| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Magdalena Jiménez-Cornejo, Gonzalo Munizaga, David Aceitun. Does adding a second antipsychotic to clozapine improve clinical response in resistant schizophrenia? Medwave. vol 16. issue Suppl5. 2017-09-04. PMID:27922589. |
we concluded adding a second antipsychotic to clozapine in patients with refractory schizophrenia probably leads to little or no difference in clinical response, and increases adverse effects. |
2017-09-04 |
2023-08-13 |
Not clear |
| Madeleine Uys, Mohammed Shahid, Jukka Sallinen, Walter Dreyer, Marike Cockeran, Brian H Harve. The α2C-adrenoceptor antagonist, ORM-10921, has antipsychotic-like effects in social isolation reared rats and bolsters the response to haloperidol. Progress in neuro-psychopharmacology & biological psychiatry. vol 71. 2017-08-30. PMID:27381554. |
the beneficial effects of clozapine in refractory schizophrenia and associated cognitive deficits have, among others, been associated with its α2c-ar modulating activity. |
2017-08-30 |
2023-08-13 |
rat |
| Suvi Koskinen, Olli Kampman, Anssi Solismaa, Leo-Pekka Lyytikäinen, Niko Seppälä, Merja Viikki, Mari Hämäläinen, Eeva Moilanen, Nina Mononen, Terho Lehtimäki, Esa Leinone. INSIG2 polymorphism and weight gain, dyslipidemia and serum adiponectin in Finnish patients with schizophrenia treated with clozapine. Pharmacogenomics. vol 17. issue 18. 2017-08-30. PMID:27885961. |
insig2 polymorphism and weight gain, dyslipidemia and serum adiponectin in finnish patients with schizophrenia treated with clozapine. |
2017-08-30 |
2023-08-13 |
Not clear |
| Selvizhi Subramanian, Birgit A Völlm, Nick Huban. Clozapine dose for schizophrenia. The Cochrane database of systematic reviews. vol 6. 2017-08-16. PMID:28613395. |
clozapine dose for schizophrenia. |
2017-08-16 |
2023-08-13 |
Not clear |
| Selvizhi Subramanian, Birgit A Völlm, Nick Huban. Clozapine dose for schizophrenia. The Cochrane database of systematic reviews. vol 6. 2017-08-16. PMID:28613395. |
clozapine is useful in the treatment of schizophrenia and related disorders, particularly when other antipsychotic medications have failed. |
2017-08-16 |
2023-08-13 |
Not clear |
| Yuzuki Kanda, Miho Okada, Rina Ikarashi, Eri Morioka, Takashi Kondo, Masayuki Iked. Bimodal modulation of store-operated Ca Neuroscience letters. vol 635. 2017-08-15. PMID:27769892. |
bimodal modulation of store-operated ca clozapine (clz) and olanzapine (olz) are second generation (atypical) antipsychotics, used widely for treating schizophrenia and bipolar disorder. |
2017-08-15 |
2023-08-13 |
rat |
| C Zhang, Y Zhang, J Cai, M Chen, L Son. Complement 3 and metabolic syndrome induced by clozapine: a cross-sectional study and retrospective cohort analysis. The pharmacogenomics journal. vol 17. issue 1. 2017-07-31. PMID:26503818. |
we recruited 576 schizophrenia patients taking clozapine and measured the serum levels of fasting metabolic parameters. |
2017-07-31 |
2023-08-13 |
Not clear |
| Adam J Prus, Laura E Wise, Alan L Pehrson, Scott D Philibin, Benny Bang-Andersen, Jørn Arnt, Joseph H Porte. Discriminative stimulus properties of 1.25mg/kg clozapine in rats: Mediation by serotonin 5-HT2 and dopamine D4 receptors. Brain research. vol 1648. issue Pt A. 2017-07-26. PMID:27502027. |
the atypical antipsychotic drug clozapine remains one of most effective treatments for schizophrenia, given a lack of extrapyramidal side effects, improvements in negative symptoms, cognitive impairment, and in symptoms in treatment-resistant schizophrenia. |
2017-07-26 |
2023-08-13 |
rat |
| Sukhtej Sahni, B S Chavan, Ajeet Sidana, Priyanka Kalra, Gurjit Kau. Comparative study of clozapine versus risperidone in treatment-naive, first-episode schizophrenia: A pilot study. The Indian journal of medical research. vol 144. issue 5. 2017-07-21. PMID:28361822. |
comparative study of clozapine versus risperidone in treatment-naive, first-episode schizophrenia: a pilot study. |
2017-07-21 |
2023-08-13 |
Not clear |
| Sukhtej Sahni, B S Chavan, Ajeet Sidana, Priyanka Kalra, Gurjit Kau. Comparative study of clozapine versus risperidone in treatment-naive, first-episode schizophrenia: A pilot study. The Indian journal of medical research. vol 144. issue 5. 2017-07-21. PMID:28361822. |
clozapine may be more useful in treatment-naive patients with first-episode schizophrenia for better symptoms control and improving quality of life. |
2017-07-21 |
2023-08-13 |
Not clear |
| Sukhtej Sahni, B S Chavan, Ajeet Sidana, Priyanka Kalra, Gurjit Kau. Comparative study of clozapine versus risperidone in treatment-naive, first-episode schizophrenia: A pilot study. The Indian journal of medical research. vol 144. issue 5. 2017-07-21. PMID:28361822. |
the current study was carried out to compare the efficacy and tolerability of clozapine versus risperidone in treatment-naive, first-episode patients of schizophrenia. |
2017-07-21 |
2023-08-13 |
Not clear |
| Sarah Barber, Uwaila Olotu, Martina Corsi, Andrea Ciprian. Clozapine combined with different antipsychotic drugs for treatment-resistant schizophrenia. The Cochrane database of systematic reviews. vol 3. 2017-07-20. PMID:28333365. |
clozapine combined with different antipsychotic drugs for treatment-resistant schizophrenia. |
2017-07-20 |
2023-08-13 |
Not clear |
| Sarah Barber, Uwaila Olotu, Martina Corsi, Andrea Ciprian. Clozapine combined with different antipsychotic drugs for treatment-resistant schizophrenia. The Cochrane database of systematic reviews. vol 3. 2017-07-20. PMID:28333365. |
between 40% and 70% of people with treatment-resistant schizophrenia do not respond to clozapine, despite adequate blood levels. |
2017-07-20 |
2023-08-13 |
Not clear |
| Wei Zheng, Xiao-Lan Cao, Gabor S Ungvari, Ying-Qiang Xiang, Tong Guo, Zheng-Rong Liu, Yuan-Yuan Wang, Brent P Forester, Stephen J Seiner, Yu-Tao Xian. Electroconvulsive Therapy Added to Non-Clozapine Antipsychotic Medication for Treatment Resistant Schizophrenia: Meta-Analysis of Randomized Controlled Trials. PloS one. vol 11. issue 6. 2017-07-10. PMID:27285996. |
this meta-analysis of randomized controlled trials (rcts) examined the efficacy and safety of the combination of electroconvulsive therapy (ect) and antipsychotic medication (except for clozapine) versus the same antipsychotic monotherapy for treatment-resistant schizophrenia (trs). |
2017-07-10 |
2023-08-13 |
Not clear |
| Wei Zheng, Yu-Tao Xiang, Xin-Hu Yang, Ying-Qiang Xiang, Jose de Leo. Clozapine Augmentation With Antiepileptic Drugs for Treatment-Resistant Schizophrenia: A Meta-Analysis of Randomized Controlled Trials. The Journal of clinical psychiatry. vol 78. issue 5. 2017-06-16. PMID:28355041. |
clozapine augmentation with antiepileptic drugs for treatment-resistant schizophrenia: a meta-analysis of randomized controlled trials. |
2017-06-16 |
2023-08-13 |
Not clear |
| Wei Zheng, Yu-Tao Xiang, Xin-Hu Yang, Ying-Qiang Xiang, Jose de Leo. Clozapine Augmentation With Antiepileptic Drugs for Treatment-Resistant Schizophrenia: A Meta-Analysis of Randomized Controlled Trials. The Journal of clinical psychiatry. vol 78. issue 5. 2017-06-16. PMID:28355041. |
to meta-analyze randomized controlled trials (rcts) for the efficacy and safety of adjunctive antiepileptic drugs (aeds) to augment clozapine therapy for treatment-resistant schizophrenia. |
2017-06-16 |
2023-08-13 |
Not clear |
| Susan L Rossell, Paul S Francis, Cherrie Galletly, Anthony Harris, Dan Siskind, Michael Berk, Kiymet Bozaoglu, Frances Dark, Olivia Dean, Dennis Liu, Denny Meyer, Erica Neill, Andrea Phillipou, Jerome Sarris, David J Castl. N-acetylcysteine (NAC) in schizophrenia resistant to clozapine: a double blind randomised placebo controlled trial targeting negative symptoms. BMC psychiatry. vol 16. issue 1. 2017-06-15. PMID:27629871. |
n-acetylcysteine (nac) in schizophrenia resistant to clozapine: a double blind randomised placebo controlled trial targeting negative symptoms. |
2017-06-15 |
2023-08-13 |
Not clear |
| Susan L Rossell, Paul S Francis, Cherrie Galletly, Anthony Harris, Dan Siskind, Michael Berk, Kiymet Bozaoglu, Frances Dark, Olivia Dean, Dennis Liu, Denny Meyer, Erica Neill, Andrea Phillipou, Jerome Sarris, David J Castl. N-acetylcysteine (NAC) in schizophrenia resistant to clozapine: a double blind randomised placebo controlled trial targeting negative symptoms. BMC psychiatry. vol 16. issue 1. 2017-06-15. PMID:27629871. |
clozapine is an effective treatment for a proportion of people with schizophrenia (sz) who are resistant to the beneficial effects of other antipsychotic drugs. |
2017-06-15 |
2023-08-13 |
Not clear |
| Erlend Bugge, Trygve Nissen, Rolf Wyn. Probable clozapine-induced parenchymal lung disease and perimyocarditis: a case report. BMC psychiatry. vol 16. issue 1. 2017-06-09. PMID:27931201. |
clozapine is the archetypical atypical antipsychotic, its primary indication being treatment resistant schizophrenia. |
2017-06-09 |
2023-08-13 |
Not clear |
| Hiroyoshi Takeuchi, Jimmy Lee, Gagan Fervaha, George Foussias, Ofer Agid, Gary Remingto. Switching to Clozapine Using Immediate Versus Gradual Antipsychotic Discontinuation: A Pilot, Double-Blind, Randomized Controlled Trial. The Journal of clinical psychiatry. vol 78. issue 2. 2017-06-08. PMID:28234436. |
to examine effects of different antipsychotic discontinuation strategies on clinical outcomes in patients with schizophrenia undergoing a switch to clozapine. |
2017-06-08 |
2023-08-13 |
Not clear |