| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Uriel Heresco-Lev. Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 7. 2004-02-24. PMID:14642971. |
furthermore, the results of the first generation of clinical trials with glycine (gly) site agonists of the nmda receptor in schizophrenia suggest that this type of compounds (1) have efficacy and side effects profiles different than those of conventional neuroleptics and (2) differ in their synergic effects when used in addition to conventional neuroleptics versus clozapine and possibly additional atypical antipsychotics. |
2004-02-24 |
2023-08-12 |
Not clear |
| Tonmoy Sharma, Catherine Hughes, William Soni, Veena Kumar. Cognitive effects of olanzapine and clozapine treatment in chronic schizophrenia. Psychopharmacology. vol 169. issue 3-4. 2004-02-23. PMID:12845415. |
cognitive effects of olanzapine and clozapine treatment in chronic schizophrenia. |
2004-02-23 |
2023-08-12 |
Not clear |
| Uriel Heresco-Levy, Marina Ermilov, Pesah Lichtenberg, Gali Bar, Daniel C Javit. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biological psychiatry. vol 55. issue 2. 2004-02-23. PMID:14732596. |
clinical trials indicate that glycine site agonists of the n-methyl-d-aspartate (nmda) receptors may reduce negative and cognitive symptoms in treatment-resistant schizophrenia when used as adjuvants to conventional antipsychotics but possibly not to clozapine. |
2004-02-23 |
2023-08-12 |
Not clear |
| Istvan Bitter, Martin R K Dossenbach, Shlomo Brook, Peter D Feldman, Stephen Metcalfe, Carlo A Gagiano, János Füredi, György Bartko, Zoltan Janka, Csaba M Banki, Gabor Kovacs, Alan Breie. Olanzapine versus clozapine in treatment-resistant or treatment-intolerant schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 28. issue 1. 2004-02-18. PMID:14687871. |
olanzapine versus clozapine in treatment-resistant or treatment-intolerant schizophrenia. |
2004-02-18 |
2023-08-12 |
Not clear |
| Istvan Bitter, Martin R K Dossenbach, Shlomo Brook, Peter D Feldman, Stephen Metcalfe, Carlo A Gagiano, János Füredi, György Bartko, Zoltan Janka, Csaba M Banki, Gabor Kovacs, Alan Breie. Olanzapine versus clozapine in treatment-resistant or treatment-intolerant schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 28. issue 1. 2004-02-18. PMID:14687871. |
clozapine has been the gold standard for treatment of patients with refractory schizophrenia but is associated with serious safety liabilities. |
2004-02-18 |
2023-08-12 |
Not clear |
| Istvan Bitter, Martin R K Dossenbach, Shlomo Brook, Peter D Feldman, Stephen Metcalfe, Carlo A Gagiano, János Füredi, György Bartko, Zoltan Janka, Csaba M Banki, Gabor Kovacs, Alan Breie. Olanzapine versus clozapine in treatment-resistant or treatment-intolerant schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 28. issue 1. 2004-02-18. PMID:14687871. |
this 18-week, randomized, double-blind, parallel study compared treatment with either olanzapine (5-25 mg/day, n=75) or clozapine (100-500 mg/day, n=72) in patients with schizophrenia who were nonresponsive to, or intolerant of, standard acceptable antipsychotic therapy. |
2004-02-18 |
2023-08-12 |
Not clear |
| Adrienne C Lahti, Henry H Holcomb, Martin A Weiler, Deborah R Medoff, Kristin N Frey, Michael Hardin, Carol A Tamming. Clozapine but not haloperidol Re-establishes normal task-activated rCBF patterns in schizophrenia within the anterior cingulate cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 1. 2004-02-17. PMID:14520337. |
clozapine but not haloperidol re-establishes normal task-activated rcbf patterns in schizophrenia within the anterior cingulate cortex. |
2004-02-17 |
2023-08-12 |
human |
| Adrienne C Lahti, Henry H Holcomb, Martin A Weiler, Deborah R Medoff, Kristin N Frey, Michael Hardin, Carol A Tamming. Clozapine but not haloperidol Re-establishes normal task-activated rCBF patterns in schizophrenia within the anterior cingulate cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 1. 2004-02-17. PMID:14520337. |
using positron emission tomography (pet) with (15)o water, we compared task-induced rcbf patterns induced by haloperidol or clozapine in individuals with schizophrenia. |
2004-02-17 |
2023-08-12 |
human |
| Adrienne C Lahti, Henry H Holcomb, Martin A Weiler, Deborah R Medoff, Kristin N Frey, Michael Hardin, Carol A Tamming. Clozapine but not haloperidol Re-establishes normal task-activated rCBF patterns in schizophrenia within the anterior cingulate cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 1. 2004-02-17. PMID:14520337. |
the pattern seen in the haloperidol-treated sv group was similar to the unmedicated sv group in that acc activation was seen during the control task and no further activation was seen during the dec. we report that clozapine, but not haloperidol, normalizes anterior cingulate rcbf patterns in schizophrenia during a cognitive task. |
2004-02-17 |
2023-08-12 |
human |
| Ann M Mortime. Antipsychotic treatment in schizophrenia: atypical options and NICE guidance. European psychiatry : the journal of the Association of European Psychiatrists. vol 18. issue 5. 2004-02-06. PMID:12927321. |
following the reintroduction of clozapine, several atypical antipsychotics have become available for the treatment of schizophrenia. |
2004-02-06 |
2023-08-12 |
Not clear |
| A Urban, J Libiger, L Hosák, K Kupk. Comorbidity of parkinsonism and schizophrenia in a patient treated with clozapine. European psychiatry : the journal of the Association of European Psychiatrists. vol 18. issue 5. 2004-02-06. PMID:12927328. |
comorbidity of parkinsonism and schizophrenia in a patient treated with clozapine. |
2004-02-06 |
2023-08-12 |
Not clear |
| Svetlana Semenova, Athina Marko. Clozapine treatment attenuated somatic and affective signs of nicotine and amphetamine withdrawal in subsets of rats exhibiting hyposensitivity to the initial effects of clozapine. Biological psychiatry. vol 54. issue 11. 2004-02-04. PMID:14643093. |
based on the phenomenologic similarity between symptoms of drug withdrawal and the negative symptoms of schizophrenia (e.g., anhedonia), we hypothesized that treatment with clozapine may be effective against nicotine and amphetamine withdrawal. |
2004-02-04 |
2023-08-12 |
rat |
| Nadeem H Bhanji, Howard C Margolese, Guy Chouinard, Luc Turnie. Late-onset agranulocytosis in a patient with schizophrenia after 17 months of clozapine treatment. Journal of clinical psychopharmacology. vol 23. issue 5. 2004-01-30. PMID:14520134. |
late-onset agranulocytosis in a patient with schizophrenia after 17 months of clozapine treatment. |
2004-01-30 |
2023-08-12 |
Not clear |
| Vicente Molina, Santiago Reig, Fernando Sarramea, Javier Sanz, Juan Francisco Artaloytia, Rogelio Luque, María Aragüés, Javier Pascau, Carlos Benito, Tomás Palomo, Manuel Desc. Anatomical and functional brain variables associated with clozapine response in treatment-resistant schizophrenia. Psychiatry research. vol 124. issue 3. 2004-01-29. PMID:14623067. |
anatomical and functional brain variables associated with clozapine response in treatment-resistant schizophrenia. |
2004-01-29 |
2023-08-12 |
Not clear |
| Verinder Sharm. Atypical antipsychotics and suicide in mood and anxiety disorders. Bipolar disorders. vol 5 Suppl 2. 2004-01-26. PMID:14700012. |
in addition, data in patients with schizophrenia have demonstrated a significant improvement in the incidence of suicidal behavior with clozapine compared with olanzapine. |
2004-01-26 |
2023-08-12 |
Not clear |
| Arturo Borzutzky, Esteban Avello, Hana Rumie, Enrique Pari. Accidental clozapine intoxication in a ten-year-old child. Veterinary and human toxicology. vol 45. issue 6. 2004-01-16. PMID:14640481. |
clozapine is a tricyclic dibenzodiazepine derivative used commonly in the treatment of schizophrenia. |
2004-01-16 |
2023-08-12 |
Not clear |
| Bruno Müller-Oerlinghausen, Anne Berghöfer, Bernd Ahren. The antisuicidal and mortality-reducing effect of lithium prophylaxis: consequences for guidelines in clinical psychiatry. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 48. issue 7. 2004-01-15. PMID:12971012. |
clozapine appears to reduce the suicide rate in schizophrenia patients. |
2004-01-15 |
2023-08-12 |
Not clear |
| William S Stone, Larry J Seidman, Joanne D Wojcik, Alan I Gree. Glucose effects on cognition in schizophrenia. Schizophrenia research. vol 62. issue 1-2. 2004-01-08. PMID:12765749. |
clozapine has been shown to improve verbal declarative memory and other cognitive functions in chronic schizophrenia. |
2004-01-08 |
2023-08-12 |
human |
| William S Stone, Larry J Seidman, Joanne D Wojcik, Alan I Gree. Glucose effects on cognition in schizophrenia. Schizophrenia research. vol 62. issue 1-2. 2004-01-08. PMID:12765749. |
twelve outpatients with schizophrenia who received treatment with clozapine participated in a double-blind, counterbalanced, crossover study. |
2004-01-08 |
2023-08-12 |
human |
| William S Stone, Larry J Seidman, Joanne D Wojcik, Alan I Gree. Glucose effects on cognition in schizophrenia. Schizophrenia research. vol 62. issue 1-2. 2004-01-08. PMID:12765749. |
these findings provide evidence that glucose improves declarative memory in patients with schizophrenia who were treated with clozapine, and underscore the possibility of developing effective protocols to reduce cognitive dysfunctions in the disorder. |
2004-01-08 |
2023-08-12 |
human |