| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan M Manzaneque, Paul F Brain, Jose F Navarr. Effect of low doses of clozapine on behaviour of isolated and group-housed male mice in the elevated plus-maze test. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 2. 2002-07-22. PMID:11817513. |
clozapine is effective over a low and narrow dose range in the treatment of the negative symptoms of schizophrenia. |
2002-07-22 |
2023-08-12 |
mouse |
| Glen L Stimmel, Mary A Gutierrez, Vivian Le. Ziprasidone: an atypical antipsychotic drug for the treatment of schizophrenia. Clinical therapeutics. vol 24. issue 1. 2002-07-10. PMID:11833834. |
over the past decade, use of the atypical antipsychotic drugs clozapine, risperidone, olanzapine, and quetiapine has significantly changed the treatment of schizophrenia in the united states. |
2002-07-10 |
2023-08-12 |
Not clear |
| Long Chen, Charles R Yan. Interaction of dopamine D1 and NMDA receptors mediates acute clozapine potentiation of glutamate EPSPs in rat prefrontal cortex. Journal of neurophysiology. vol 87. issue 5. 2002-06-28. PMID:11976371. |
the atypical antipsychotic drug clozapine effectively alleviates both negative and positive symptoms of schizophrenia via unclear cellular mechanisms. |
2002-06-28 |
2023-08-12 |
rat |
| Long Chen, Charles R Yan. Interaction of dopamine D1 and NMDA receptors mediates acute clozapine potentiation of glutamate EPSPs in rat prefrontal cortex. Journal of neurophysiology. vol 87. issue 5. 2002-06-28. PMID:11976371. |
this sequence of early synaptic events induced by acute clozapine may comprise part of the activity that leads to later cognitive improvement in schizophrenia. |
2002-06-28 |
2023-08-12 |
rat |
| S Avissar, G Roitman, G Schreibe. Differential effects of the antipsychotics haloperidol and clozapine on G protein measures in mononuclear leukocytes of patients with schizophrenia. Cellular and molecular neurobiology. vol 21. issue 6. 2002-06-25. PMID:12043849. |
differential effects of the antipsychotics haloperidol and clozapine on g protein measures in mononuclear leukocytes of patients with schizophrenia. |
2002-06-25 |
2023-08-12 |
Not clear |
| S Avissar, G Roitman, G Schreibe. Differential effects of the antipsychotics haloperidol and clozapine on G protein measures in mononuclear leukocytes of patients with schizophrenia. Cellular and molecular neurobiology. vol 21. issue 6. 2002-06-25. PMID:12043849. |
the present study aims at investigating the effect of antipsychotic medications on dopamine-induced gs protein hyperfunction in schizophrenia comparing the classical antipsychotic haloperidol and the newer antipsychotic clozapine, which is devoid of extrapyramidal side effects, on g protein measures. |
2002-06-25 |
2023-08-12 |
Not clear |
| Robert M Bilder, Robert S Goldman, Jan Volavka, Pal Czobor, Matthew Hoptman, Brian Sheitman, Jean-Pierre Lindenmayer, Leslie Citrome, Joseph McEvoy, Michal Kunz, Miranda Chakos, Thomas B Cooper, Terri L Horowitz, Jeffrey A Lieberma. Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder. The American journal of psychiatry. vol 159. issue 6. 2002-06-21. PMID:12042192. |
neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder. |
2002-06-21 |
2023-08-12 |
Not clear |
| Daniel S Umbricht, William C Wirshing, Donna A Wirshing, Marjorie McMeniman, Nina R Schooler, Stephen R Marder, John M Kan. Clinical predictors of response to clozapine treatment in ambulatory patients with schizophrenia. The Journal of clinical psychiatry. vol 63. issue 5. 2002-06-06. PMID:12019667. |
clinical predictors of response to clozapine treatment in ambulatory patients with schizophrenia. |
2002-06-06 |
2023-08-12 |
Not clear |
| Michael Maes, Luisella Bocchio Chiavetto, Stefano Bignotti, Giani-Jean Battisa Tura, Rosaria Pioli, Francesco Boin, Gunter Kenis, Eugene Bosmans, Raf de Jongh, Carlo A Altamur. Increased serum interleukin-8 and interleukin-10 in schizophrenic patients resistant to treatment with neuroleptics and the stimulatory effects of clozapine on serum leukemia inhibitory factor receptor. Schizophrenia research. vol 54. issue 3. 2002-06-04. PMID:11950553. |
it is concluded that: (1) schizophrenia is characterized by an activation of both pro-inflammatory and anti-inflammatory aspects of cell-mediated immunity; (2) prolonged treatment with atypical antipsychotics may increase the anti-inflammatory capacity of the serum in schizophrenic patients by increasing serum lif-r concentrations; and (3) short-term treatment with clozapine may induce signs of immune activation which disappear upon prolonged treatment. |
2002-06-04 |
2023-08-12 |
human |
| Mary C Borovicka, Matthew A Fuller, P Eric Konicki, John C White, Vickie M Steele, George E Jaski. Phenylpropanolamine appears not to promote weight loss in patients with schizophrenia who have gained weight during clozapine treatment. The Journal of clinical psychiatry. vol 63. issue 4. 2002-05-31. PMID:12000209. |
phenylpropanolamine appears not to promote weight loss in patients with schizophrenia who have gained weight during clozapine treatment. |
2002-05-31 |
2023-08-12 |
Not clear |
| V Raitasu. [Clozapine in the treatment of schizophrenia]. Duodecim; laaketieteellinen aikakauskirja. vol 116. issue 11. 2002-05-24. PMID:11989005. |
[clozapine in the treatment of schizophrenia]. |
2002-05-24 |
2023-08-12 |
Not clear |
| K Zavitsanou, X F Huan. Decreased [(3)H]spiperone binding in the anterior cingulate cortex of schizophrenia patients: an autoradiographic study. Neuroscience. vol 109. issue 4. 2002-05-23. PMID:11927153. |
competition experiments were performed in order to examine the pharmacological profile of [(3)h]spiperone binding, and revealed that: (i) displacement of [(3)h]spiperone binding by clozapine and mianserin was significantly reduced in the schizophrenia group as compared to the control group (-26% and -16% respectively); (ii) the order of displacement potency of the drugs tested was: haloperidol>mianserin>butaclamol approximately risperidone>clozapine>2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene. |
2002-05-23 |
2023-08-12 |
Not clear |
| C J Hong, Y W Yu, C H Lin, C Y Cheng, S J Tsa. Association analysis for NMDA receptor subunit 2B (GRIN2B) genetic variants and psychopathology and clozapine response in schizophrenia. Psychiatric genetics. vol 11. issue 4. 2002-05-17. PMID:11807413. |
association analysis for nmda receptor subunit 2b (grin2b) genetic variants and psychopathology and clozapine response in schizophrenia. |
2002-05-17 |
2023-08-12 |
Not clear |
| C J Hong, Y W Yu, C H Lin, C Y Cheng, S J Tsa. Association analysis for NMDA receptor subunit 2B (GRIN2B) genetic variants and psychopathology and clozapine response in schizophrenia. Psychiatric genetics. vol 11. issue 4. 2002-05-17. PMID:11807413. |
it has also been demonstrated that the level of an ionotropic n-methyl-d-aspartate 2b subunit (grin2b) of the glutamate receptor tends to increase after subchronic administration of clozapine, suggesting that grin2b may play an active role in the pathogenesis of schizophrenia and the function of clozapine medication. |
2002-05-17 |
2023-08-12 |
Not clear |
| V Ozdemir, W Kalow, A B Okey, M S Lam, L J Albers, C Reist, J Fourie, P Posner, E J Collins, R Ro. Treatment-resistance to clozapine in association with ultrarapid CYP1A2 activity and the C-->A polymorphism in intron 1 of the CYP1A2 gene: effect of grapefruit juice and low-dose fluvoxamine. Journal of clinical psychopharmacology. vol 21. issue 6. 2002-05-07. PMID:11763009. |
antipsychotic response to clozapine varies markedly among patients with schizophrenia. |
2002-05-07 |
2023-08-12 |
Not clear |
| Sudabeh Shirazi-Southall, Dana Ellen Rodriguez, George G Nomiko. Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 26. issue 5. 2002-05-07. PMID:11927183. |
thus, olanzapine and clozapine increased ach to a greater extent than other tested antipsychotics, explaining perhaps their purported beneficial effect in cognitive function in schizophrenia. |
2002-05-07 |
2023-08-12 |
rat |
| G Saba, G Dumortier, K Kalalou, R Benadhira, K Degrassat, J Glikman, D Janue. Lamotrigine--clozapine combination in refractory schizophrenia: three cases. The Journal of neuropsychiatry and clinical neurosciences. vol 14. issue 1. 2002-05-02. PMID:11884664. |
lamotrigine--clozapine combination in refractory schizophrenia: three cases. |
2002-05-02 |
2023-08-12 |
Not clear |
| Pierre-Michel Llorca, Christophe Lancon, Béatrice Disdier, Jean Farisse, Christophe Sapin, Pascal Auquie. Effectiveness of clozapine in neuroleptic-resistant schizophrenia: clinical response and plasma concentrations. Journal of psychiatry & neuroscience : JPN. vol 27. issue 1. 2002-04-09. PMID:11836974. |
effectiveness of clozapine in neuroleptic-resistant schizophrenia: clinical response and plasma concentrations. |
2002-04-09 |
2023-08-12 |
Not clear |
| Pierre-Michel Llorca, Christophe Lancon, Béatrice Disdier, Jean Farisse, Christophe Sapin, Pascal Auquie. Effectiveness of clozapine in neuroleptic-resistant schizophrenia: clinical response and plasma concentrations. Journal of psychiatry & neuroscience : JPN. vol 27. issue 1. 2002-04-09. PMID:11836974. |
to assess the relation between plasma concentrations of clozapine and its 2 main metabolites desmethyl clozapine and clozapine n-oxide, and clinical change in a sample of inpatients with schizophrenia who were resistant to conventional neuroleptics. |
2002-04-09 |
2023-08-12 |
Not clear |
| E Lindström, T Lewander, U Malm, U F Malt, H Lublin, U G Ahlfor. Patient-rated versus clinician-rated side effects of drug treatment in schizophrenia. Clinical validation of a self-rating version of the UKU Side Effect Rating Scale (UKU-SERS-Pat). Nordic journal of psychiatry. vol 55 Suppl 44. 2002-04-04. PMID:11860666. |
the patient sample consisted of 63 patients with schizophrenia under maintenance treatment with risperidone, clozapine or classical antipsychotics. |
2002-04-04 |
2023-08-12 |
Not clear |