| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Kohn, R P Ebstein, U Heresco-Levy, B Shapira, L Nemanov, I Gritsenko, M Avnon, B Lere. Dopamine D4 receptor gene polymorphisms: relation to ethnicity, no association with schizophrenia and response to clozapine in Israeli subjects. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 7. issue 1. 1997-07-23. PMID:9088883. |
previous work has not found linkage or association of a polymorphism in exon 3 of this gene with diagnosis of schizophrenia or response to clozapine. |
1997-07-23 |
2023-08-12 |
human |
| B L Murphy, R H Roth, A F Arnste. Clozapine reverses the spatial working memory deficits induced by FG7142 in monkeys. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 16. issue 6. 1997-07-17. PMID:9165499. |
these results from nonhuman primates suggest that the clozapine doses commonly used to treat schizophrenia may not be optimal for treating the pfc cognitive deficits associated with this illness. |
1997-07-17 |
2023-08-12 |
rat |
| A M Mortime. Cognitive function in schizophrenia--do neuroleptics make a difference? Pharmacology, biochemistry, and behavior. vol 56. issue 4. 1997-07-07. PMID:9130306. |
atypical neuroleptics may, owing to their novel mechanisms of action, have the capacity to remediate cognitive impairment in schizophrenia: there is some evidence that clozapine has a "cognitive sparing" effect, but further research is needed in this area, particularly with other new drugs. |
1997-07-07 |
2023-08-12 |
Not clear |
| D E Fujii, I Ahmed, M Jokumsen, J M Compto. The effects of clozapine on cognitive functioning in treatment-resistant schizophrenic patients. The Journal of neuropsychiatry and clinical neurosciences. vol 9. issue 2. 1997-07-07. PMID:9144103. |
it was concluded that clozapine treatment is associated with global cognitive improvements in patients with treatment-resistant schizophrenia. |
1997-07-07 |
2023-08-12 |
Not clear |
| T Sumiyoshi, M Hasegawa, K Jayathilake, H Y Meltze. Prediction of short-term changes in symptom severity by baseline plasma homovanillic acid levels in schizophrenic patients receiving clozapine. Psychiatry research. vol 69. issue 2-3. 1997-07-03. PMID:9109179. |
the relationship between pretreatment levels of plasma homovanillic acid (phva) and the outcome of clozapine treatment was studied in 18 male patients with schizophrenia who were resistant to treatment with conventional neuroleptics. |
1997-07-03 |
2023-08-12 |
Not clear |
| T Sumiyoshi, M Hasegawa, K Jayathilake, H Y Meltze. Prediction of short-term changes in symptom severity by baseline plasma homovanillic acid levels in schizophrenic patients receiving clozapine. Psychiatry research. vol 69. issue 2-3. 1997-07-03. PMID:9109179. |
these results suggest that pretreatment levels of phva can be used to predict relatively short-term changes in the positive symptoms of patients with schizophrenia receiving clozapine treatment, particularly for clozapine responders. |
1997-07-03 |
2023-08-12 |
Not clear |
| A Meyer-Lindenberg, H Gruppe, U Bauer, S Lis, S Krieger, B Gallhofe. Improvement of cognitive function in schizophrenic patients receiving clozapine or zotepine: results from a double-blind study. Pharmacopsychiatry. vol 30. issue 2. 1997-07-01. PMID:9131723. |
we report on a double-blind randomized study designed to evaluate the impact of zotepine and clozapine on cognitive dysfunction in schizophrenia. |
1997-07-01 |
2023-08-12 |
Not clear |
| A Meyer-Lindenberg, H Gruppe, U Bauer, S Lis, S Krieger, B Gallhofe. Improvement of cognitive function in schizophrenic patients receiving clozapine or zotepine: results from a double-blind study. Pharmacopsychiatry. vol 30. issue 2. 1997-07-01. PMID:9131723. |
the study confirms previous results on the efficacy of clozapine and zotepine in treating negative symptoms of schizophrenia. |
1997-07-01 |
2023-08-12 |
Not clear |
| S A Chong, C H Tan, Y M Khoo, H S Lee, K E Wong, F Ngui, M Winslo. Clinical evaluation and plasma clozapine concentrations in Chinese patients with schizophrenia. Therapeutic drug monitoring. vol 19. issue 2. 1997-06-27. PMID:9108654. |
clinical evaluation and plasma clozapine concentrations in chinese patients with schizophrenia. |
1997-06-27 |
2023-08-12 |
Not clear |
| M S Kramer, B Last, A Getson, S A Reine. The effects of a selective D4 dopamine receptor antagonist (L-745,870) in acutely psychotic inpatients with schizophrenia. D4 Dopamine Antagonist Group. Archives of general psychiatry. vol 54. issue 6. 1997-06-27. PMID:9193198. |
based mainly on the selective antagonism of clozapine at d4 compared with d2 dopamine receptors, hopes have run high that a selective d4 dopamine receptor antagonist might improve the pharmacological treatment of patients with schizophrenia. |
1997-06-27 |
2023-08-12 |
Not clear |
| T H MacEwan, M J Morto. Use of clozapine in a child with treatment-resistant schizophrenia. The British journal of psychiatry : the journal of mental science. vol 168. issue 3. 1997-05-30. PMID:8833696. |
use of clozapine in a child with treatment-resistant schizophrenia. |
1997-05-30 |
2023-08-12 |
Not clear |
| T H MacEwan, M J Morto. Use of clozapine in a child with treatment-resistant schizophrenia. The British journal of psychiatry : the journal of mental science. vol 168. issue 3. 1997-05-30. PMID:8833696. |
clozapine is used effectively in adults with treatment-resistant schizophrenia but little is published on the use of clozapine in children. |
1997-05-30 |
2023-08-12 |
Not clear |
| M A Laune. Long-term treatment with clozapine in schizophrenia. The British journal of psychiatry : the journal of mental science. vol 168. issue 3. 1997-05-30. PMID:8833701. |
long-term treatment with clozapine in schizophrenia. |
1997-05-30 |
2023-08-12 |
Not clear |
| B Macfarlane, S Davies, K Mannan, R Sarsam, D Pariente, J Doole. Fatal acute fulminant liver failure due to clozapine: a case report and review of clozapine-induced hepatotoxicity. Gastroenterology. vol 112. issue 5. 1997-05-27. PMID:9136851. |
this report describes fatal acute fulminant liver failure caused by clozapine in a 39-year-old man with chronic paranoid schizophrenia. |
1997-05-27 |
2023-08-12 |
Not clear |
| G Joffe, E Venäläinen, J Tupala, O Hiltunen, K Wahlbeck, R Gädeke, R Rimo. The effect of clozapine on the course of illness in chronic schizophrenia: focus on treatment outcome in out-patients. International clinical psychopharmacology. vol 11. issue 4. 1997-05-22. PMID:9031993. |
the effect of clozapine on the course of illness in chronic schizophrenia: focus on treatment outcome in out-patients. |
1997-05-22 |
2023-08-12 |
Not clear |
| G Joffe, E Venäläinen, J Tupala, O Hiltunen, K Wahlbeck, R Gädeke, R Rimo. The effect of clozapine on the course of illness in chronic schizophrenia: focus on treatment outcome in out-patients. International clinical psychopharmacology. vol 11. issue 4. 1997-05-22. PMID:9031993. |
there appears to be a subgroup of hebephrenic patients who benefit from clozapine more than patients with other types of schizophrenia. |
1997-05-22 |
2023-08-12 |
Not clear |
| J Rabinowitz, M Avnon, V Rosenber. Effect of clozapine on physical and verbal aggression. Schizophrenia research. vol 22. issue 3. 1997-05-19. PMID:9000322. |
the hypothesis that clozapine reduced serious physically and verbally aggressive behavior of persons with schizophrenia whose symptoms did not respond to typical neuroleptic treatment was tested. |
1997-05-19 |
2023-08-12 |
Not clear |
| D J Freeman, L K Oyewum. Will routine therapeutic drug monitoring have a place in clozapine therapy? Clinical pharmacokinetics. vol 32. issue 2. 1997-05-13. PMID:9068925. |
clozapine is an atypical antipsychotic medication with proven efficacy in the management of refractory schizophrenia. |
1997-05-13 |
2023-08-12 |
Not clear |
| D J Still, P G Dorson, M L Crismon, C Pousso. Effects of switching inpatients with treatment-resistant schizophrenia from clozapine to risperidone. Psychiatric services (Washington, D.C.). vol 47. issue 12. 1997-04-23. PMID:9117479. |
effects of switching inpatients with treatment-resistant schizophrenia from clozapine to risperidone. |
1997-04-23 |
2023-08-12 |
Not clear |
| D J Still, P G Dorson, M L Crismon, C Pousso. Effects of switching inpatients with treatment-resistant schizophrenia from clozapine to risperidone. Psychiatric services (Washington, D.C.). vol 47. issue 12. 1997-04-23. PMID:9117479. |
a prospective, open-label study in a 400-bed state psychiatric hospital evaluated change in therapeutic response among ten patients with treatment-resistant schizophrenia who were switched from clozapine to risperidone. |
1997-04-23 |
2023-08-12 |
Not clear |