| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ann M Mortime. Antipsychotic treatment in schizophrenia: atypical options and NICE guidance. European psychiatry : the journal of the Association of European Psychiatrists. vol 18. issue 5. 2004-02-06. PMID:12927321. |
following the reintroduction of clozapine, several atypical antipsychotics have become available for the treatment of schizophrenia. |
2004-02-06 |
2023-08-12 |
Not clear |
| A Urban, J Libiger, L Hosák, K Kupk. Comorbidity of parkinsonism and schizophrenia in a patient treated with clozapine. European psychiatry : the journal of the Association of European Psychiatrists. vol 18. issue 5. 2004-02-06. PMID:12927328. |
comorbidity of parkinsonism and schizophrenia in a patient treated with clozapine. |
2004-02-06 |
2023-08-12 |
Not clear |
| Svetlana Semenova, Athina Marko. Clozapine treatment attenuated somatic and affective signs of nicotine and amphetamine withdrawal in subsets of rats exhibiting hyposensitivity to the initial effects of clozapine. Biological psychiatry. vol 54. issue 11. 2004-02-04. PMID:14643093. |
based on the phenomenologic similarity between symptoms of drug withdrawal and the negative symptoms of schizophrenia (e.g., anhedonia), we hypothesized that treatment with clozapine may be effective against nicotine and amphetamine withdrawal. |
2004-02-04 |
2023-08-12 |
rat |
| Nadeem H Bhanji, Howard C Margolese, Guy Chouinard, Luc Turnie. Late-onset agranulocytosis in a patient with schizophrenia after 17 months of clozapine treatment. Journal of clinical psychopharmacology. vol 23. issue 5. 2004-01-30. PMID:14520134. |
late-onset agranulocytosis in a patient with schizophrenia after 17 months of clozapine treatment. |
2004-01-30 |
2023-08-12 |
Not clear |
| Vicente Molina, Santiago Reig, Fernando Sarramea, Javier Sanz, Juan Francisco Artaloytia, Rogelio Luque, María Aragüés, Javier Pascau, Carlos Benito, Tomás Palomo, Manuel Desc. Anatomical and functional brain variables associated with clozapine response in treatment-resistant schizophrenia. Psychiatry research. vol 124. issue 3. 2004-01-29. PMID:14623067. |
anatomical and functional brain variables associated with clozapine response in treatment-resistant schizophrenia. |
2004-01-29 |
2023-08-12 |
Not clear |
| Verinder Sharm. Atypical antipsychotics and suicide in mood and anxiety disorders. Bipolar disorders. vol 5 Suppl 2. 2004-01-26. PMID:14700012. |
in addition, data in patients with schizophrenia have demonstrated a significant improvement in the incidence of suicidal behavior with clozapine compared with olanzapine. |
2004-01-26 |
2023-08-12 |
Not clear |
| Arturo Borzutzky, Esteban Avello, Hana Rumie, Enrique Pari. Accidental clozapine intoxication in a ten-year-old child. Veterinary and human toxicology. vol 45. issue 6. 2004-01-16. PMID:14640481. |
clozapine is a tricyclic dibenzodiazepine derivative used commonly in the treatment of schizophrenia. |
2004-01-16 |
2023-08-12 |
Not clear |
| Bruno Müller-Oerlinghausen, Anne Berghöfer, Bernd Ahren. The antisuicidal and mortality-reducing effect of lithium prophylaxis: consequences for guidelines in clinical psychiatry. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 48. issue 7. 2004-01-15. PMID:12971012. |
clozapine appears to reduce the suicide rate in schizophrenia patients. |
2004-01-15 |
2023-08-12 |
Not clear |
| William S Stone, Larry J Seidman, Joanne D Wojcik, Alan I Gree. Glucose effects on cognition in schizophrenia. Schizophrenia research. vol 62. issue 1-2. 2004-01-08. PMID:12765749. |
clozapine has been shown to improve verbal declarative memory and other cognitive functions in chronic schizophrenia. |
2004-01-08 |
2023-08-12 |
human |
| William S Stone, Larry J Seidman, Joanne D Wojcik, Alan I Gree. Glucose effects on cognition in schizophrenia. Schizophrenia research. vol 62. issue 1-2. 2004-01-08. PMID:12765749. |
twelve outpatients with schizophrenia who received treatment with clozapine participated in a double-blind, counterbalanced, crossover study. |
2004-01-08 |
2023-08-12 |
human |
| William S Stone, Larry J Seidman, Joanne D Wojcik, Alan I Gree. Glucose effects on cognition in schizophrenia. Schizophrenia research. vol 62. issue 1-2. 2004-01-08. PMID:12765749. |
these findings provide evidence that glucose improves declarative memory in patients with schizophrenia who were treated with clozapine, and underscore the possibility of developing effective protocols to reduce cognitive dysfunctions in the disorder. |
2004-01-08 |
2023-08-12 |
human |
| Ola Gefvert, Leif H Lindström, Nicholas Waters, Susanna Waters, Arvid Carlsson, Joakim Tedrof. Different corticostriatal patterns of L-DOPA utilization in patients with untreated schizophrenia and patients treated with classical antipsychotics or clozapine. Scandinavian journal of psychology. vol 44. issue 3. 2004-01-06. PMID:12914593. |
different corticostriatal patterns of l-dopa utilization in patients with untreated schizophrenia and patients treated with classical antipsychotics or clozapine. |
2004-01-06 |
2023-08-12 |
human |
| Ola Gefvert, Leif H Lindström, Nicholas Waters, Susanna Waters, Arvid Carlsson, Joakim Tedrof. Different corticostriatal patterns of L-DOPA utilization in patients with untreated schizophrenia and patients treated with classical antipsychotics or clozapine. Scandinavian journal of psychology. vol 44. issue 3. 2004-01-06. PMID:12914593. |
stable optimal treatment with either classical neuroleptics or clozapine partially, albeit differentially, reversed the aberrant patterns seen in drug-free schizophrenia. |
2004-01-06 |
2023-08-12 |
human |
| Ola Gefvert, Leif H Lindström, Nicholas Waters, Susanna Waters, Arvid Carlsson, Joakim Tedrof. Different corticostriatal patterns of L-DOPA utilization in patients with untreated schizophrenia and patients treated with classical antipsychotics or clozapine. Scandinavian journal of psychology. vol 44. issue 3. 2004-01-06. PMID:12914593. |
treatment with clozapine or classical neuroleptics induces partial, albeit differential, normalization of the abnormal patterns seen in untreated schizophrenia. |
2004-01-06 |
2023-08-12 |
human |
| Douglas L Noordsy, Alan I Gree. Pharmacotherapy for schizophrenia and co-occurring substance use disorders. Current psychiatry reports. vol 5. issue 5. 2004-01-06. PMID:13678553. |
the preferential use of novel antipsychotics, a lower threshold for prescription of clozapine, the use of bupropion for smoking cessation, careful monitoring of compliance, and possible use of other medications for substance use disorders when indicated are recommended in pharmacologic management for people with co-occurring substance use disorders and schizophrenia. |
2004-01-06 |
2023-08-12 |
Not clear |
| Cyrille Sur, Pierre J Mallorga, Marion Wittmann, Marlene A Jacobson, Danette Pascarella, Jacinta B Williams, Philip E Brandish, Douglas J Pettibone, Edward M Scolnick, P Jeffrey Con. N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14595031. |
the molecular and neuronal substrates conferring on clozapine its unique and superior efficacy in the treatment of schizophrenia remain elusive. |
2004-01-05 |
2023-08-12 |
human |
| B J Turner, A Rembach, R Spark, E C Lopes, S S Cheem. Opposing effects of low and high-dose clozapine on survival of transgenic amyotrophic lateral sclerosis mice. Journal of neuroscience research. vol 74. issue 4. 2003-12-23. PMID:14598305. |
clozapine is a potent atypical neuroleptic or antipsychotic agent used to relieve symptoms of early-diagnosed schizophrenia. |
2003-12-23 |
2023-08-12 |
mouse |
| Lilly Schwieler, Sophie Erhard. Inhibitory action of clozapine on rat ventral tegmental area dopamine neurons following increased levels of endogenous kynurenic acid. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 10. 2003-12-05. PMID:12865892. |
in the present in vivo electrophysiological study, we investigate the effects of haloperidol (a typical antipsychotic drug) and clozapine on ventral tegmental area (vta) dopamine (da) neurons in a situation of hyperdopaminergic activity in order to mimic tentatively a condition similar to that seen in schizophrenia. |
2003-12-05 |
2023-08-12 |
rat |
| Lilly Schwieler, Sophie Erhard. Inhibitory action of clozapine on rat ventral tegmental area dopamine neurons following increased levels of endogenous kynurenic acid. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 10. 2003-12-05. PMID:12865892. |
such an effect of clozapine may be related to its unique effect in also ameliorating negative symptoms of schizophrenia. |
2003-12-05 |
2023-08-12 |
rat |
| Chen-Jee Hong, Younger W-Y Yu, Ching-Hua Lin, Shih-Jen Tsa. An association study of a brain-derived neurotrophic factor Val66Met polymorphism and clozapine response of schizophrenic patients. Neuroscience letters. vol 349. issue 3. 2003-12-04. PMID:12951204. |
the present study tested the hypothesis that the bdnf-gene val66met polymorphism is associated with schizophrenia and clozapine's therapeutic response. |
2003-12-04 |
2023-08-12 |
Not clear |