| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C J Hong, Y L Lee, C B Sim, H G Hw. Dopamine D4 receptor variants in Chinese sporadic and familial schizophrenics. American journal of medical genetics. vol 74. issue 4. 1997-11-06. PMID:9259377. |
the number of repetitions of the 48bp unit was shown to influence the binding of clozapine, which suggests that different alleles may function differently in vivo and affect the pathogenesis of schizophrenia. |
1997-11-06 |
2023-08-12 |
Not clear |
| I Leykin, R Mayer, M Shinitzk. Short and long-term immunosuppressive effects of clozapine and haloperidol. Immunopharmacology. vol 37. issue 1. 1997-10-29. PMID:9285246. |
in line with the autoimmune hypothesis of schizophrenia we have tested in this study whether the commonly used neuroleptics, clozapine and haloperidol can also act as systemic immunosuppressants. |
1997-10-29 |
2023-08-12 |
mouse |
| M Turetz, T Mozes, P Toren, N Chernauzan, R Yoran-Hegesh, R Mester, N Wittenberg, S Tyano, A Weizma. An open trial of clozapine in neuroleptic-resistant childhood-onset schizophrenia. The British journal of psychiatry : the journal of mental science. vol 170. 1997-10-28. PMID:9330014. |
an open trial of clozapine in neuroleptic-resistant childhood-onset schizophrenia. |
1997-10-28 |
2023-08-12 |
Not clear |
| S Sanyal, H H Van To. Review the role of dopamine D4 receptors in schizophrenia and antipsychotic action. Journal of psychiatric research. vol 31. issue 2. 1997-10-23. PMID:9278187. |
the observations which support the idea that d4 might serve as a target for clozapine have significantly modified and extended our understanding of mechanisms underlying atypical antipsychotic treatment of schizophrenia, as well as the dopamine hypothesis for schizophrenia. |
1997-10-23 |
2023-08-12 |
Not clear |
| H Weigmann, J Bierbrauer, S Härtter, C Hiemk. Automated determination of clozapine and major metabolites in serum and urine. Therapeutic drug monitoring. vol 19. issue 4. 1997-09-29. PMID:9263393. |
clozapine is an atypical neuroleptic that is increasingly used for the treatment of schizophrenia. |
1997-09-29 |
2023-08-12 |
human |
| W H Chang, S K Lin, H Y Lane, W H Hu, M W Jann, H N Li. Clozapine dosages and plasma drug concentrations. Journal of the Formosan Medical Association = Taiwan yi zhi. vol 96. issue 8. 1997-09-25. PMID:9290269. |
steady-state plasma concentrations of clozapine and its metabolites, desmethylclozapine and clozapine-n-oxide, were measured in 162 taiwanese patients with refractory schizophrenia. |
1997-09-25 |
2023-08-12 |
Not clear |
| P Monteleone, M Fabrazzo, A Tortorella, M Ma. Plasma levels of interleukin-6 and tumor necrosis factor alpha in chronic schizophrenia: effects of clozapine treatment. Psychiatry research. vol 71. issue 1. 1997-09-23. PMID:9247977. |
plasma levels of interleukin-6 and tumor necrosis factor alpha in chronic schizophrenia: effects of clozapine treatment. |
1997-09-23 |
2023-08-12 |
human |
| C J Hong, J Y Chen, H J Chiu, C B Si. A double-blind comparative study of clozapine versus chlorpromazine on Chinese patients with treatment-refractory schizophrenia. International clinical psychopharmacology. vol 12. issue 3. 1997-09-22. PMID:9248867. |
a double-blind comparative study of clozapine versus chlorpromazine on chinese patients with treatment-refractory schizophrenia. |
1997-09-22 |
2023-08-12 |
Not clear |
| C J Hong, J Y Chen, H J Chiu, C B Si. A double-blind comparative study of clozapine versus chlorpromazine on Chinese patients with treatment-refractory schizophrenia. International clinical psychopharmacology. vol 12. issue 3. 1997-09-22. PMID:9248867. |
clozapine has been shown to have superior effectiveness compared with classic neuroleptics in treating refractory schizophrenia in caucasians, but its efficacy and safety in chinese have not been adequately studied. |
1997-09-22 |
2023-08-12 |
Not clear |
| C R Young, J G Longhurst, M B Bowers, C M Mazur. The expanding indications for clozapine. Experimental and clinical psychopharmacology. vol 5. issue 3. 1997-09-22. PMID:9260069. |
clozapine is increasingly being used for clinical indications in addition to treatment-resistant schizophrenia; this article reviews the relevant literature. |
1997-09-22 |
2023-08-12 |
Not clear |
| R R Conley, W T Carpenter, C A Tamming. Time to clozapine response in a standardized trial. The American journal of psychiatry. vol 154. issue 9. 1997-09-18. PMID:9286183. |
the authors sought to determine the time to clozapine response in treatment-refractory patients with schizophrenia. |
1997-09-18 |
2023-08-12 |
Not clear |
| R Rosenheck, J Cramer, W Xu, J Thomas, W Henderson, L Frisman, C Fye, D Charne. A comparison of clozapine and haloperidol in hospitalized patients with refractory schizophrenia. Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory Schizophrenia. The New England journal of medicine. vol 337. issue 12. 1997-09-18. PMID:9295240. |
a comparison of clozapine and haloperidol in hospitalized patients with refractory schizophrenia. |
1997-09-18 |
2023-08-12 |
Not clear |
| R Rosenheck, J Cramer, W Xu, J Thomas, W Henderson, L Frisman, C Fye, D Charne. A comparison of clozapine and haloperidol in hospitalized patients with refractory schizophrenia. Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory Schizophrenia. The New England journal of medicine. vol 337. issue 12. 1997-09-18. PMID:9295240. |
department of veterans affairs cooperative study group on clozapine in refractory schizophrenia. |
1997-09-18 |
2023-08-12 |
Not clear |
| R Rosenheck, J Cramer, W Xu, J Thomas, W Henderson, L Frisman, C Fye, D Charne. A comparison of clozapine and haloperidol in hospitalized patients with refractory schizophrenia. Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory Schizophrenia. The New England journal of medicine. vol 337. issue 12. 1997-09-18. PMID:9295240. |
clozapine, a relatively expensive antipsychotic drug, is widely used to treat patients with refractory schizophrenia. |
1997-09-18 |
2023-08-12 |
Not clear |
| D J Healy, J H Meador-Woodruf. Clozapine and haloperidol differentially affect AMPA and kainate receptor subunit mRNA levels in rat cortex and striatum. Brain research. Molecular brain research. vol 47. issue 1-2. 1997-09-17. PMID:9221932. |
these dissimilarities may represent an interesting mechanism for some of the differential therapeutic or toxic effects of clozapine and haloperidol, and also may be relevant to our understanding of dopamine-glutamate interactions in schizophrenia. |
1997-09-17 |
2023-08-12 |
rat |
| P F Buckley, Z Y Ibrahim, B Singer, B Orr, K Donenwirth, P S Bra. Aggression and schizophrenia: efficacy of risperidone. The journal of the American Academy of Psychiatry and the Law. vol 25. issue 2. 1997-08-28. PMID:9213289. |
in this regard, clozapine has been particularly effective in reducing aggressive behavior in patients with schizophrenia. |
1997-08-28 |
2023-08-12 |
Not clear |
| O Freudenreich, R D Weiner, J P McEvo. Clozapine-induced electroencephalogram changes as a function of clozapine serum levels. Biological psychiatry. vol 42. issue 2. 1997-08-19. PMID:9209730. |
specific electroencephalogram (eeg) changes during clozapine therapy were prospectively studied in a cohort of 50 chronic state hospital patients with schizophrenia who were randomly assigned to one of three nonoverlapping clozapine serum level ranges (50-150 ng/ml, 200-300 ng/ml, and 350-450 ng/ml). |
1997-08-19 |
2023-08-12 |
Not clear |
| E Schulz, C Fleischhaker, H E Remschmid. Correlated changes in symptoms and neurotransmitter indices during maintenance treatment with clozapine or conventional neuroleptics in adolescents and young adults with schizophrenia. Journal of child and adolescent psychopharmacology. vol 6. issue 2. 1997-08-15. PMID:9231304. |
correlated changes in symptoms and neurotransmitter indices during maintenance treatment with clozapine or conventional neuroleptics in adolescents and young adults with schizophrenia. |
1997-08-15 |
2023-08-12 |
Not clear |
| E Schulz, C Fleischhaker, H E Remschmid. Correlated changes in symptoms and neurotransmitter indices during maintenance treatment with clozapine or conventional neuroleptics in adolescents and young adults with schizophrenia. Journal of child and adolescent psychopharmacology. vol 6. issue 2. 1997-08-15. PMID:9231304. |
these findings suggest involvement of norepinephrine and serotonin in the pathophysiology of schizophrenia (with depression associated with lower mhpg levels and negative symptoms associated with lower serotonin levels) and in the therapeutic actions of clozapine. |
1997-08-15 |
2023-08-12 |
Not clear |
| Y Kohn, R P Ebstein, U Heresco-Levy, B Shapira, L Nemanov, I Gritsenko, M Avnon, B Lere. Dopamine D4 receptor gene polymorphisms: relation to ethnicity, no association with schizophrenia and response to clozapine in Israeli subjects. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 7. issue 1. 1997-07-23. PMID:9088883. |
dopamine d4 receptor gene polymorphisms: relation to ethnicity, no association with schizophrenia and response to clozapine in israeli subjects. |
1997-07-23 |
2023-08-12 |
human |