dopamine supersensitivity psychosis in schizophrenia. International clinical psychopharmacology. vol 32. issue 3. 2017-12-18. PMID:28067751. |
although the effectiveness of clozapine (clz) for patients with treatment-resistant schizophrenia (trs) has been well established, its active mechanism has not been completely clarified. |
2017-12-18 |
2023-08-13 |
Not clear |
| Lauren I Kasoff, Kwangmi Ahn, Peter Gochman, Diane D Broadnax, Judith L Rapopor. Strong Treatment Response and High Maintenance Rates of Clozapine in Childhood-Onset Schizophrenia. Journal of child and adolescent psychopharmacology. vol 26. issue 5. 2017-12-14. PMID:26784704. |
strong treatment response and high maintenance rates of clozapine in childhood-onset schizophrenia. |
2017-12-14 |
2023-08-13 |
Not clear |
| Amir Krivoy, Irit Gil-Ad, Igor Tarasenko, Abraham Weizman, Michal Tale. Trans-generation enrichment of clozapine-responsiveness trait in mice using a subchronic hypo-glutamatergic model of schizophrenia:A preliminary study. Behavioural brain research. vol 323. 2017-12-13. PMID:28167336. |
schizophrenia patients who do not respond to clozapine treatment represent the most debilitating type of schizophrenia with unmet needs for novel interventions. |
2017-12-13 |
2023-08-13 |
mouse |
| Taylor M Mehta, Ryan J Van Lieshou. A review of the safety of clozapine during pregnancy and lactation. Archives of women's mental health. vol 20. issue 1. 2017-12-11. PMID:27704220. |
clozapine is an antipsychotic used in the management of treatment-resistant schizophrenia. |
2017-12-11 |
2023-08-13 |
Not clear |
| Taylor M Mehta, Ryan J Van Lieshou. A review of the safety of clozapine during pregnancy and lactation. Archives of women's mental health. vol 20. issue 1. 2017-12-11. PMID:27704220. |
while the available literature on clozapine use during the perinatal period is very limited, the risks of clozapine use during pregnancy and the postpartum period should be discussed with women and weighed against those associated with other treatments and partially or untreated schizophrenia. |
2017-12-11 |
2023-08-13 |
Not clear |
| S R T Veerman, P F J Schulte, J D Smith, L de Haa. Memantine augmentation in clozapine-refractory schizophrenia: a randomized, double-blind, placebo-controlled crossover study. Psychological medicine. vol 46. issue 9. 2017-11-28. PMID:27048954. |
clozapine augmentation with memantine targets altered nmda receptor-mediated neurotransmission in schizophrenia and showed substantial beneficial effects on several symptom domains in a small proof-of-concept study. |
2017-11-28 |
2023-08-13 |
Not clear |
| S R T Veerman, P F J Schulte, J D Smith, L de Haa. Memantine augmentation in clozapine-refractory schizophrenia: a randomized, double-blind, placebo-controlled crossover study. Psychological medicine. vol 46. issue 9. 2017-11-28. PMID:27048954. |
we evaluate effects of memantine add-on treatment to clozapine for memory and executive function, and negative and positive symptoms in schizophrenia. |
2017-11-28 |
2023-08-13 |
Not clear |
| Amir Krivoy, Fiona Gaughran, Abraham Weizman, Gerome Breen, James H MacCab. Gene polymorphisms potentially related to the pharmacokinetics of clozapine: a systematic review. International clinical psychopharmacology. vol 31. issue 4. 2017-11-27. PMID:25563806. |
clozapine is currently the ultimate effective therapy for otherwise treatment-refractory schizophrenia. |
2017-11-27 |
2023-08-13 |
Not clear |
| Ryan S Sultan, Mark Olfson, Christoph U Correll, Erica J Dunca. Evaluating the Effect of the Changes in FDA Guidelines for Clozapine Monitoring. The Journal of clinical psychiatry. vol 78. issue 8. 2017-11-20. PMID:28742291. |
concerns exist that clozapine is underutilized in the management of treatment-resistant schizophrenia. |
2017-11-20 |
2023-08-13 |
Not clear |
| Alper Bas, Gozde Gultekin, Said Incir, Tuba Ocek Bas, Murat Emul, Alaatin Dura. Level of serum thioredoxin and correlation with neurocognitive functions in patients with schizophrenia using clozapine and other atypical antipsychotics. Psychiatry research. vol 247. 2017-11-17. PMID:27871032. |
level of serum thioredoxin and correlation with neurocognitive functions in patients with schizophrenia using clozapine and other atypical antipsychotics. |
2017-11-17 |
2023-08-13 |
Not clear |
| Alper Bas, Gozde Gultekin, Said Incir, Tuba Ocek Bas, Murat Emul, Alaatin Dura. Level of serum thioredoxin and correlation with neurocognitive functions in patients with schizophrenia using clozapine and other atypical antipsychotics. Psychiatry research. vol 247. 2017-11-17. PMID:27871032. |
the aim of this study is investigating the relationship between serum thioredoxin levels and cognitive functions in acute psychotic episode and remission state patients with schizophrenia; and examining whether there were differences between patients using clozapine and other atypical antipsychotics; including risperidone, olanzapine and amisulpride. |
2017-11-17 |
2023-08-13 |
Not clear |
| J Lally, O Ajnakina, M Di Forti, A Trotta, A Demjaha, A Kolliakou, V Mondelli, T Reis Marques, C Pariante, P Dazzan, S S Shergil, O D Howes, A S David, J H MacCabe, F Gaughran, R M Murra. Two distinct patterns of treatment resistance: clinical predictors of treatment resistance in first-episode schizophrenia spectrum psychoses. Psychological medicine. vol 46. issue 15. 2017-11-16. PMID:27605254. |
clozapine remains the only evidence-based antipsychotic for treatment-resistant schizophrenia (trs). |
2017-11-16 |
2023-08-13 |
Not clear |