| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P L Needham, J Atkinson, M J Skill, D J Hea. Zotepine: preclinical tests predict antipsychotic efficacy and an atypical profile. Psychopharmacology bulletin. vol 32. issue 1. 1996-11-27. PMID:8927661. |
zotepine, an atypical antipsychotic structurally similar to clozapine, is in phase iii clinical trials in the united states and europe for the treatment and management of acute and chronic schizophrenia. |
1996-11-27 |
2023-08-12 |
human |
| R Benatov, P Sirota, S Megge. Neuroleptic-resistant schizophrenia treated with clozapine and ECT. Convulsive therapy. vol 12. issue 2. 1996-11-25. PMID:8744173. |
neuroleptic-resistant schizophrenia treated with clozapine and ect. |
1996-11-25 |
2023-08-12 |
Not clear |
| R Benatov, P Sirota, S Megge. Neuroleptic-resistant schizophrenia treated with clozapine and ECT. Convulsive therapy. vol 12. issue 2. 1996-11-25. PMID:8744173. |
we present four patients with schizophrenia treated with clozapine and ect. |
1996-11-25 |
2023-08-12 |
Not clear |
| G P Reynold. The importance of dopamine D4 receptors in the action and development of antipsychotic agents. Drugs. vol 51. issue 1. 1996-11-07. PMID:8741229. |
although it has a lower affinity than the d2 receptor for most antipsychotic drugs, the d4 receptor has a higher affinity for clozapine, which may explain the unique efficacy of clozapine in the treatment of schizophrenia. |
1996-11-07 |
2023-08-12 |
Not clear |
| G P Reynold. The importance of dopamine D4 receptors in the action and development of antipsychotic agents. Drugs. vol 51. issue 1. 1996-11-07. PMID:8741229. |
however, there is no association between genetic alterations of the d4 gene and either the development of schizophrenia or response to clozapine administration, nor is the absence of the receptor related to major neuropsychiatric deficits. |
1996-11-07 |
2023-08-12 |
Not clear |
| J A Bennett, P E Kec. A target-dose finding study of clozapine in patients with schizophrenia. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. vol 8. issue 1. 1996-11-07. PMID:8743644. |
a target-dose finding study of clozapine in patients with schizophrenia. |
1996-11-07 |
2023-08-12 |
Not clear |
| J A Bennett, P E Kec. A target-dose finding study of clozapine in patients with schizophrenia. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. vol 8. issue 1. 1996-11-07. PMID:8743644. |
twelve patients with schizophrenia by dsm-iii-r criteria who were refractory to treatment with standard antipsychotics were treated with clozapine utilizing a 10- to 14-day titration to a target dose of 6 mg/kg/day. |
1996-11-07 |
2023-08-12 |
Not clear |
| F Vahid-Ansari, Y Nakabeppu, G S Robertso. Contrasting effects of chronic clozapine, Seroquel(TM) (ICI 204,636) and haloperidol administration of deltaFosB-like immunoreactivity in the rodent forebrain. The European journal of neuroscience. vol 8. issue 5. 1996-11-06. PMID:8743740. |
these results suggest that a preferential action on limbic structures such as the prefrontal cortex, ventral striatum and lateral septal nucleus may account for the ability of chronic clozapine and ici 204, 636 administration to reduce the symptoms of schizophrenia without generating extrapyramidal side effects. |
1996-11-06 |
2023-08-12 |
rat |
| M Zhang, R R Owen, S K Pope, G R Smit. Cost-effectiveness of clozapine monitoring after the first 6 months. Archives of general psychiatry. vol 53. issue 10. 1996-11-06. PMID:8857873. |
clozapine is effective in treating patients with schizophrenia who do not respond to conventional neuroleptic drugs. |
1996-11-06 |
2023-08-12 |
Not clear |
| G J Remington, D Addington, E J Collins, B D Jones, P Lalonde, D J MacCrimmon, G W MacEwa. Clozapine: current status and role in the pharmacotherapy of schizophrenia. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 41. issue 3. 1996-10-31. PMID:8722645. |
clozapine: current status and role in the pharmacotherapy of schizophrenia. |
1996-10-31 |
2023-08-12 |
Not clear |
| G J Remington, D Addington, E J Collins, B D Jones, P Lalonde, D J MacCrimmon, G W MacEwa. Clozapine: current status and role in the pharmacotherapy of schizophrenia. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 41. issue 3. 1996-10-31. PMID:8722645. |
this study evaluates clozapine and its present role in the pharmacotherapy of schizophrenia. |
1996-10-31 |
2023-08-12 |
Not clear |
| J Grace, S B Bellus, M L Raulin, M I Herz, B L Priest, V Brenner, K Donnelly, P Smith, S Gun. Long-term impact of clozapine and psychosocial treatment on psychiatric symptoms and cognitive functioning. Psychiatric services (Washington, D.C.). vol 47. issue 1. 1996-10-28. PMID:8925344. |
the long-term effects of a combination of clozapine and psychosocial treatment were evaluated in a sample of treatment-refractory state hospital patients with schizophrenia. |
1996-10-28 |
2023-08-12 |
Not clear |
| A A Menditto, N C Beck, P Stuve, J A Fisher, M Stacy, M B Logue, L J Baldwi. Effectiveness of clozapine and a social learning program for severely disabled psychiatric inpatients. Psychiatric services (Washington, D.C.). vol 47. issue 1. 1996-10-28. PMID:8925345. |
this study examined the combined effectiveness of clozapine and a comprehensive inpatient psychosocial rehabilitation program on the clinical functioning and aggressive behaviors of patients with chronic schizophrenia. |
1996-10-28 |
2023-08-12 |
Not clear |
| R G Hammock, S R Schroeder, W R Levin. The effect of clozapine on self-injurious behavior. Journal of autism and developmental disorders. vol 25. issue 6. 1996-10-25. PMID:8720030. |
clozapine, a neuroleptic recently introduced in the united states, has proven effective in treatment of refractory cases of schizophrenia and is known to have an affinity for blocking d1 receptors. |
1996-10-25 |
2023-08-12 |
human |
| H C Liu, W H Chang, F C Wei, S K Lin, S K Lin, M W Jan. Monitoring of plasma clozapine levels and its metabolites in refractory schizophrenic patients. Therapeutic drug monitoring. vol 18. issue 2. 1996-10-21. PMID:8721285. |
plasma concentrations of clozapine and its metabolites desmethylclozapine and clozapine n-oxide were measured in 61 patients with refractory schizophrenia. |
1996-10-21 |
2023-08-12 |
Not clear |
| Y Talmon, N Guy, N Wittenber. [Clozapine for resistant schizophrenia and characteristics of those responding]. Harefuah. vol 129. issue 11. 1996-10-18. PMID:8846949. |
[clozapine for resistant schizophrenia and characteristics of those responding]. |
1996-10-18 |
2023-08-12 |
Not clear |
| Y Talmon, N Guy, N Wittenber. [Clozapine for resistant schizophrenia and characteristics of those responding]. Harefuah. vol 129. issue 11. 1996-10-18. PMID:8846949. |
clozapine (leponex) is an atypical antipsychotic drug which is effective in the treatment of resistant schizophrenia. |
1996-10-18 |
2023-08-12 |
Not clear |
| M S Sodhi, M J Arranz, D Curtis, D M Ball, P Sham, G W Roberts, J Price, D A Collier, R W Kerwi. Association between clozapine response and allelic variation in the 5-HT2C receptor gene. Neuroreport. vol 7. issue 1. 1996-10-17. PMID:8742444. |
we investigated this polymorphism in subjects with schizophrenia resistant to conventional neuroleptic drugs, and analysed our data for allelic association between the disease state or clinical response to the atypical antipsychotic drug, clozapine. |
1996-10-17 |
2023-08-12 |
human |
| M S Sodhi, M J Arranz, D Curtis, D M Ball, P Sham, G W Roberts, J Price, D A Collier, R W Kerwi. Association between clozapine response and allelic variation in the 5-HT2C receptor gene. Neuroreport. vol 7. issue 1. 1996-10-17. PMID:8742444. |
there was no association between schizophrenia and the 5-ht2cser allele, but our results indicate that the 5-ht2c receptor may contain the major site of action through which clozapine mediates its antipsychotic effects. |
1996-10-17 |
2023-08-12 |
human |
| M Avnon, J Rabinowit. Effectiveness of clozapine in hospitalised people with chronic neuroleptic-resistant schizophrenia. The British journal of psychiatry : the journal of mental science. vol 167. issue 6. 1996-10-17. PMID:8829743. |
effectiveness of clozapine in hospitalised people with chronic neuroleptic-resistant schizophrenia. |
1996-10-17 |
2023-08-12 |
Not clear |