| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hreinn Stefansson, Engilbert Sigurdsson, Valgerdur Steinthorsdottir, Soley Bjornsdottir, Thordur Sigmundsson, Shyamali Ghosh, Jon Brynjolfsson, Steinunn Gunnarsdottir, Omar Ivarsson, Thomas T Chou, Omar Hjaltason, Birgitta Birgisdottir, Helgi Jonsson, Vala G Gudnadottir, Elsa Gudmundsdottir, Asgeir Bjornsson, Brynjolfur Ingvarsson, Andres Ingason, Sigmundur Sigfusson, Hronn Hardardottir, Richard P Harvey, Donna Lai, Mingdong Zhou, Daniela Brunner, Vincent Mutel, Acuna Gonzalo, Greg Lemke, Jesus Sainz, Gardar Johannesson, Thorkell Andresson, Daniel Gudbjartsson, Andrei Manolescu, Michael L Frigge, Mark E Gurney, Augustine Kong, Jeffrey R Gulcher, Hannes Petursson, Kari Stefansso. Neuregulin 1 and susceptibility to schizophrenia. American journal of human genetics. vol 71. issue 4. 2002-10-28. PMID:12145742. |
we also demonstrate that the behavioral phenotypes of the nrg1 hypomorphs are partially reversible with clozapine, an atypical antipsychotic drug used to treat schizophrenia. |
2002-10-28 |
2023-08-12 |
mouse |
| Herbert Y Meltze. Commentary on "clinical studies on the mechanism of action of clozapine; the dopamine-serotonin hypothesis of schizophrenia." Psychopharmacology (1989) 99:S18-S27. Psychopharmacology. vol 163. issue 1. 2002-10-16. PMID:12185394. |
commentary on "clinical studies on the mechanism of action of clozapine; the dopamine-serotonin hypothesis of schizophrenia." |
2002-10-16 |
2023-08-12 |
Not clear |
| Carla M Canuso, Jill M Goldstein, Joanne Wojcik, Ree Dawson, Danielle Brandman, Anne Klibanski, Joseph J Schildkraut, Alan I Gree. Antipsychotic medication, prolactin elevation, and ovarian function in women with schizophrenia and schizoaffective disorder. Psychiatry research. vol 111. issue 1. 2002-10-10. PMID:12140115. |
sixteen premenopausal women with schizophrenia and schizoaffective disorder, eight treated with an antipsychotic with prolactin-elevating potential (five with typical antipsychotics and three with risperidone) and eight treated with an antipsychotic with prolactin-sparing potential (seven with olanzapine and one with clozapine), were studied for eight weeks. |
2002-10-10 |
2023-08-12 |
human |
| Herbert Y Meltze. Suicidality in schizophrenia: a review of the evidence for risk factors and treatment options. Current psychiatry reports. vol 4. issue 4. 2002-10-09. PMID:12126596. |
there is significant evidence suggesting that clozapine reduces the suicide rate in patients with schizophrenia and schizoaffective disorder. |
2002-10-09 |
2023-08-12 |
Not clear |
| Herbert Y Meltze. Suicidality in schizophrenia: a review of the evidence for risk factors and treatment options. Current psychiatry reports. vol 4. issue 4. 2002-10-09. PMID:12126596. |
the results support the superiority of clozapine over olanzapine to reduce the risk of suicidality and suggest its use should be considered for all patients with schizophrenia with high risk for suicide. |
2002-10-09 |
2023-08-12 |
Not clear |
| Zoe Thornton-Jones, Joanna C Neill, Gavin P Reynold. The atypical antipsychotic olanzapine enhances ingestive behaviour in the rat: a preliminary study. Journal of psychopharmacology (Oxford, England). vol 16. issue 1. 2002-10-08. PMID:11949769. |
the weight gain associated with several antipsychotic drugs, most notably the newer 'atypical' compounds olanzapine and clozapine, introduces problems of compliance and morbidity in the treatment of schizophrenia. |
2002-10-08 |
2023-08-12 |
rat |
| Scott P Baymiller, Patricia Ball, Robert P McMahon, Robert W Buchana. Weight and blood pressure change during clozapine treatment. Clinical neuropharmacology. vol 25. issue 4. 2002-09-27. PMID:12151907. |
weight gain and mean arterial blood pressure changes were assessed in 61 outpatients with schizophrenia who were randomly assigned to either clozapine or haloperidol in a 10-week parallel group, double-blind study and in 55 patients who chose to continue to receive clozapine in a subsequent 1-year open-label prospective study. |
2002-09-27 |
2023-08-12 |
Not clear |
| Palmiero Monteleone, Michele Fabrazzo, Alfonso Tortorella, Silvestro La Pia, Mario Ma. Pronounced early increase in circulating leptin predicts a lower weight gain during clozapine treatment. Journal of clinical psychopharmacology. vol 22. issue 4. 2002-09-18. PMID:12172344. |
body weight and plasma levels of leptin were prospectively measured in 22 patients (13 men and 9 women) with drug-resistant schizophrenia undergoing a long-term treatment with clozapine. |
2002-09-18 |
2023-08-12 |
Not clear |
| Ines Gaertner, Hans Jorg Gaertner, Reinhard Vonthein, Klaus Diet. Prospective 6-year trial with clozapine: negative symptoms in outpatients with schizophrenia improve despite intermittent positive symptoms. Journal of clinical psychopharmacology. vol 22. issue 4. 2002-09-18. PMID:12172348. |
prospective 6-year trial with clozapine: negative symptoms in outpatients with schizophrenia improve despite intermittent positive symptoms. |
2002-09-18 |
2023-08-12 |
Not clear |
| Paul Oestreiche. Genaissance pharmaceuticals, inc. Pharmacogenomics. vol 3. issue 2. 2002-08-23. PMID:11972448. |
the company has initiated the development of its own pipeline of products -- hap clozapine for schizophrenia and hap statin for cholesterol management -- utilizing its proprietary genetic markers. |
2002-08-23 |
2023-08-12 |
Not clear |
| Nadine Snyder, Gerald Goldstei. Decreased psychopathology & family burden. Associated with clozapine treatment of patients with refractory schizophrenia. Journal of psychosocial nursing and mental health services. vol 40. issue 5. 2002-08-20. PMID:12016691. |
associated with clozapine treatment of patients with refractory schizophrenia. |
2002-08-20 |
2023-08-12 |
Not clear |
| Gwenaëlle Le Pen, Jean-Luc Morea. Disruption of prepulse inhibition of startle reflex in a neurodevelopmental model of schizophrenia: reversal by clozapine, olanzapine and risperidone but not by haloperidol. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 1. 2002-08-08. PMID:12062902. |
disruption of prepulse inhibition of startle reflex in a neurodevelopmental model of schizophrenia: reversal by clozapine, olanzapine and risperidone but not by haloperidol. |
2002-08-08 |
2023-08-12 |
rat |
| Igor Elman, David S Goldstein, Alan I Green, Graeme Eisenhofer, Carol J Folio, Courtney S Holmes, David Pickar, Alan Breie. Effects of risperidone on the peripheral noradrenegic system in patients with schizophrenia: a comparison with clozapine and placebo. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 2. 2002-08-07. PMID:12093603. |
effects of risperidone on the peripheral noradrenegic system in patients with schizophrenia: a comparison with clozapine and placebo. |
2002-08-07 |
2023-08-12 |
Not clear |
| Hassan S Dinakar, Robert N Sobel, James H Bopp, Anita Daniels, Sondra Maur. Efficacy of olanzapine and risperidone for treatment-refractory schizophrenia among long-stay state hospital patients. Psychiatric services (Washington, D.C.). vol 53. issue 6. 2002-08-01. PMID:12045315. |
the authors studied the efficacy of olanzapine and risperidone among patients with treatment-refractory schizophrenia who had been hospitalized for more than five years and who were not suitable candidates for a clozapine trial. |
2002-08-01 |
2023-08-12 |
Not clear |
| Arja Tuunainen, Kristian Wahlbeck, Simon Gilbod. Newer atypical antipsychotic medication in comparison to clozapine: a systematic review of randomized trials. Schizophrenia research. vol 56. issue 1-2. 2002-07-31. PMID:12084413. |
the aim of this study was to evaluate the effectiveness of newer atypical antipsychotic drugs in comparison to clozapine for schizophrenia. |
2002-07-31 |
2023-08-12 |
Not clear |
| G W Eschweiler, M Bartels, G Längle, B Wild, I Gaertner, M Nickol. Heart-rate variability (HRV) in the ECG trace of routine EEGs: fast monitoring for the anticholinergic effects of clozapine and olanzapine? Pharmacopsychiatry. vol 35. issue 3. 2002-07-31. PMID:12107853. |
the plasma concentrations of the atypical antipsychotics clozapine and olanzapine correlated with parameters of hrv in 59 patients suffering from schizophrenia or schizoaffective disorder. |
2002-07-31 |
2023-08-12 |
Not clear |
| K Raaska, V Raitasuo, P J Neuvone. Effect of influenza vaccination on serum clozapine and its main metabolite concentrations in patients with schizophrenia. European journal of clinical pharmacology. vol 57. issue 10. 2002-07-23. PMID:11829199. |
effect of influenza vaccination on serum clozapine and its main metabolite concentrations in patients with schizophrenia. |
2002-07-23 |
2023-08-12 |
Not clear |
| K Raaska, V Raitasuo, P J Neuvone. Effect of influenza vaccination on serum clozapine and its main metabolite concentrations in patients with schizophrenia. European journal of clinical pharmacology. vol 57. issue 10. 2002-07-23. PMID:11829199. |
to study the effect of influenza vaccine on serum clozapine, n-desmethylclozapine and clozapine-n-oxide steady-state concentrations in patients with schizophrenia. |
2002-07-23 |
2023-08-12 |
Not clear |
| Dalu Mancama, Maria J Arranz, Robert W Kerwi. Genetic predictors of therapeutic response to clozapine: current status of research. CNS drugs. vol 16. issue 5. 2002-07-23. PMID:11994021. |
clozapine is one of the most clinically potent drugs currently available for treating the symptoms of schizophrenia. |
2002-07-23 |
2023-08-12 |
Not clear |
| Thomas A Pugsley, Yu Hsin Shih, Steven Z Whetzel, Kim Zoski, Don Van Leeuwen, Hyacinth Akunne, R Mackenzie, Thomas G Heffner, David Wustrow, Lawrence D Wis. The discovery of PD 89211 and related compounds: selective dopamine D4 receptor antagonists. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 2. 2002-07-22. PMID:11817497. |
the da d4 receptor is of interest as a target for drugs to treat schizophrenia based upon its high affinity for the atypical antipsychotic clozapine and its localization to the limbic and cortical regions of the brain. |
2002-07-22 |
2023-08-12 |
mouse |