| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Shaikh, D A Collier, P C Sham, D Ball, K Aitchison, H Vallada, I Smith, M Gill, R W Kerwi. Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia. Human genetics. vol 97. issue 6. 1996-07-12. PMID:8641685. |
we examined a ser-9-gly polymorphism in the dopamine d3 receptor gene for allelic association with schizophrenia in 133 patients currently treated with clozapine and 109 controls. |
1996-07-12 |
2023-08-12 |
Not clear |
| L G Cohen, S Chesley, L Eugenio, J G Flood, J Fisch, D C Gof. Erythromycin-induced clozapine toxic reaction. Archives of internal medicine. vol 156. issue 6. 1996-06-27. PMID:8629881. |
clozapine, used in the treatment of patients with schizophrenia resistant to other neuroleptic medication, is metabolized by the hepatic microsomal system to demethyl-clozapine and clozapine-n-oxide. |
1996-06-27 |
2023-08-12 |
Not clear |
| L Mrzljak, C Bergson, M Pappy, R Huff, R Levenson, P S Goldman-Raki. Localization of dopamine D4 receptors in GABAergic neurons of the primate brain. Nature. vol 381. issue 6579. 1996-06-19. PMID:8622768. |
our findings suggest that clozapine's beneficial effects in schizophrenia may be achieved, in part, through d4-mediated gaba modulation, possibly implicating disinhibition of excitatory transmission in intrinsic cortical, thalamocortical and extrapyramidal pathways. |
1996-06-19 |
2023-08-12 |
Not clear |
| B J Gordon, D J Milk. Dose related response to clozapine in a state psychiatric hospital population: a naturalistic study. The Psychiatric quarterly. vol 67. issue 1. 1996-06-14. PMID:8623040. |
this naturalistic study suggests that the use of low dose clozapine provides effective treatment for chronic, severely treatment resistant inpatients with schizophrenia or schizo-affective illness, at the same time reducing the potential for significant side effects. |
1996-06-14 |
2023-08-12 |
Not clear |
| D G Daniel, T E Goldberg, D R Weinberger, J E Kleinman, D Pickar, L J Lubick, T S William. Different side effect profiles of risperidone and clozapine in 20 outpatients with schizophrenia or schizoaffective disorder: a pilot study. The American journal of psychiatry. vol 153. issue 3. 1996-05-24. PMID:8610833. |
different side effect profiles of risperidone and clozapine in 20 outpatients with schizophrenia or schizoaffective disorder: a pilot study. |
1996-05-24 |
2023-08-12 |
Not clear |
| N Brunello, C Masotto, L Steardo, R Markstein, G Racagn. New insights into the biology of schizophrenia through the mechanism of action of clozapine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 13. issue 3. 1996-05-15. PMID:8602893. |
new insights into the biology of schizophrenia through the mechanism of action of clozapine. |
1996-05-15 |
2023-08-12 |
Not clear |
| N Brunello, C Masotto, L Steardo, R Markstein, G Racagn. New insights into the biology of schizophrenia through the mechanism of action of clozapine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 13. issue 3. 1996-05-15. PMID:8602893. |
probably the d1 antagonistic activity exerted by clozapine at low doses enhances preferentially the extracellular concentration of dopamine in specific areas of the brain, such as the prefrontal cortex, where a dopaminergic hypoactivity has been suggested to be in part responsible for negative symptoms of schizophrenia. |
1996-05-15 |
2023-08-12 |
Not clear |
| N Brunello, C Masotto, L Steardo, R Markstein, G Racagn. New insights into the biology of schizophrenia through the mechanism of action of clozapine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 13. issue 3. 1996-05-15. PMID:8602893. |
the clozapine enhancement of dopaminergic activity in this brain area might explain its efficacy against schizophrenia negative symptoms. |
1996-05-15 |
2023-08-12 |
Not clear |
| R D Or. Clozapine for treatment of schizophrenia. JAMA. vol 275. issue 3. 1996-05-15. PMID:8604168. |
clozapine for treatment of schizophrenia. |
1996-05-15 |
2023-08-12 |
Not clear |
| S Kapur, G Remingto. Serotonin-dopamine interaction and its relevance to schizophrenia. The American journal of psychiatry. vol 153. issue 4. 1996-04-24. PMID:8599393. |
the therapeutic success of clozapine and risperidone has focused attention on the interaction between serotonin and dopamine systems as an avenue for superior therapeutics in schizophrenia. |
1996-04-24 |
2023-08-12 |
Not clear |
| J A Frazier, J N Giedd, D Kaysen, K Albus, S Hamburger, J Alaghband-Rad, M C Lenane, K McKenna, A Breier, J L Rapopor. Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment. The American journal of psychiatry. vol 153. issue 4. 1996-04-24. PMID:8599409. |
childhood-onset schizophrenia: brain mri rescan after 2 years of clozapine maintenance treatment. |
1996-04-24 |
2023-08-12 |
Not clear |
| J A Frazier, J N Giedd, D Kaysen, K Albus, S Hamburger, J Alaghband-Rad, M C Lenane, K McKenna, A Breier, J L Rapopor. Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment. The American journal of psychiatry. vol 153. issue 4. 1996-04-24. PMID:8599409. |
the effect of clozapine on striatal morphology was examined in adolescents with childhood-onset schizophrenia. |
1996-04-24 |
2023-08-12 |
Not clear |
| E D Risby, C M Epstein, R D Jewart, B V Nguyen, W N Morgan, S C Risch, K V Thrivikraman, R L Lewin. Clozapine-induced EEG abnormalities and clinical response to clozapine. The Journal of neuropsychiatry and clinical neurosciences. vol 7. issue 4. 1996-02-27. PMID:8555749. |
the clinical eegs and the brief psychiatric rating scale (bprs) scores of 12 patients with schizophrenia and 4 patients with schizoaffective disorder were compared before and during treatment with clozapine. |
1996-02-27 |
2023-08-12 |
human |
| A Petronis, F Macciardi, A Athanassiades, A D Paterson, M Verga, H Y Meltzer, P Cola, J A Buchanan, H H Van Tol, J L Kenned. Association study between the dopamine D4 receptor gene and schizophrenia. American journal of medical genetics. vol 60. issue 5. 1996-02-13. PMID:8546161. |
the dopamine d4 receptor is of major interest in schizophrenia research due to its high affinity for the atypical neuroleptic clozapine and a high degree of variability in the receptor gene (drd4). |
1996-02-13 |
2023-08-12 |
Not clear |
| D Lacroix, Y Chaput, J P Rodriguez, M Filion, D Morrison, P St-Denis, J M Alber. Quantified EEG changes associated with a positive clinical response to clozapine in schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 19. issue 5. 1996-02-07. PMID:8539424. |
quantified eeg changes associated with a positive clinical response to clozapine in schizophrenia. |
1996-02-07 |
2023-08-12 |
Not clear |
| W G Honer, G N Smith, J S Lapointe, G W MacEwan, L Kopala, S Altma. Regional cortical anatomy and clozapine response in refractory schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 13. issue 1. 1996-01-29. PMID:8526974. |
regional cortical anatomy and clozapine response in refractory schizophrenia. |
1996-01-29 |
2023-08-12 |
Not clear |
| J W Olney, N B Farbe. Glutamate receptor dysfunction and schizophrenia. Archives of general psychiatry. vol 52. issue 12. 1996-01-04. PMID:7492260. |
we propose that since n-methyl-d-aspartate receptor hypofunction can cause psychosis in humans and corticolimbic neurodegenerative changes in the rat brain, and since these changes are prevented by certain antipsychotic drugs, including atypical neuroleptic agents (clozapine, olanzapine, fluperlapine), a better understanding of the n-methyl-d-aspartate receptor hypofunction mechanism and ways of preventing its neurodegenerative consequences in the rat brain may lead to improved pharmacotherapy in schizophrenia. |
1996-01-04 |
2023-08-12 |
rat |
| D Jonsson, J Wålinde. Cost-effectiveness of clozapine treatment in therapy-refractory schizophrenia. Acta psychiatrica Scandinavica. vol 92. issue 3. 1995-12-22. PMID:7484198. |
cost-effectiveness of clozapine treatment in therapy-refractory schizophrenia. |
1995-12-22 |
2023-08-12 |
Not clear |
| J S Vasile, S Steingar. Clozapine and the development of salivary gland swelling: a case study. The Journal of clinical psychiatry. vol 56. issue 11. 1995-12-12. PMID:7592503. |
clozapine is a novel antipsychotic that is effective in 30% to 50% of treatment-resistant schizophrenia. |
1995-12-12 |
2023-08-12 |
Not clear |
| M Kurz, M Hummer, I Kurzthaler, H Oberbauer, W W Fleischhacke. Efficacy of medium-dose clozapine for treatment-resistant schizophrenia. The American journal of psychiatry. vol 152. issue 11. 1995-12-06. PMID:7485642. |
efficacy of medium-dose clozapine for treatment-resistant schizophrenia. |
1995-12-06 |
2023-08-12 |
Not clear |